The document discusses differential diagnosis of upper and lower respiratory tract infections, defining URTI as infections above the larynx including common cold, tonsillitis, and sinusitis, while LRTI refers to infections below the larynx such as bronchitis, bronchiolitis, and pneumonia. It provides details on symptoms, risk factors, clinical assessment, and differential diagnosis for various respiratory conditions commonly seen in primary care. The document emphasizes tachypnea as an important clinical sign for diagnosing pneumonia and differentiating it from other potential causes of respiratory distress in children.
What is bronchiolitis and its definition, the age group, signs and symptoms and clinical presentation The clinical practice guidelines, how to diagnosis, clinical criteria, what are the severity degrees and How to assess the severity, what are the investigations that may be needed, Is there any diagnostic test, what is the prognosis
What is the management,
What is bronchiolitis and its definition, the age group, signs and symptoms and clinical presentation The clinical practice guidelines, how to diagnosis, clinical criteria, what are the severity degrees and How to assess the severity, what are the investigations that may be needed, Is there any diagnostic test, what is the prognosis
What is the management,
Measles and its prevention - Slideset by professor EdwardsWAidid
In this study Professor Kathryn M. Edwards (Sarah H. Sell and Cornelius Vanderbilt Professor - Division of Pediatric Infectious Diseases - Vanderbilt University Medical Center) provides an update on measles and its prevention.
To learn more, please visit www.waidid.org!
This presentation is not about emergency & trauma per se but it is about how to save Non-COVID Hospital from COVID patients, as 70% of COVID positive patients are asymptomatic
To develop effective patient flow map and staff practices to prevent admission of asymptomatic COVID positive patient in a Non COVID hospital that can cause shut down of that hospital or its services
The Art of the Pitch: WordPress Relationships and SalesLaura Byrne
Clients don’t know what they don’t know. What web solutions are right for them? How does WordPress come into the picture? How do you make sure you understand scope and timeline? What do you do if sometime changes?
All these questions and more will be explored as we talk about matching clients’ needs with what your agency offers without pulling teeth or pulling your hair out. Practical tips, and strategies for successful relationship building that leads to closing the deal.
Securing your Kubernetes cluster_ a step-by-step guide to success !KatiaHIMEUR1
Today, after several years of existence, an extremely active community and an ultra-dynamic ecosystem, Kubernetes has established itself as the de facto standard in container orchestration. Thanks to a wide range of managed services, it has never been so easy to set up a ready-to-use Kubernetes cluster.
However, this ease of use means that the subject of security in Kubernetes is often left for later, or even neglected. This exposes companies to significant risks.
In this talk, I'll show you step-by-step how to secure your Kubernetes cluster for greater peace of mind and reliability.
State of ICS and IoT Cyber Threat Landscape Report 2024 previewPrayukth K V
The IoT and OT threat landscape report has been prepared by the Threat Research Team at Sectrio using data from Sectrio, cyber threat intelligence farming facilities spread across over 85 cities around the world. In addition, Sectrio also runs AI-based advanced threat and payload engagement facilities that serve as sinks to attract and engage sophisticated threat actors, and newer malware including new variants and latent threats that are at an earlier stage of development.
The latest edition of the OT/ICS and IoT security Threat Landscape Report 2024 also covers:
State of global ICS asset and network exposure
Sectoral targets and attacks as well as the cost of ransom
Global APT activity, AI usage, actor and tactic profiles, and implications
Rise in volumes of AI-powered cyberattacks
Major cyber events in 2024
Malware and malicious payload trends
Cyberattack types and targets
Vulnerability exploit attempts on CVEs
Attacks on counties – USA
Expansion of bot farms – how, where, and why
In-depth analysis of the cyber threat landscape across North America, South America, Europe, APAC, and the Middle East
Why are attacks on smart factories rising?
