This document discusses anti-leprosy drugs used to treat leprosy caused by Mycobacterium leprae. It classifies these drugs into sulfones like dapsone, antitubercular drugs like rifampicin, phenazine derivatives like clofazimine, and antibiotics like ofloxacin. It outlines the mechanisms and dosages of major drugs. The WHO recommended multidrug therapy regimen combines dapsone, clofazimine and rifampicin given daily or monthly depending on type of leprosy. It also discusses drugs used to treat type II leprosy reactions like corticosteroids. Nursing responsibilities involve assessing patients for side effects and providing education on long term adherence

1. ANTI LEPROSY DRUGS
PREPARED BY:
USHA RANI KANDULA,
ASSISTANT PROFESSOR,
DEPARTMENT OF ADULT HEALTH NURSING,
ARSI UNIVERSITY,ASELLA,ETHIOPIA,
SOUTH EAST AFRICA.

2. DEFINITION
A leprostatic agent is a drug that
interferes with proliferation of the
bacterium that causes leprosy.

3. CLASSIFICATION
OF
ANTI LEPROSY DRUGS

4. CLASSIFICATION
Sulfones
Antitubercular drugs
Phenazine derivative
Antibiotics

5. 1.sulfones
Dapsone ( DDS)
-Dose : 100mg daily oral.

6. Dapsone ( DDA) MOA
Bacteriostatic
Bactericidal at high doses
Antagonists of para-
aminobenzoic acid (PABA)
prevent formation of folic acid,
inhibiting bacterial growth.

7. 2.Antitubercular drugs
 Rifampicin
- 600mg monthly oral.
 Ethionamide
- 250 mg/ day.

8. 3.Phenazine derivative
Clofazimine
- 50 mg daily.
- 300 mg once monthly.

9. Clofazimine MOA
Bactericidal action.
It binds to mycobacterial DNA.
Uses :
Leprosy
Tuberculosis ( second line).

10. 4.Antibiotics
Ofloxacin - Fluoroquinolones
- 400 mg/day
Moxifloxacin
Minocycline – Tettacycline
- 100 mg/day
Clarithromycin – Macrolides
- 500mg/day

11. Multidrug therapy plan
( MDT) recommended by the
WHO

12. Type of
leprosy
Daily Monthly Months of
treatment
paucibacillary
Dapsone 100 mg Rifampicin 600mg 6-12
Multibacillary Dapsone 100mg
Clofazimine 50mg
Rifampicin 600mg
Clofazimine
300mg (WHO)
24
Paediatric Dapsone 2mg/kg
Clofazimine 1mg/kg
Rifampicin 10
mg/kg
Clofazimine
Same as
adults

13. Drugs for type II lepra
reactions

14. Drug Dose/route
Corticosteroid /
prednisone
1mg/kg up to 80 mg /day tapered
over several months.
Thalidomide Initial dose is 100-300mg/day; once
symptoms subside tapered by 50
mg every 2-4 weeks.
Pentoxiphylline 400-800 mg 3 times/day.

15. Nursing
responsibilities

16. Assess -
 Signs of anemia(Hb)
 Liver function test
 Renal function test
 Allergy to any of the drugs in the
regimen.

17. Patient education

18. Patient education
Importance of long term
therapy.
Who has nerve damage, self
care techniques to prevent
disability.

19. Con--------
Hygiene
Proper footwear - to prevent
ulcer formation and tissue
damage.


20. THANKING YOU