The document provides an overview of the endocrine system, including:
1. The endocrine system uses chemical messengers called hormones to allow cells to communicate and regulate activities throughout the body. Hormones are secreted into the bloodstream and travel to target tissues.
2. The endocrine system consists of endocrine glands and specialized cells that secrete minute amounts of hormones. Hormones travel via the bloodstream to specific target sites where they elicit effects.
3. The endocrine and nervous systems both regulate homeostasis but differ in their modes of transport (hormones travel via bloodstream vs neurotransmitters acting locally) and speeds/durations of response.
This is on the basic details of the endocrine system including the different types of hormones. It describes the mechanisms of actions of hormones. The general control mechanisms of hormone production and release are also included.
A chemical substance produced in the body that controls and regulates the activity of certain cells or organs. Many hormones are secreted by special glands, such as thyroid hormone produced by the thyroid gland.
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Introduction of endocrine
AT THE END OF THIS SESSION, STUDENT SHOULD BE ABLE TO:
Define and differentiate between various chemical messengers in the body.
Define hormones and list the major functions of hormones in the body.
Enumerate the hormone secreting tissues and their hormones.
Classify hormones according to their chemical nature.
Describe briefly the major mechanisms for hormone actions.
Describe nervous-endocrine relationship.
Revise feedback as a mechanism of control of hormone secretion.
This is on the basic details of the endocrine system including the different types of hormones. It describes the mechanisms of actions of hormones. The general control mechanisms of hormone production and release are also included.
A chemical substance produced in the body that controls and regulates the activity of certain cells or organs. Many hormones are secreted by special glands, such as thyroid hormone produced by the thyroid gland.
follow med_students0
Introduction of endocrine
AT THE END OF THIS SESSION, STUDENT SHOULD BE ABLE TO:
Define and differentiate between various chemical messengers in the body.
Define hormones and list the major functions of hormones in the body.
Enumerate the hormone secreting tissues and their hormones.
Classify hormones according to their chemical nature.
Describe briefly the major mechanisms for hormone actions.
Describe nervous-endocrine relationship.
Revise feedback as a mechanism of control of hormone secretion.
Hormones are chemical messengers that are secreted directly into the blood, which carries them to organs and tissues of the body to exert their functions. There are many types of hormones that act on different aspects of bodily functions and processes.
GENERAL MECHANISM OF PEPTIDE AND STEROID HORMONE ACTION.pdfApoorva Rajagopal
Hormones are a type of signaling molecules that are produced by the endocrine glands. They are natural organic substance produced in minute quantity to regulate growth, metabolism and other functions.
Hormones are the member of a class of signaling molecules produced by glands in multicellular organism that are transported by the circulatory system to target distant organ to regulate physiology and behavior.
Hormones are used to communicate between organs and tissue for physiological regulation and behavioral activities.
such as digestion, metabolism, respiration, tissue function, sensory perception, excretion, lactation, stress, growth, and development, movement, reproduction and mood.
Hormones are chemical messengers that are secreted directly into the blood, which carries them to organs and tissues of the body to exert their functions. There are many types of hormones that act on different aspects of bodily functions and processes.
GENERAL MECHANISM OF PEPTIDE AND STEROID HORMONE ACTION.pdfApoorva Rajagopal
Hormones are a type of signaling molecules that are produced by the endocrine glands. They are natural organic substance produced in minute quantity to regulate growth, metabolism and other functions.
Hormones are the member of a class of signaling molecules produced by glands in multicellular organism that are transported by the circulatory system to target distant organ to regulate physiology and behavior.
Hormones are used to communicate between organs and tissue for physiological regulation and behavioral activities.
such as digestion, metabolism, respiration, tissue function, sensory perception, excretion, lactation, stress, growth, and development, movement, reproduction and mood.
Archer USMLE step 3 Endocrinology lecture notes. These lecture notes are samples and are intended for use with Archer video lectures. For video lectures, please log in at http://www.ccsworkshop.com/Pay_Per_View.html
Describes the different types of chemical messengers in mammalian body. This explains their synthesis and mode of action also. A short account of neurohormones and neuroendocrine function is also included.