Cyber risk predictions
Axis of attacks – Europe
Systemic attacks in the Middle East
Download the full report from here:
https://sectrio.com/resources/ot-threat-landscape-reports/sectrio-releases-ot-ics-and-iot-security-threat-landscape-report-2024/
Neuro-symbolic is not enough, we need neuro-*semantic*Frank van Harmelen
Neuro-symbolic (NeSy) AI is on the rise. However, simply machine learning on just any symbolic structure is not sufficient to really harvest the gains of NeSy. These will only be gained when the symbolic structures have an actual semantics. I give an operational definition of semantics as “predictable inference”.
All of this illustrated with link prediction over knowledge graphs, but the argument is general.
Slack (or Teams) Automation for Bonterra Impact Management (fka Social Soluti...Jeffrey Haguewood
Sidekick Solutions uses Bonterra Impact Management (fka Social Solutions Apricot) and automation solutions to integrate data for business workflows.
We believe integration and automation are essential to user experience and the promise of efficient work through technology. Automation is the critical ingredient to realizing that full vision. We develop integration products and services for Bonterra Case Management software to support the deployment of automations for a variety of use cases.
This video focuses on the notifications, alerts, and approval requests using Slack for Bonterra Impact Management. The solutions covered in this webinar can also be deployed for Microsoft Teams.
Interested in deploying notification automations for Bonterra Impact Management? Contact us at sales@sidekicksolutionsllc.com to discuss next steps.
DevOps and Testing slides at DASA ConnectKari Kakkonen
My and Rik Marselis slides at 30.5.2024 DASA Connect conference. We discuss about what is testing, then what is agile testing and finally what is Testing in DevOps. Finally we had lovely workshop with the participants trying to find out different ways to think about quality and testing in different parts of the DevOps infinity loop.
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After immersing yourself in the blue book and its red counterpart, attending DDD-focused conferences, and applying tactical patterns, you're left with a crucial question: How do I ensure my design is effective? Tactical patterns within Domain-Driven Design (DDD) serve as guiding principles for creating clear and manageable domain models. However, achieving success with these patterns requires additional guidance. Interestingly, we've observed that a set of constraints initially designed for training purposes remarkably aligns with effective pattern implementation, offering a more ‘mechanical’ approach. Let's explore together how Object Calisthenics can elevate the design of your tactical DDD patterns, offering concrete help for those venturing into DDD for the first time!
GraphRAG is All You need? LLM & Knowledge GraphGuy Korland
Guy Korland, CEO and Co-founder of FalkorDB, will review two articles on the integration of language models with knowledge graphs.
1. Unifying Large Language Models and Knowledge Graphs: A Roadmap.
https://arxiv.org/abs/2306.08302
2. Microsoft Research's GraphRAG paper and a review paper on various uses of knowledge graphs:
https://www.microsoft.com/en-us/research/blog/graphrag-unlocking-llm-discovery-on-narrative-private-data/
Connector Corner: Automate dynamic content and events by pushing a buttonDianaGray10
Here is something new! In our next Connector Corner webinar, we will demonstrate how you can use a single workflow to:
Create a campaign using Mailchimp with merge tags/fields
Send an interactive Slack channel message (using buttons)
Have the message received by managers and peers along with a test email for review
But there’s more:
In a second workflow supporting the same use case, you’ll see:
Your campaign sent to target colleagues for approval
If the “Approve” button is clicked, a Jira/Zendesk ticket is created for the marketing design team
But—if the “Reject” button is pushed, colleagues will be alerted via Slack message
Join us to learn more about this new, human-in-the-loop capability, brought to you by Integration Service connectors.
And...
Speakers:
Akshay Agnihotri, Product Manager
Charlie Greenberg, Host
Builder.ai Founder Sachin Dev Duggal's Strategic Approach to Create an Innova...Ramesh Iyer
In today's fast-changing business world, Companies that adapt and embrace new ideas often need help to keep up with the competition. However, fostering a culture of innovation takes much work. It takes vision, leadership and willingness to take risks in the right proportion. Sachin Dev Duggal, co-founder of Builder.ai, has perfected the art of this balance, creating a company culture where creativity and growth are nurtured at each stage.
