The document provides an overview of key concepts in biology by summarizing 7 points:
1) New properties emerge at higher levels of biological organization from molecules to ecosystems.
2) Organisms interact with their physical environment and other organisms in complex relationships.
3) Life requires the transfer and transformation of energy to carry out functions.
4) Structure and function are closely related at all levels from cells to organisms.
5) The cell is the basic unit of structure and function in organisms.
6) The continuity of life is based on heritable DNA containing genetic information.
7) Feedback mechanisms allow biological processes to self-regulate themselves.
Polysaccharides (Greek: Poly = many) or Glycans
Polysaccharides are polymers consisting of hundreds or
thousands of monosaccharide units. They are also called
glycans or complex carbohydrates. They may be either
linear, (e.g. cellulose) or branched, (e.g. glycogen) in
structure.
Monosaccharides (Greek: Mono = one)
Monosaccharides are also called simple sugars. The term
sugar is applied to carbohydrates that are soluble in
water and sweet to taste. They consist of a single
polyhydroxy aldehyde or ketone unit
Endoplasmic Reticulum (ER)
ï Endoplasmic reticulum is the interconnected network
of tubular and flat vesicular structures in the
cytoplasm (Figures 1.4A and B).
ï Endoplasmic reticulum forms the link between
nucleus and cell membrane by connecting the cell
membrane at one end and the outer membrane of
the nucleus at the other end (see Figure 1.1).
ï A large number of minute granular particles called
Polysaccharides (Greek: Poly = many) or Glycans
Polysaccharides are polymers consisting of hundreds or
thousands of monosaccharide units. They are also called
glycans or complex carbohydrates. They may be either
linear, (e.g. cellulose) or branched, (e.g. glycogen) in
structure.
Monosaccharides (Greek: Mono = one)
Monosaccharides are also called simple sugars. The term
sugar is applied to carbohydrates that are soluble in
water and sweet to taste. They consist of a single
polyhydroxy aldehyde or ketone unit
Endoplasmic Reticulum (ER)
ï Endoplasmic reticulum is the interconnected network
of tubular and flat vesicular structures in the
cytoplasm (Figures 1.4A and B).
ï Endoplasmic reticulum forms the link between
nucleus and cell membrane by connecting the cell
membrane at one end and the outer membrane of
the nucleus at the other end (see Figure 1.1).
ï A large number of minute granular particles called
Oligosaccharides (Greek: oligo = few)
Oligosaccharides consist of a short chain of monosaccharide
units (2 to 10 units), joined together by a characteristic bond
called glycosidic bond which, on hydrolysis, gives two to
ten molecules of simple sugar (monosaccharide) units
lassification Based on Chemical Nature
of the Amino Acid in Solution
According to this type of classification, amino acids are
classified as follows:
i. Neutral amino acids
ii. Acidic amino acids
iii. Basic amino acids.
Simple Lipids
These are esters of fatty acids with various alcohols.
Depending on the type of alcohols, these are sub-
classified as:
1. Neutral fats or triacylglycerol or triglycerides
2. Waxes.
ow on damp nuts. Nut meats are frequently contaminated with molds especially the storage molds Penicillium, Aspergillus, and Fusarium. The mold composition changes from "field fungi" to "storage fungi" from harvest through processing to storage. Aflatoxin is a concern because of mold growth and mycot
ction that occurs in the body.
Proteins are linear chains of amino acids that are linked
together by covalent, peptide bonds. Each protein has
specific and unique sequence of amino acids that defines
both its three-dimensional structure and its biologic
function.
[2:40 pm, 31/12/2023] Aarav (@): Neutral amino acids
The amino acids which are neutral in solution and are
monoamino-monocarboxylic acids (i.e. having one
amino group and one carboxylic group), e.g.
[2:40 pm, 31/12/2023] Aarav (@): Acidic amino acid
These are acidic in solution and are monoamino dicarboxylic
acids, e.g.
ï Aspartic acid
Waxes
True waxes
These are esters of fatty acids with higher molecular
weight monohydric long chain alcohols. These com-
pounds have no importance as far as human metabolism
is concerned. For example,
ï Lanolin (from lamb’s wool)
ï Bees-wax
ï Spermacetic oil (from whales).
Complex or Compound Lipids
These are esters of fatty acids, with alcohol containing
additional (prosthetic) groups. These are subclassified
according to the type of prosthetic group present in the
lipid as follows:
1. Phospholipids
2. Glycolipids
3. Lipoproteins.
GENERAL NATURE OF AMINO ACIDS
ï There are approximately 300 amino acids present in
various animal, plant and microbial systems, but only
20 amino acids are involved in the formation of proteins.
