This document discusses chemical hazards in antibiotics, specifically:
1. It categorizes chemical hazards into naturally occurring, intentionally added, and unintentionally added chemicals. Antibiotics can contain unintentionally added chemicals from raw materials or packaging.
2. It describes various mechanisms of action of antibacterial drugs including inhibition of cell wall synthesis, protein synthesis, nucleic acid synthesis, and metabolic pathways.
3. It discusses EU legislation around antibiotic residues in food including definitions of maximum residue limits and prohibited substances. Monitoring programs help enforce regulations and issue alerts when risks are detected.
Without color additives, colas wouldn’t be brown, margarine wouldn’t be yellow, and mint ice cream wouldn’t be green. Here at the FDA, we’re committed to making sure the color additives in your food are safe.
Color additives are used in foods to:
Offset color loss due to exposure to light, air, temperature extremes, moisture, or storage conditions
Make natural variations in color look more uniform
Enhance colors that occur naturally
Provide color to colorless and “fun” foods, like those brightly colored popsicles that are perfect for beating the summer heat.
The FDA regulates color additives used in food and dietary supplements marketed in the United States. FDA is responsible for making sure all foods containing color additives are safe for consumption, contain only approved ingredients, and are properly labeled.
So how do we ensure that these colors are safe?
First of all, the FDA uses the best science available to determine whether there is “a reasonable certainty of no harm” to consumers when the color additive is used properly (at its intended level and for its intended purpose). When the FDA approves a color additive, the Agency issues strict requirements for it. Among other things, these requirements specify :
The types of foods in which it can be used
The maximum amounts allowed to be used
How it should be identified on the food label.
This seminar talks about what is sensory evaluation, types and needs for sensory evaluation. Quality control and quality assurance and the use of sensory evaluation in food industries. Minimum requirement and new developments in QC/Sensory program.
Intellectual Property Rights Protection in Food Industry: An Indian Perspective Workshop was conducted on March 21, 2016 at Better Process Control School (USFDA). The venue for the workshop was Bhaskaracharya College of Applied Sciences (BCAS), University of Delhi.
Currently, a lot research and development is taking place in food based industries in India. Indian food manufacturers produce hundreds of different varieties of vacuum packed ready-to-eat dinner entrees that are imported into the United States. Before 2011, no in-country Better Process Control School (BPCS) was available for the Indian food based manufacturers. Currently, Better Process Control School (BPCS) is being managed by Bhaskaracharya College of Applied Sciences (BCAS), University of Delhi.
Nevertheless, the importance of intellectual property right protection for food based industry is very important. The agenda of the intellectual property based presentation was to ensure that Indian Market players are able to compete well with MNCs in Global Marketplace.
A Food safety hazard is a biological, chemical or physical agent or condition of food with the potential to cause harm or an adverse health affect at the time of consumption.
DETERMINATION OF ENGINEERING PROPERTIES OF POMEGRANATE FRUIT TO CALCULATION ...IJSIT Editor
In avoiding damage to fruit species the permissible falling height and permissible static pressure are
of great importance. The former is important in planning harvesting and handling operations, the latter in
selecting the height of transport containers. Fruits are generally transported in containers. The static and
dynamic forces which then act on the fruit will cause damage if they exceed given value. The static force may
be calculated from the weight of the fruit column being transported while the dynamic load is a consequence
of vibration caused by transport. The permitted static load for a given fruit may be determined
experimentally. In this study, physical properties of interest were determined for fresh pomegranate fruit
then calculations for the design of a suitable height were conducted based on the measured properties using
Ross and Isaacs’s theory. Maximum height for packing and storing of fresh pomegranate fruit in the box was
determined to be less than 123 cm based on a rupture force of 40.7 N.
Without color additives, colas wouldn’t be brown, margarine wouldn’t be yellow, and mint ice cream wouldn’t be green. Here at the FDA, we’re committed to making sure the color additives in your food are safe.
