Waseem, a 27-year-old technician, presents with a 5-year history of skin rashes and 1-year history of joint pains. Recently he has developed a cough and hemoptysis. Examination finds a vesicular rash on his lower limbs and he is cANCA positive. Investigations reveal granulomatosis with polyangitis (GPA, formerly Wegener's granulomatosis). As GPA can be fatal if untreated, induction therapy with corticosteroids and cyclophosphamide is planned to induce remission, followed by rituximab to maintain remission.
This document describes the case of a 22-year-old female patient who presented with fever, difficulty opening her mouth, ear discharge, oral ulcers, breathing difficulties, and cough after a recent tooth extraction. Testing showed sinusitis, oral candidiasis, low lymphocyte counts, and elevated inflammatory markers. A CT scan found lung lesions and the patient was diagnosed with Wegener's granulomatosis based on a positive C-ANCA and lung biopsy showing necrotizing vasculitis. Treatment with steroids and rituximab led to improvement of symptoms. Wegener's is a rare autoimmune disease characterized by necrotizing vasculitis affecting the respiratory tract and kidneys.
A 4-year-old Filipino boy presented with fever and joint pain for 2 weeks. Physical exam found swelling of both ankles and knees with slight limitation of movement. Tests showed leukocytosis and elevated ASO and ESR levels. He was diagnosed with rheumatic fever based on meeting major Jones criteria of polyarthritis and minor criteria of fever, leukocytosis and elevated ESR. He was treated with antibiotics and aspirin and showed improvement before discharge.
Ms. J.P., a 77-year-old female, presents with persistent diarrhea for 3 weeks. She has a history of pseudomembranous colitis in 2010 likely due to antibiotic use. Her workup shows an elevated lactic acid and asymptomatic bacteriuria. Her treatment plan includes completing her Flagyl dosage, re-sending stool samples for testing, IV fluids for rehydration, and considering vancomycin. She will also follow up with her rheumatologist for her psoriatic arthritis.
This document summarizes the case of a 19-year old male patient who presented with breathlessness, fever, and pain and discoloration of the toes. After examination and investigation, he was diagnosed with reactivated central nervous system tuberculosis, rheumatoid-related interstitial lung disease, bronchiectasis, and secondary antiphospholipid syndrome. Antiphospholipid syndrome is an autoimmune condition characterized by vascular thrombosis and/or pregnancy complications associated with antiphospholipid antibodies. It can occur primarily or secondary to other autoimmune diseases.
This case discusses an 18-year-old female patient presenting with easy fatigability and other symptoms over several months. After examination and investigations, she was diagnosed with systemic lupus erythematosus affecting multiple organs including the lungs, skin, kidneys, and central nervous system. She was started on treatment including steroids, antibiotics, and other medications. The case highlights the approach to diagnosing and managing SLE, a chronic autoimmune disease with diverse clinical manifestations and organ involvement.
A 49-year-old female PLHA presented with a rapidly enlarging swelling on the right side of her neck over the past 9 months. FNAC and biopsy results showed findings suggestive of lymphoma. She was diagnosed with NHL stage 1 on the right side of the neck and WHO stage 4. Treatment options including chemotherapy first versus starting HAART first were discussed, along with using chemotherapy and HAART simultaneously or treating any OIs first before starting HAART. Sea vegetables were also discussed as a potential complementary treatment due to their anti-cancer properties.
Morbidity & mortality/GI Kaposi SarcomaVidya Kollu
This document describes the case of a 48-year-old man with HIV/AIDS who presented with worsening dysphagia. He has a history of Kaposi sarcoma, pneumocystis pneumonia, and oral thrush. On examination, he has violaceous skin lesions and perianal ulcers. The leading diagnoses for his dysphagia are opportunistic infections such as candida esophagitis or herpes. He is being treated with antiretrovirals and antibiotics but his condition deteriorates and he passes away.
