Bleeding
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This document discusses various causes of hemorrhagic diathesis, or increased bleeding tendency. It describes vessel wall abnormalities that can cause less serious bleeding with normal coagulation tests. These include microbial damage, scurvy, drugs, and amyloid infiltration. Thrombocytopenia can also cause bleeding and can result from decreased platelet production or survival. Specific causes mentioned include immune thrombocytopenic purpura in children and adults. Thrombotic microangiopathies like thrombotic thrombocytopenic purpura and hemolytic uremic syndrome involve microthrombi formation and can lead to multiple organ failure.
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Bleeding diathesis dr . Thamir alotaify
Bleeding diathesis refers to a group of hematological diseases that interfere with normal hemostasis and cause a bleeding tendency. There are two main types: hypocoagulability and hypercoagulability. Normal hemostasis involves vasoconstriction, platelet plug formation, and coagulation cascade in response to hemorrhage. Bleeding disorders can be caused by abnormalities in vasculature, platelets, or coagulation factors. Clinical features depend on whether the disorder affects platelets or coagulation factors, and include petechiae, ecchymoses, hemarthrosis, and hematomas. Treatment involves corticosteroids, intravenous immunoglobulin, splenectomy, immunosuppress
Hemorrhagic diathesis i (bleeding disorders)
1. The document discusses common screening tests for bleeding disorders including bleeding time, platelet count, prothrombin time, and partial thromboplastin time.
2. It also lists and describes common bleeding disorders such as immune thrombocytopenic purpura, hemophilia A, hemophilia B, von Willebrand disease, and disseminated intravascular coagulation.
3. The pathogenesis, clinical features, and treatment of immune thrombocytopenic purpura are explained in detail, noting it is caused by autoantibodies destroying platelets and treated commonly with corticosteroids or splenectomy.
hemorrhagic diathesis & hematological melignancy
This document discusses various types of hemorrhagic diathesis including hemophilia, thrombocytopenia, hemoblastosis, and acute and chronic leukemia. It provides diagnostic criteria and treatment approaches for each condition. Hemophilia is described as a congenital bleeding disorder caused by a deficiency in coagulation factors. Thrombocytopenia involves a low platelet count and can cause bruising. Hemoblastosis refers to cancers of the blood system including acute and chronic forms of leukemia.
Bleeding disorders
A summarized review article containing the following items:
Causes of Mild Bleeding Disorders , Inherited causes, Acquired causes, Clinical Manifestations of Mild Bleeding Disorders, Items of value in bleeding histories, Prevalence of mild bleeding symptoms, A staged approach to diagnostic testing for mild bleeding problems, Commonly Faced Problems in Management of Mild Bleeding Disorders.
Treatment Options: Factor concentrates, Prothrombin complex concentrate (PCC) , Fresh Frozen Plasma, Indications of Plasma transfusion, Cryoprecipitate,Desmopressin, Thrombin, Antifibrinolytic drugs Tranexamic Acid and Aminocaproic Acid, Platelet transfusion, Fibrin glue, Vitamin K, Hormonal therapy, and intrauterine devices
Bleeding disorder
Discussed the conditions which leads to excessive bleeding in Humans.includes Hemophilia, Thrombocytopenia,DIC and vitamin k deficiency.
Bleeding disorder
Bleeding disorders are medical conditions that cause abnormal or excessive bleeding due to defects in the blood clotting process. The document discusses the main types of bleeding disorders: platelet disorders like thrombocytopenia and thrombocytosis; vessel wall abnormalities like scurvy and hereditary hemorrhagic telangiectasia; and clotting disorders like hemophilia A, hemophilia B, and von Willebrand disease. Specific conditions are defined and their signs, symptoms, causes, diagnosis, treatment and dental implications are explained. The document provides an overview of different bleeding disorders, their etiology and clinical manifestations.
