Back pain is a common problem that affects up to 90% of the population. It can be classified as acute (less than 6 weeks), subacute (6-12 weeks), or chronic (more than 12 weeks). Red flags on history and exam can indicate more serious underlying causes like cancer, infection, or fracture that require further evaluation. For nonspecific back pain without red flags, treatment focuses on analgesics, activity modification, and physical modalities. Referral is considered if red flags are present, pain persists after 4-6 weeks, or neurological deficits develop.
Differential Diagnosis of Lower Back Painwestwriters
Low back pain is pain, muscle tension, or stiffness localized below the costal margin and above the inferior gluteal folds, with or without sciatica, and is defined as chronic when it persists for 12 weeks or more.
Differential Diagnosis of Lower Back Painwestwriters
Low back pain is pain, muscle tension, or stiffness localized below the costal margin and above the inferior gluteal folds, with or without sciatica, and is defined as chronic when it persists for 12 weeks or more.
Detailed history and its evaluation , examination of spine in general and local with special tests in cervical , thoracic outlet syndrome , lumbar spine and SI joint with diagrams, neurological examination both sensory and motor.
Back pain
Etiology
Anatomical & pathophysiological concepts
Diagnostic approach
Clinical approach
Red flags & yellow flags
Investigations
Back pain in children & elderly
The evaluation of back pain can be a pain in the neck or a back-breaking exercise, so to speak. However, the diagnosis hinges always on a focused History and Physical Exam and not really on labs or imaging. Knowing what to ask and where to look can make the evaluation of this all-too-common condition manageable for the internist.
This lecture focuses on the evaluation of low back pain and will guide the reader on the key points in the Hx and PE and prevent unnecessary testing/imaging. It also presents 3 "unusual" cases of low back pain which may be disabling if not recognized immediately.
Detailed history and its evaluation , examination of spine in general and local with special tests in cervical , thoracic outlet syndrome , lumbar spine and SI joint with diagrams, neurological examination both sensory and motor.
Back pain
Etiology
Anatomical & pathophysiological concepts
Diagnostic approach
Clinical approach
Red flags & yellow flags
Investigations
Back pain in children & elderly
The evaluation of back pain can be a pain in the neck or a back-breaking exercise, so to speak. However, the diagnosis hinges always on a focused History and Physical Exam and not really on labs or imaging. Knowing what to ask and where to look can make the evaluation of this all-too-common condition manageable for the internist.
This lecture focuses on the evaluation of low back pain and will guide the reader on the key points in the Hx and PE and prevent unnecessary testing/imaging. It also presents 3 "unusual" cases of low back pain which may be disabling if not recognized immediately.
This presentation is a comprehensive summary about all aspects of back pain. Back pain is one of the most common orthopaedic morbidity or orthopedic disability. Sciatica and lumbar disc diseases are common cause of spinal disability. Back pain are divided into Red flags, green flags and yellow flags for quick clinical screening. both treatment, prevention aspects are covered. Spinal anatomy and Biomechanics are covered. Epidemiology and role of various types of spine surgery, microdiscectomy, endoscopic spine surgery are also described.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
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2 Case Reports of Gastric Ultrasound
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
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5th edition of the Diagnostic and Statistical Manual of Mental Disorders
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disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
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of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
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- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
1. Ammar Al-Kashmiri, MDAmmar Al-Kashmiri, MD
Emergency PhysicianEmergency Physician
Khoula HospitalKhoula Hospital
Back Pain Made EZ!
Primary Health Care Physicians Wo
4. Epidemiology
Affects up to 90% of population at some point in
their lives
∼ 4% of emergency department visits
Highest economic burden after heart disease &
stroke
85% have no definite etiology
90% with nonspecific back pain symptoms resolve
within 1 month
5. Risk Factors
Increasing age
Heavy physical work (long periods of static work
postures, heavy lifting, twisting, and vibration)
Psychosocial factors (including work dissatisfaction
and monotonous work)
Depression
Obesity (BMI > 30)
Smoking
Drug abuse
History of headache
7. Nonspecific back pain (majority)
= localized
Back pain + radiculopathy/sciatica
= radiating
Back pain associated with another specific cause
= referred
Classification
8. Clinical Presentation
Ranges :
mild (muscle spasm) → severe/unrelenting (epidural abscess)
NOT important → recognize a particular classic
presentation for various diseases
IMPORTANT → evaluate for the red flags
Identification of red flags will direct whether further
evaluation is required
11. Less Serious Pathology
Spinal fractures
Spinal stenosis
Spondylolysis / spondylolisthesis
Regular disc herniations
usually lateral and compress nerves on one side and
not the cord / cauda
12. Red Flags
History
Age <18,>50
>6 weeks
*Systemic complaints:
fever/chills/night sweats
undesired weight loss
malaise
Trauma (minor in OP, elderly)
Cancer (0.7% → 9%)
Immunocompromise
IVDU
16. Gradual onset of back pain
Malignancy or infection usually progress over weeks to months
Age <18
Congenital, spondylolysis/spondylolisthesis
Age >50
AAA, malignancy, compression fracture
Thoracic back pain
Aortic dissection, SEA, Vertebral osteomyelitis, malignancy
Most common site of malignant spine lesions is thoracic spines
(accounts for 60% of cases)
History
17. History
Pain > 6 weeks
Malignancy, infection, spinal stenosis, spondylolysis
Hx of trauma
Fracture
MVA in normal, fall in elderly/osteoporotic
Fever/chills/night sweats, weight loss
Malignancy or infection
Pain worse when supine
Malignancy or infection
18. History
Pain worse at night
Malignancy or infection
Pain despite good analgesics
Malignancy or infection
Hx of malignancy
Hello? Can you guess?
