This document provides an overview of biology as the study of life. It discusses that biology examines life at multiple levels, from cells to ecosystems. Some key points covered include:
- Biology examines characteristics of living things like growth, response to stimuli, reproduction, metabolism, and evolution.
- Major fields include zoology, botany, anatomy, physiology, ecology, and genetics.
- Central themes revolve around the cellular basis of life, heredity, matter and energy, growth and development, homeostasis, and evolution.
- Biology aims to understand the unity and diversity of life on Earth through scientific inquiry.
Introduction to Life Science and The Theories on the Origin of LifeSimple ABbieC
I. Introduction to Life Science
II. The Concept of Life
III. Characteristics of Life
IV. Theories on the Origin of Life
V. Unifying Themes in the Study of Life
Origin Of Life: Are we here by chance? Theories on origin of life, Scientific and Special Creation. Different Theories of life's origin including Aristotle's theory, Pasteur, Redi and Leuwenhook experiment, Abiogenesis, etc.
Fossils and its evolutionary significance.
Introduction to Life Science and The Theories on the Origin of LifeSimple ABbieC
I. Introduction to Life Science
II. The Concept of Life
III. Characteristics of Life
IV. Theories on the Origin of Life
V. Unifying Themes in the Study of Life
Origin Of Life: Are we here by chance? Theories on origin of life, Scientific and Special Creation. Different Theories of life's origin including Aristotle's theory, Pasteur, Redi and Leuwenhook experiment, Abiogenesis, etc.
Fossils and its evolutionary significance.
WORKFORCE MANAGEMENT HARDWARE AND SOFTWARE: BUSINESS DEVELOPMENT STRATEGIES ...Kim Boggio
WORKFORCE MANAGEMENT HARDWARE AND SOFTWARE: BUSINESS DEVELOPMENT STRATEGIES FOR THE TELECOM, WIRELESS, BROADBAND AND FAST (FIELD AUTOMATION SERVICE TEAM) MARKETS
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
2. Like a small boat
On the ocean
Sending big waves
Into motion
Like how a single word
Can make a heart open
I might only have one match
But I can make an explosion
And all those things I didn't say
Wrecking balls inside my brain
I will scream them loud tonight
Can you hear my voice this time?
This is my fight song
Take back my life song
Prove I'm alright song
My power's turned on
Starting right now I'll be strong
I'll play my fight song
And I don't really care if nobody else believes
'Cause I've still got a lot of fight left in me
Losing friends and I'm chasing sleep
Everybody's worried about me
In too deep
Say I'm in too deep (in too deep)
And it's been two years I miss my home
But there's a fire burning in my bones
Still believe
Yeah, I still believe
Fight Song
Rachel Platten
3. Next Gen Science
• Crosscutting Concepts
• Science and Engineering Practices
• Disciplinary Core Ideas
4. Next Gen Science
• Emphasis on STEM, Collaboration, Higher
Order thinking
5. WHAT IS BIOLOGY?
• The Study of life
• From the Greek Bios – life
• ology – the study of
6. • Chemistry
• Physics
• Meteorology
• Oceanography
• Mathematics/ Statistics
• Geology
• Soils
• Geosphere
• Hydrologic Cycle
• Computers
When studying Biology,
you need to know something about:
8. – Biology is the study of life. But what is life?
– No single characteristic is enough to describe a
living thing. Also, some nonliving things share one
or more traits with organisms.
– Some things, such as viruses, exist at the border
between organisms and nonliving things.
WHAT IS LIFE?
9. Characteristics of Living Things
– are based on a universal genetic code.
– All organisms store the complex information they need to live,
grow, and reproduce in a genetic code written in a molecule
called DNA.
– That information is copied and passed from parent to
offspring and is almost identical in every organism on Earth.
10. CHARACTERISTICS OF LIFE
Movement/ Locomotion
Excretion
Reproduction
Respiration
Response to Stimuli
Nutrition
Growth
11. Characteristics of Living Things
– Living things grow and develop.
– During development, a single fertilized egg
divides again and again.
– As these cells divide, they differentiate,
which means they begin to look different from
one another and to perform different
functions.
12. – Living things respond to their environment.
– A stimulus is a signal to which an organism
responds.
– For example, some plants can produce
unsavory chemicals to ward off caterpillars
that feed on their leaves.
Characteristics of Living Things
13. – Living things reproduce, which means that
they produce new similar organisms.
– Most plants and animals engage in sexual
reproduction, in which cells from two parents
unite to form the first cell of a new organism.
Characteristics of Living
Things
14. – Most plants and animals engage in sexual
reproduction, in which cells from two parents
unite to form the first cell of a new organism.
Characteristics of Living Things
15. – Other organisms reproduce through asexual
reproduction, in which a single organism
produces offspring identical to itself.
– Beautiful blossoms are part of an apple
tree’s cycle of sexual reproduction.
Characteristics of Living Things
16. – Living things maintain a relatively stable internal
environment, even when external conditions change
dramatically.
– All living organisms expend energy to keep
conditions inside their cells within certain limits. This
condition/process is called homeostasis.
– For example, specialized cells help leaves regulate
gases that enter and leave the plant.
Characteristics of Living Things
17. Characteristics of Living Things
– Living things obtain and use material and energy to
grow, develop, and reproduce.
– The combination of chemical reactions through
which an organism builds up or breaks down
materials is called metabolism.
– For example, leaves obtain energy from the sun and
gases from the air. These materials then take part in
various metabolic reactions within the leaves.
18. Characteristics of Living Things
– Living things are made up of one or more cells—the
smallest units considered fully alive.
– Cells can grow, respond to their surroundings, and
reproduce.
– Despite their small size, cells are complex and
highly organized.