Bleeding-disorder
Dr. Mehdi Ashik Chowdhury
M.B.B.S. MD. (BSMMU)
Assistant Professor &
Head of the Department of Pathology
Tairunnessa Memorial Medical College
Common bleeding and clotting disorders
Bleeding disorders result from problems with blood clotting and can range from mild to life-threatening. The coagulation cascade describes the series of biochemical reactions involved in clotting. There are two pathways - intrinsic and extrinsic - that activate clotting factors and ultimately form a fibrin clot. Common symptoms include bruising, nosebleeds, and heavy periods. Investigations may include blood tests of clotting factors and bleeding time. Specific deficiencies are diagnosed through factor assays and gene analysis. Treatment depends on the underlying condition.
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Bleeding diathesis dr . Thamir alotaify
Bleeding diathesis refers to a group of hematological diseases that interfere with normal hemostasis and cause a bleeding tendency. There are two main types: hypocoagulability and hypercoagulability. Normal hemostasis involves vasoconstriction, platelet plug formation, and coagulation cascade in response to hemorrhage. Bleeding disorders can be caused by abnormalities in vasculature, platelets, or coagulation factors. Clinical features depend on whether the disorder affects platelets or coagulation factors, and include petechiae, ecchymoses, hemarthrosis, and hematomas. Treatment involves corticosteroids, intravenous immunoglobulin, splenectomy, immunosuppress
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1. The document discusses common screening tests for bleeding disorders including bleeding time, platelet count, prothrombin time, and partial thromboplastin time.
2. It also lists and describes common bleeding disorders such as immune thrombocytopenic purpura, hemophilia A, hemophilia B, von Willebrand disease, and disseminated intravascular coagulation.
3. The pathogenesis, clinical features, and treatment of immune thrombocytopenic purpura are explained in detail, noting it is caused by autoantibodies destroying platelets and treated commonly with corticosteroids or splenectomy.
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This document discusses various types of hemorrhagic diathesis including hemophilia, thrombocytopenia, hemoblastosis, and acute and chronic leukemia. It provides diagnostic criteria and treatment approaches for each condition. Hemophilia is described as a congenital bleeding disorder caused by a deficiency in coagulation factors. Thrombocytopenia involves a low platelet count and can cause bruising. Hemoblastosis refers to cancers of the blood system including acute and chronic forms of leukemia.
Bleeding disorders
A summarized review article containing the following items:
Causes of Mild Bleeding Disorders , Inherited causes, Acquired causes, Clinical Manifestations of Mild Bleeding Disorders, Items of value in bleeding histories, Prevalence of mild bleeding symptoms, A staged approach to diagnostic testing for mild bleeding problems, Commonly Faced Problems in Management of Mild Bleeding Disorders.
Treatment Options: Factor concentrates, Prothrombin complex concentrate (PCC) , Fresh Frozen Plasma, Indications of Plasma transfusion, Cryoprecipitate,Desmopressin, Thrombin, Antifibrinolytic drugs Tranexamic Acid and Aminocaproic Acid, Platelet transfusion, Fibrin glue, Vitamin K, Hormonal therapy, and intrauterine devices
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Discussed the conditions which leads to excessive bleeding in Humans.includes Hemophilia, Thrombocytopenia,DIC and vitamin k deficiency.
Bleeding disorder
Bleeding disorders are medical conditions that cause abnormal or excessive bleeding due to defects in the blood clotting process. The document discusses the main types of bleeding disorders: platelet disorders like thrombocytopenia and thrombocytosis; vessel wall abnormalities like scurvy and hereditary hemorrhagic telangiectasia; and clotting disorders like hemophilia A, hemophilia B, and von Willebrand disease. Specific conditions are defined and their signs, symptoms, causes, diagnosis, treatment and dental implications are explained. The document provides an overview of different bleeding disorders, their etiology and clinical manifestations.
Bleeding-disorder
Dr. Mehdi Ashik Chowdhury
M.B.B.S. MD. (BSMMU)
Assistant Professor &
Head of the Department of Pathology
Tairunnessa Memorial Medical College
Common bleeding and clotting disorders
Bleeding disorders result from problems with blood clotting and can range from mild to life-threatening. The coagulation cascade describes the series of biochemical reactions involved in clotting. There are two pathways - intrinsic and extrinsic - that activate clotting factors and ultimately form a fibrin clot. Common symptoms include bruising, nosebleeds, and heavy periods. Investigations may include blood tests of clotting factors and bleeding time. Specific deficiencies are diagnosed through factor assays and gene analysis. Treatment depends on the underlying condition.
