Hormones bind to specific receptors that initiate cellular responses. Water-soluble hormones bind to membrane receptors, while lipid-soluble hormones bind to intracellular receptors. Receptor activation leads to second messenger systems or direct gene activation, amplifying the hormone's effects and eliciting responses like muscle contraction, secretion, transport changes, or metabolic effects.
Anterior pituitary gland and GH by Pandian M. Dept of Physiology DYPMCKOP, th...Pandian M
Introduction
ANTERIOR PITUITARY HORMONES
Growth hormone
Structure, synthesis and secretion
Regulation of GH secretion
Plasma levels, binding and metabolism
Growth hormone receptors and mechanism of action
Actions of growth hormone
Growth hormone receptors and mechanism of action of GH
Mechanism of action of GH
Growth promoting actions of GH
Metabolic actions of GH
Effect on lactation
Human prolactin
Structure, secretion and plasma concentration
Control of prolactin secretion
Physiological effects of prolactin
Applied aspects: abnormalities of anterior pituitary hormones
Hypopituitarism
Abnormalities of growth hormone secretion
Hyperactivity of anterior pituitary
Hypoactivity of anterior pituitary
Anterior pituitary gland and GH by Pandian M. Dept of Physiology DYPMCKOP, th...Pandian M
Introduction
ANTERIOR PITUITARY HORMONES
Growth hormone
Structure, synthesis and secretion
Regulation of GH secretion
Plasma levels, binding and metabolism
Growth hormone receptors and mechanism of action
Actions of growth hormone
Growth hormone receptors and mechanism of action of GH
Mechanism of action of GH
Growth promoting actions of GH
Metabolic actions of GH
Effect on lactation
Human prolactin
Structure, secretion and plasma concentration
Control of prolactin secretion
Physiological effects of prolactin
Applied aspects: abnormalities of anterior pituitary hormones
Hypopituitarism
Abnormalities of growth hormone secretion
Hyperactivity of anterior pituitary
Hypoactivity of anterior pituitary
Biochemistry Of Hormones
Contains All Important topics with best key points....
Made By Sanjay kumar (Student Of PharmD Faculty of Pharmacy Hamdard University)
Describes the different pathways involved in the synthesis of different eicosanoids like prostaglandins, leukotrienes, lipoxins etc along with different enzymes involved.
Biochemistry Of Hormones
Contains All Important topics with best key points....
Made By Sanjay kumar (Student Of PharmD Faculty of Pharmacy Hamdard University)
Describes the different pathways involved in the synthesis of different eicosanoids like prostaglandins, leukotrienes, lipoxins etc along with different enzymes involved.
Cells of the nervous system: Neurons & Glial cells
▫ Glial cells:
most abundant cells, are of 3 main types
A. Microglia: Phagocytic (immune) cells,
B. Astrocytes: Support & nutrition of the neurons
(provide neurons with lactate from glucose and
regulate the content of ECF by removing K+ &
excess neurotransmitters)
C. Oligodendrocytes: form myelin sheathe in CNS
Schwan cells form myelin sheaths in PNS
Ependymal cells: line brain & spinal cord cavities
using their cilia to allow for the circulation of the
A chemical substance produced in the body that controls and regulates the activity of certain cells or organs. Many hormones are secreted by special glands, such as thyroid hormone produced by the thyroid gland.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
1. Actions of Hormones on Target Cells
Graphics are used with permission of:
Pearson Education Inc., publishing as Benjamin Cummings (http://www.aw-bc.com)
Page 1. Actions of Hormones on Target Cells
Hormones influence their target cells by binding to specific receptors.
The hormone-receptor interaction initiates the process of transforming the chemical
message into a cell response.
Page 2. Goals/ What You Need to Know
Goals
To learn about hormone receptors.
To describe common second messenger systems and transcription factors.
To review insulin.
To understand that hormones induce changes in cellular metabolism.
What You Need to Know
That changing the shape of a molecule can activate or inactivate it.
The terminology of carbohydrate, lipid and protein metabolism.
The difference between the absorptive and postabsorptive states of the body.
Page 3. Target Cell Responses to Hormones
Hormones bind with receptors to initiate the cellular response to a chemical signal.
Target cells convert the signal into a biochemical change inside the cell.
Via second messenger systems.
Via direct gene activation.
