This presentation covers on complete blood cells count and it's differentials. Starting with RBC count, WBC count and Platelets interpretation as a whole.
This presentation covers on complete blood cells count and it's differentials. Starting with RBC count, WBC count and Platelets interpretation as a whole.
Anaemias, causes, pathophysiology, morphological and aetiological types, Investigations and treatment, including blood transfusion were discussed in this presentation
This presentation is focused on diagnostic utility of Red blood cell indices which will be very useful for undergraduate and postgraduate of medical field.
Sickle cell Anemia: A worldwide popular blood disorder, basically a inheritable disease. This document provides you with basic introduction to blood, Anemia its general considerations, signs and symptoms and lastly about Sickle cell Anemia in detail.
An overview about approach to diagnosis of anemia for new learners. It is not all about approach to anemia, approach to anemia really needs a lot of knowledge about each groups of anemia such as microcytic, normocytic and macrocytic anemia.
Anaemias, causes, pathophysiology, morphological and aetiological types, Investigations and treatment, including blood transfusion were discussed in this presentation
This presentation is focused on diagnostic utility of Red blood cell indices which will be very useful for undergraduate and postgraduate of medical field.
Sickle cell Anemia: A worldwide popular blood disorder, basically a inheritable disease. This document provides you with basic introduction to blood, Anemia its general considerations, signs and symptoms and lastly about Sickle cell Anemia in detail.
An overview about approach to diagnosis of anemia for new learners. It is not all about approach to anemia, approach to anemia really needs a lot of knowledge about each groups of anemia such as microcytic, normocytic and macrocytic anemia.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
2. DEFINITION OF ANEMIA
In its broadest sense, anemia is a
functional inability of the blood to
supply the tissue with adequate O2 for
proper metabolic function.
Anemia is not a disease, but rather the
expression of an underlying disorder
or disease.
A specific diagnosis is made by:
3. DEFINITION OF ANEMIA
Patient history
Patient physical exam
Signs and symptoms exhibited by the patient
Hematologic lab findings
Identification of the cause of anemia is
important so that appropriate therapy is
used to treat the anemia.
Anemia is usually associated with
decreased levels of hemoglobin and/or
a decreased packed cell volume
(hematocrit), and/or a decreased RBC
count.
4. DEFINITION OF ANEMIA
Occasionally there is an abnormal
hemoglobin with an increased O2
affinity resulting in an anemia with
normal or raised hemoglobin levels,
hematocrit, or RBC count.
Before making a diagnosis of anemia,
one must consider:
Age
5. DEFINITION OF ANEMIA
Sex
Geographic location
Presence or absence of lung disease
Remember that the bone marrow has
the capacity to increase RBC
production 5-10 times the normal
production.
Thus, if all necessary raw products are
available, the RBC life span can decrease
to about 18 days before bone marrow
compensation is inadequate and anemia
develops.
6. DEFINITION OF ANEMIA
An increased production of RBCs in
the bone marrow is seen in the
peripheral smear as an increased
reticulocyte count since new RBCs
are released as reticulocytes.
If the bone marrow production of
RBCs remains the same or is
decreased with RBCs that have a
decreased survival time, anemia will
rapidly develop.
7. DEFINITION OF ANEMIA
There is no mechanism for
increasing RBC survival time when
there is an inadequate bone marrow
response, so anemia will develop
rapidly.
In summary, anemia may develop:
When RBC loss or destruction exceeds
the maximal capacity of bone marrow
RBC production or
When bone marrow production is
impaired
8. DEFINITION OF ANEMIA
Various diseases and disorders are
associated with decreased hemoglobin
levels. These include:
Nutritional deficiencies
External or internal blood loss
Increased destruction of RBCs
Ineffective or decreased production of
RBCs
9. DEFINITION OF ANEMIA
Abnormal hemoglobin synthesis
Bone marrow suppression by toxins,
chemicals, or radiation
Infection
Bone marrow replacement by malignant
cells
10. SIGNIFICANCE OF ANEMIA AND
COMPENSATORY MECHANISMS
The signs and symptoms of anemia
range from slight fatigue to life
threatening reactions depending upon
Rate of onset
Severity
Ability of the body to adapt
11. RATE OF ONSET AND SEVERITY
With rapid loss of blood:
Up to 20% may be lost without clinical
signs at rest, but with mild exercise the
patient may experience tachycardia.
Loss of 30-40% leads to circulatory
collapse and shock
Loss of 50% means that death in
imminent
12. RATE OF ONSET AND SEVERITY
In slowly developing anemia's, a very
severe drop in hemoglobin of up to
50% may occur without the threat of
shock or death.
This is because the body has adaptive or
compensatory mechanisms to allow the
organs to function at hemoglobin levels of
50% of normal. These include:
13. ADAPTIVE OR COMPENSATORY MECHANISMS
An increased heart rate, increased circulation
rate, and increased cardiac output.
Preferential shunting of blood flow to the vital
organs.
Increased production of 2,3 DPG, resulting in a
shift to the right in the O2 dissociation curve,
thus permitting tissues to extract more O2 from
the blood.