Color additives are used in foods to:
Offset color loss due to exposure to light, air, temperature extremes, moisture, or storage conditions
Make natural variations in color look more uniform
Enhance colors that occur naturally
Provide color to colorless and “fun” foods, like those brightly colored popsicles that are perfect for beating the summer heat.
The FDA regulates color additives used in food and dietary supplements marketed in the United States. FDA is responsible for making sure all foods containing color additives are safe for consumption, contain only approved ingredients, and are properly labeled.
So how do we ensure that these colors are safe?
First of all, the FDA uses the best science available to determine whether there is “a reasonable certainty of no harm” to consumers when the color additive is used properly (at its intended level and for its intended purpose). When the FDA approves a color additive, the Agency issues strict requirements for it. Among other things, these requirements specify :
The types of foods in which it can be used
The maximum amounts allowed to be used
How it should be identified on the food label.
This seminar talks about what is sensory evaluation, types and needs for sensory evaluation. Quality control and quality assurance and the use of sensory evaluation in food industries. Minimum requirement and new developments in QC/Sensory program.
Intellectual Property Rights Protection in Food Industry: An Indian Perspective Workshop was conducted on March 21, 2016 at Better Process Control School (USFDA). The venue for the workshop was Bhaskaracharya College of Applied Sciences (BCAS), University of Delhi.
Currently, a lot research and development is taking place in food based industries in India. Indian food manufacturers produce hundreds of different varieties of vacuum packed ready-to-eat dinner entrees that are imported into the United States. Before 2011, no in-country Better Process Control School (BPCS) was available for the Indian food based manufacturers. Currently, Better Process Control School (BPCS) is being managed by Bhaskaracharya College of Applied Sciences (BCAS), University of Delhi.
Nevertheless, the importance of intellectual property right protection for food based industry is very important. The agenda of the intellectual property based presentation was to ensure that Indian Market players are able to compete well with MNCs in Global Marketplace.
A Food safety hazard is a biological, chemical or physical agent or condition of food with the potential to cause harm or an adverse health affect at the time of consumption.
DETERMINATION OF ENGINEERING PROPERTIES OF POMEGRANATE FRUIT TO CALCULATION ...IJSIT Editor
In avoiding damage to fruit species the permissible falling height and permissible static pressure are
of great importance. The former is important in planning harvesting and handling operations, the latter in
selecting the height of transport containers. Fruits are generally transported in containers. The static and
dynamic forces which then act on the fruit will cause damage if they exceed given value. The static force may
be calculated from the weight of the fruit column being transported while the dynamic load is a consequence
of vibration caused by transport. The permitted static load for a given fruit may be determined
experimentally. In this study, physical properties of interest were determined for fresh pomegranate fruit
then calculations for the design of a suitable height were conducted based on the measured properties using
Ross and Isaacs’s theory. Maximum height for packing and storing of fresh pomegranate fruit in the box was
determined to be less than 123 cm based on a rupture force of 40.7 N.
Mechanism of action of major antibiotic classes including betal lactam agents, aminoglycosides, macrolides, tetracyclines, quinolons, vancomycin, oxazolidionons. Detailed review and illustrations
1. chemotherapy principles and problems JagirPatel3
The objective of chemotherapy is to study and to apply the drugs that have highly selective toxicity to the pathogenic microorganisms in the host body and have no or less toxicity to the host, so as to prevent and cure infective diseases caused by pathogens
Antibiotics-1 /certified fixed orthodontic courses by Indian dental academy Indian dental academy
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Neuro-symbolic is not enough, we need neuro-*semantic*Frank van Harmelen
Neuro-symbolic (NeSy) AI is on the rise. However, simply machine learning on just any symbolic structure is not sufficient to really harvest the gains of NeSy. These will only be gained when the symbolic structures have an actual semantics. I give an operational definition of semantics as “predictable inference”.
All of this illustrated with link prediction over knowledge graphs, but the argument is general.
Kubernetes & AI - Beauty and the Beast !?! @KCD Istanbul 2024Tobias Schneck
As AI technology is pushing into IT I was wondering myself, as an “infrastructure container kubernetes guy”, how get this fancy AI technology get managed from an infrastructure operational view? Is it possible to apply our lovely cloud native principals as well? What benefit’s both technologies could bring to each other?