This document describes the case of a 22-year-old female patient who presented with fever, difficulty opening her mouth, ear discharge, oral ulcers, breathing difficulties, and cough after a recent tooth extraction. Testing showed sinusitis, oral candidiasis, low lymphocyte counts, and elevated inflammatory markers. A CT scan found lung lesions and the patient was diagnosed with Wegener's granulomatosis based on a positive C-ANCA and lung biopsy showing necrotizing vasculitis. Treatment with steroids and rituximab led to improvement of symptoms. Wegener's is a rare autoimmune disease characterized by necrotizing vasculitis affecting the respiratory tract and kidneys.
A 4-year-old Filipino boy presented with fever and joint pain for 2 weeks. Physical exam found swelling of both ankles and knees with slight limitation of movement. Tests showed leukocytosis and elevated ASO and ESR levels. He was diagnosed with rheumatic fever based on meeting major Jones criteria of polyarthritis and minor criteria of fever, leukocytosis and elevated ESR. He was treated with antibiotics and aspirin and showed improvement before discharge.
Ms. J.P., a 77-year-old female, presents with persistent diarrhea for 3 weeks. She has a history of pseudomembranous colitis in 2010 likely due to antibiotic use. Her workup shows an elevated lactic acid and asymptomatic bacteriuria. Her treatment plan includes completing her Flagyl dosage, re-sending stool samples for testing, IV fluids for rehydration, and considering vancomycin. She will also follow up with her rheumatologist for her psoriatic arthritis.
This document summarizes the case of a 19-year old male patient who presented with breathlessness, fever, and pain and discoloration of the toes. After examination and investigation, he was diagnosed with reactivated central nervous system tuberculosis, rheumatoid-related interstitial lung disease, bronchiectasis, and secondary antiphospholipid syndrome. Antiphospholipid syndrome is an autoimmune condition characterized by vascular thrombosis and/or pregnancy complications associated with antiphospholipid antibodies. It can occur primarily or secondary to other autoimmune diseases.
This case discusses an 18-year-old female patient presenting with easy fatigability and other symptoms over several months. After examination and investigations, she was diagnosed with systemic lupus erythematosus affecting multiple organs including the lungs, skin, kidneys, and central nervous system. She was started on treatment including steroids, antibiotics, and other medications. The case highlights the approach to diagnosing and managing SLE, a chronic autoimmune disease with diverse clinical manifestations and organ involvement.
A 49-year-old female PLHA presented with a rapidly enlarging swelling on the right side of her neck over the past 9 months. FNAC and biopsy results showed findings suggestive of lymphoma. She was diagnosed with NHL stage 1 on the right side of the neck and WHO stage 4. Treatment options including chemotherapy first versus starting HAART first were discussed, along with using chemotherapy and HAART simultaneously or treating any OIs first before starting HAART. Sea vegetables were also discussed as a potential complementary treatment due to their anti-cancer properties.
Morbidity & mortality/GI Kaposi SarcomaVidya Kollu
This document describes the case of a 48-year-old man with HIV/AIDS who presented with worsening dysphagia. He has a history of Kaposi sarcoma, pneumocystis pneumonia, and oral thrush. On examination, he has violaceous skin lesions and perianal ulcers. The leading diagnoses for his dysphagia are opportunistic infections such as candida esophagitis or herpes. He is being treated with antiretrovirals and antibiotics but his condition deteriorates and he passes away.
This document describes the case of a 65-year-old man who presented with 2 months of fever, body aches, joint pains, and headache. He was evaluated in multiple hospitals without a diagnosis. On examination, he had daily fever but no other abnormalities. Investigations showed anemia, elevated inflammatory markers, and elevated alkaline phosphatase. Cultures were repeatedly negative. The document discusses evaluating the patient thoroughly with a focus on history and detailed physical examination, as subtle findings could provide clues to the diagnosis in this challenging case of pyrexia of unknown origin.
C.M. presented with chronic diarrhea, abdominal pain, and weight loss. Her symptoms progressed to include bloody stools. Physical exam revealed arthritis in her left knee and abdominal tenderness. Stool exam showed red and white blood cells but no infectious cause was found. The most likely cause is inflammatory bowel disease (IBD), specifically ulcerative colitis (UC). UC causes inflammation and ulcers confined to the colonic mucosa. C.M.'s symptoms, physical exam findings, and stool exam results provide evidence for a diagnosis of UC. Her signs and symptoms should be managed with medications aimed at inducing remission of her UC.