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Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
2. Principles of Chemical Communication
• Chemical Messengers
– Allow cells to communicate with each other to
regulate activities
– 4 classes of chemical messengers based on the
source of the chemical messenger and its mode of
transport in the body
• Autocrine chemical messengers
• Paracrine chemical messengers
• Neurotransmitters
• Endocrine chemical messengers
3.
4. Characteristics of the Endocrine
System
• Composed of endocrine glands and
specialized endocrine cells located throughout
the body
• Secrete minute amounts of chemical
messengers (hormones) into the bloodstream
• Hormones travel a distance from their source
through the bloodstream to specific sites
(target tissues or effectors)
5.
6.
7. Comparison of the Nervous System
and Endocrine Systems
• Nervous system and the endocrine system
regulate and coordinate the activities of
essentially all body structures to achieve and
maintain homeostasis
– Nervous system functions as a communication
system
– Endocrine system sends information to the cells it
controls in the form of hormones, which are
carried by the bloodstream to all parts of the body
8. Similarities
• Structures associated with the brain
– E.g. hypothalamus
• Same molecule is a neurotransmitter for the
nervous system and a hormone for the
endocrine system
– E.g. epinephrine
• Work together to regulate critical body
processes
– E.g epinephrine
10. Differences
• Mode of transport
– Endocrine system secretes hormones which are
transported in the bloodstream
– Nervous system secretes neurotransmitters which
are released directly onto their target cells
• Speed of response
– Nervous system responds faster than the
endocrine
11. Differences cont.
• Duration of response
– Nervous system activates its targets quickly
– Endocrine system tends to have longer-lasting
effects
12. Hormones
• Characteristics
– Stability
• Life span of hormone varies with its chemical nature
• Expressed as half-life – amount of time it takes for 50% of
the circulating hormone to be removed from the circulation
and excreted
– Communication
• Able to regulate specific cellular pathways once they arrive
at their targets
– Distribution
• Transported by the blood to many locations
13. Chemical Nature of Hormones
• Lipid soluble
– Steroid hormones, thyroid hormones and fatty
acid derivative hormones
– Travel in bloodstream bound to binding proteins
• Water soluble
– Protein hormones, peptide hormones and most
amino acid derivative hormone
– Circulate as free hormones
– Relatively short half-lives
14.
15.
16. Patterns of Hormone Secretion
• 3 main patterns of hormone secretion
– Chronic hormone secretion
– Acute hormone secretion
– Episodic hormone secretion
• Steroid reproductive hormones
17. Control of Hormone Secretion
• 3 types of stimuli regulate hormone release
– Humoral
• Blood-borne molecules can directly stimulate the
release of some hormones
– Neural
• Involves neural stimuli of endocrine glands
– Hormonal
• Hormone is secreted that stimulates the secretion of
other hormones
23. Hormone Receptors and Mechanisms
of Action
• Hormones exert their actions by binding to
proteins called receptors
– Only can stimulate cells that have the receptor for
that hormone
– Specific
26. Classes of Receptors
• Lipid-soluble hormones bind to nuclear
receptors
– Relatively small
– Able to diffuse through the plasma membrane and
bind to nuclear receptors
27. • Water-soluble hormones bind to membrane-
bound receptors
– Large molecules and cannot pass through the
plasma membrane
– Interact with membrane-bound receptors
29. Membrane-Bound Receptors and
Signal Amplification
• Membrane-bound receptors activate
responses in 2-ways
– Receptors may alter the activity of G proteins at
the inner surface of the plasma membrane
– Receptors may directly alter the activity of
intracellular enzymes
– Second messenger system
30. Receptors that activate G Proteins
• G proteins
– 3 subunits
• Alpha, beta and gamma
• Guanine nucleotide bound to alpha subunit
– Inactive state – GDP bound
– Active state – GTP bound
35. Receptors that Phosphorylate
Intracellular Proteins
• Hormones bind to
membrane-bound
receptors.
• Part of receptor protein
on inside of membrane
acts as an enzyme to
phosphorylate proteins
• E.g., insulin receptors
bound to insulin cause
phosphorylation of
proteins and cell
responds to presence of
insulin.