Anti adrenergic drugs notes for d.pharmacy (pharmacology)
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This document discusses anti-adrenergic drugs, which antagonize the receptor action of adrenaline. It classifies anti-adrenergic drugs into alpha-blockers and beta-blockers, and describes their mechanism of action in blocking or inhibiting catecholamines. It provides details on the pharmacokinetics of propranolol and pharmacological actions of beta-blocking drugs on the cardiovascular, renal, central nervous and other body systems. Finally, it lists common uses such as for hypertension and myocardial infarction, and potential adverse drug reactions including bradycardia and nightmares.
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Anti adrenergic drugs notes for d.pharmacy (pharmacology)
- 2. Content- 1. Definition 2. Classification 3. Mechanism of action 4. Pharmacokinetics 5. Pharmacological action 6. Uses 7. ADRs
- 3. Anti-adrenergic Drugs (Sympatholytic Drugs)- “These are drugs which antagonize the receptor action of adrenaline and related drugs.” Classification of Anti-adrenergic drugs- 1.Alpha-Blockers i) Non-Selective ii) Selective - Ergotamine - Prazosin -Chlorpromazine -Terazosin 2.Beta-Blockers i) Non-Selective ii) Selective - Propranolol (1st Gen.) - Metopralol (2nd Gen.) - Labetalol (3rd Gen.) - Atenolol (2nd Gen.)
- 4. MECHANISM OF ACTION- -Anti-adrenergic agents block or inhibit the release and action of Catecholamines ( epinephrine,dopamine and nprepinephrine). -they are alpha and beta adrenergic receptor antagonists or blockers. -Alpha-2 agonists inhibit release of neuroepinephrine in brain-decrease effects on entire body, results decrease in B.P.
- 5. #PHARMACOKINETICS-Propranolol is well absorbed, low bioavailability and metabolism- depends on hepatic blood flow. #PHARMACOLOGICAL ACTION (BETA BLOCKING DRUGS)- 1) Effect on CVS- decrease heart rate. - decrease force of contraction - decrease B.P. 2) Effect on kidney- decrease renin secretion from kidney. 3) Effect on CNS- Increased dreaming and nightmare. 4) Effect on skeletal muscle- decrease tremor. 5) Effect on uterus- relaxant activity. 6) Effect on Eyes- no effect on pupil size.
- 6. # Uses of anti-adrenergic drugs- 1) hypertention 2) stable angina 3) cardiac arrhythmias 4) myocardial infraction 5) CHF 6) Migrane 7) anxity 8 essential tremor and glaucoma # ADRs- 1) Bradycardia 2) Cold hands and feet 3) G.I. upset. 4) Nightmare and hallucination.