This document summarizes the case of a 7-year-old Filipino girl who presented with fever, cough, periorbital and neck swelling, and weight gain for 2-3 weeks. Her examination found edema, arthritis, a facial rash, hemolytic anemia, thrombocytopenia, proteinuria, and low complement levels. Her hospital course involved worsening edema, ascites, oliguria, and gastrointestinal bleeding. Testing found positive antinuclear antibodies, anti-DNA antibodies, and low complement levels consistent with systemic lupus erythematosus. The document provides background information on SLE including definitions, epidemiology, clinical manifestations, diagnostic criteria, and laboratory findings.
The first document describes two emergency cases seen at the hospital on October 6th, 2022. The first case involves a 37-year-old man brought to the emergency department for worsening lethargy and abdominal pain. On examination, he appears weak with low blood pressure and pale conjunctiva. The second case involves a 3-year-old girl brought to the emergency department for intermittent abdominal pain and vomiting blood. On examination, she appears weak with a palpable mass in her right lower abdomen. The tutor leads a discussion on identifying and discussing the problems in these cases chronologically while considering all possible diagnoses. References are also provided for some laboratory results.
1. The patient is exhibiting signs and symptoms consistent with Kawasaki disease, including prolonged fever, oral ulcers, conjunctivitis, rash, lymphadenopathy, and extremity changes.
2. Kawasaki disease does occur in Egypt, with an estimated 280 cases diagnosed annually.
3. Treatment for Kawasaki disease involves intravenous immunoglobulin and aspirin to prevent coronary artery aneurysms, which develop in around 25% of untreated patients.
This document summarizes the medical records of a 32-year-old male patient admitted to the hospital with fever, headache, and altered sensorium. Brain imaging showed multiple lesions consistent with cerebral toxoplasmosis. The patient had a suppressed immune system due to HIV. He was diagnosed with HIV/AIDS complicated by cerebral toxoplasmosis based on clinical presentation, imaging and lab findings. He was started on cotrimoxazole and steroids, and showed improvement in symptoms within a week.
This document describes the case of a 55-year-old man who experienced episodes of sweating, shortness of breath, and diarrhea for 10 months. Imaging showed a mass in his jejunum, which was resected and found to be a carcinoid tumor. Carcinoid tumors are often associated with heart lesions due to secretion of vasoactive substances. The expected heart lesion in this case would be carcinoid heart disease, characterized by plaque-like lesions in the heart valves.
Dengue is a mosquito-borne viral disease spread by the Aedes aegypti mosquito. It causes a spectrum of clinical symptoms and has unpredictable outcomes. In Indonesia, over 150,000 cases were reported in 2007 with high numbers in Jakarta and West Java. Secondary infections pose greater risks and can lead to dengue hemorrhagic fever. Proper fluid management is critical to treatment but outcomes depend on early detection and clinical monitoring of warning signs. Prevention requires controlling mosquito breeding sites and promoting environmental modifications.
The document discusses different ways pneumonia can be classified and described in more detail, such as whether it is typical or atypical, and whether it affects the upper, middle or lower lobes of the lungs based on x-ray findings. More precise classifications help provide a better understanding of the specific illness but do not typically change the treatment approach.
This document outlines objectives and content for a case presentation on cryptococcal meningitis. The objectives are to discuss global statistics on cryptococcal meningitis, the pathophysiology of the disease, signs and symptoms, and medical and nursing management. The document then provides definitions of cryptococcal meningitis and related terms. It also shares some facts about cryptococcal meningitis and its relationship to AIDS.
Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis. It commonly affects the lungs but can also affect bones and joints. Tuberculosis of the hip joint, also known as Pott's disease of the hip, is a form of extra-pulmonary tuberculosis that constitutes 1-3% of all bone and joint tuberculosis cases. It is characterized by insidious onset of pain in the hip with limping and can progress to destruction of the femoral head and acetabulum if left untreated. Treatment involves a combination of anti-tubercular chemotherapy for a minimum of 6 months along with surgical intervention if needed to correct deformities and obtain a painless mobile joint.
