Antifungal agents include both systemic and topical drugs used to treat fungal infections. There are two main types of fungi - yeasts which reproduce by budding and molds which have long branching filaments. Mycotic infections can be cutaneous, subcutaneous, superficial, or systemic and life-threatening in immunocompromised patients. Common antifungal agents include polyenes such as amphotericin B, azoles including fluconazole and ketoconazole, flucytosine, and griseofulvin. These drugs work by various mechanisms including binding to fungal cell membranes, inhibiting DNA synthesis, or disrupting cell division.
Tetracyclines slide contains full information about uses, adverse effect, marketed preparation, precaution, route of drug administration, antimicrobial spectrum, mechanism of action, pharmacokineticks and pharmacodynamics of tetracyclines. This slide is very helpful for pharmacy and pharmacology student for the study about tetracyclines.
Hello friends. In this PPT I am talking about Anti-viral drugs drugs. If you like it, please do let me know in the comments section. A single word of appreciation from you will encourage me to make more of such videos. Thanks. Enjoy and welcome to the beautiful world of pharmacology where pharmacology comes to life. This video is intended for MBBS, BDS, paramedical and any person who wishes to have a basic understanding of the subject in the simplest way.
Sulfonamide (also called sulphonamide, sulfa drugs or sulpha drugs) is the basis of several groups of drugs. The original antibacterial sulfonamides are synthetic antimicrobial agents that contain the sulfonamide group.
A introduction on Viral vaccine for medical students.Although most attenuated vaccines are viral, some are bacterial in nature. Examples include the viral diseases yellow fever, measles, rubella, and mumps, and the bacterial disease typhoid.
Tetracyclines slide contains full information about uses, adverse effect, marketed preparation, precaution, route of drug administration, antimicrobial spectrum, mechanism of action, pharmacokineticks and pharmacodynamics of tetracyclines. This slide is very helpful for pharmacy and pharmacology student for the study about tetracyclines.
Hello friends. In this PPT I am talking about Anti-viral drugs drugs. If you like it, please do let me know in the comments section. A single word of appreciation from you will encourage me to make more of such videos. Thanks. Enjoy and welcome to the beautiful world of pharmacology where pharmacology comes to life. This video is intended for MBBS, BDS, paramedical and any person who wishes to have a basic understanding of the subject in the simplest way.
Sulfonamide (also called sulphonamide, sulfa drugs or sulpha drugs) is the basis of several groups of drugs. The original antibacterial sulfonamides are synthetic antimicrobial agents that contain the sulfonamide group.
A introduction on Viral vaccine for medical students.Although most attenuated vaccines are viral, some are bacterial in nature. Examples include the viral diseases yellow fever, measles, rubella, and mumps, and the bacterial disease typhoid.
An antifungal medication is a pharmaceutical fungicide used to treat and prevent mycoses such as athlete's foot, ringworm, candidiasis (thrush), serious systemic infections such as cryptococcal meningitis, and others. Such drugs are usually obtained by a doctor's prescription, but a few are available OTC (over-the-counter).
Antifungals work by exploiting differences between mammalian and fungal cells to kill the fungal organism with fewer adverse effects to the host. Unlike bacteria, both fungi and humans are eukaryotes. Thus, fungal and human cells are similar at the biological level. This makes it more difficult to discover drugs that target fungi without affecting human cells. As a consequence, many antifungal drugs cause side-effects. Some of these side-effects can be life-threatening if the drugs are not used properly.
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this slides includes overview of antimicrobial drugs, their classifications, antimicrobial resistance, adverse effects and toxicity, choice of antimicrobial drugs and its uses
24. Drug of Choice for most systemic fungal infections. Even those susceptible to others but where the disease rapidly progressive, in Immunocompromized or involves CNS. www.freelivedoctor.com
25. Model for Amphotericin B induced Pore in Cell Membrane In fungi: ergosterol in membranes: higher affinity than mammalian cholesterol for AmB www.freelivedoctor.com
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27. Q A SNGFR R E R A P GC ΔP P T K f Influence of Amphotericin B Infusion on Determinants of Single Nephron GFR www.freelivedoctor.com
28. Influence of Amphotericin B on intracellular Ca ++ levels in glomerular mesangial cells Theory Pore ↑ Na entry Depolarization Voltage-dep. Ca channels Contraction www.freelivedoctor.com
29. Calcium channel blockers are protective against AmB- nephrotoxicity in-vivo in rats Salt loading is protective against nephrotoxicity in vivo in animals www.freelivedoctor.com
30. Salt loading or Supplements Protect Against AmB- Nephrotoxicity In Humans www.freelivedoctor.com
34. f-AmB L-AmB f-AmB L-AmB AmB-DOC Differential Effects of L-AmB on Mammalian and Fungal Cells, in Contrast to free AmB RBC Fungal Cell www.freelivedoctor.com
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