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This document discusses the approach to disorders of bleeding and thrombosis. It covers the main components of hemostasis including the vascular endothelium, platelets, coagulation system, and fibrinolysis. It then discusses specific factors, disorders, investigations, and treatments related to bleeding and thrombotic disorders. The key points are that a thorough history, examination, and screening coagulation tests are needed to evaluate a patient. Additional targeted tests may be needed to identify the underlying cause, which could include a deficiency or inhibitor. Treatment depends on the specific disorder diagnosed.
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Approach to a bleeding disorder: These presentation has the approach for a patient of bleeding disorder. it has History, physical finding, Investigations.
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The document summarizes various bleeding disorders including their clinical features and classifications. Platelet disorders can cause petechiae and purpurae due to decreased platelet production, increased destruction, or sequestration. Clotting factor deficiencies like hemophilia A and B are inherited and cause hemarthroses, hematomas, and bleeding after trauma. Von Willebrand disease is the most common inherited bleeding disorder caused by a defect in von Willebrand factor.
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This document discusses bleeding disorders and summarizes key points about hemostasis and platelet function. It begins by defining hemostasis and its functions in maintaining a fluid blood state and inducing clotting at sites of injury. Bleeding disorders are then classified based on defects in vascular, platelet, or coagulation systems. Specific inherited and acquired bleeding disorders that result from vascular defects like hereditary telangiectasia and scurvy are described. Platelet disorders are also outlined, distinguishing quantitative issues like thrombocytopenia from qualitative defects. Causes of decreased platelet count or production and increased platelet destruction are summarized.
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The document summarizes normal hemostasis and various bleeding disorders. It describes the three stages of normal coagulation as primary hemostasis involving platelets, secondary hemostasis involving clotting factors, and tertiary hemostasis involving fibrin formation and resolution. Causes of bleeding disorders include vessel wall abnormalities, platelet deficiencies or dysfunctions, and clotting factor derangements. Specific disorders discussed include immune thrombocytopenic purpura, hemophilia, von Willebrand disease, and thrombotic thrombocytopenic purpura. Tests used to evaluate bleeding disorders and clinical manifestations of different disorders are also summarized.
Bleeding Disorders
The document outlines an approach to evaluating and diagnosing bleeding disorders. It discusses:
1. Obtaining a clinical history and performing screening laboratory tests like PT, PTT, and platelet count to classify the bleeding as a platelet, coagulation factor, or other disorder.
2. Using specialized tests like mixing studies and inhibitor assays to identify specific factor deficiencies or inhibitors.
3. Considering rare causes if screening tests are normal, like defects in fibrinolysis or factor XIII.
4. Evaluating acquired bleeding in settings like liver disease and surgery.
A detailed approach with diagnostic algorithms is provided.
Bleeding and clotting disorders
This document discusses bleeding and clotting disorders. It describes various causes of excessive bleeding such as vitamin K deficiency, hemophilia, and thrombocytopenia. It also discusses thromboembolic conditions that result from blood clots forming in vessels. Tests for bleeding disorders are mentioned, including bleeding time, clotting time, and prothrombin time. Therapies for certain conditions are also noted, such as using tissue plasminogen activator to dissolve blood clots or treating hemophilia with purified Factor VIII injections.
Bleeding disorders Causes, Types, and Diagnosis
https://userupload.net/v3l4i8jsk7wq
Factor II, V, VII, X, or XII deficiencies are bleeding disorders related to blood clotting problems or abnormal bleeding problems. Von Willebrand's disease isthe most common inherited bleeding disorder. It develops when the blood lacks von Willebrand factor, which helps the blood to clot.