Decreased O2 in the tissues leads to anaerobic
glycolysis, which leads to the production of
lactic acid, which leads to a decreased pH and
a shift to the right in the O2 dissociation curve.
Thus, more O2 is delivered to the tissues per
red blood cell.
14. DIAGNOSIS OF ANEMIA
How does one make a clinical
diagnosis of anemia?
Patient history
Dietary habits
Medication
Possible exposure to chemicals and/or toxins
Description and duration of symptoms
15. DIAGNOSIS OF ANEMIA
Tiredness
Muscle fatigue and weakness
Headache and vertigo
Dyspnia from exertion
G I problems
Overt signs of blood loss such as hematuria
(blood in urine) or black stools
16. DIAGNOSIS OF ANEMIA
Physical exam
General findings might include
Hepato or splenomegaly
Heart abnormalities
Skin pallor
Specific findings may help to establish
the underlying cause:
In vitamin B12 deficiency there may be signs
of malnutrition and neurological changes
In iron deficiency there may be severe pallor,
a smooth tongue, and esophageal webs
In hemolytic anemias there may be jaundice
due to the increased levels of bilirubin from
increased RBC destruction
17. DIAGNOSIS OF ANEMIA
Lab investigation. A complete blood
count, CBC, will include:
An RBC count:
At birth the normal range is 3.9-5.9 x 106/ul
(1012/L)
The normal range for males is 4.5-5.9 x
106/ul
The normal range for females is 3.8-5.2 x
106/ul
Note that the normal ranges may vary
slightly depending upon the patient
population.
18. DIAGNOSIS OF ANEMIA
Hematocrit (Hct) or packed cell volume
in % or (L/L)
At birth the normal range is 42-60% (.42-
.60)
The normal range for males is 41-53%
(.41-.53)
The normal range for females is 38-46%
(.38-.46)
Note that the normal ranges may vary
slightly depending upon the patient
population.
19. DIAGNOSIS OF ANEMIA
Hemoglobin concentration in
grams/deciliter - the RBCs are lysed
and the hemoglobin is measured
spectrophotometrically
At birth the normal range is 13.5-20 g/dl
The normal range for males is 13.5-17.5 g/dl
The normal range for females is 12-16 g/dl
Note that the normal ranges may vary
slightly depending upon the patient
population.
RBC indices – these utilize results of
the RBC count, hematocrit, and
hemoglobin to calculate 4 parameters:
20. DIAGNOSIS OF ANEMIA
Mean corpuscular volume (MCV) – is the
average volume/RBC in femtoliters (10-15 L)
Hct (in %)/RBC (x 1012/L) x 10
At birth the normal range is 98-123
In adults the normal range is 80-100
The MCV is used to classify RBCs as:
Normocytic (80-100)
Microcytic (<80)
Macrocytic (>100)
24. DIAGNOSIS OF ANEMIA
Mean corpuscular hemoglobin
concentration (MCHC) – is the
average concentration of
hemoglobin in g/dl (or %)
Hgb (in g/dl)/Hct (in %) x 100
At birth the normal range is 30-36
In adults the normal range is 31-37
The MVHC is used to classify RBCs as:
Normochromic (31-37)
Hypochromic (<31)
Some RBCs are called hyperchromic, but
they don’t really have a higher than normal
hgb concentration, they just have
decreased amount of membrane.
28. DIAGNOSIS OF ANEMIA
Mean corpuscular hemoglobin (MCH)
– is the average weight of
hemoglobin/cell in picograms (pg= 10-
12 g)
Hgb (in g/dl)/RBC(x 1012/L) x 10
At birth the normal range is 31-37
In adults the normal range is 26-34
This is not used much anymore because it
does not take into account the size of the
cell.
29. DIAGNOSIS OF ANEMIA
Red cell distribution width (RDW) – is
a measurement of the variation in
RBC cell size
Standard deviation/mean MCV x 100
The range for normal values is 11.5-14.5%
A value > 14.5 means that there is
increased variation in cell size above the
normal amount (anisocytosis)
A value < 11.5 means that the RBC
population is more uniform in size than
normal.
31. DIAGNOSIS OF ANEMIA
Reticulocyte count gives an
indication of the level of the bone
marrow activity.
Done by staining a peripheral blood
smear with new methylene blue to
help visualize remaining ribosomes
and ER. The number of
reticulocytes/1000 RBC is counted
and reported as a %.
32. DIAGNOSIS OF ANEMIA
At birth the normal range is 1.8-8%
The normal range in an adult (i.e. in
an individual with no anemia) is .5-
1.5%. Note that this % is not
normal for anemia where the bone
marrow should be working harder
and throwing out more
reticulocytes per day. In anemia
the reticulocyte count should be
elevated above the normal values.
34. DIAGNOSIS OF ANEMIA
The numbers reported above are only
relative values. To get a better indication
of what is really going on, a corrected
reticulocyte count (patients Hct/.45 (a
normal Hct) x the reticulocyte count) or an
absolute count (% reticulocytes x RBC
count) should be done.