This document presents two case histories of patients presenting with symptoms of dengue fever. The first case involves a 21-year-old male with fever, rash and low platelet count, diagnosed with dengue fever based on symptoms and a positive tourniquet test. The second case involves a 30-year-old male initially diagnosed with a respiratory infection but later found to have dengue hemorrhagic fever, evidenced by bleeding, low platelets and pleural effusion. The document then provides overview information on dengue virus, transmission, clinical features, diagnosis, management and prevention.
Approach to child with leg pain-Septic arthritisAtheer Al-zubedi
Septic arthritis is a "diagnosis not to miss" in the evaluation of a child with hip pain, given the potential for rapid joint destruction and long-term morbidity that can accompany delay in diagnosis and treatment.
29-2-40
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)Apollo Hospitals
This case report describes a 24-year-old man who presented with fever, rash, abdominal pain, and vomiting. He had been taking carbamazepine for seizures. His symptoms and lab results met the criteria for Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), also known as drug hypersensitivity syndrome. DRESS is caused by certain drugs and is characterized by fever, rash, eosinophilia, and involvement of internal organs like the liver or lungs. Carbamazepine was withdrawn and steroids were started, leading to improvement. The report reviews the characteristics, diagnosis, and treatment of DRESS, noting it is important to identify the causative drug and avoid re-
This document outlines the case study of a 39-year-old man presenting with fever and right lumbar pain. It discusses typhoid fever including its definition, epidemiology, risk factors, transmission, pathophysiology, signs and symptoms, diagnostic methods, treatment, complications, differential diagnoses, and prevention. The patient was diagnosed with typhoid fever based on a positive typhoid-specific test and treated with antibiotics and rehydration.
This document discusses dengue fever and chikungunya fever, which commonly present as acute febrile illness in children. Dengue is caused by one of four serotypes of dengue virus transmitted by Aedes mosquitoes. It presents with high fever, body aches, and potentially severe bleeding or organ dysfunction. Chikungunya causes high fever and severe joint pain transmitted by the same mosquitoes. Both require supportive care but dengue may require hospitalization and IV fluids depending on severity of symptoms and warning signs. Accurate diagnosis is important given changing epidemiology and impact on healthcare systems.
This document describes the case of an 8 month old boy who presented with fever, cough and breathlessness. Examination found decreased breathing sounds and chest rise on the right side. Imaging showed a right pneumothorax and collapsed right lung. Further imaging identified multicystic lesions in the right lower lobe, consistent with Congenital Cystic Adenomatoid Malformation Type 1 (CCAM). The patient underwent right lung lobectomy and improved with treatment. CCAM is a rare congenital pulmonary disorder caused by an embryological insult, and can present as pneumothorax in infants.
This document provides an overview of suppurative arthritis, including its epidemiology, etiology, clinical presentation, diagnosis, treatment, complications and prognosis. Suppurative arthritis is most common in young children under 5 years old and is usually caused by bacteria such as Staphylococcus aureus entering the bloodstream and infecting the joints. The key clinical sign is pain with passive motion of the joint. Diagnosis involves joint aspiration and culture. Treatment consists of intravenous antibiotics for 3-6 weeks along with surgery and physical therapy if needed. Complications can include osteonecrosis, premature osteoarthritis and growth abnormalities if not treated promptly.
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
This document describes the case of a 65-year-old man who presented with 2 months of fever, body aches, joint pains, and headache. He was evaluated in multiple hospitals without a diagnosis. On examination, he had daily fever but no other abnormalities. Investigations showed anemia, elevated inflammatory markers, and elevated alkaline phosphatase. Cultures were repeatedly negative. The document discusses evaluating the patient thoroughly with a focus on history and detailed physical examination, as subtle findings could provide clues to the diagnosis in this challenging case of pyrexia of unknown origin.