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This document provides information on evaluating and diagnosing bleeding disorders. It discusses evaluating a patient's history for signs of platelet defects, coagulation factor defects, or vascular abnormalities. The examination focuses on findings like petechiae, purpura, echymosis, and joint bleeding. Initial investigations include a CBC, bleeding time, prothrombin time, partial thromboplastin time, and thrombin time. Further tests may include a blood film, platelet function tests, fibrinolysis tests, coagulation factor assays, mixing tests, and von Willebrand factor assay. Based on these evaluations, specific diagnoses can be made, such as hemophilia A, von Willebrand disease, immune thrombocytopenic purp
7a..bleeding disorder.
This document discusses various bleeding disorders including:
- Definition as a disorder characterized by spontaneous or excessive bleeding following trauma.
- Etiologies including vessel wall abnormalities (congenital or acquired like vasculitis) and platelet functional disorders.
- Specific disorders discussed in more detail include von Willebrand disease, hemophilia, Bernard-Soulier syndrome, and Glanzmann's thrombasthenia.
- Clinical features, laboratory findings, and treatment approaches are provided for many of the disorders.
[Int. med] bleeding disorders from SIMS Lahore
This document discusses bleeding and clotting disorders. It provides details on:
1. The normal physiology of hemostasis including vascular, platelet and plasma factors that prevent bleeding.
2. Specific platelet and plasma factor deficiencies that can cause bleeding disorders.
3. The classification of bleeding disorders into defects of blood vessels, platelet disorders, and clotting factor deficiencies.
4. Diagnostic tests for evaluating bleeding patients including screening coagulation tests, specific factor assays, and platelet function tests.
Bleeding and clotting disorders dr anoop k r
This document discusses bleeding and clotting disorders, including the diagnosis and evaluation of bleeding problems. It describes the principal presentations of bleeding disorders such as easy bruising, bleeding from mucous membranes, and excessive bleeding after trauma. It then covers specific types of bleeding disorders like those affecting platelets or coagulation factors. The document outlines typical screening tests used to evaluate bleeding disorders and describes both inherited and acquired causes of platelet and coagulation abnormalities.
Bleeding disorders and their management
This document provides an overview of bleeding disorders, their causes, and management. It discusses how bleeding disorders are caused by abnormalities in hemostasis and coagulation that result in spontaneous or easy bruising. Various types of bleeding disorders are described, including those caused by platelet disorders like thrombocytopenia or vascular defects like vitamin C deficiency. Screening tests for bleeding disorders like platelet count, bleeding time, and INR are also outlined. Effective management of bleeding disorders depends on accurately identifying the underlying cause.
Platelet disoders
Thank you for the informative presentation on platelet disorders. Please let me know if you need any clarification on the concepts covered.
Bleeding disorders(Disorders of Platelets and vessel wall)
(1) Bleeding disorders refer to functional impairments in the normal hemostatic process that result in bleeding even without an anatomical cause.
(2) Common signs of bleeding disorders include petechiae, purpura, hemarthrosis, ecchymoses, and hematomas. Coagulation disorders particularly present with hemarthrosis.
(3) Causes of bleeding disorders include problems with the vascular, platelet, and coagulation phases of hemostasis. Qualitative and quantitative platelet disorders as well as inherited and acquired coagulation factor deficiencies can all result in a bleeding tendency.
hematology.wustl.edu/conferences/presentations/bli... hematology.wustl.edu/...
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Coagulation factor disorders like hemophilia A and B cause prolonged PT or PTT and bleeding. They are treated with replacement factors or adjuvant drugs.
Platelet disorders can be quantitative or qualitative and cause petechiae or mucocutaneous bleeding. Treatment involves platelet transfusion.
Adjuvant drugs like aminocaproic acid, DDAVP, fresh frozen plasma, cryoprecipitate, and recombinant factor VIIa can help treat bleeding from various coagulation disorders.Investigation of bleeding disorder || bleeding disorder
This document discusses abnormal bleeding and its investigation and management. It begins by outlining the components involved in hemostasis and some common causes of abnormal bleeding such as vascular, platelet, and coagulation disorders. It then describes various screening and confirmatory tests used to evaluate bleeding disorders, including tests for platelets, coagulation factors, and von Willebrand factor. The document concludes by discussing treatment approaches for bleeding patients such as blood product transfusions and medications.
