This document discusses information systems approaches for non-profit organizations. It outlines trends in the sector including declining costs, increased use of cloud-based and browser applications, and a convergence of proprietary and custom-built systems. Case studies are presented on a legal charity, local council, and grant-making trust to illustrate opportunities to standardize processes, implement self-service options, and leverage data to drive efficiencies. The key takeaways are that an organizational information strategy is needed to guide technology choices and maximize value over the long run.