1. Anemia is defined as a low hemoglobin level caused by underlying diseases or conditions. It is classified based on red blood cell size, cause, and bone marrow activity.
2. Common causes include blood loss, impaired red blood cell production, and increased red blood cell destruction. Symptoms vary depending on severity and can include fatigue, weakness, and palpitations.
3. Evaluation of anemia involves medical history, physical exam, hematological tests like complete blood count and peripheral smear, and other tests to identify the underlying cause. This helps determine the appropriate treatment.
non-skeletal mesodermal tissues: adipose tissue, fibrous tissue, muscle, blood vessels and peripheral nerves (despite neuroectodermal origin)
benign, malignant and intermediate (low-grade malignant – locally aggressive, can recur, no metastatic potential)
originate from primitive mesenchymal stem cells
classification according to differentiation lines (e.g. liposarcoma is not a tumor arising from adipose tissue but exhibiting lipoblastic differentiation)
causes of macrocytic anemia pathopysiology, sign and symptoms and the difference between macrocytic anemia megaloblastIc anemia. causes of hypersegmented neutrophils and its association between them. investigation and medical management plus pictures illustration.
non-skeletal mesodermal tissues: adipose tissue, fibrous tissue, muscle, blood vessels and peripheral nerves (despite neuroectodermal origin)
benign, malignant and intermediate (low-grade malignant – locally aggressive, can recur, no metastatic potential)
originate from primitive mesenchymal stem cells
classification according to differentiation lines (e.g. liposarcoma is not a tumor arising from adipose tissue but exhibiting lipoblastic differentiation)
causes of macrocytic anemia pathopysiology, sign and symptoms and the difference between macrocytic anemia megaloblastIc anemia. causes of hypersegmented neutrophils and its association between them. investigation and medical management plus pictures illustration.
Aplastic anemia is one of the stem cell disorder which leads to pancytopenia in the peripheral blood and decrease production of all cell line in bone marrow. it require bone marrow transplantation to cure the patient.
UAEU - CMHS - Hematology-Oncology Course - MMH 302 - HONC 320. Education material for medical students - It cover basic principles of hematology and oncology, including CAR-T and gene editing. It can be used for study and review. It illustrates main principles of hematology and oncology.
Aplastic anemia is one of the stem cell disorder which leads to pancytopenia in the peripheral blood and decrease production of all cell line in bone marrow. it require bone marrow transplantation to cure the patient.
UAEU - CMHS - Hematology-Oncology Course - MMH 302 - HONC 320. Education material for medical students - It cover basic principles of hematology and oncology, including CAR-T and gene editing. It can be used for study and review. It illustrates main principles of hematology and oncology.
What causes anemia in CKD? Anemia in people with CKD often has more than one cause. When your kidneys are damaged, they produce less erythropoietin (EPO), a hormone that signals your bone marrow—the spongy tissue inside most of your bones—to make red blood cells.
Sickle cell Anemia: A worldwide popular blood disorder, basically a inheritable disease. This document provides you with basic introduction to blood, Anemia its general considerations, signs and symptoms and lastly about Sickle cell Anemia in detail.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
2. ANAEMIA
• Anemia is defined as the reduced Hb con. in
blood below the lower limit of the normal
range for the age and sex of the individual
• Normal Hb values
Males :- 14- 16gm/dl
Females :- 12-14 gm/dl
• New born infants :- 15-17 gm /dl
• In western Males< 13.2 gm /dl
• Females < 11.7 gm /dl taken as anemia
3.
4. • Anemia is not a diseases but it is the
expression of underlying disease and from
the treatment point of view , it is necessary
to identify the cause of anemia
5. WHO criteria
• Adult M <13gm/dl
• Adult F< 12gm/dl
• Infant & children's up to 12 yrs <11gm/dl
• Pregnant women <11gm/dl
• Other parameters
• RBC count, PCV, & absolute values( MCV,
MCH, MCHC) are the other alternative
parameters
8. Morphological classification
• Based on the red cell size, Hb content , red
cell indices
• Classified in to 3 types
Microcytic hypochromic
Normocytic normochromic
Macrocytic normochromic
9.
