This document discusses HIV/AIDS and considerations for surgery in HIV-infected patients. It covers the epidemiology and transmission of HIV, surgical procedures commonly performed in HIV patients like draining abscesses, anorectal surgeries, and managing acute abdominal issues. Occupational risks for surgeons are addressed, including post-exposure prophylaxis guidelines. Universal precautions like barriers, vaccination, and waste disposal are emphasized to prevent transmission during procedures.
Surgical hemostasis is one of the pillars of modern surgery. Adequate hemostasis in a surgical patient involves a detailed perioperative clinical evaluation and investigation, and various intra operative techniques and options. Ensuring adequate surgical hemostasis reduces morbidity and mortality by modulating the metabolic response to trauma, decreasing the incidence of post operative anemia, reduces rates of surgical site infection and ultimately improving wound healing
Surgical hemostasis is one of the pillars of modern surgery. Adequate hemostasis in a surgical patient involves a detailed perioperative clinical evaluation and investigation, and various intra operative techniques and options. Ensuring adequate surgical hemostasis reduces morbidity and mortality by modulating the metabolic response to trauma, decreasing the incidence of post operative anemia, reduces rates of surgical site infection and ultimately improving wound healing
HIV stigma and discrimination in health care settings in the Eastern Medite...danbernard
Presentation at the symposium “Family, the Millennium Development Goals and AIDS in the Middle East and North Africa region: Linkages, challenges and opportunities,” Doha, Qatar, hosted by the Doha International Institute for Family Studies and Development, UNAIDS, and UNICEF, November 2, 2011.
Current concepts in Asepsis and Infection control in a Dental ClinincArun1g
Current concepts in Asepsis and Infection control in a Dental Clininic. Lecture deilevered to Indian dental association Malanadu Branch.kerala, India.
By Dr Arun George MDS, Cosultant Maxillofacial surgeon India
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The theme for the 2020 observance is “Ending the HIV/AIDS Epidemic: Resilience and Impact” (“Erradicar la epidemia del VIH/SIDA: Resiliencia e Impacto”). World AIDS Day was first observed in 1988.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
2. GENERAL EPIDEMIOLOGY OF AIDS
SURGERY IN HIV INFETED PATIENTS
OCCUPATIONAL RISK OF HIV TRANSMISSION
IN SURGEONS
PRECAUTIONARY MEASURES
MANAGEMENT STRATEGY IN EVENT OF
EXPOSURE.
3. AIDS is a viral disease caused by a retrovirus
of lentivirus family called HIV.
Contains a core containing two single
stranded RNA, Reverse Transcriptase enzyme,
and core proteins.
The envelope contains a glycoprotien (gp120)
– affinity for CD4 antigens.
CD4+ cells are the target for HIV infection,
most commonly being the T-helper cells.
Also involves macrophages, dendritic cells
etc.
5. After infecting the CD4+ cells, leads to the
rapid destruction of such cells leading to
different manifestations.
Most common cell involved being T-helper
cells, leads to immunodeficiency and hence
several opportunistic infections.
Some neoplasms (Kaposi’s sarcoma and
Lymphoma) also associated with HIV
infection.
8. For diagnosis of AIDS related infection or
neoplasm.
For surgical complications of AIDS.
For other indications as in general
population.
9. Lymph nodes almost always show follicular
hyperplasia, so not reliable for diagnosis.
Excision/Incision biopsy of lymph node or
soft tissues required for diagnosis of
lymphoma, sarcoma, tuberculosis etc.
Due to the risk of transmission, FNAC should
be considered first and surgical biopsy be
reserved for inconclusive FNAC reports.
11. With profound immunodeficiency, abscesses
are common presentations in HIV+ patients.
Young adult patients of either sex with
pyomyositis are particulary likely to have
AIDS.
Treatment consists of simple Incision &
Drainage as in normal conditions.
12. Most frequent reason for surgical
interventions in HIV+ patients.
HIV+ male homosexuals have higher
incidence of such disorders than other HIV+
patients.
Perianal sepsis, Fissures, Fistula, Warts,
Squamous cell carcinoma commonly seen.
Large perianal incisions and division of
internal anal sphincter should be avoided.
Setons are ideal for fistulas.
13. Anal warts are mostly resistant to medical
therapy with podophyllin. So electrocautery or
laser should be used.
Other conditions may mimic perianal sepsis
like:-
◦ Massive ulceration following Herpes simplex.
◦ Kaposi’s sarcoma presenting as bleeding
hemorrhoids.
◦ Lymphoma as perianal abscess.
◦ Chronic indolent ulcer caused by M. avium
intracellulare.