ï All the 20 amino acids found in proteins (Table 4.1)
have a carboxyl group (-COOH) and an amino acid
group (-NH2) bound to the same carbon atom called
the α-carbon
Neutral fats or triacylglycerol or triglycerides
These are esters of fatty acids with alcohol glycerol, e.g.
tripalmitin. Because they are uncharged, they are termed
as neutral fat. The fat we eat are mostly triglycerides. A
fat in liquid state is called an oil, e.g. vegetable oils like
groundnut oil, mustard oil, corn oil, etc.
Derived Lipids
Derived lipids include the products obtained after the
hydrolysis of simple and compound lipids which
possess the characteristics of lipids, e.g.
ï Fatty acids
ï Steroids
ï Cholesterol
ï Lipid soluble vitamins and hormones
ï Ketone bodies.
INTRODUCTION
Proteins are the most abundant macromolecules in
living cells. The term ‘protein’ was first used by
Berzelius in 1838 and was derived from the Greek word
“protos” which means primary or holding first place.
As the name indicates, protein is the most important of
cell constituents. They are responsible for almost every
function that occurs in the body.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Oligosaccharides (Greek: oligo = few)
Oligosaccharides consist of a short chain of monosaccharide
units (2 to 10 units), joined together by a characteristic bond
called glycosidic bond which, on hydrolysis, gives two to
ten molecules of simple sugar (monosaccharide) units
lassification Based on Chemical Nature
of the Amino Acid in Solution
According to this type of classification, amino acids are
classified as follows:
i. Neutral amino acids
ii. Acidic amino acids
iii. Basic amino acids.
Simple Lipids
These are esters of fatty acids with various alcohols.
Depending on the type of alcohols, these are sub-
classified as:
1. Neutral fats or triacylglycerol or triglycerides
2. Waxes.
ow on damp nuts. Nut meats are frequently contaminated with molds especially the storage molds Penicillium, Aspergillus, and Fusarium. The mold composition changes from "field fungi" to "storage fungi" from harvest through processing to storage. Aflatoxin is a concern because of mold growth and mycot
ction that occurs in the body.
Proteins are linear chains of amino acids that are linked
together by covalent, peptide bonds. Each protein has
specific and unique sequence of amino acids that defines
both its three-dimensional structure and its biologic
function.
[2:40 pm, 31/12/2023] Aarav (@): Neutral amino acids
The amino acids which are neutral in solution and are
monoamino-monocarboxylic acids (i.e. having one
amino group and one carboxylic group), e.g.
[2:40 pm, 31/12/2023] Aarav (@): Acidic amino acid
These are acidic in solution and are monoamino dicarboxylic
acids, e.g.
ï Aspartic acid
Waxes
True waxes
These are esters of fatty acids with higher molecular
weight monohydric long chain alcohols. These com-
pounds have no importance as far as human metabolism
is concerned. For example,
ï Lanolin (from lamb’s wool)
ï Bees-wax
ï Spermacetic oil (from whales).
Complex or Compound Lipids
These are esters of fatty acids, with alcohol containing
additional (prosthetic) groups. These are subclassified
according to the type of prosthetic group present in the
lipid as follows:
1. Phospholipids
2. Glycolipids
3. Lipoproteins.
GENERAL NATURE OF AMINO ACIDS
ï There are approximately 300 amino acids present in
various animal, plant and microbial systems, but only
20 amino acids are involved in the formation of proteins.
ï All the 20 amino acids found in proteins (Table 4.1)
have a carboxyl group (-COOH) and an amino acid
group (-NH2) bound to the same carbon atom called
the α-carbon
Neutral fats or triacylglycerol or triglycerides
These are esters of fatty acids with alcohol glycerol, e.g.
tripalmitin. Because they are uncharged, they are termed
as neutral fat. The fat we eat are mostly triglycerides. A
fat in liquid state is called an oil, e.g. vegetable oils like
groundnut oil, mustard oil, corn oil, etc.
Derived Lipids
Derived lipids include the products obtained after the
hydrolysis of simple and compound lipids which
possess the characteristics of lipids, e.g.
ï Fatty acids
ï Steroids
ï Cholesterol
ï Lipid soluble vitamins and hormones
ï Ketone bodies.
INTRODUCTION
Proteins are the most abundant macromolecules in
living cells. The term ‘protein’ was first used by
Berzelius in 1838 and was derived from the Greek word
“protos” which means primary or holding first place.
As the name indicates, protein is the most important of
cell constituents. They are responsible for almost every
function that occurs in the body.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
2. • Biology is the scientific study of life
• Biologists ask questions such as
– How does a single cell develop into an organism?
– How does the human mind work?
– How do living things interact in communities?
• How do we know if something is living? Is a virus alive
or dead?