As an anemia gets more severe, younger
cells that take longer than 24 hours to
mature, are thrown out into the peripheral
blood (shift reticulocyte). This may also be
corrected for to give the reticulocyte
production index (RPI) which is a truer
indication of the real bone marrow activity.
35. DIAGNOSIS OF ANEMIA
Blood smear examination using a
Wright’s or Giemsa stain. The
smear should be evaluated for the
following:
Poikilocytosis – describes a variation
in the shape of the RBCs. It is normal
to have some variation in shape, but
some shapes are characteristic of a
hematologic disorder or malignancy.
38. DIAGNOSIS OF ANEMIA
Erythrocyte inclusions – the RBCs in the peripheral smear
should also be examined for the presence of inclusions or a
variation in erythrocyte distribution :
39. DIAGNOSIS OF ANEMIA
A variation in size should be noted (anisocytosis) and cells
should be classified as
Normocytic
Microcytic
Macrocytic
A variation in hemoglobin concentration (color) should be
noted and the cells should be classified as
Normochromic
Hypochromic
Hyperchromic
Polychromasia (pinkish-blue color due to an increased % of
reticulocytes) should be noted.
Variation in shape should be noted (poikilocytosis) and the
different shapes found should be indicated
Variation in the RBC distribution should be noted
(agglutination or rouleaux formation)
41. DIAGNOSIS OF ANEMIA
The peripheral smear should also be examined for
abnormalities in leukocytes or platlets.
Some nutritional deficiencies, stem cell disorders, and bone
marrow abnormalities will also effect production, function, and/or
morphology of platlets and/or granulocytes.
Finding abnormalities in the leukocytes and/or platlets may
provide clues as to the cause of the anemia.
The lab investigation may also include:
A bone marrow smear and biopsy
Used when other tests are not conclusive
42. DIAGNOSIS OF ANEMIA
In a bone marrow sample, the following things should be
noted:
Maturation of RBC and WBC series
Ratio of myeloid to erythroid series
Abundance of iron stores (ringed sideroblasts)
Presence or absence of granulomas or tumor cells
Red to yellow ratio
Presence of megakaryocytes
Hemoglobin electrophoresis – can be used to identify
the presence of an abnormal hemoglobin (called
hemoglobinopathies). Different hgbs will move to
different regions of the gel and the type of hemoglobin
may be identified by its position on the gel after
electrophoresis.
43. DIAGNOSIS OF ANEMIA
Antiglobulin testing – tests for the presence of antibody
or complement on the surface of the RBC and can be
used to support a diagnosis of an autoimmune hemolytic
anemia.
Osmotic fragility test – measures the RBC sensitivity to
a hypotonic solution of saline. Saline concentrations of 0
to .9% are incubated with RBCs at room temperature
and the percent of hemolysis is measured. Patients with
spherocytes (missing some membrane) have increased
osmotic fragility. They have a limited ability take up
water in a hypotonic solution and will, therefore, lyse at a
higher sodium concentration than will normal RBCs
45. DIAGNOSIS OF ANEMIA
Sucrose hemolysis test – sucrose provides a low ionic strength
that permits binding of complement to RBCs. In paroxysmal
nocturnal hemoglobinuria (PNH), the RBCs are abnormally
sensitive to this complement mediated hemolysis. This is used
in screening for PNH.
Acidified serum test (Ham’s test) – is the definitive diagnostic
test for PNH. In acidified serum, complement is activated by
the alternate pathway, binds to RBCs, and lyses the abnormal
RBCs found in PNH.
46. DIAGNOSIS OF ANEMIA
Evaluation of RBC enzymes and metabolic pathways –
enzyme deficiencies in carbohydrate metabolic
pathways are usually associated with a hemolytic
anemia.
Evaluation of erythropoietin levels – is used to determine
if a proper bone marrow response is occurring.
Low levels of RBCs could be due to a bone marrow problem
or to a lack of erythropoietin production.
Serum iron, iron binding capacity and % saturation –
used to diagnose iron deficiency anemias (more on this
later)
Bone marrow cultures – used to determine the viability
of stem cells.
47. CLASSIFICATION OF ANEMIAS
Anemias may be classified morphologically based
on the average size of the cells and the hemoglobin
concentration into:
Macrocytic
Normochromic, normocytic
Hypochromic, microcytic
48. CLASSIFICATION OF ANEMIAS
Anemias may also be classified functionally into:
Hypoproliferative (when there is a proliferation defect)
Ineffective (when there is a maturation defect)
Hemolytic (when there is a survival defect)
Editor's Notes
The numbers reported above are only relative values. To get a better indication of what is really going on, a corrected reticulocyte count (patients Hct/.45 (a normal Hct) x the reticulocyte count) or an absolute count (% reticulocytes x RBC count) should be done.
As an anemia gets more severe, younger cells that take longer than 24 hours to mature, are thrown out into the peripheral blood (shift reticulocyte). This may also be corrected for to give the reticulocyte production index (RPI) which is a truer indication of the real bone marrow activity.