Clotting disorders 1/ dental implant courses
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
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www.indiandentalacademy.com
Oral consideration and laboratory investigations of bleeding and clotting dis...
This document provides information on bleeding and clotting disorders. It discusses the pathophysiology of hemostasis including the vascular, platelet, coagulation, and fibrinolytic phases. It describes different types of bleeding disorders like vessel wall disorders, platelet disorders, and coagulation disorders. Laboratory tests for identifying bleeding disorders are outlined. Oral manifestations and dental considerations for management are summarized. Local hemostatic agents and systemic agents for different bleeding disorders are also mentioned.
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This document discusses the approach to disorders of bleeding and thrombosis. It covers the main components of hemostasis including the vascular endothelium, platelets, coagulation system, and fibrinolysis. It then discusses specific factors, disorders, investigations, and treatments related to bleeding and thrombotic disorders. The key points are that a thorough history, examination, and screening coagulation tests are needed to evaluate a patient. Additional targeted tests may be needed to identify the underlying cause, which could include a deficiency or inhibitor. Treatment depends on the specific disorder diagnosed.
Approach to bleeding disorder
Approach to a bleeding disorder: These presentation has the approach for a patient of bleeding disorder. it has History, physical finding, Investigations.
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The document summarizes various bleeding disorders including their clinical features and classifications. Platelet disorders can cause petechiae and purpurae due to decreased platelet production, increased destruction, or sequestration. Clotting factor deficiencies like hemophilia A and B are inherited and cause hemarthroses, hematomas, and bleeding after trauma. Von Willebrand disease is the most common inherited bleeding disorder caused by a defect in von Willebrand factor.
Approach to diagnosis of bleeding disorders
This document discusses normal hemostasis and bleeding disorders. It begins by describing the normal mechanisms of hemostasis, including the primary and secondary stages. It then discusses various bleeding disorders that can result from defects in blood vessels, platelets, or coagulation factors. Common laboratory tests for evaluation of hemostasis are also presented, including prothrombin time, activated partial thromboplastin time, thrombin time, and fibrinogen levels. Interpretation of laboratory findings and secondary tests like mixing studies are outlined. Causes of abnormal bleeding including qualitative and quantitative platelet and coagulation factor disorders are explored.
Bleeding disorders
This document discusses bleeding disorders and summarizes key points about hemostasis and platelet function. It begins by defining hemostasis and its functions in maintaining a fluid blood state and inducing clotting at sites of injury. Bleeding disorders are then classified based on defects in vascular, platelet, or coagulation systems. Specific inherited and acquired bleeding disorders that result from vascular defects like hereditary telangiectasia and scurvy are described. Platelet disorders are also outlined, distinguishing quantitative issues like thrombocytopenia from qualitative defects. Causes of decreased platelet count or production and increased platelet destruction are summarized.
Bleeding disorders Pathology Dr. UMME HABIBA
The document summarizes normal hemostasis and various bleeding disorders. It describes the three stages of normal coagulation as primary hemostasis involving platelets, secondary hemostasis involving clotting factors, and tertiary hemostasis involving fibrin formation and resolution. Causes of bleeding disorders include vessel wall abnormalities, platelet deficiencies or dysfunctions, and clotting factor derangements. Specific disorders discussed include immune thrombocytopenic purpura, hemophilia, von Willebrand disease, and thrombotic thrombocytopenic purpura. Tests used to evaluate bleeding disorders and clinical manifestations of different disorders are also summarized.
Bleeding Disorders
The document outlines an approach to evaluating and diagnosing bleeding disorders. It discusses:
1. Obtaining a clinical history and performing screening laboratory tests like PT, PTT, and platelet count to classify the bleeding as a platelet, coagulation factor, or other disorder.
2. Using specialized tests like mixing studies and inhibitor assays to identify specific factor deficiencies or inhibitors.
3. Considering rare causes if screening tests are normal, like defects in fibrinolysis or factor XIII.
4. Evaluating acquired bleeding in settings like liver disease and surgery.
A detailed approach with diagnostic algorithms is provided.
