Validation of new blood bags for blood fractioning using reveos systemBanc de Sang i Teixits
Validation of new blood bags for blood fractioning using reveos system by Susana G Gomez, head of Blood and Cell Processing Laboratory (Blood and Tissue Bank of Catalonia)
This presentation describes the blood components. It also describes the problems in storing those component and what methods are used to overcome them.
Validation of new blood bags for blood fractioning using reveos systemBanc de Sang i Teixits
Validation of new blood bags for blood fractioning using reveos system by Susana G Gomez, head of Blood and Cell Processing Laboratory (Blood and Tissue Bank of Catalonia)
This presentation describes the blood components. It also describes the problems in storing those component and what methods are used to overcome them.
Blood products:Collection, Processing and Storage of whole human blood, dried...Steffi Thomas
blood and its components, conditions for being a donor, anti-coagulants, whole human blood, changes in composition during storage, red blood cells, concentrated platelets, plasma, dried human plasma, fresh frozen plasma, dried human serum, plasma substitutes, ideal properties of plasma substitute, dextran, gum saline, polyvinylpyrrolidone
Components Of Blood (For Transfusion)
• Each unit of blood is tested for evidence of hepatitis-b,
hepatitis-c, Human Immune deficiency Virus I & II.
• The blood is then processed into sub-components.
• Whole blood
• Packed cell volume
• Fresh frozen plasma
• Platelets
• Cryoprecipitate
blood and blood component have an important role in transfusion medicine. when blood contain all its part and no separation is done thats known as whole blood but when you centrifuge and separate it that is know as component. transfusion of whole blood is now adays absolute from transfusion service and blood components are transfuses now a days which is a good practice and beneficial for the patient
This presentation will provide you about the detailed structure, process and outcome of bloodbank in atertiary care hospital in terms of Quality management.
Visual inspection guide for blood compopnentsqueueup
This guide has been produced for use by both Canadian
Blood Services and hospital personnel.
This guide is divided into four sections covering the
four blood components. Each section begins with a
brief explanation of the component, a description of the
variations in appearance for that component and criteria for
acceptability.
Blood products:Collection, Processing and Storage of whole human blood, dried...Steffi Thomas
blood and its components, conditions for being a donor, anti-coagulants, whole human blood, changes in composition during storage, red blood cells, concentrated platelets, plasma, dried human plasma, fresh frozen plasma, dried human serum, plasma substitutes, ideal properties of plasma substitute, dextran, gum saline, polyvinylpyrrolidone
Components Of Blood (For Transfusion)
• Each unit of blood is tested for evidence of hepatitis-b,
hepatitis-c, Human Immune deficiency Virus I & II.
• The blood is then processed into sub-components.
• Whole blood
• Packed cell volume
• Fresh frozen plasma
• Platelets
• Cryoprecipitate
blood and blood component have an important role in transfusion medicine. when blood contain all its part and no separation is done thats known as whole blood but when you centrifuge and separate it that is know as component. transfusion of whole blood is now adays absolute from transfusion service and blood components are transfuses now a days which is a good practice and beneficial for the patient
This presentation will provide you about the detailed structure, process and outcome of bloodbank in atertiary care hospital in terms of Quality management.
Visual inspection guide for blood compopnentsqueueup
This guide has been produced for use by both Canadian
Blood Services and hospital personnel.
This guide is divided into four sections covering the
four blood components. Each section begins with a
brief explanation of the component, a description of the
variations in appearance for that component and criteria for
acceptability.
The first four papers are part of our ongoing process of publishing research papers in topics related to supply chain management and logistics that raise new research insights. In addition, JOSCM also presents three best papers award nominated in the XX Simpósio de Administração da Produção, Logística e Operações Internacionais (SIMPOI 2017), which occurs annually in Sao Paulo bringing together academic and practitioners in the Operations Management field.
In this new edition of Journal of Operations and Supply Chain Management (JOSCM), the first four papers are part of our ongoing process of publishing research papers in topics related to supply chain management and logistics that raise new research insights. In addition, JOSCM also presents three best papers award nominated in the XX Simpósio de Administração da Produção, Logística e Operações Internacionais (SIMPOI 2017), which occurs annually in Sao Paulo bringing together academic and practitioners in the Operations Management field.
at SciVerse ScienceDirectBiomaterials 34 (2013) 30e41Con.docxrock73
at SciVerse ScienceDirect
Biomaterials 34 (2013) 30e41
Contents lists available
Biomaterials
journal homepage: www.elsevier.com/locate/biomaterials
The blood and vascular cell compatibility of heparin-modified ePTFE vascular
grafts
Ryan A. Hoshi a, Robert Van Lith a, Michele C. Jen a, Josephine B. Allen b, Karen A. Lapidos a,
Guillermo Ameer a,c,*
a Biomedical Engineering Department, Northwestern University, Evanston, IL 60208, USA
b Material Science and Engineering Department, University of Florida, Gainesville, FL 32611, USA
c Department of Surgery, Feinberg School of Medicine, Chicago, IL 60611, USA
a r t i c l e i n f o
Article history:
Received 16 July 2012
Accepted 21 September 2012
Available online 12 October 2012
Keywords:
Vascular graft
Elastomer
Endothelial cell
Progenitor cell
Smooth muscle cell
Heparin
Hemocompatibility
Aminated poly(1,8-octanediol-co-citrate)
(POC)
* Corresponding author.
