This document presents two case studies of patients seen in rheumatology clinics with various musculoskeletal and gastrointestinal symptoms. Case 1 is a 54-year-old woman with back, hip and ankle pain who is found to have spondyloarthritis likely related to inflammatory bowel disease. Case 2 is a 29-year-old woman with neck stiffness, back pain, and diarrhea who is diagnosed with spondyloarthritis related to psoriasis or inflammatory bowel disease. Both patients undergo testing including imaging and are treated with medications.