Bleeding and clotting disorders
This document discusses bleeding and clotting disorders. It describes various causes of excessive bleeding such as vitamin K deficiency, hemophilia, and thrombocytopenia. It also discusses thromboembolic conditions that result from blood clots forming in vessels. Tests for bleeding disorders are mentioned, including bleeding time, clotting time, and prothrombin time. Therapies for certain conditions are also noted, such as using tissue plasminogen activator to dissolve blood clots or treating hemophilia with purified Factor VIII injections.
Bleeding disorders Causes, Types, and Diagnosis
https://userupload.net/v3l4i8jsk7wq
Factor II, V, VII, X, or XII deficiencies are bleeding disorders related to blood clotting problems or abnormal bleeding problems. Von Willebrand's disease isthe most common inherited bleeding disorder. It develops when the blood lacks von Willebrand factor, which helps the blood to clot.
Bleeding disorder
This document provides information on evaluating and diagnosing bleeding disorders. It discusses evaluating a patient's history for signs of platelet defects, coagulation factor defects, or vascular abnormalities. The examination focuses on findings like petechiae, purpura, echymosis, and joint bleeding. Initial investigations include a CBC, bleeding time, prothrombin time, partial thromboplastin time, and thrombin time. Further tests may include a blood film, platelet function tests, fibrinolysis tests, coagulation factor assays, mixing tests, and von Willebrand factor assay. Based on these evaluations, specific diagnoses can be made, such as hemophilia A, von Willebrand disease, immune thrombocytopenic purp
7a..bleeding disorder.
This document discusses various bleeding disorders including:
- Definition as a disorder characterized by spontaneous or excessive bleeding following trauma.
- Etiologies including vessel wall abnormalities (congenital or acquired like vasculitis) and platelet functional disorders.
- Specific disorders discussed in more detail include von Willebrand disease, hemophilia, Bernard-Soulier syndrome, and Glanzmann's thrombasthenia.
- Clinical features, laboratory findings, and treatment approaches are provided for many of the disorders.
[Int. med] bleeding disorders from SIMS Lahore
This document discusses bleeding and clotting disorders. It provides details on:
1. The normal physiology of hemostasis including vascular, platelet and plasma factors that prevent bleeding.
2. Specific platelet and plasma factor deficiencies that can cause bleeding disorders.
3. The classification of bleeding disorders into defects of blood vessels, platelet disorders, and clotting factor deficiencies.
4. Diagnostic tests for evaluating bleeding patients including screening coagulation tests, specific factor assays, and platelet function tests.
Bleeding and clotting disorders dr anoop k r
This document discusses bleeding and clotting disorders, including the diagnosis and evaluation of bleeding problems. It describes the principal presentations of bleeding disorders such as easy bruising, bleeding from mucous membranes, and excessive bleeding after trauma. It then covers specific types of bleeding disorders like those affecting platelets or coagulation factors. The document outlines typical screening tests used to evaluate bleeding disorders and describes both inherited and acquired causes of platelet and coagulation abnormalities.
Bleeding disorders and their management
This document provides an overview of bleeding disorders, their causes, and management. It discusses how bleeding disorders are caused by abnormalities in hemostasis and coagulation that result in spontaneous or easy bruising. Various types of bleeding disorders are described, including those caused by platelet disorders like thrombocytopenia or vascular defects like vitamin C deficiency. Screening tests for bleeding disorders like platelet count, bleeding time, and INR are also outlined. Effective management of bleeding disorders depends on accurately identifying the underlying cause.
Platelet disoders
Thank you for the informative presentation on platelet disorders. Please let me know if you need any clarification on the concepts covered.
Bleeding disorders(Disorders of Platelets and vessel wall)
(1) Bleeding disorders refer to functional impairments in the normal hemostatic process that result in bleeding even without an anatomical cause.
(2) Common signs of bleeding disorders include petechiae, purpura, hemarthrosis, ecchymoses, and hematomas. Coagulation disorders particularly present with hemarthrosis.
