A 70-year-old woman presented with dyspnea, orthopnea, ankle edema, and fatigue over the past week. Her medical history included ischemic heart disease treated for 2 years. Investigations revealed anemia, thrombocytosis, leukocytosis, enlarged liver and spleen, and bone marrow biopsy showed features consistent with essential thrombocytosis. She was diagnosed with essential thrombocytosis complicated by congestive heart failure. Treatment focused on minimizing her thrombotic risk factors and administering cytoreductive therapy such as hydroxyurea based on her risk profile.