This document discusses organizational change and how to ensure successful change. It begins by outlining some key questions about change including what and why change is needed, how to ensure successful change, and how to manage change in a fast-paced business environment. It then provides examples of changes made in the pharmaceutical industry and challenges to change. Finally, it discusses keys to successful change including conducting root cause analysis, setting goals and communication, and implementing effective measurement systems with technology. The most important key is said to be supporting leadership through training, mentoring, and rewards while also implementing proper change management practices.