Anti-debugging techniques can be used to detect the presence of a debugger. There are three main categories of anti-debugging techniques: API based detection, exception based detection, and direct structure access based detection. API based techniques use functions like IsDebuggerPresent() and CheckRemoteDebuggerPresent() to check debugger flags. Exception based techniques check for differences in exception handling when exceptions like INT3 are triggered. Direct structure access techniques directly check debugger flags in the Process Environment Block structure and heap for differences when being debugged. The document provides examples of specific techniques in each category to detect the presence of a debugger.