INTRODUCTION :
4. To know what is biology, we need to understand:
1. New properties emerge at each level in the biological
hierarchy
2. Organisms interact with other organisms and the physical
environment
3. Life requires energy transfer and transformation
4. Structure and function are correlated at all levels of
biological organization
5. The cell is an organism’s basic unit of structure and
function
6. The continuity of life is based on heritable information in
the form of DNA
7. Feedback mechanisms regulate biological systems
5. 1. New Properties Emerge at Each Level
in the Biological Hierarchy
• Life can be studied at different levels, from molecules
of microscopic scale to global scale of the entire living
planet
• The study of life can be divided into different levels of
biological organization
7. Emergent Properties
• Emergent properties result from the arrangement and
interaction of parts within a system
• Emergent properties characterize non-biological entities
as well
– For example, a functioning bicycle emerges only when
all of the necessary parts connect in the correct way
8. • These emergent properties are due to the
arrangement and interaction of parts as
complexity increases :
a cell is much more than a bag of molecules
eg: components of a chloroplast & photosynthesis
our thoughts and memories are emergent properties
of a complex network of neurons
• This show the importance of structural
arrangements
• Emergent properties of life reflect a hierarchy of
structural organization
9. • The complex organization of life makes it difficult to
study the biological processes.
• cannot fully explain higher level of organization by
breaking down into its components (a dissected
animal no longer functions)
• at the same time, it is futile to analyze an organism or
cells without taking it apart
• This is where ‘Reductionism’ plays an important role
in understanding the biological processes of complex
organization.
• Reductionism = the reduction of complex systems
to simpler components that are more manageable to
study.
10. The Power and Limitations of Reductionism
• Reductionism is the reduction of complex systems to
simpler components that are more manageable to
study
– For example, studying the molecular structure of DNA
helps us to understand the chemical basis of
inheritance
• An understanding of biology balances reductionism
with the study of emergent properties
– For example, new understanding comes from studying
the interactions of DNA with other molecules
11. • To understand the larger scale how parts of
cells, organisms and higher levels of orders
such as ecosystems work together an
approach called system biology was used
12. Systems Biology
• A system is a combination of components that
function together
• Systems biology constructs models for the dynamic
behavior of whole biological systems
• The systems approach poses questions such as
– How does a drug for blood pressure affect other
organs?
– How does increasing CO2 alter the biosphere?
• A successful model predicts how a change in one or
more variables affect other components and the
whole system
13. 2. Organisms Interact with Other
Organisms and the Physical Environment
• Every organism interacts with its environment,
including non-living factors and other organisms
• Both organisms and their environments are affected by
the interactions between them
– For example, a tree takes up water and minerals from
the soil and carbon dioxide from the air; the tree
releases oxygen to the air and roots help form soil
14. Animals eat
leaves and fruit
from the tree.
Leaves take in
carbon dioxide
from the air
and release
oxygen.
Sunlight
CO2
O2
Cycling
of
chemical
nutrients
Leaves fall to
the ground and
are decomposed
by organisms
that return
minerals to the
soil.
Water and
minerals in
the soil are
taken up by
the tree
through
its roots.
Leaves absorb
light energy from
the sun.
15. • Humans have modified our environment
– For example, half the human-generated CO2 stays in
the atmosphere and contributes to global warming
• Global warming is a major aspect of global climate
change
• It is important to understand the effects of global
climate change on the Earth and its populations
16. 3. Life Requires Energy Transfer and
Transformation
• A fundamental characteristic of living organisms is their use of
energy to carry out life’s activities
• Work, including moving, growing, and reproducing, requires a
source of energy
• Living organisms transform energy from one form to another
• Energy flows through an ecosystem, usually entering as light and
exiting as heat
For example,
– plant absorb light energy and convert it to chemical energy
stored in sugar molecules
– animals convert chemical energy (consume plant products) to
kinetic energy (motion)
– some of this energy is converted to thermal energy (heat)
17. Figure 1.6
Heat
Producers absorb light
energy and transform it into
chemical energy.
Chemical
energy
Chemical energy in
food is transferred
from plants to
consumers.
(b) Using energy to do work
(a) Energy flow from sunlight to
producers to consumers
Sunlight
An animal’s muscle
cells convert
chemical energy
from food to kinetic
energy, the energy
of motion.
When energy is used
to do work, some
energy is converted to
thermal energy, which
is lost as heat.
A plant’s cells use
chemical energy to do
work such as growing
new leaves.