C.M. presented with chronic diarrhea, abdominal pain, and weight loss. Her symptoms progressed to include bloody stools. Physical exam revealed arthritis in her left knee and abdominal tenderness. Stool exam showed red and white blood cells but no infectious cause was found. The most likely cause is inflammatory bowel disease (IBD), specifically ulcerative colitis (UC). UC causes inflammation and ulcers confined to the colonic mucosa. C.M.'s symptoms, physical exam findings, and stool exam results provide evidence for a diagnosis of UC. Her signs and symptoms should be managed with medications aimed at inducing remission of her UC.
This document summarizes the case of a 7-year-old Filipino girl who presented with fever, cough, periorbital and neck swelling, and weight gain for 2-3 weeks. Her examination found edema, arthritis, a facial rash, hemolytic anemia, thrombocytopenia, proteinuria, and low complement levels. Her hospital course involved worsening edema, ascites, oliguria, and gastrointestinal bleeding. Testing found positive antinuclear antibodies, anti-DNA antibodies, and low complement levels consistent with systemic lupus erythematosus. The document provides background information on SLE including definitions, epidemiology, clinical manifestations, diagnostic criteria, and laboratory findings.
The first document describes two emergency cases seen at the hospital on October 6th, 2022. The first case involves a 37-year-old man brought to the emergency department for worsening lethargy and abdominal pain. On examination, he appears weak with low blood pressure and pale conjunctiva. The second case involves a 3-year-old girl brought to the emergency department for intermittent abdominal pain and vomiting blood. On examination, she appears weak with a palpable mass in her right lower abdomen. The tutor leads a discussion on identifying and discussing the problems in these cases chronologically while considering all possible diagnoses. References are also provided for some laboratory results.
1. The patient is exhibiting signs and symptoms consistent with Kawasaki disease, including prolonged fever, oral ulcers, conjunctivitis, rash, lymphadenopathy, and extremity changes.
2. Kawasaki disease does occur in Egypt, with an estimated 280 cases diagnosed annually.
3. Treatment for Kawasaki disease involves intravenous immunoglobulin and aspirin to prevent coronary artery aneurysms, which develop in around 25% of untreated patients.
This document summarizes the medical records of a 32-year-old male patient admitted to the hospital with fever, headache, and altered sensorium. Brain imaging showed multiple lesions consistent with cerebral toxoplasmosis. The patient had a suppressed immune system due to HIV. He was diagnosed with HIV/AIDS complicated by cerebral toxoplasmosis based on clinical presentation, imaging and lab findings. He was started on cotrimoxazole and steroids, and showed improvement in symptoms within a week.
This document describes the case of a 55-year-old man who experienced episodes of sweating, shortness of breath, and diarrhea for 10 months. Imaging showed a mass in his jejunum, which was resected and found to be a carcinoid tumor. Carcinoid tumors are often associated with heart lesions due to secretion of vasoactive substances. The expected heart lesion in this case would be carcinoid heart disease, characterized by plaque-like lesions in the heart valves.
Dengue is a mosquito-borne viral disease spread by the Aedes aegypti mosquito. It causes a spectrum of clinical symptoms and has unpredictable outcomes. In Indonesia, over 150,000 cases were reported in 2007 with high numbers in Jakarta and West Java. Secondary infections pose greater risks and can lead to dengue hemorrhagic fever. Proper fluid management is critical to treatment but outcomes depend on early detection and clinical monitoring of warning signs. Prevention requires controlling mosquito breeding sites and promoting environmental modifications.
The document discusses different ways pneumonia can be classified and described in more detail, such as whether it is typical or atypical, and whether it affects the upper, middle or lower lobes of the lungs based on x-ray findings. More precise classifications help provide a better understanding of the specific illness but do not typically change the treatment approach.
This document outlines objectives and content for a case presentation on cryptococcal meningitis. The objectives are to discuss global statistics on cryptococcal meningitis, the pathophysiology of the disease, signs and symptoms, and medical and nursing management. The document then provides definitions of cryptococcal meningitis and related terms. It also shares some facts about cryptococcal meningitis and its relationship to AIDS.
Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis. It commonly affects the lungs but can also affect bones and joints. Tuberculosis of the hip joint, also known as Pott's disease of the hip, is a form of extra-pulmonary tuberculosis that constitutes 1-3% of all bone and joint tuberculosis cases. It is characterized by insidious onset of pain in the hip with limping and can progress to destruction of the femoral head and acetabulum if left untreated. Treatment involves a combination of anti-tubercular chemotherapy for a minimum of 6 months along with surgical intervention if needed to correct deformities and obtain a painless mobile joint.
This document presents two case histories of patients presenting with symptoms of dengue fever. The first case involves a 21-year-old male with fever, rash and low platelet count, diagnosed with dengue fever based on symptoms and a positive tourniquet test. The second case involves a 30-year-old male initially diagnosed with a respiratory infection but later found to have dengue hemorrhagic fever, evidenced by bleeding, low platelets and pleural effusion. The document then provides overview information on dengue virus, transmission, clinical features, diagnosis, management and prevention.
Approach to child with leg pain-Septic arthritisAtheer Al-zubedi
Septic arthritis is a "diagnosis not to miss" in the evaluation of a child with hip pain, given the potential for rapid joint destruction and long-term morbidity that can accompany delay in diagnosis and treatment.
29-2-40
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)Apollo Hospitals
This case report describes a 24-year-old man who presented with fever, rash, abdominal pain, and vomiting. He had been taking carbamazepine for seizures. His symptoms and lab results met the criteria for Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), also known as drug hypersensitivity syndrome. DRESS is caused by certain drugs and is characterized by fever, rash, eosinophilia, and involvement of internal organs like the liver or lungs. Carbamazepine was withdrawn and steroids were started, leading to improvement. The report reviews the characteristics, diagnosis, and treatment of DRESS, noting it is important to identify the causative drug and avoid re-
This document outlines the case study of a 39-year-old man presenting with fever and right lumbar pain. It discusses typhoid fever including its definition, epidemiology, risk factors, transmission, pathophysiology, signs and symptoms, diagnostic methods, treatment, complications, differential diagnoses, and prevention. The patient was diagnosed with typhoid fever based on a positive typhoid-specific test and treated with antibiotics and rehydration.
This document discusses dengue fever and chikungunya fever, which commonly present as acute febrile illness in children. Dengue is caused by one of four serotypes of dengue virus transmitted by Aedes mosquitoes. It presents with high fever, body aches, and potentially severe bleeding or organ dysfunction. Chikungunya causes high fever and severe joint pain transmitted by the same mosquitoes. Both require supportive care but dengue may require hospitalization and IV fluids depending on severity of symptoms and warning signs. Accurate diagnosis is important given changing epidemiology and impact on healthcare systems.
This document describes the case of an 8 month old boy who presented with fever, cough and breathlessness. Examination found decreased breathing sounds and chest rise on the right side. Imaging showed a right pneumothorax and collapsed right lung. Further imaging identified multicystic lesions in the right lower lobe, consistent with Congenital Cystic Adenomatoid Malformation Type 1 (CCAM). The patient underwent right lung lobectomy and improved with treatment. CCAM is a rare congenital pulmonary disorder caused by an embryological insult, and can present as pneumothorax in infants.
This document provides an overview of suppurative arthritis, including its epidemiology, etiology, clinical presentation, diagnosis, treatment, complications and prognosis. Suppurative arthritis is most common in young children under 5 years old and is usually caused by bacteria such as Staphylococcus aureus entering the bloodstream and infecting the joints. The key clinical sign is pain with passive motion of the joint. Diagnosis involves joint aspiration and culture. Treatment consists of intravenous antibiotics for 3-6 weeks along with surgery and physical therapy if needed. Complications can include osteonecrosis, premature osteoarthritis and growth abnormalities if not treated promptly.
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Adhd Medication Shortage Uk - trinexpharmacy.comreignlana06
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
5.