Hx of immunosup (corticosteroids)
Infection, osteoporosis
19. History
Recent procedure causing bacteremia
Infection
GU or GI procedures
Hx of IV drug abuse
Infection
Bowel or bladder incontinence
SCCS
Saddle numbness
Cauda compression
20. Red Flags
Examination
General appearance
o lies still Vs writhes in pain
Vital signs
o BP : ↑,↓, R to L difference
o Fever
Pulsatile abdominal mass
Spinal process tenderness
Neurological deficits
22. Examination
Fever
Infection BUT fever may not always be present
(especially vertebral osteomyelitis)
Hypotension
Ruptured AAA
Extreme hypertension
AD, especially if thoracic back pain
Pulsatile abdominal mass
AAA
23. Examination
BP difference > 20 mm Hg in arms
AD, but: BP difference > 20mm Hg in arms only
found in 40% of aortic dissections
- 20% of normals have this difference
Spinal process tenderness
Fracture, osteomylelitis, SEA, malignancy
Focal neuro signs
SCCS
24. Examination
Acute urinary incontinence
SCCS / Cauda compression
Actually is overflow incontinence
Check for urinary residual > 150cc post void
Perianal numbness, loss of rectal tone
SCCS / Cauda compression
25. Neurological Examination of the Back
Straight Leg Raise (SLR) Test
Motor
L3-S1
Sensory
L3-S1
Rectal tone
Perianal sensation
Urinary retention
27. SLR
+ SLR ∼ 80% sensitive for herniated
disk at L4-L5/L5-S1 (95% of DH)
Leg passively elevated up to 7o°
+ test = new/worsening pain below
knee along path of a nerve root
between 30-70° of elevation
Reproduction of back pain or pain in
the hamstring is NOT a + test
28. + test can be verified by:
Ankle dorsiflexion
Internal rotation
Head flexion
Crossed SLR
SLR
31. A Word about S1
S1 radiculopathy cause weakness of plantar flexion,
but is difficult to detect until quite advanced
To illicit have the patient raise up on tip-toe three
times in a row, on one foot alone and then the other
32.
33. Waddell Signs
≥3/5 signs more likely to have non-organic disease
Excessive Tenderness
Superficial: Widespread sensitivity to light touch of the
skin over a wide area of the lumbar skin
Nonanatomic: felt over a wide area, not localized to one
structure, and often extends to the thoracic spine,
sacrum, or pelvis
Stimulation
Axial loading: ↑LBP with light pressure on skull while
standing
Rotation: ↑LBP with passive rotation of shoulders and
pelvis in same plane, in standing position
34. Distraction
Inconsistent findings when patient is distracted, most
commonly seen when testing sitting versus supine SLR
Regional Disturbance
Motor: Generalized giving way or cogwheel resistance in
manual muscle
Sensory: Glove or stocking, nondermatomal loss of sensation
Overreaction
Disproportionate verbalization or facial expression with
movement
Assisted movement
Rigid or slow movement
Collapsing
Waddell Signs
35. Caution!
use in conjunction with entire presentation and not
as sole basis of discounting a patient’s symptoms
Waddell Signs
36. Diagnostic Studies
When is a diagnostic work-up required?
When there are no red flags, a good history and physical
examination suffice
When red flags are elucidated, further evaluation is
warranted
38. Plain Radiography
There is a sense among many patients that they should receive
x-rays as part of their evaluation!
Plain radiographs rarely add helpful information in
establishing the diagnosis
X-ray early in the course of LBP do not improve outcomes or
reduce costs of care
They add cost, time and unnecessary radiation
Normal plain films do not exclude malignancy or infection in
patients with a suspicious history
39. Radiation Risks
Gonadal radiation from a two view x-ray of the
lumbar spine = radiation exposure from a CXR taken
daily for > 1 year!!