Cells respond to this stimulus in several different ways:
1. Cause contraction of muscle tissue.
2. Secretion of cellular products.
3. Effecting ion exchange through channels.
4. Cause synthesis of new peptides and proteins.
5. Cause breakdown of storage molecules.
Receptors are complex proteins that only respond to specific hormones.
Receptors for water-soluble hormones are found on the plasma membrane.
Receptors for lipid-soluble hormones are found in the cytoplasm or the nucleus.
Receptors will down-regulate and decrease sensitivity when there is prolonged exposure
to high levels of a hormone.
Receptors have the ability to up-regulate and increase sensitivity in response to sustained
low levels of a hormone.
Not all cells have receptors for all hormones and some cell respond differently to different
concentrations of hormone.
**Now is a good time to go to the quiz question #1.
Click the quiz button on the left side of the screen.
Click on the scrolling page list at the top of the screen and complete question 1.
When you are finished you can click the return from link button on the left side of the
screen to return to the topic.
2. Page 4.Water-soluble Hormones and Receptor Responses
The water soluble hormones are the peptide and catecholamines.
They bind to receptors on the outside surface of the cell.
Two common classes of membrane bound receptors are:
o Receptors that activate G-proteins.
o Receptors that activate protein kinases.
1. G-protein moderated second messenger systems
cAMP second messenger.
Hormone (first messenger) binds to receptor on outside of cell membrane.
Receptor changes shape and activates G-protein on inside of cell membrane.
GTP binds to G-protein and causes it to activate adenylate cyclase.
Adenylate cyclase converts ATP into cyclic AMP (cAMP).
cAMP acts as a second messenger and phosphorylates kinases inside the cell.
The kinases can activate or inhibit activities of the cell.
The process continues as long as long as the G-protein is active.
Phosphodiesterase degrades cAMP and stops the process.
Amplification – greatly increases the effect that single hormone molecule has on the
activity of a cell.
DAG and IP3 second messengers.
Diacylglycerol (DAG) and inositol triphosphate (IP3) are other G-protein moderated
second messengers.
Hormone binds to receptor on outside of cell membrane which changes shape and
stimulates the G-protein.
Activated G-protein binds to phospholipase C on inside of cell membrane.
Phospholipase C converts membrane phospholipids into DAG and IP3.
DAG remains in the cell membrane and activates protein kinase C which
influences cell response.
IP3 causes the endoplasmic reticulum to release Ca++, which acts like a second
messenger.
Ca++ can bind to the protein calmodulin and enhance the response of the cell.
**Now is a good time to go to the quiz question #2.
Click the quiz button on the left side of the screen.
Click on the scrolling page list at the top of the screen and complete question 2.
When you are finished you can click the return from link button on the left side of the
screen to return to the topic.
2. Receptors that activate protein kinases.
Some hormones bind with tyrosine kinase receptors on the outside of the cell
membrane.
When two receptors are bound their interior surfaces intertwine which causes the
phosphorylation of neighboring phosphate groups on the receptor.
The active phosphate sites provide a docking site for intracellular relay proteins.
The relay protein phosphorylates other kinases within the cell that causes the
cellular response.
3. Catecholamines and insulin are water-soluble hormones that bind to plasma membrane
receptors and are good examples of how hormones can have multiple and varied effects on
their target tissues.
Now is a good time to go to the quiz question #3.
Click the quiz button on the left side of the screen.
Click on the scrolling page list at the top of the screen and complete question 3.
When you are finished you can click the return from link button on the left side of the
screen to return to the topic.
Page 5. Insulin Review
*Be sure to view all the steps in the animation on this page and make notes in the space
provided below.
4. Secretion
Transport
Cellular Mechanism of Action
Synthesis
Functions
Breakdown
** Now is a good time to go to the quiz question #4.
Click the quiz button on the left side of the screen.
Click on the scrolling page list at the top of the screen and complete question 4.
When you are finished you can click the return from link button on the left side of the
screen to return to the topic.
Page 6.Diabetes Mellitus
There are two types of diabetes mellitus:
1. Type I – characterized by insulin deficiency or absence.
2. Type 2 –characterized by normal or elevated insulin levels, but resistance of target
cells to insulin.
Complete the table exercise and then fill in the blanks in the copy of the same chart below.
1
2
3
4
5. Be sure to also click on the muscle and adipose tissue to see other ways in which insulin
secretion can be affected.
Page 7.Lipid-soluble Hormones
The lipid-soluble hormones are steroids and TH.
