Nirvana's "Lithium" describes symptoms of bipolar disorder such as mood swings from extreme happiness to extreme sadness. The song references feeling lonely but okay with it, shaving one's head, and feeling excited yet unsure, alluding to the unpredictable nature of the illness. It also references lighting candles in a daze and finding God, suggestive of manic episodes where judgment may be impaired. The lyrics portray the experience of living with bipolar disorder.
This a project for a high school AP Psychology course. This is a fictionalized account of having a psychological ailment. For questions about this blog project or its content please email the teacher, Laura Astorian: laura.astorian@cobbk12.org
This a project for a high school AP Psychology course. This is a fictionalized account of having a psychological ailment. For questions about this blog project or its content please email the teacher, Laura Astorian: laura.astorian@cobbk12.org
This powerpoint presentation represents definition of the Somatoform disorder, its subtypes, etiology in perspective of theories along differential diagnosis in an attempt to shed light on the disorder adequately
This powerpoint presentation represents definition of the Somatoform disorder, its subtypes, etiology in perspective of theories along differential diagnosis in an attempt to shed light on the disorder adequately
This is a project for a high school AP Psychology course. This is a fictionalized account of having a psychological ailment. For questions about this blog project or its content please email the teacher, Laura Astorian: laura.astorian@cobbk12.org
This is a project for a high school AP psychology course. This is a fictionalized account of having a psychological ailment. For questions about this blog project or it’s content please email the teacher Chris Jocham: jocham@fultonschools.org.
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
1. Nirvana’s Lithium
I'm so happy 'cause today I've found my friends
They're in my head I'm so ugly, but that's okay, 'cause so are you...
We've broken our mirrors
Sunday morning is everyday for all I care...
And I'm not scared
Light my candles in a daze...
'Cause I've found god - yeah, yeah, yeah
I'm so lonely but that's okay I shaved my head...
And I'm not sad
And just maybe I'm to blame for all I've heard...
But I'm not sure I'm so excited, I can't wait to meet you there...
But I don't care I'm so horny but that's okay...
My will is good - yeah, yeah, yeah I like it - I'm not gonna crack
I miss you
I'm not gonna crack
I love you
I'm not gonna crack
I kill you
I'm not gonna crack
2. Bipolar Disorder
Also known as manic depression, a mental
illness that causes a person’s moods to
swing from extremely happy and energized
(mania) to extremely sad (depression)
Chronic illness; can be life-threatening
Most often diagnosed in adolescence
4. Unipolar Bipolar
Depressive Disorder, NOS
Dysthymia
Major Depression
-Single Episode
-Recurrent
- - -
Seasonal Affective
Disorder (SAD)
Postpartum Depression
Mood Disorder, NOS
Cyclothymia
Bipolar II Disorder
Bipolar I Disorder
Bipolar Disorder, NOS
5. Mania/Hypomania
-Extreme euphoria
-Lack of need for sleep
-Inflated Ego and Self-Esteem
-Loose Associations/Flight of Ideas
(from topic to topic)
-May become psychotic when in episode
(in mania only)
6. Continuum of Causes of Affective
Disorders
Biological Bipolar
Major Depression
Environmental Dysthymia
8. Mood Disorders
Growing consensus that Bipolar is
organically based with a notable genetic
factor
Like Major Depression, Bipolar Disorder
linked to low serotonin activity
Theory: low serotonin dysregulation of
other important neurotransmitters, e.g.,
norepinephrine
Etiology of Bipolar Disorder
9. Mood Disorders
“Defective Membrane” Theory of
Bipolar Disorder
1. Nerve impulse moves along
neuron electro-chemically
2. Impulse carried via
exchange of Na & K ions
across neural membrane
Na
K
3. Defect in process
impulse carried too
quickly or too slowly
10. GRK3 regulates sensitivity to
neurotransmitters
Decreases the sensitivity of neurons
to neurotransmitters
Acts as a brake to stress
Maintains balance in the brain
11. GRK3 is a Gene For
Bipolar Disorder
GRK3 is inherited with bipolar disorder
GRK3 is turned on by amphetamine
A mutation in GRK3 increases risk to
bipolar disorder 3 fold
12. Mood Disorders
Genetic studies, especially of twins,
indicate a genetic predisposition for
bipolar disorder
40% of identical twins concordant, vs. 5 to
10% of fraternal twins
Etiology of Bipolar Disorder
13. Epidemiology of Bipolar Disorder
Prevalence: 1% of population Adults =
Adolescents
Males = Females
2-3 million American adults are diagnosed
with bipolar disorder
NIMH estimates that one in very one
hundred people will develop the disorder
14. Controversy
Severity and duration
Onset before puberty is estimated to be
rare
Developmental variability
Retrospective study of adults
15. Vincent Van Gogh
“It isn’t possible to get
values and color. You
can’t be at the pole
and the equator at the
same time. You must
choose your own line,
as I hope to do, and it
will probably be color.”