14.
15.
16.
17. Acute abdomen may be a presentation in
about 12-45% of AIDS patients but surgery is
required in only upto 5% cases mainly for
appendicitis, obstruction or perforation.
CMV infection, Kaposi’s sarcoma, Lymphoma
all may present with bowel obstruction or
perforation or even obstructive appendicitis.
Requires laparotomy for perforations and
acute obstructions.
30% of all acute appendicitis are related to
AIDS related illness. Requires appendectomy.
18. Appendicitis carries higher risk of perforation
and abscess formation.
Typhlitis common presentation in AIDS
patients.
Other opportunistic infections of GIT may
also present as acute abdominal
emergencies.
19. Chronic hepatits B and C infections are
common co-infections with AIDS.
Small liver abscesses secondary to infections
with cryptococcus, histoplasma, candida etc
are common.
Acute acalculous cholecystitis more common
in AIDS patients. Require cholecysectomy.
Biliary obstruction due to compression by
enlarged portal lymph node or due to
infection with cryptosporidium, CMV or
mirosporidium may be seen.
20. Multiple splenic abscesses leading to
splenomegaly is common.
Splenectomy may be required for traumatic or
spontaneous rupture of spleen found to be
more common in patients with AIDS.
May also be required for associated
thrombocytopenia.
21. Kaposi’s sarcoma and Non Hodgkin’s
lymphoma common neoplasms associated
with AIDS infection.
Surgery often required for biopsy purposes or
for other complications.
22. In HIV positive patients, toxoplasmosis
causes brain abscess. If medical treatment
fails then CT guided stereotatic needle
aspiration.
23. Necrotizing arteriopathy leading to aneurysm
formation common in HIV infected patients.
Salmonella arteritis especially common
leading to pseudoaneurysm.
Infected pseudoaneurysms also common in IV
drug abusers (high risk group for HIV
infection).
Vascular reconstructions usually helpful.
24. Studies show same rate of post-operative
complications in HIV positive as with
asymptomatic HIV negative patients.
Incidence of infection after anorectal surgery
in HIV positive patients is independent of
CD4 cell counts.
Relation between viral load and post
operative infection is still under trial.
25. The surgeon is regularly exposed to blood,
which is the most infective medium for HIV
transmission. Incidence of accidental
exposure to infected patients blood is 6.4%.
Risk is greater when there are more HIV
particles in blood i.e. during the earliest
and later stages of the disease.
Risk with needle stick injury is 0.3%
Risk of transmission in surgery is 1 in
28000-50000 per hour of operations.
26. Extent of risk of infection to the surgeons
depends on:
◦ Prevalence of HIV in patient population.
◦ Number of procedures carried out by the
surgeon.
◦ Length of the period of risk.
Risk is more when
◦ When surgery lasted for > 3 hours.
◦ > 300ml blood loss present during surgery.
◦ In major vascular, intra-abdominal and
gynaecological surgeries.
27. Most common mode
Risk of HIV:- 0.3%
1ml of infected blood has
50 HIV RNA compared
with 109 HBV particles
Hollow needles 10 times
more dangerous than
solid needles
Most of needle
injuries(27%) occurs from
improper disposal.
28. Deep injury.
Visible blood on instrument.
Prick directly into vein or artery.
High viral load.
Hollow needle > solid needle
Large diameter needles.
29. Recommended by CDC (USA) in 1987.
Every patient to be treated and precautions
observed as if he/she has the infection.
Use of protective barriers while dealing with
body fluids like blood, semen, vaginal
secretions, CSF, synovial fluid, pleural,
pericardial, peritoneal and amniotic fluids.
Feces, sweat, tear, saliva, urine, vomitus,
nasal secretions not included.
30. Corner stone of any precautionary program.
All HCWs should be trained and educated
about different aspects of the infection that
include:
◦ Mode of transmission.
◦ Standard precutionary guidelines.
◦ Method of disposal.
◦ Social stigma and discrimination issues.
◦ Posting of warning signs for others.
31. Screening of patients
Screening of patients for HIV,
HBV, HCV is very important
Even if HIV test is negative, it
is not 100% sure that patient
is not infected.
Patient may be in window
period when HIV antibodies
have not yet formed in the
patient (detected by the HIV
test kits)
So precautionary measures
are very important.
32. Revised CDC reommendations (2006) for HIV
testing in health care settings and screening
pregnant women:
◦ HIV screenings is recommended for patients in all health
care settings including pregnant women after the patient
is notified that the testing will be performed unless the
patient declines (opt-out testing).
◦ Persons at high risk for HIV infection should be screened
for HIV at least annually.