Receptors are located inside cells, typically inside the nucleus.
Each receptor has a site that binds to the hormone and a site that binds to DNA.
The DNA site is covered by a chaperone molecule when no hormone is present.
When a hormone binds the chaperone is released and the hormone receptor complex
binds to DNA and acts as a transcription factor.
The hormone receptor complex can trigger the synthesis of mRNA and stimulate or it can
inhibit gene activity.
If mRNA is stimulated then new proteins will be synthesized.
Cortisol
Cortisol binds with receptors in the nucleus.
The hormone-receptor complex acts as a transcription factor.
Thyroid Hormone
6. T4 is converted into T3 inside cells.
T3 receptors are located on the DNA in the nucleus.
Now is a good time to go to the quiz question #5.
Click the quiz button on the left side of the screen.
Click on the scrolling page list at the top of the screen and complete question 5.
When you are finished you can click the return from link button on the left side of the
screen to return to the topic.
Page 8: Summary
Hormone receptors are proteins located in the plasma membrane or the interior of the cell.
Water-soluble hormones bind to plasma membrane receptors, and lipid-soluble hormones
typically bind to intracellular receptors.
Receptor activation engages cellular machinery that leads to the response of the cell.
The effects of a single molecule of hormone are amplified by the cellular machinery.
All about insulin, diabetes mellitus, and the causes and consequences of hypersecretion of
insulin.
Notes on Quiz Questions:
Quiz Question #1: Hormone Receptors
The first part of this question requires you to place hormone receptors in their correct
positions on the cell membrane or inside the cell.
The second part of this question asks you to pick which receptors are for water-soluble
hormones and which receptors are for lipid-soluble hormones.
Quiz Question #2: Second Messenger Systems
This question requires you to put the events that lead to a cell response in the correct
chronological order. Be sure to review the action of plasma membrane receptors before
answering this question.
Quiz Question #3: Insulin
This question requires you to put the events that occur when insulin binds with its
receptors in the correct order.
Quiz Question #4: Insulin vs. Glucagon
You must complete a table that contrasts the antagonistic effects of insulin and glucagon.
Take note that there are two pages to this table.
Quiz Question #5: Steroid Hormones
You must put the elements of a steroid based hormone response in the correct sequence.
Study Questions on Action of Hormones and Hormone Receptors
1. (Page 1.) How do hormones influence their target cells?
2. (Page 3.) What are the two ways in which the chemical message of a hormone is
converted into a cell response inside the cell?
3. (Page 3.) List the 5 ways in which cells respond to activation by hormones.
7. a.
b.
c.
d.
e.
4. (Page 3.) Receptors for water-soluble hormones are found on the _____________
of target cells, while receptors for lipid-soluble hormones are found in the
________ or________ of cells.
5. (Page 3.) Target cells tend to ______ _______ the number of their
receptors when there are sustained high levels of hormone present.
6. (Page 3.) True or False: All cells have receptors for all hormones.
7. (Page 4.) Put the steps of the cAMP second messenger system in the correct
chronological sequence.
1. G-protein binds to adenylate cyclase which converts ATP into cAMP.
2. Activated protein kinases elicit the cell response.
3. Hormone binds with Receptor.
4. cAMP phosphorylates protein kinases.
5. Receptor changes shape and activates G-protein.
8. (Page 4.) ______________ is the process whereby a single hormone can elicit the
response of many second messengers within single target cell.
9. (Page 4.) Complete this sequence:
hormonereceptorG-protein______________ IP3 and ____.
10. (Page 4.) When insulin binds to a tyrosine kinase receptor on its target cell what is the
main result?
11. (Page 5.) List the main stimuli for insulin secretion.
a.
b.
c.
d.
12. (Page 5.) How is insulin transported through the blood?
13. (Page 5.) What are the two major functions of insulin?
14. (Page 6.) ________ diabetes is characterized by insulin absence or deficiency, while
________ diabetes is caused by resistance of target cells to the action of
insulin.
15. (Page 6.) Excess glucose in the urine is known as __________
8. 16. (Page 7) When a lipid soluble hormone binds to its receptor molecule it acts as a
17. (Page 7) Put these events in the correct chronological sequence.
1. mRNA is transcribed.
2. New protein is synthesized in the cell.
3. Cortisol binds to receptor-chaperone complex.
4. Hormone-receptor complex binds to DNA.
5. Cell response is initiated.