The document describes the anatomy and functions of the urinary system. It discusses the key components, including the kidneys, nephrons, ureters, bladder, and urethra. The kidneys filter blood via nephrons to form urine, which travels through the ureters to the bladder. When full, the bladder contracts to expel urine through the urethra. Common diseases like cystitis and kidney stones are also outlined.
I. Major Structures and Organs
A. Kidneys- pair of glandular organs, which remove, waste products from the blood to form urine
B. Ureters- muscular tubes which convey urine from the kidneys to the urinary bladder.
C. Urinary Bladder- muscular sac that stores urine until micturation can occur.
D. Urethra- tube like structure which conveys urine outside the body.
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I. Major Structures and Organs
A. Kidneys- pair of glandular organs, which remove, waste products from the blood to form urine
B. Ureters- muscular tubes which convey urine from the kidneys to the urinary bladder.
C. Urinary Bladder- muscular sac that stores urine until micturation can occur.
D. Urethra- tube like structure which conveys urine outside the body.
If you want to help or donate please donate at my paypal:
dyokimura@gmail.com
SUPPORT ME:
https://www.buymeacoffee.com/dyokimura6
CHECK MY GAMING CHANNEL:
https://www.youtube.com/channel/UCoKOObshfyyxhVkw1VjyQNA
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
2. Learning Outcomes
30-2
.1 Describe the structure, location, and functions of the kidney.
.2 Define the term nephron and describe its structure.
.3 Explain how nephrons filter blood and form urine.
.4 List substances normally found in urine.
1/9/2024
By Shemsedin A.
3. Learning Outcomes (cont.)
30-3
.5 Describe the locations, structures, and functions of the
ureters, bladder, and urethra.
.6 Explain how urination is controlled.
.7 Describe the causes, signs and symptoms, and treatments
of various diseases and disorders of the urinary system.
1/9/2024
By Shemsedin A.
4. Introduction
30-4
System functions to remove waste products from the blood
Main functional units of the kidneys are the nephrons
Nephrons filter the blood and form the urine
Kidneys
Ureters
Bladder
Urethra
1/9/2024
By Shemsedin A.
5. The Kidneys
30-5
Functions
Remove metabolic waste products from the blood
Secrete the hormone erythropoietin, which stimulates
bone marrow to produce red blood cells
Secrete the hormone renin, which helps regulate blood
pressure
Description
The kidneys are bean-shaped organs that lie behind the
peritoneal cavity (retroperitoneal) on either side of the
vertebral column.
1/9/2024
By Shemsedin A.
6. The Kidneys (cont.)
30-6
Renal sinus – concave depression of the surface of the kidney
Hilum – point of entry for the renal artery, renal vein, and ureter
Renal pelvis – expansion of the ureter that further divides into
calyces
Renal cortex – outermost portion of the kidney that covers the
pyramids and dips down between them
Renal medulla – middle portion that also divides into renal pyramids
Renal column – portion of the cortex between pyramids
Kidney
1/9/2024
By Shemsedin A.
7. The Kidneys: Nephrons
30-8
Removes waste products from the blood
Each kidney contains about 1 million nephrons
Made of a renal corpuscle and a renal tubule
Renal
Corpuscles
Composed of a group of capillaries
called a glomerulus
Glomerulus is surrounded by
Bowman’s capsule
Blood filtration occurs in corpuscle
Extend from the Bowman’s
capsule of a nephron
Consist of three parts:
Proximal convoluted tubule
Loop of Henle
Distal convoluted tubule
Renal
Tubules
Glomerulus
1/9/2024
By Shemsedin A.
8. The Kidneys – Nephrons (cont.)
30-10
Veins of the Kidney
Afferent Arteriole
Glomerulus
Efferent Arteriole
Peritubular Capillaries
Afferent arterioles deliver
blood to the glomeruli
Efferent arterioles carry
blood from the glomeruli to
peritubular capillaries
1/9/2024
By Shemsedin A.
9. 30-11
Apply Your Knowledge
What are the functions of the kidney?
ANSWER: The kidney removes metabolic waste products from the blood, secretes erythropoietin to help
regulate RBC production, and secretes renin to help regulate the BP.
Correct!
1/9/2024
By Shemsedin A.
10. Urine Formation:
Glomerular Filtration
First process occurs in renal
corpuscles
Fluid part of the blood is forced from
glomerulous into Bowman’s capsule
Becomes glomerular filtrate
30-12
Glomerulus
11. Urine Formation:
Glomerular Filtration (cont.)
Factors affecting glomerular filtration
Filtration pressure – amount of pressure that forces
filtrate from the glomerulus into Bowman’s capsule.