(3) Causes of bleeding disorders include problems with the vascular, platelet, and coagulation phases of hemostasis. Qualitative and quantitative platelet disorders as well as inherited and acquired coagulation factor deficiencies can all result in a bleeding tendency.
hematology.wustl.edu/conferences/presentations/bli... hematology.wustl.edu/...
hematology.wustl.edu/conferences/presentations/bli... hematology.wustl.edu/...MedicineAndHealthCancer
Coagulation factor disorders like hemophilia A and B cause prolonged PT or PTT and bleeding. They are treated with replacement factors or adjuvant drugs.
Platelet disorders can be quantitative or qualitative and cause petechiae or mucocutaneous bleeding. Treatment involves platelet transfusion.
Adjuvant drugs like aminocaproic acid, DDAVP, fresh frozen plasma, cryoprecipitate, and recombinant factor VIIa can help treat bleeding from various coagulation disorders.Investigation of bleeding disorder || bleeding disorder
This document discusses abnormal bleeding and its investigation and management. It begins by outlining the components involved in hemostasis and some common causes of abnormal bleeding such as vascular, platelet, and coagulation disorders. It then describes various screening and confirmatory tests used to evaluate bleeding disorders, including tests for platelets, coagulation factors, and von Willebrand factor. The document concludes by discussing treatment approaches for bleeding patients such as blood product transfusions and medications.
Clotting disorders 1/ dental implant courses
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Oral consideration and laboratory investigations of bleeding and clotting dis...
This document provides information on bleeding and clotting disorders. It discusses the pathophysiology of hemostasis including the vascular, platelet, coagulation, and fibrinolytic phases. It describes different types of bleeding disorders like vessel wall disorders, platelet disorders, and coagulation disorders. Laboratory tests for identifying bleeding disorders are outlined. Oral manifestations and dental considerations for management are summarized. Local hemostatic agents and systemic agents for different bleeding disorders are also mentioned.
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This document discusses leukemia, which are cancers of the white blood cells. It describes the main types of leukemia - acute and chronic forms of myeloid and lymphoblastic leukemia. Acute leukemias involve immature white blood cells while chronic leukemias involve more mature cells. The most common chronic leukemia is chronic myeloid leukemia, which results from a genetic abnormality known as the Philadelphia chromosome. Signs, symptoms, diagnosis and treatment of acute myeloid leukemia and chronic myeloid leukemia are summarized.
Pathology of blood
This document summarizes various blood disorders that affect red blood cells. It begins by describing anemia of blood loss from acute hemorrhage or chronic blood loss. It then discusses hemolytic anemias, where red blood cells are destroyed faster than normal, including hereditary spherocytosis, sickle cell anemia, and thalassemia. Hereditary spherocytosis is caused by inherited defects in the red blood cell membrane. Sickle cell anemia results from a genetic mutation that causes hemoglobin to polymerize and distort the red blood cells into a sickle shape. Thalassemias are caused by mutations that decrease alpha or beta globin synthesis. The document also reviews impaired red cell production and other acquired
Antibody mediated rejection pathology histopathology
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Hemorrhagic Syndromes
Hello Docs ! My name is Maharshika It's my small presentation on hemorrhagic syndromes, hemostasis and It's Disorder i hope you guys likes it. Please like it and share it and keep studying 🙂
Ppt Presentation For Pac 5110
This document provides an overview of hemolytic anemias, with a focus on sickle cell disease. It describes the general diagnostic findings of hemolytic anemia and classifies hemolytic anemias as either hereditary (defects within red blood cells) or acquired (external causes). For sickle cell disease specifically, it identifies complications, diagnostic findings, and treatments including health care maintenance and management of painful crises.
hemolytic anemia (cell membrane defect)
This document discusses various types of hemolytic anemia, including abnormalities of red blood cells, red blood cell membranes, and extrinsic factors. Red blood cell membrane disorders include hereditary spherocytosis, elliptocytosis, and stomatocytosis. Immune hemolytic anemia can be drug-related, alloimmune due to blood transfusions or hemolytic disease of the newborn, or autoimmune including warm or cold types. Other causes discussed include enzymopathies like glucose-6-phosphate dehydrogenase deficiency and paroxysmal nocturnal hemoglobinuria.