Let me take this questions and provide you a short journey through existing deployment models and use cases for AI software. On practical examples, we discuss what cloud/on-premise strategy we may need for applying it to our own infrastructure to get it to work from an enterprise perspective. I want to give an overview about infrastructure requirements and technologies, what could be beneficial or limiting your AI use cases in an enterprise environment. An interactive Demo will give you some insides, what approaches I got already working for real.
Essentials of Automations: Optimizing FME Workflows with ParametersSafe Software
Are you looking to streamline your workflows and boost your projects’ efficiency? Do you find yourself searching for ways to add flexibility and control over your FME workflows? If so, you’re in the right place.
Join us for an insightful dive into the world of FME parameters, a critical element in optimizing workflow efficiency. This webinar marks the beginning of our three-part “Essentials of Automation” series. This first webinar is designed to equip you with the knowledge and skills to utilize parameters effectively: enhancing the flexibility, maintainability, and user control of your FME projects.
Here’s what you’ll gain:
- Essentials of FME Parameters: Understand the pivotal role of parameters, including Reader/Writer, Transformer, User, and FME Flow categories. Discover how they are the key to unlocking automation and optimization within your workflows.
- Practical Applications in FME Form: Delve into key user parameter types including choice, connections, and file URLs. Allow users to control how a workflow runs, making your workflows more reusable. Learn to import values and deliver the best user experience for your workflows while enhancing accuracy.
- Optimization Strategies in FME Flow: Explore the creation and strategic deployment of parameters in FME Flow, including the use of deployment and geometry parameters, to maximize workflow efficiency.
- Pro Tips for Success: Gain insights on parameterizing connections and leveraging new features like Conditional Visibility for clarity and simplicity.
We’ll wrap up with a glimpse into future webinars, followed by a Q&A session to address your specific questions surrounding this topic.
Don’t miss this opportunity to elevate your FME expertise and drive your projects to new heights of efficiency.
Epistemic Interaction - tuning interfaces to provide information for AI supportAlan Dix
Paper presented at SYNERGY workshop at AVI 2024, Genoa, Italy. 3rd June 2024
https://alandix.com/academic/papers/synergy2024-epistemic/
As machine learning integrates deeper into human-computer interactions, the concept of epistemic interaction emerges, aiming to refine these interactions to enhance system adaptability. This approach encourages minor, intentional adjustments in user behaviour to enrich the data available for system learning. This paper introduces epistemic interaction within the context of human-system communication, illustrating how deliberate interaction design can improve system understanding and adaptation. Through concrete examples, we demonstrate the potential of epistemic interaction to significantly advance human-computer interaction by leveraging intuitive human communication strategies to inform system design and functionality, offering a novel pathway for enriching user-system engagements.
PHP Frameworks: I want to break free (IPC Berlin 2024)Ralf Eggert
In this presentation, we examine the challenges and limitations of relying too heavily on PHP frameworks in web development. We discuss the history of PHP and its frameworks to understand how this dependence has evolved. The focus will be on providing concrete tips and strategies to reduce reliance on these frameworks, based on real-world examples and practical considerations. The goal is to equip developers with the skills and knowledge to create more flexible and future-proof web applications. We'll explore the importance of maintaining autonomy in a rapidly changing tech landscape and how to make informed decisions in PHP development.
This talk is aimed at encouraging a more independent approach to using PHP frameworks, moving towards a more flexible and future-proof approach to PHP development.
The Art of the Pitch: WordPress Relationships and SalesLaura Byrne
Clients don’t know what they don’t know. What web solutions are right for them? How does WordPress come into the picture? How do you make sure you understand scope and timeline? What do you do if sometime changes?
All these questions and more will be explored as we talk about matching clients’ needs with what your agency offers without pulling teeth or pulling your hair out. Practical tips, and strategies for successful relationship building that leads to closing the deal.