Oblique views substantially increase risks of
radiation and add little diagnostic information
40. Indications for Back X-rays
Age ≤18 years or ≥50 years
Constitutional symptoms
Pain > 6 weeks
History of traumatic onset
History of malignancy
Osteoporosis
Infectious risk (e.g. IVDU,
immunosuppression, indwelling
urinary catheter, steroids, skin
infection or UTI, recent procedures)
Progressive focal neurologic deficit
41. MRI
Gold standard for evaluation for
epidural compression
syndromes
spinal infection (osteomyelitis
and epidural abscess)
spinal cord injury
intervertebral disk herniation
(may be delayed 4-6 weeks)
*MRI evaluation to provide reassurance does not
lead to better prognosis
42. Management
Nonspecific back pain (∅radiculopathy/∅ red flags)
important to educate patients that they will
respond to conservative management over 4-6
weeks (many respond well after several days)
Approach to treatment is focused:
analgesic medications (combination therapy)
activity modification
physical modalities
44. NSAIDs
Most are equally efficacious
Lowest dose needed to reach pain reduction should
be attempted
COX-2 inhibitors should be used sparingly and only
after discussion with the patient about the risks
Analgesics
45. The most common recommended approach is to use
a combination of Paracetamol and NSAIDs
One suggested regimen =
Paracetamol 500-1000 mg QID
+/-
Ibuprofen 400-800 mg TID
or Naproxen 250-500 mg BID
Analgesics
46. Analgesics
Opiates
Liberal use recommended for patients with
moderate-severe pain
Allows patients to break pain cycle
Gives stronger option when exacerbations of pain
occur
Only for short period (7-10 days) to ↓ development
of dependence
Warn patients of problems of driving
47. Muscle Relaxants
e.g. Diazepam
Cause sedation + addiction with chronic use
May be useful if patient demonstrates significant
muscle spasm of the paraspinal musculature
Exert benefit only in first 4 days when muscular
spasm is at its peak (rarely a significant component
of symptoms after 1st
week of injury)
Analgesics
48. Activity Modification/Physical Modalities
Continue routine activities as tolerated + use pain as guide for
activity modification
Bed rest has no benefit and may ultimately be harmful in the
recovery (not even 2 days!)
Active exercise/back strengthening exercises not beneficial
during acute crisis
Moderate stretching and strengthening of abdominal muscles
and back muscles beneficial when acute pain subsides
Thermal and ice therapy ?marginally effective
49. Other Modalities
None of the following treatments has shown
significant improvement in the recovery rate from
acute LBP:
Traction
Diathermy
Cutaneous laser therapy
Ultrasound
Corsets & Lumbar braces
Homeopathy
Acupuncture
Massage
TENS
50. Management directed at restoring function and
supporting adaptive techniques:
Exercise
Reduction in body weight
Improving cardiovascular fitness
Smoking cessation
Massage- beneficial when combined with exercise
Acupuncture-may be beneficial
TENS-no benefit
Spinal manipulation-no benefit
Subacute/Chronic LBP
54. LBP with Sciatica
1% -4% of individuals with LBP
Young = herniated disc, Older = spinal stenosis
Herniated disk
50% recover in 6 weeks
5-10% ultimately require surgery
Surgery beneficial only in first 2 years
No difference in symptoms at 4 and 10 years post
operatively
55. Management similar to patient with uncomplicated
LBP
Analgesics- Paracetamol, NSAIDs, short-term opiates
Activity- routine, use pain as limiting factor
Epidural steroid injection- mild-moderate pain
reduction
Must be diligent to detect progressive neurological
function
Patient should be educated to return earlier if the
symptoms are worsening
LBP with Sciatica
56. Indications for Referral
Cauda equina syndrome – bowel and bladder dysfunction, saddle
anesthesia, bilateral leg weakness and numbness = surgical
emergency
Suspected spinal cord compression – acute neurologic deficits in a
patient with cancer and risk of spinal metastases
Progressive or severe neurologic deficit
Neuromotor deficit that persists after 4-6 weeks of conservative
therapy
Persistent sciatica, sensory deficit, or reflex loss after 4-6 weeks in a
patient with positive SLR , consistent clinical findings
Fractures
57. Conclusions
Back pain is a costly and common problem
Evaluation done best by categorizing into 3 categories:
nonspecific back pain/back pain with radiculopathy/back
pain with specific cause
Systematic approach is key. Know your red flags well!
Remember radiation risk and x-ray only when indicated
Chronic back pain is complex and needs comprehensive
approach
1st presentation at 6 weeks with no other flags, treat and wait 2-3 weeks i.e. don’t workup
Trauma-minor in elderly and chronic steroid use
*frequently not asked about---show of hands!!