Anemiahemol
This document discusses hemolytic anemias, which are classified based on whether there is a red blood cell abnormality or an extracorpuscular factor causing hemolysis. Specific types covered include hereditary spherocytosis, glucose-6-phosphate dehydrogenase deficiency, sickle cell anemia, autoimmune hemolytic anemia, paroxysmal nocturnal hemoglobinuria, and hereditary microspherocytosis. The mechanisms, clinical features, laboratory findings, diagnosis, and treatment are described for several of these hemolytic anemia subtypes.
Aplastic and hypoproliferative anemias
This document summarizes aplastic and hypoplastic anemias. Aplastic anemia is a life-threatening condition where the bone marrow fails to produce red blood cells, white blood cells, and platelets, leading to pancytopenia. It can be acquired through exposure to radiation, chemicals, infections or idiopathically. Congenital causes include Fanconi's anemia and familial aplastic anemia. Clinical manifestations include fatigue, pallor, infections, and bleeding. Treatment involves removing causative agents if known, blood transfusions, and bone marrow transplant. Related disorders with pancytopenia include myelodysplastic syndromes and pure red cell aplasia.
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Bleeding
- 1. Hemorrhagic Diathesis Causes: Increased fragility of vessels Platelet deficiency or dysfunction Derangement of coagulation
- 2. Vessel Wall Abnormalities Common but bleeding is LESS Serious Normal Coagulation test 1. Microbial damage to Microvasculature or DIC 2. Scurvy – Impaired formation of collagen needed for vessel wall support
- 3. 3. Drugs – immune complex deposits in vessel wall 4. Hemoch-Scheonleinpurpura – unknown systemic hypersensitivity disease involve vessels throughout the body & glomerularmesangium 5. Amyloid Infiltration of blood vessels – weakens the wall Vessel Wall Abnormalities
- 4. R/T THROMBOCYTOPENIA Decrease production Aplastic anemia Leukemias Megalobalstic anemia Decrease platelet survival Immune – mediated Non-immune – mechanical
- 5. Sequestration – seen in marked splenomegaly Dilutional – blood stored > 24hours has less viable platelets R/T THROMBOCYTOPENIA
- 6. Idiopathic Immune Thrombocytopenic Purpura ( Autoimmune ) 1. Acute Self-limited Hgicdisease Resolve w/in 6mos. Children after Viral infxn 2 week later Sudden petechiae, purpura Risk for cerebral bleed Severe cases Tx w/ corticosteroids
- 7. 2. Chronic Adults women < 40y/o Associated with Collagen Vascular Disease CLL HIV Repeated episodes of Bleeding Tx Steroids. IgG, Splenectomy in severe cases Idiopathic Immune Thrombocytopenic Purpura ( Autoimmune )
- 9. Deposition of Ig fragments in Amyloidosis
- 13. Thrombotic Microangipathies I. Thrombotic Thrombocytopenic Purpura 1. Fever 2. Thrombocytopenia 3. Microangioapthic hemolytic anemia 4. Transient Neurological damage 5. Renal Failure Deficiency of ADAMTS 13 enzyme Results to accumulation of VHMW vWF promote widesopread platelet Microaggregation
- 14. II. Hemolytic –Uremic Syndrome 1. MicroangiopathicHemolytic anemia 2. Thrombocytopenia 3. Prominence of renal failure 4. No Neurological damage Hx of Enteric infection E. coli Release of Shiga –like toxin Absorbed in GIT Binds and Damage endothelial cells in Glomerulus & other sites Platelet Activation & Aggregation Thrombotic Microangipathies
- 15. Widespread formation of hyaline thrombi in microcircualtion Platelet consumption & Intravascular thrombi Microangiopathic hemolytic anemia Multiple Organ failure Activation of coagualtion cascades is NOT OF PRIMARY IMPORTANCE PT/PTT – usually Normal Thrombotic Microangipathies
- 16. Plasmin Act. Proteolysis of clotting facotrs