Smart TV Buyer Insights Survey 2024 by 91mobiles.pdf91mobiles
91mobiles recently conducted a Smart TV Buyer Insights Survey in which we asked over 3,000 respondents about the TV they own, aspects they look at on a new TV, and their TV buying preferences.
Software Delivery At the Speed of AI: Inflectra Invests In AI-Powered QualityInflectra
In this insightful webinar, Inflectra explores how artificial intelligence (AI) is transforming software development and testing. Discover how AI-powered tools are revolutionizing every stage of the software development lifecycle (SDLC), from design and prototyping to testing, deployment, and monitoring.
Learn about:
• The Future of Testing: How AI is shifting testing towards verification, analysis, and higher-level skills, while reducing repetitive tasks.
• Test Automation: How AI-powered test case generation, optimization, and self-healing tests are making testing more efficient and effective.
• Visual Testing: Explore the emerging capabilities of AI in visual testing and how it's set to revolutionize UI verification.
• Inflectra's AI Solutions: See demonstrations of Inflectra's cutting-edge AI tools like the ChatGPT plugin and Azure Open AI platform, designed to streamline your testing process.
Whether you're a developer, tester, or QA professional, this webinar will give you valuable insights into how AI is shaping the future of software delivery.
GraphRAG is All You need? LLM & Knowledge GraphGuy Korland
Guy Korland, CEO and Co-founder of FalkorDB, will review two articles on the integration of language models with knowledge graphs.
1. Unifying Large Language Models and Knowledge Graphs: A Roadmap.
https://arxiv.org/abs/2306.08302
2. Microsoft Research's GraphRAG paper and a review paper on various uses of knowledge graphs:
https://www.microsoft.com/en-us/research/blog/graphrag-unlocking-llm-discovery-on-narrative-private-data/
JMeter webinar - integration with InfluxDB and GrafanaRTTS
Watch this recorded webinar about real-time monitoring of application performance. See how to integrate Apache JMeter, the open-source leader in performance testing, with InfluxDB, the open-source time-series database, and Grafana, the open-source analytics and visualization application.
In this webinar, we will review the benefits of leveraging InfluxDB and Grafana when executing load tests and demonstrate how these tools are used to visualize performance metrics.
Length: 30 minutes
Session Overview
-------------------------------------------
During this webinar, we will cover the following topics while demonstrating the integrations of JMeter, InfluxDB and Grafana:
- What out-of-the-box solutions are available for real-time monitoring JMeter tests?
- What are the benefits of integrating InfluxDB and Grafana into the load testing stack?
- Which features are provided by Grafana?
- Demonstration of InfluxDB and Grafana using a practice web application
To view the webinar recording, go to:
https://www.rttsweb.com/jmeter-integration-webinar
Connector Corner: Automate dynamic content and events by pushing a buttonDianaGray10
Here is something new! In our next Connector Corner webinar, we will demonstrate how you can use a single workflow to:
Create a campaign using Mailchimp with merge tags/fields
Send an interactive Slack channel message (using buttons)
Have the message received by managers and peers along with a test email for review
But there’s more:
In a second workflow supporting the same use case, you’ll see:
Your campaign sent to target colleagues for approval
If the “Approve” button is clicked, a Jira/Zendesk ticket is created for the marketing design team
But—if the “Reject” button is pushed, colleagues will be alerted via Slack message
Join us to learn more about this new, human-in-the-loop capability, brought to you by Integration Service connectors.
And...
Speakers:
Akshay Agnihotri, Product Manager
Charlie Greenberg, Host
5. Unintentionally or Incidentially Added Chemicals: Chemicals can become part of a food without being intentionally added. These incidental chemicals might already be in a food ingredient when it is received. For example, certain seafood may contain small but legal residues of approved antibiotics. Packaging materials that are in direct contact with ingredients or the product can be a source of incidental chemicals, such as sanitizers or inks. Most incidental chemicals have no effect on food safety, and others are only a concern if they are present in too high an amount.