10. Microcytic hypochromic :-
Many RBCs smaller than normal(MCV<80fL)
TheRBCs are usually hypochromic(MCH<27pg)
Increased zoneof centralpallor
Cells are various in shape &size
MCV,MCH,MCHC are reduced
o Eg:- iron deficiency anemia(IDA)
o And in certain non iron deficicient anaemia
(Sideroblastic anemia),
o Thalassaemia,
o Anaemia of chronic disorder(ACD)
14. Normocytic anaemia can be presented with
elevation of reticulocyte count or a reduction of
reticulocyte count.
Elevated
reticulocytecount
• Blood loss
anaemia
• Haemolytic
anaemia
Normal or low
reticulocyte count
• Bone marrow
disorders(Aplasti
c anaemia)
• Chronicdisease
• Kidney disease
14JTV/KMC/Patho
15. Macrocytic normochromic
Theaveragesizeof RBCsare larger
than normal(>100fL) ie MCV is raised.
{MCHCis normal or high}
Eg:- megaloblastic anaemia( vit B12 &
folic acid deficiency)
2 types of macrocytes
Oval macrocytes are seen in
megaloblastic anaemia
Round macrocytes are seen in liver
disease.
17. ETIOLOGICAL CLASSIFICATION
• A) ANAEMIA DUE TO BLOOD LOSS
2 TYPES
1. A/C blood loss
Eg :Accidents
Surgery
2. Anaemia of chronic blood loss
Eg: Peptic ulcer
Parasitic infection
GIT bleeding
18. B.ANAEMIA DUE TO IMPAIRED RED
CELL FORMATION
a)Defect in Hematopoietic stem cell
proliferation and differentiation
- Aplastic anaemia
- Pure red cell aplasia
• b)Cytoplasmic metabolic defect
-Deficient haem synthesis(IDA)
-Deficient globin synthesis(Thalassaemia)
19. c)Nuclear maturation defect
-Vit B12 & Folic acid def(megaloblastic)
d)Nutritional deficiency
IDA ,MBA
e)Anaemia of chronic disorders
- Anemia due to inflammation/ infections
- Anaemia in renal disease
- Anaemia in liver disease
21. C) Anaemia due to increased red
destruction/ Haemolytic anaemia
1.Intrinsic red cell abnormalities(Intracorpuscular)
2.Extrinsic red cell abnormalities (Extracorpuscular)
(acquired haemolytic anaemia)
Intrinsic
Hereditary Acquired
PNH
Infections
23. KINETIC CLASSIFICATION
• Based On Reticulocyte Production Index
• RPI = Reticulocyte count x HCT
Reticulocyte maturation time x0.4
Hypocellular RPI < 2
Hypercellular RPI > 3
24.
25. Pathophysiology of anaemia
• Subnormal level of Hb causes lowered O2
carrying of blood
• This initiates compensatory physiologic
adaptations
Increased release of O2 from blood
Increased blood flow to tissue
Maintains of blood volume
• Redistribution of blood flow to maintain
cerebral blood supply.
26. Clinical Features Of Anaemia
1.Speed of onset of anaemia
• Rapidly progressive anaemia cause more
symptoms than that of slow on set anaemia,
less time for physiologic adaptation
2.Severity of anaemia
• No signs & symptoms in some anaemia
Mild 9.1 -10.5 g/dl
Moderate -6-9 g/dl
Severe <6 g/dl of Hb
27. 3.Age of the patient
Young patient due to good cardiovascular
compensation tolerate Anaemia
Elderly people develop cardiac & cerebral
symptoms
4.Spurious anaemia
Red cell concentration decreases due to
hemodilution as in 3rd trimester of pregnancy
36. HISTORY
• Onset of symptoms –A/C or insidious
• History of drug intake,exposure to chemicals
• Family history of similar d/s
• Occupation of pt
• Glossitis,stomatitis
• Haematuria, tarry stools
• No. of pregnancies
• H/o of jaundice
• Pain in legs