HOPC
According to my patient, he was in his usual state of health 5 years
back when he started developing wounds/ rash even after minor
scratch or itch on skin (more on lower limbs). But it was not
hindering him from routine chores and was not associated with
fever or any other complain. But 1 year ago he developed joint
pains and swellings which shifted from 1 joint to other, each joined
remained involved for 1 to 2 days and 2 to 3 joints remained
involved at a time. Large joints were involved more especially hip
and knee joints. Meanwhile his skin wounds changed into rash
involving bilateral legs below knee. Rash was pruritic in nature and
pus and blood oozed out of each lesion.
6.
HOPC
His rash and joint pains were associated with low grade fever,
undocumented weight loss and malaise, more at night time.
Patient was put on antipsychotics but it did not help. Later on
some GP prescribed him tab deltacortil 3x BD for 1 week,
then 2 x BD for next week. This treatment improved his joint
pains, he remained asymptomatic and gained weight in next 6
months but had mild joint pains occasionally associated with
taking protein rich diet. His rash started involving upper
limbs too then 5 months back he got skin biopsy which
revealed Reactive Perforating Collagenosis.
7.
HOPC
Few weeks back he again developed similar joint pains,
associated with low grade fever, worsening rash (involving
thighs & buttocks) and malaise. He took some aurvedic
treatment for 3 weeks which initially improved his condition
but when he withdrew this medicine, his condition worsened
and he started developing dry cough which gradually
worsened and he noticed hemoptysis 1 week before
presentation. Blood was dark red to brown in color, ½ table
spoon in quantity early morning and mild bleed throughout
the day. He has lost 3 kg weight in 1 month during this
episode.
8.
Past Medical Hx
He has hx of some STD leading to genital ulcers 5 months
after marriage
Past Surgical Hx
Not significant
Drug Hx
Deltacortil, aurvedic medications at different intervals
Vaccination Hx
Fully vaccinated with EPI vaccines in childhood
Received three doses of covid vaccine
9.
Family Hx
His mother has RA since young
His maternal uncles and aunts had pul TB. Last exposure was
in 2009
Personal Hx
Normal appetite
normal sleep wake cycle
Normal bowel habits
Married for 6 years and has 2 alive, healthy children
10.
No hx of blood transfusions,
No hx addictions
He has history of dust allergy(sneezing and Upper
respiratory symptoms on dust exposure)
Australian parrots as pets at home
11.
Travel Hx: Nil
Socioeconomic Hx:
He lives in a joint family with his parents, a brother & his
family. He, his brother and their father are earners, have own
home in city with basic facilities available
Systemic Inquiry:
Insignificant
12.
Clinical examination
A young male patient, average height and built sitting on
hospital bed, well oriented in time, place and person (GCS
15/15) with vitals of
BP: 120/80 mmHg, Pulse: 80 /min, SaO2: 95% on air
RR: 10 /min, Temp: afebrile,
GPE
14.
He has no joint swelling or tenderness at the moment
and has vesicular rash on lower limbs which is black in
color, painful, blood oozes out of active lesion and
healed lesions leave a black colored scar.
Skin and joints
15.
Respiratory
He has bilateral clear chest with no added sounds
Abdomen
Soft, non tender
CVS
Audible 1st and 2nd heart sound
CNS
GCS 15/15
CNS,Abdomen & CVS
26.
ATT for latent TB
Myrin p fort 4x OD
Tab Vita 6 x OD
Modified d/t raised ALT to ethambutol, amikacin and moxifloxacin
Tab Nuberol fort x SOS
Cap Risek
Tab Deltacortil
Inj Ristova/rituximab is in plan after 3 months of completion of
ATT
Management
28.
ANCA associated
vasculitis of small to medium vessels (arteries, arterioles,
capillaries)
Necrotizing granulomatous lesion of upper and lower
respiratory tract
Glomerulonephritis and
Other organ manifestations
What it is…..
29.
With an incidence of
12 cases per million per year
In 4th and 5th decades of life
Affects both genders equally
Prognosis
Generalized disease is inevitably fatal with less than 1 year
survival after diagnosis
30.