Determined by blood pressure
Rate of filtration – sympathetic nervous system control
Constriction of afferent arterioles decreases filtration pressure
30-13
12. Urine Formation: Tubular Reabsorption
30-14
Second process in urine formation
Glomerular filtrate proximal convoluted tubule
Nutrients, water, and ions pass through the walls of the renal tubule into
the peritubular capillaries
Water reabsorption depends on hormones
Antidiuretic hormone (ADH)
Aldosterone
Both increase water reabsorption, which decreases urine production
Tubular
Reabsorption
1/9/2024
By Shemsedin A.
13. Urine Formation: Tubular Secretion
30-15
Third process of urine
formation
Substances move from
blood in the peritubular
capillaries into the renal
tubules
Secreted substances
Drugs
Hydrogen ions
Waste products
Tubular
Secretion
1/9/2024
By Shemsedin A.
14. Urine Formation (cont.)
30-17
Urine composition
Mostly water
Urea and uric acid
Formed by the breakdown of proteins and nucleic acids
Trace amounts of amino acids and various ions
Secretion of waste products helps maintain the acid-base balance
1/9/2024
By Shemsedin A.
15. 30-18
Apply Your Knowledge
Match the following:
___ Second process in urine formation A. Glomerular filtration
___ Substances move from blood into renal tubules B. Tubular reabsorption
___ Depends on filtration pressure C. Tubular secretion
___ Third process of urine formation
___ First process of urine formation
___ Filtrate flows into the proximal convoluted tubule
C
C
B
A
A
B
ANSWER:
Nice Job!
1/9/2024
By Shemsedin A.
16. Ureters, Urinary Bladder, and Urethra (cont.)
30-20
Urinary bladder
Expandable muscular organ
Stores up to 600 ml urine on average
Detrusor muscle – smooth muscle in wall of bladder
Trigone – triangle on internal floor of bladder formed by urethra and
ureters
Micturation
Process of urination
Stretching of bladder triggers process
Approximately 150cc of urine
Bladder
1/9/2024
By Shemsedin A.
17. Ureters, Urinary Bladder, and Urethra (cont.)
30-21
Urination
External urethral sphincter
relaxes
Micturation reflex – impulses
from pons and hypothalamus
Detrusor muscle contracts
Urine expelled
Impulses to contract
urethra; inhibit micturition
impulse until ready to
urinate
Bladder
distends
Stretch
receptors
Spinal cord
Parasympathetic nerves
stimulate detrusor muscle
Brain stem
and
cerebral
cortex
1/9/2024
By Shemsedin A.
18. Ureters, Urinary Bladder, and Urethra (cont.)
30-22
Urethra
Tube that moves urine from the bladder to the outside world
Shorter in females – patient education
Urinate when urge occurs
Drink adequate clear fluids
Wipe front to back
Urinate after intercourse
1/9/2024
By Shemsedin A.
19. Apply Your Knowledge
30-23
True or False:
___ Ureters move urine by peristalsis.
___ The detrusor is formed by the openings of the ureters and urethra.
___ The process of micturition is triggered when the bladder contains about
150 ml urine.
___ The urethra move urine from the kidney to the bladder.
___ The urethra is longer in females.
___ Contraction of the detrusor muscle pushes urine from the bladder.
F
F
T
F
T
trigone
males
ureters
T
ANSWER:
1/9/2024
By Shemsedin A.
20. Diseases and Disorders of the Urinary
System
Disease/Disorder Description
Acute renal failure Sudden loss of kidney function; may be reversible with treatment
Chronic renal failure Kidneys slowly use ability to function; not reversible
Cystitis Urinary bladder infection; more common in females
Glomerulonephritis Inflammation of the glomeruli of the kidney; one cause of
chronic renal failure
Incontinence Inability to control urination
30-24
21. Diseases and Disorders of the Urinary System
Disease/Disorder Description
Polycystic kidney
disease
Enlargement of kidneys because of the presence of
many cysts within them; slow, progressive disease
Pyelonephritis Complicated urinary tract infection; starts with a
bladder infection and spreads to both kidneys; can be
acute or chronic
Renal calculi Kidney stones; can become lodged in ducts within
kidneys or ureters
30-25
22. 30-26
Apply Your Knowledge
Matching:
___ Complicated urinary tract infection A. Pyelonephritis
___ Inability to control urination B. Glomerulonephritis
___ Kidney stones C. Incontinence
___ Slow loss of kidney function D. Chronic renal failure
___ Bladder infection E. Renal calculi
___ Inflammation of the glomeruli F. Cystitis
___ Kidney enlargement due to cysts G. Acute renal failure
___ Sudden loss of kidney function H. Polycystic kidney disease
H
G
F
E
D
C
B
A
ANSWER:
GOOD JOB !
1/9/2024
By Shemsedin A.
23. In Summary
30-27
The organs of the urinary system include the kidneys, ureters,
bladder, and urethra
The kidneys remove metabolic waste products from the blood and
secrete erythropoietin and renin
Urine travels through the ureters to the bladder
Stretching of the bladder triggers micturition reflex
Urine travels from the bladder through the urethra to the outside
world
1/9/2024
By Shemsedin A.