◦ Written informed consent from the individual should not
be required; general consent for medical care is
sufficient and encompasses consent for HIV testing.
◦ HIV screening should be included in the routine panel of
prenatal screening for pregnant women.
◦ HIV diagnostic testing as part of prevention counseling
associated with controlling HIV transmission or as part
of HIV screening program is not required.
33. Noncompliance with recommendations on
universal precautions amounts to upto 84% in
emergency conditions.
Hence, certain basic standard precautions
must be observed like wearing gloved while
drawing blood or inserting cannula.
Routine wearing of gloves for examination of
AIDS patients are not recommended unless
for open wounds.
34. Needles and sharps must always be disposed
in puncture-proof containers.
Such containers should be present as near as
practically possible.
Proper waste disposal.
Additional precautions are to be observed
while performing on HIV+ patients:
◦ Barrier method
◦ Methodical approach
35. DOUBLE GLOVES
(reduces risk by 5
fold)
CAP AND MASK
EYE GLASSES OR
SHIELDS
PLASTIC
APRON/GOWN
FOOTWEAR(wellington
shoes)
36. Undue haste should be avoided.
Assistants and other staffs should be
minimum.
Incisions should be large so as to have
minimal requirement of retraction by
assistants.
Surgery should be done in orderly manner
with meticulous attention to avoid as much
blood loss as possible.
Clumsy transfer of instruments should be
avoided. Sharps preferably be transferred in
kidney dishes.
37. TREATMENT OF EXPOSED LOCAL SITE:
◦ Skin: thorough cleaning with soap water. Never put
fingers reflexly into mouth.
◦ Eyes: Irrigation with fresh water.
◦ Oral cavity: spit out immediately and rinse with
water several times.
Prompt exposure report regarding the time,
nature etc of exposure should be reported.
38. Source
◦ HIV testing after proper consent. If known to be HIV
positive then assess the health status and the
possibility of drug resistance if on anti retro-viral
therapy
Recipient
◦ Baseline serological testing for HIV, HBV and HCV.
Nature of exposure.
39. Depending upon the risk and toxicity
balance.
Decision to start PEP depends on:
◦ Severity of exposure (Exposure Code, EC)
◦ HIV status of source (Status Code, SC).
If required, should be started within 2-24
hours of exposure and not later than 72
hours.
Effectivity decreases with increasing duration
since exposure.
40.
41.
42. EC SC. PEP recommendation
1 1 PEP may not be warranted. NO known risk
1 2 Basic regimen. Negligible risk
2 1 Basic Regimen. Negligible risk
2 2 Expanded Regimen. Increased transmission
risk.
2/3 Unknown Basic Regimen
43. Consists of two NRTIs for 1 month.
Zidovudine 300mg BD+Lamivudine 150mg
BD.
Zidovudine 300mg BD+Stavudine 40mg BD.
Didanosine 200mg BD+Stavudine 40mg BD.
44. Consists of 2 NRTIs+ 1 PI for 1 month.
Any of the basic regimen+ any one of the
following:
◦ Indinavir 800mg TDS.
◦ Ritonavir 100mg BD.
◦ Saquinavir 1000mg BD.
◦ Lopinavir 400mg BD.
45. Side effects
PEP is very toxic so its use is weighed against
toxicity
Should not be used for exposure that poses
negligible risk
Don’t use three drug regimen for all HIV exposure
Most common is nausea and diarrhea
Mild and reversible may be relieved by
domperidone and loperamide
PIs cause peripheral neuropathy
Indinavir:- Nephrolithiasis, Hyperbilirubinemia
NRTI Abacavir causes hypersensitivity reaction
NNRTI not used causes acute fulminant liver failure
Efavirenz is teratogenic, Steven Johnson Syndrome,
dizziness, insomnia, psychiatric illness
46. Investigations before prescribing
PEP
Full medical history
Risk of pregnancy
CBC
LFT
RFT
Zidovudine + Lamivudine + Ritonavir are
safe in pregnancy
Alone Zidovudine gives 80% protection.
Combinations provide extra protection
47. Follow up
Perform baseline HIV test of HCW at the time
of exposure which will be negative then repeat
at 6 wk, 12wk and 6 month interval to see any
seroconversion
Follow up every 1-2 wk to check side effects,
toxicity and adherence to regimen
Instruct to seek medical advice immediately if
experiences acute viral symptoms
Advise to:- have safe sex
Use barrier methods during intercourse
Don’t donate blood or organs during follow up
period
Safe to continue performing exposure prone
procedure as risk of seroconversion is low and
the risk of onward transmission is remote