This document discusses various antispasmodic and anticholinergic drugs including atropine, hyoscyamine, timonium, mebeverine, coloverin, oxybutynin, tolterodine, and trospium. It provides information on their mechanisms of action, current uses such as treatment of organophosphorus poisoning with atropine, dosing schedules including three times daily doses for some drugs, and references for further information.

1. Anti-spasmodics
Atropine like action

2. Sympathetic vs parasympathetic

3. Parasympathetic MOA

4. ATROPINE

5. Atropine like action

6. Current uses of atropine
• treatment of poisoning by organophosphorus
nerve agents having anticholinesterase activity
as well as insecticides in adults and pediatric
patients weighing more than 41 kg
• Dose: Three (3) Atropine autoinjectors should
be injected to patient; one (1) for mild
symptoms plus two (2) more for severe
symptoms

7. Spasmolytic drugs
• Hyoscyamine
• Timonium
• Mebeverine
• Dose : 3 times
Daily ½ hour
Before meals

8. Coloverin
• Coloverin A for anxeity
• Coloverin D for distention
• Colverin SR twice daily

9. Overactive bladder (OAB)
medications
• Oxybutynin
• Tolterodine
• trospium

10. references
• https://www.rxlist.com/atropine-
drug.htm#description
• https://www.drugs.com/drug-
class/anticholinergics-antispasmodics.html