6. Unintentionally or Incidentially Added Chemicals: Incidental chemicals also include accidental additions of prohibited substances such as poisons or insecticides that may not be allowed at any level. • Agricultural chemicals (e.g., pesticides, fungicides, herbicides, fertilizers, antibiotics and growth hormones) • Prohibited substances (Code of Federal Regulations, Chapter 21, Section 189) • Toxic elements and compounds (e.g., lead, zinc, arsenic, mercury, cyanide) • Secondary direct and indirect - Plant chemicals (e.g.,lubricants, cleaning compounds , sanitizers, paint)
30. The feeding of antibiotics is associated with decreases in animal gut mass, increased intestinal absorption of nutrients and energy sparing. This results in a reduction in the nutrient cost for maintenance, so that a larger portion of consumed nutrients can be used for growth and production, thereby improving the efficiency of nutrient use. Antibiotics act by eliminating the subclinical population of pathogenic microorganisms. Eradicating this metabolic drain allows more efficient use of nutrients for food production. Antibiotics alter the non-pathogenic intestinal flora, producing beneficial effects on digestive processes and more efficient utilization of nutrients in feeds. Antibiotics as growth promoters
31. It has been estimated that around 6 percent of the energy in a pig’s diet could be lost due to microbial fermentation occurring in the stomach and small intestine. Intestinal bacteria inactivate pancreatic enzymes and metabolize dietary protein with the production of ammonia and biogenic amines. Antibiotics inhibit these activities and increase the digestibility of dietary protein. Experimental results obtained with some antibiotics commonly used as growth promoters (chlortetracycline, penicillin and sulfamethazine) have shown that treated pigs have higher serum levels of an insulin-like growth factor. (Committee on Drug Use in Food Animals, 1999; Doyle, 2001). Antibiotics as growth promoters
64. FLOW-CHART OF ACTIVITIES CARRIED OUT BY SANCO-RASFF NEWS MEMBER STATE NOTIFICATION RASFF ASSESSMENT FEEDBACK FROM MEMBER STATES TRANSMISSION VIA CIRCA/E-MAIL ELABORATION OF THE NOTIFICATION INFORMATION ALERT TRANSMISSION OF NOTIFICATIONS TO THE THIRD COUNTRIES CONCERNED MEMBER STATES COMMISSION SERVICES E-MAIL FAX REPORTS/ STATISTICS
65.
66.
67.
68. Table 2. Directive 96/23 list of substances Group A – Substances having anabolic effect and unauthorised substances (A1) Stilbenes, stilbene derivatives, and their salts and esters (A2) Antithyroid agents (A3) Steroids (A4) Resorcylic acid lactones including zeranol (A5) Beta-agonists (A6) Compounds included in Annex IV to Regulation (EEC) 2377/90 Group B – Vete rinary drugs†and contaminants (B1) Antibacterial substances, including sulphonamides, quinolones (B2) Other veterinary drugs (B2a) Anthelmintics (B2b) Anticoccidials, inc. nitroimidazoles (B2c) Carbamates and pyrethroids (B2d) Sedatives (B2e) Non-steroidal anti-inflammatory drugs (NSAIDs) (B2f) Other pharmacologically active substances (B3) Other substances and environmental contaminants (B3a) Organochlorine compounds including PcBs (B3b) Organophosphorus compounds (B3c) Chemical elements (B3d) Mycotoxins (B3e) Dyes (B3f) Others † Including unlicensed substances which could be used for veterinary purposes.
69. Antibiotics banned for animals intended for food production. Antibiotic Country Reason Reference Spectinomycin USA Its use is limited by the ready development of bacterial resistance USP, 2000d. Enrofloxacin USA Its use is limited by the ready development of bacterial resistance (quinolone) USP, 2000h. Cloramphenicol Argentina, Canada, EU, Japan, USA, India Induces human aplastic anaemia USP, 2000e; GESAMP, 1997; SANCO, 2001a. Nitrofurans Argentina, Canada, EU, Japan, USA,India Carcinogenicity and mutagenicty USP, 2000e; GESAMP, 1997; SANCO, 2001a Rifampin Not labelled in USA or Canada for use in animals, including food-producing animals Tumorgenicity and teratogenic effects on experimental animals USP, 2000k.