Unknown etiology but possibly triggered by
Environmental exposures including
RTIs
living in northern latitudes
farming
allergies
exposure to solvents or silica
Host factors including
Genetic factors (α-1 antitrypsin, CTLA4, PTPN22*620W,
DPB1*0401, Fcϒ receptor IIIb on neutrophils and
macrophages)
Cellular immune responses
Etiology
31.
Develops over 4-12 months
Upper respiratory tract symptoms (90% pts)
Nasal congestion, crusting, ulceration, bleeding and
perforation of nasal septum may lead to ‘saddle nose
deformity’
sinusitis
otitis media
mastoiditis
Inflammation of gums
Stridor due to subglottic stenosis
Features
32.
Lower respiratory tract symptoms (40-80%)
cough
dyspnea
hemoptysis
Migratory oligoarthritis (predilection for large joints)
Ocular disease
unilateral proptosis (orbital pseudotumor)
Red eye (scleritis, episcleritis, ant uveitis, peripheral
ulcerative keratitis)
Features
33.
Skin disorder
Purpura
other lesions
Dysesthesia
Renal involvement (3/4th of cases)
subclinical until advanced disease
will develop in majority of untreated patients
Fever, weight loss and malaise
Newly acquired HTN (rarely)
Venous thrombotic events
Features
34.
CBC
Anemia
Mild leukocytosis
ESR, CRP
ANA (0-15%)
RF (50%)
ANCA (93-96%)
PR3-ANCA/c-ANCA(>90% specificity, >95% sensitivity)
MPO-ANCA(10-25% pts)
Urine RE
Proteinurea
red cells/red cell casts
Diagnosis
36.
Biopsy/Histopath
Lung biopsy
Vasculitis, granulomatous inflammation/granulomas,
geographic necrosis, acute and chronic inflammation
Nasal biopsy
Chronic inflammation
Kidney biopsy
Pauci-immune glomerulonephritis
segmental necrotizing glomerulonephritis with multiple
crescents(characteristic but not diagnostic
37.
Early treatment is crucial
in preventing end-organ complications
and preserving life
Remission Induction
Depends on severity of disease
Mild(no significant kidney dysfunction/immediately life threatening
disease)
Severe(life or organ threatening disease/RPGN/pul hemorrhage)
Remission Maintenance
Management
38.
Severe disease
Corticosteroids plus Rituximab
375mg/m2 IV once a week for 4 weeks of Rituximab with 1mg/kg
PO prednisolone daily
Coricosteroids plus Cyclophosphamide
Remission induced in > 90% pts
Prednisolone (1mg/kg/day P/O) plus cyclophosphamide
(2mg/kg/day P/O dose adjustment required for >70y/o and with
kidney disease).
Intermittent high dose IV cyclophosphamide is associated with
higher relapse risk compared to daily oral
To avoid toxicity give cyclophosphamide for 3-6 months
Remission Induction
39.
Non severe disease
Methotrexate plus glucocorticoids
Remission Induction
40.
Azathioprine 2mg/kg/day P/O
Methotrexate 20-25mg/wk P/O or IM
Rituximab (500mg IV repeated in 14 days then 6monthly)
Mycophenolate mofetil
Rituximab is better in remission maintenance and overall
survival than other drugs
One trial showed that relapse after 28months was 5% with
rituximab and 29% with azathioprine
Remission Maintenance
41.
Relapse with severe disease manifestation
o Who are not receiving Rituximab for maintenance give
Rituximab
o Who receive rituximab switch to cyclophosphamide rather
than giving additional dose
Relapse management
42.
Switch to other therapy rather than combining both
Add IVIG to current therapy
Refractory disease
CTLA4 is involved in T cell activation
PTPN22 is with T cell activation
DPB1 is with chronic beryllium disease
Immunoflourescence assays for ANCA should be confirmed by enzyme immunoassays
Full range of pathologic changes usually evident only on lung biopsy specimen
Both rituximab and cyclophosphamide increase opportunistic infections including progressive multifocal leukoencephalopathy
Give prophylaxis for PCP with single strength trimethoprim sulphamethoxazole daily