18. 4. Structure and Function Are Correlated
at All Levels of Biological Organization
• Analyzing a biological structure gives clue about what
its function
• Knowing a function of something provides insights of
its structure
19. • Structure and function of living organisms are closely
related
– For example, a leaf is thin and flat, maximizing the
capture of light by chloroplasts
– For example, the structure of a bird’s wing is adapted
to flight (shape of wing & structure of bones)
20. 5. The Cell Is an Organism’s Basic Unit of
Structure and Function
• The cell is the lowest level of organization that can
perform all activities required for life
• All cells
– Are enclosed by a membrane
– Use DNA as their genetic information
• Two main forms of cells :
– prokaryotic (bacteria)
– eukaryotic (plants, animals)
21. 6. The Continuity of Life Is Based on
Heritable Information in the Form of
DNA
• Chromosomes contain most of a cell’s genetic
material in the form of DNA (deoxyribonucleic acid)
• DNA is the substance of genes
• Genes are the units of inheritance that transmit
information from parents to offspring
• The ability of cells to divide is the basis of all
reproduction, growth, and repair of multicellular
organisms
22. 7. Feedback Mechanisms Regulate
Biological Systems
• Feedback mechanisms allow biological processes to self-
regulate
• Common to life at all levels, from molecules to
ecosystems and the biosphere
• Negative feedback means that as more of a product
accumulates, the process that creates it slows and less of
the product is produced
• Positive feedback means that as more of a product
accumulates, the process that creates it speeds up and
more of the product is produced
23. E.g.: When excess ATP being produced by cells due to the
generation of energy, ATP “feeds back” and inhibit an enzyme
near the beginning of the pathway
24. E.g.: When blood vessel is damaged due to open wound,
platelets begin to aggregate at the site. Positive feedback occurs
as chemical released by the platelets to attract more platelets to
seal the wound.
25. The Diversity of Life
• Approximately 1.8 million species have been identified
and named to date
• This diversity include :
– 6,300 species of prokaryotes
– 100,000 fungi
– 290,000 plants
– 52,000 vertebrates
– 1 million insects
• Thousands more are identified each year
• Estimates of the total number of species that actually
exist range from 10 million to over 100 million
26. Grouping Species: The Basic Idea
• To help organize the diversity of life, biologist classify
species into groups.
• Taxonomy is the branch of biology that names and
classifies species into groups, formalizes the ordering
of species
• Domains, followed by kingdoms, are the broadest
units of classification
28. FORMS OF INQUIRY TO EXPLORE LIFE
• Science derived from the Latin verb = to know
• The heart of science = inquiry
• Two types of scientific inquiry:
- discovery science (describing nature)
- hypothesis-based science (explaining nature)
* Most scientific inquiries combine these two approaches
29. 1) Discovery Science :
Describes natural structures and processes as accurately
as possible through careful observation and analysis of
data
- discovery science build our understanding of cell
structures and is expending our databases of
genomes of diverse species
2) Types of Data
Observation is the use of the senses to gather
information, which is recorded as data
30. Hypothesis-Based Science
• In science , inquiry usually involves the proposing and
testing of hypotheses
• A hypothesis is a tentative answer to a well-framed
question
• A scientific hypothesis leads to predictions that can be
tested by additional observation or by experiments
• A type of logic called deduction is built into hypothesis-
based science
32. • A Hypothesis must be :
i) Testable – some way to check validity of idea
ii) Falsifiable – some observation or experiment that
could reveal if such idea is actually not
true
• The ideal in hypothesis-based science is to frame two or
more alternative hypotheses and design experiments to
falsify them
• No amount of experimental testing can prove a
hypothesis because it is impossible to test all alternative
hypotheses
• A hypothesis gains credibility by surviving experiments
that could falsify it, while testing falsifies alternative
hypotheses
33. • Scientific method
- idealized process of inquiry
- basic steps in Scientific method
> make observations, may come from others or results
of previous tests
> ask questions about the observations : How? Why?
When?
> generate hypotheses : phrased in such a was as to be
testable
> derive predictions : logical, testable outcomes of the
hypotheses
> developed by the use of deductive reasoning
34. • Scientific method
- basic steps in Scientific method
> predictions take the form of
“if (statement of hypothesis) is true, then
(predictions)
> test predictions: to determine if the predictions are
supported (fail to falsify) or falsified
> a hypothesis becomes credible when repeated tests
to falsify fail
- not all scientific inquiries need to follow rigidly the steps
above
35. • Scientific method
- not all scientific inquiries need to follow rigidly the steps
- discovery science has contributed much to our
understanding of nature without most of the steps of
scientific method
• Limitation of science
- these limits are set by science’s requirements that
> hypotheses be testable and falsifiable
> observations and experimental results be
repeatable
36. • Theories in Science
- a scientific theory is much more broader scope than
hypothesis
- Hypothesis : “Mimicking poisonous snakes is an
adaptation that protects nonpoisonous
snakes from predators”
- A theory is general enough to generate many new
specific hypotheses that can be tested
- A theory is generally supported by a much more greater
body of evidence
37. • Theories in Science
- theories that become widely adopted in science explain
many observations and are supported by a great deal of
evidence
- scientist may have to modify or reject theories when
new evidence is found, in spite of the body evidence
supporting a widely accepted theory
- if there is “truth” in science, it is based on a
preponderance of the available evidence