16. Calculation of
dose
Ampule 1 ml = 5 IU
Add 4 ml saline to it =1iu/ml
1IU = 1000 miu
Add 1IU in 500 ml of NS/RL.
500ml = 1000 iu
1ml = 2iu
1ml = 16 drop/min
1IU in 500 ml of RL run at the rate 8 drop/ min =1miu/min
17. Exercise
• Start 2miu/min
• 2iu is added to 500 ml of RL and running at the rate of 32 drop/min
calculate the dose I,e. miu./min
• What do you mean by strong uterine contrations?
23. Ergot derrivatives
• Ergometrine
• Methyl ergometrine
• Alkaloid isolated by Dudley & Moir from
fungus CLAVICEPS PURPURA
• Methergin - semisynthetic derived fro LSD.
• Mode of action
• Where is it can be sued ?
32. Match the fallowing drugs to its dose
Name of drug Dose Response
1.oxytocin A.100 microgram
2. Methergine B.0.5mg+5IU
3. Misoprostol(PGE1) C.5IU
4. Dinoprost (PGE2) D.250 microgram
5.Prostodine(PG F2 Alpha) E.0.2mg
6.Synometrine F.25microgram
Answer : 1-C,2-E,3-F,4-A,5-D,6-B.
33. Evaluation 1
• What is oxytocin ?
• Why we can not use oxytocin by oral route ?
• What are the indications of Oxytocin ?
• What are the routes of administration of Oxytocin ?
• What are the contraindications of Oxytocin ?
• What are the side effects of Oxytocin ?
• What are the regime of oxytocin?
• How do you prepare 5miu/min solution?
34. Evaluation 2
• What are the diagnostic use of oxytocin ?
• What is ergot ?
• What are the ergot derivatives used in clinical practice?
• What are the indication of ergot ?
• Why ergot can not be used in induction of labor?
• What are the preparation of ergot available ?
• What are the side effects of ergot ?
35. Evaluatioin 3
• What are prostaglandins ?
• What are the type PGs used in clinical practice ?
• A primigravida with full term pregnancy with h/o asthm.Indicate the
method of induction of labor &
• what we should avoid?
• What are the side effects of prostaglandins?