Anti fungal drugs
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Anti fungal drugs
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Anti fungal drugs
- 1. ANTI FUNGAL DRUGS PREPARED BY: USHA RANI KANDULA, ASSISTANT PROFESSOR, DEPARTMENT OF ADULT HEALTH NURSING, ARSI UNIVERSITY,ASELLA,ETHIOPIA, SOUTH EAST AFRICA.
- 2. ANTI FUNGAL DRUGS •ANTI FUNGAL DRUGS used to treat superficial and deep fungal infections.
- 3. CLASSIFICATION OF ANTI FUNGAL DRUGS PREPARED BY: USHA RANI KANDULA, ASSISTANT PROFESSOR, DEPARTMENT OF ADULT HEALTH NURSING, ARSI UNIVERSITY,ASELLA,ETHIOPIA, SOUTH EAST AFRICA.
- 7. AMPHOTERICIN - B MOA • It Binds to sterol (organic molecules) in fungal cell membrane, • altering cell permeability and allowing leakage of intracellular components. • Dose : 50-100 mg qid orally.
- 9. NYSTATIN Dose • 500,000 to 1 million units as oral tab tds – intestinal candidiasis. • 400,000-600,000 units oral suspension qid – oral candidiasis.
- 11. CASPOFUNGIN •It Inhibits synthesis of b (1,3)-D- glucan in susceptible aspergillus species. •Dose : 70 mg loading dose infused IV over 1 hour, •followed by 50 mg IV daily.
- 12. Con--------- • Micafungin,Anidulafungin similar action to caspofungin.
- 13. HETEROCYCLIC BENZOFURAN •Griseofulvin – MOA • it Arrests fungal cell activity by disrupting mitotic spindle structure.
- 15. Dose : • 125-200 mg qid with meals, duration depends on the site of infection: • Scalp-4weeks • Palm,soles:6-8 week • Finger nails: 6-8 month • Toe nails : 10-12 month.
- 16. ANTIMETABOLITE •Flucytosine (5-FU) MOA: •It penetrate fungal cells and cause defective protein synthesis.
- 17. DOSE •50-150 mg/kg daily per oral in four equall divided doses q6 hours.
- 18. Azoles
- 20. CLOTRIMAZOLE •It interferes with fungal cell wall synthesis by inhibiting formation of ergosterol and increasing cell wall permeability that makes the fungus susceptible to osmotic instability.
- 21. •Ergosterol is a sterol found in cell membranes of fungi and protozoa, •Because many fungi and protozoa cannot survive without ergosterol, •it is the enzymes
- 22. LOCAL APPLICATION DOSES AVAILABILITY •Applies to the following strengths: •1%; 500 mg; •100 mg-1%; •100 mg; •200 mg-1%; 200 mg; 2%
- 24. KETOCONAZOLE •Candidiasis : 200 mg PO daily in a single dose. (Candida fungus) •Onychomycosis : 200-400mg PO daily. •Tinea capitis: 3.3-6.6mg/kg PO daily.
- 25. •Onychomycosis is a fungal infection of the toenails or fingernails that may involve any component of the nail unit, including the matrix, bed, or plate.
- 26. •Tinea capitis is a disease caused by superficial fungal infection of the skin of the scalp, eyebrows, and eyelashes,
- 28. FLUCONAZOLE •It inhibits fungal cytochrome p450- enzyme activity •( responsible for fungal sterol synthesis) •and weakens fungal cell walls.
- 29. Dose : •Oropharyngeal candidiasis : 100 mg/day for 2 weeks. •Candida esophagitis : 100 mg/day for 2-3 weeks.
- 30. •Meningitis : 200-400 mg/day for 4-12 weeks/longer. •Cutaneous candidiasis : 150 mg weekly for 4 weeks.
- 31. ITRACONAZOLE DOSE •Aspergillosis – 200 mg od/bd with meals for 3 months. •Onychomycosis : 200 mg/day for 3 months. •Dermatophytosis : 100-200 mg od for 7-15 days.
- 32. VORICONAZOLE DOSE •200 mg oral bd taken 1 hour before or 1 hour after meals, •Begin iv infusion with 6 mg/kg 12 hourly infused over 2 hours twice followed by 3-4 mg/kg 12 hourly.
- 33. POSACONAZOLE DOSE •200 mg qid or 400 mg bd with meals.
- 34. ALLYLAMINE •TERBINAFINE - MOA •It inhibits squalene epoxidase •, a key enzyme in sterol biosynthesis of fungi,
- 35. • This enzyme inhibition results in a deficiency of ergosterol accumulation of sterol within fungal cell. • Dose : 250mg PO daily for 6 weeks.
- 37. Assess for --------- •Intake and output ratio •Observe for decreased urine out put •Change in specific gravity-to know renal function
- 39. THANKING YOU