E-mail address: [email protected] (G. A
0142-9612/$ e see front matter � 2012 Elsevier Ltd.
http://dx.doi.org/10.1016/j.biomaterials.2012.09.046
a b s t r a c t
Prosthetic vascular grafts do not mimic the antithrombogenic properties of native blood vessels and
therefore have higher rates of complications that involve thrombosis and restenosis. We developed an
approach for grafting bioactive heparin, a potent anticoagulant glycosaminoglycan, to the lumen of ePTFE
vascular grafts to improve their interactions with blood and vascular cells. Heparin was bound to ami-
nated poly(1,8-octanediol-co-citrate) (POC) via its carboxyl functional groups onto POC-modified ePTFE
grafts. The bioactivity and stability of the POC-immobilized heparin (POCeHeparin) were characterized
via platelet adhesion and clotting assays. The effects of POCeHeparin on the adhesion, viability and
phenotype of primary endothelial cells (EC), blood outgrowth endothelial cells (BOECs) obtained from
endothelial progenitor cells (EPCs) isolated from human peripheral blood, and smooth muscle cells were
also investigated. POCeHeparin grafts maintained bioactivity under physiologically relevant conditions
in vitro for at least one month. Specifically, POCeHeparin-coated ePTFE grafts significantly reduced
platelet adhesion and inhibited whole blood clotting kinetics. POCeHeparin supported EC and BOEC
adhesion, viability, proliferation, NO production, and expression of endothelial cell-specific markers von
Willebrand factor (vWF) and vascular endothelial-cadherin (VE-cadherin). Smooth muscle cells cultured
on POCeHeparin showed increased expression of a-actin and decreased cell proliferation. This approach
can be easily adapted to modify other blood contacting devices such as stents where antithrombogenicity
and improved endothelialization are desirable properties.
� 2012 Elsevier Ltd. All rights reserved.
1. Introduction
Cardiovascular disease is a leading cause of death and morbidity
in developed countries and patients diagnosed with this disease
often require revascularization ...
Measuring Tissue Perfusion and PO2 in Conscious Animals to Investigate Organ ...InsideScientific
During this webinar, sponsored by Scintica Instrumentation, Professor Clive May and Dr. Yugeesh Lankadeva, from the Florey Institute of Neuroscience and Mental Health in Melbourne, discuss their research investigating the causes of acute renal failure in large animal models, the effects of resuscitation with volume or vasopressor drugs on renal perfusion and oxygenation in sepsis, and the measurement of bladder urinary pO2 as a real-time estimate of renal medullary ptiO2.
First, they present the development and validation of methodology to measure renal cortical and medullary tissue perfusion and oxygenation long-term in conscious animals. Specifically, they review selective changes in renal cortical and medullary tissue perfusion and oxygenation in response to alterations in total organ blood flow and administration of drugs.
In addition, Professor May and Dr. Lankadeva share data from their studies demonstrating changes in total renal blood flow, renal function and differential changes in renal cortical and medullary perfusion, and pO2 during resuscitation and in models of sepsis. They conclude the presentation with a focus on why the study of septic acute kidney injury is so important.
Similar to Automation in blood bank processing: where we go? (20)
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
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We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
1. AUTOMATION IN BLOOD BANK PROCESSING: WHERE WE GO?
R. Fernandez, Ll. Puig, P. Ortiz, J. Ovejo, N. Martinez, E. Valdivia & S.G. Gomez
Banc de Sang i Teixits. Barcelona (Spain)
BACKGROUND
Nowadays, blood banking is requiring new strategies to manufacture blood components, due to the increase on their
production. At Banc de Sang i Teixits (BST), we have implemented during the last years automation manufacturing,
including lean management methods, to be able to process our needs of over 250.000 blood donations for an area with
more than 7 million people.
Orbisac
(2005)
Atreus
2C
(2007)
Atreus
3C
(2011)
Reveos
(2013)
METHOD
BST has been implementing different equipment (Fig. 1) and final products
were different:
-Orbisac (2005): buffy coat and platelet concentrate.
-Atreus 2C and Atreus 3C (2007 & 2011): red blood cells, buffy coat and fresh
frozen plasma.
-Reveos (2013): red cell concentrate, plasma, platelets and leukocyte residue.
In 2009, an engineer was incorporated in the team for implementing Lean
Manufacturing thinking. Briefly, lean thinking major value is to eliminate all
waste processes and chose all these activities that add value to the procedure
(Fig. 2). Figure 1. Banc de Sang i Teixits cronogram
Figure 2. Lean Thinking principles
RESULTS
During the period when the different equipment was changed
and implemented, hemoglobin content per red blood cell unit
increased from 52.2 g to 56.0 g. Platelet content in the
average pool unit increased from 2.5 x1011, to 3.1 x 1011,
with four or five IPU units (table I).
Automation had am impact on staff and how it was
organized. The staff working hours to obtain blood
components decreased from 25.7 to 17.8 per 100 whole
blood units (table II).
The attrition rate for RBCs decreased from 1.11% (2008) to
0.81% (2016). Regarding platelets, attrition rate also
decreased (table III).
CONCLUSIONS
It’s obvious that automation in blood banking makes more efficient the manufacturing of blood components, getting
better quality of them. We encourage maintaining lean philosophy in order to keep improving our methods and
identifying those activities that add value to our process. In a globalized and industrialized world, where everything
changes very fast, these improvements are necessary to be on top of the field and be a state of the art blood bank.
Table I. Evolution of blood components
Table II. Evolution of staff needs (in hours)
Table III. Attrition rates