16. Assessment/Diagnosis of Bipolar
Disorder
Often very complicated; it mimics
many other disorders and has
comorbidity (presents with other
disorders)
Alphabet soup diagnosis
Half of bipolar children have
relatives with bipolar disorder
It is important to first rule
out the possibility of any
other organic diagnosis:
Thyroid disorder
Seizure disorder
Multiple sclerosis
Infectious, toxic, and drug-
induced disorders
17. Mood history
Mania
Giddy, goofy, laughing fits, class
clown
Explosive (how often, how long,
how destructive and aggressive)
Irritable, cranky, angry,
disrespectful, threatening
Grandiosity may present as
EXTREME defiance and
oppositionality
Depression
Low frustration tolerance, self-
destructive, no pleasure, lower
level of irritability
DSM Criteria :A
distinct period
of abnormally
and persistently
elevated,
expansive, or
irritable mood
DIGFAST
acronym (at
least 3 of 7
symptoms)
18. DIGFAST – Mental Status Exam
Distractible
Increased activity/psychomotor agitation
Grandiosity/Super-hero mentality
Flight of ideas or racing thoughts
Activities that are dangerous or
hypersexual
Sleep decreased
Talkative or pressured speech
19. Bipolar Disorder
Significant functional impairment
Bipolar I people go through cycles of major
depression and mania
Bipolar II similar to Bipolar I except that
people have hypomanic episodes, a milder
form of mania
Rapid cyclers
20. Suicide Risk Factors
22% of adolescents with completed
suicides had bipolar disorder
Family history of suicide
Substance abuse i.e. adolescent with
impulse control disorder, depression,
suicidality, substance use and access to a
weapon is potential for lethality
21. Major depression often presents first
(estimated that 20 - 40% of children
presenting with major depression within 5
years will be bipolar)
Comorbidity
70 - 90 % of adolescents have other
disorders
ADHD, Conduct Disorder, Substance
abuse
22. Pediatric-Onset Bipolar Disorder
Geller (American Journal of Psychiatry,
2001) followed up 72 depressed
prepubertal children into adulthood
48.6% (N=35) developed bipolar disorder
by mean age 20.7 years
23. Atypical presentation in juveniles-
exacerbation of disruptive behavior,
moodiness, low frustration tolerance,
explosive anger and difficulty sleeping at
night
Comorbidity of ADHD/BPD more severe
presentation, often severe affect
dysregulation, marked impairment,
violent temper outbursts
24. Pediatric-Onset Bipolar Disorder:
Differential Diagnosis with ADHD
ADHD confusion although identifying presence
of mood disorder helpful in guiding treatment
Talkativeness
Physical
hyperactivity
Distractibility
29. Improvement is seen when mood
stabilizers are used
Kowatch et al (JAACAP 2000)
Response rates:
53% depakote
38% lithium
38% carbamazepine
30. Geller et al.
High relapse rate
Geller longitudinal study
1 year f/u recovery rate 37%
Relapse rate 38%
32. Atypical Antipsychotics
Risperidol
Olanzapine (Zyprexa)
Quetiapine (Seroquel)
Abilify
Geodon
Increasingly used
because they can
cause rapid
patient
stabilization
Zyprexa can help
with depression,
mania and
psychosis
Weight gain
33. Key Point
Just because a child improves on a mood
stabilizer does not prove the diagnosis.
Mood stabilizers have been used for a long
time to help with aggression in children.