– For example, a single branch of a tree contains
millions of cells.
19. Characteristics of Living Things
– Over generations, groups of organisms
evolve, or change over time.
– Evolutionary change links all forms of life to a
common origin more than 3.5 billion years
ago.
20. Characteristics of Living Things
– Evidence of this shared history is found in all
aspects of living and fossil organisms, from
physical features to structures of proteins to
sequences of information in DNA.
– For example, signs of one of the first land
plants, Cooksonia, are preserved in rock over
400 million years old.
23. Fields of Study in Biology
• Major fields of study are:
• Zoology (Animals/Fauna)
• Botany (Plants/Flora)
24. Biology: Disciplines
• Morphology – structures and forms
• Anatomy – internal structures
• Histology – tissues
• Physiology – functions and parts of organism
• Ecology – organism and environment
• Taxonomy – classification
• Genetics
• Microbiology
• Biochemistry
• Pathology
• Entomology - Insects
• Ornithology - Birds
• Ichthyology - Fish
• Mammalogy - Mammals
• Dendrology - Trees
25. Biotechnology
– The field of biotechnology is based on our
ability to “edit” and rewrite the genetic code.
We may soon learn to correct or replace
damaged genes that cause inherited diseases
or genetically engineer bacteria to clean up
toxic wastes.
– Biotechnology raises enormous ethical,
legal, and social questions.
26. Global Ecology
– Life on Earth is shaped by weather patterns and
processes in the atmosphere that we are just
beginning to understand.
– Activities of living organisms—including humans—
profoundly affect both the atmosphere and climate.
– Global ecological studies are enabling us to learn
about our global impact, which affects all life on Earth.
– For example, an ecologist may monitor lichens in a
forest in efforts to study the effects of air pollution on
forest health.
27. Homework:
What are we (humans) made of?
If you had to choose an area of Biology
Specialization what would it be? Why?
28. Big Ideas in Biology
What are the central themes of biology?
The study of biology revolves around several
interlocking big ideas:
– The cellular basis of life
– information and heredity
– matter and energy
– growth, development, and reproduction
– homeostasis
– evolution
– structure and function
– unity and diversity of life
– interdependence in nature
– science as a way of knowing.
29. Cellular Basis of Life
– Living things are made of cells.
– Many living things consist of only a single
cell and are called unicellular organisms.
– Plants and animals are multicellular. Cells in
multicellular organisms display many different
sizes, shapes, and functions.
30. Information and Heredity
Living things are based on a
universal genetic code.
The information coded in your DNA is
similar to organisms that lived 3.5 billion
years ago.
The DNA inside your cells right now can
influence your future—your risk of getting
cancer, the amount of cholesterol in your
blood, and the color of your children’s
hair.
31. Matter and Energy
E = MC²
– Life requires matter that serves as nutrients to build
body structures, and energy that fuels life’s
processes.
– Some organisms, such as plants, obtain energy from
sunlight and take up nutrients from air, water, and soil.
– Other organisms, including most animals, eat plants
or other animals to obtain both nutrients and energy.
– The need for matter and energy link all living things
on Earth in a web of interdependent relationships.
32. Growth, Development, and
Reproduction
– All living things reproduce. Newly produced
individuals grow and develop as they mature.
– During growth and development, generalized
cells typically become more different and
specialized for particular functions.
– Specialized cells build tissues, such as
brains, muscles, and digestive organs, that
serve various functions.
33. Homeostasis
– Living things maintain a relatively stable
internal environment.
– For most organisms, any breakdown of
homeostasis may have serious or even fatal
consequences.
– Specialized plant cells help leaves regulate
gases that enter and leave the plant.
34. Evolution
• Groups of living things evolve. Evolutionary
change links all forms of life to a common origin
more than 3.5 billion years ago.
• Evidence of this shared history is found in all
aspects of living and fossil organisms, from
physical features to structures of proteins to
sequences of information in DNA.
• Evolutionary theory is the central organizing
principle of all biological and biomedical
sciences.
35. Structure and Function
– Each major group of organisms has evolved
its own collection of structures that have
evolved in ways that make particular functions
possible.
– Organisms use structures that have evolved
into different forms as species have adapted
to life in different environments.
36. Unity and Diversity of Life
– Life takes a variety of forms. Yet, all living things are
fundamentally similar at the molecular level.
– All organisms are composed of a common set of
carbon-based molecules, store information in a
common genetic code, and use proteins to build their
structures and carry out their functions.
– Evolutionary theory explains both this unity of life
and its diversity.
37. Interdependence in Nature
– All forms of life on Earth are connected into a
biosphere, or “living planet.”
– Within the biosphere, organisms are linked to
one another and to the land, water, and air
around them.
– Relationships between organisms and their
environments depend on the cycling of matter
and the flow of energy.
38. Science as a Way of Knowing
– The job of science is to use
observations, questions,
and experiments to explain
the natural world in terms of
natural forces and events.
– Successful scientific
research reveals rules and
patterns that can explain
and predict at least some
events in nature.
39. Science as a Way of Knowing
– Science enables us to
take actions that affect
events in the world
around us.
– To make certain that
scientific knowledge is
used for the benefit of
society, all of us must
understand the nature
of science.
40.
41. Eucaryotes vs. Procaryotes
• Eucaryotes: Nuclear membrane - humans
• Procaryotes: No Nuclear membrane –
some bacteria
42. Mitosis vs. Mieosis
• Mieosis: Production of sex cells –
a type of cell division that results in four daughter cells each with half
the number of chromosomes of the parent cell, as in the production
of gametes and plant spores.
• Mitosis: Cell Division – a type of cell division that results in two
daughter cells each having the same number and kind of
chromosomes as the parent nucleus, typical of ordinary tissue
growth