2. What’s the Need
Magnitude of Problem
ARI is emerging as one of the leading causes of
morbidity and mortality in the developing world.
Of the 12 million deaths occurring annually under 5
years of age, ARI constitutes 19% of these deaths.
20 to 25% ARI deaths occur < 2 months, 50 to 60%
occur in infants and very few deaths occur between 1
to 5 years.
Nearly 25% outpatient visits and 15% of all hospital
admissions are of ARI.
In urban set up ARI accounts for 3-5 episodes /child
/year, while in rural areas it is 1-3 episodes/child/year.
3. Magnitude of Problem
WHO report 1999, estimates 27% of disabled
adjusted life years (DALY) due to ARI.
CFR (case fatality rate) of pneumonia is the
highest amongst ARI viz 10 to 15%.
ARI contributes to 15-30% of all under
five deaths in India and most of these
deaths are preventable
4. What constitutes ARI
• ARI is defined as acute invasion of any
part of respiratory tract starting from nose
to alveoli of lungs by micro-organisms
Upper
• Rhinitis (common
cold)
• Pharyngitis
• Tonsillitis
• Acute epiglottitis
Lower
• Laryngitis
• Tracheo-bronchitis
• Bronchiolitis
• Pneumonia
5. Definition
• An upper respiratory tract infection (URTI) is an
illness caused by an infection, which involves
the upper respiratory tract, including the nose,
sinuses, pharynx, or larynx.
6. Risk factors for URIs
• Contact: Close contact with small children settings, such as school or daycare,
increases the risk of URI.
• Travel: , exposure to large numbers of individuals in closed settings. Increased
exposure to respiratory pathogens
• Environmental factors such as passive smoking and exposure to pollutants
• Immunocompromise that affects cellular or humoral immunity: Splenectomy, HIV
infection, corticosteroids, immunosuppressive treatment , familial predisposition with
immunological defects or anatomical and/or physiological features
• Malnutrition
• Lack of breast-feeding
• Cilia dyskinesia syndrome and cystic fibrosis
• Anatomic changes due to facial dysmorphisms
• Upper airway trauma, and nasal polyposis
• Anemia, rickets, malnutrition
8. Common cold
• The common cold is an acute, self-limiting viral
infection of the upper respiratory tract involving the
nose, sinuses, pharynx and larynx.
Symptoms
• Runny or stuffy nose
• Sore throat
• Cough
• Congestion
• Slight body aches or a mild headache
• Sneezing
• Low-grade fever
• Generally feeling unwell (malaise)
https://www.mayoclinic.org/diseases
10. Influenza: biology & impact
• Single-stranded, enveloped, RNA virus
(orthomyxoviridae family)
• Influenza A
– Potentially severe illness; epidemic and pandemics
– Rapidly changing
• Influenza B
– Usually less severe illness; may cause epidemics
– More uniform
• Influenza C
– Usually mild or asymptomatic illness
11. Structure of the Influenza Virus
Polymerase (P) Proteins
Hemagglutinin (HA)
Neuraminidase (NA)
M2
Nucleoprotein (NP)
M1
Adapted from: Hayden FG et al. Clin Virol. 1997:911-42.
12. Viral Nomenclature
1. CDC. Atkinson W, et al. Chapter 13: Influenza. In: Epidemiology and Prevention of Vaccine-Preventable Diseases, 4th ed. Department of Health
and Human Services, Public Health Service, 1998, 220
A / Sydney / 184 / 93 (H3N2)
Type of Nuclear
Material
Virus
type
Geographic
origin
Strain
number
Year of
isolation
Hemagglutinin
Virus
subtype
Neuraminidase
13. Bridges CB et al. Clin Infect Dis. 2003;37:1094-101. Heikkinen T et al. Lancet. 2003;361:51-9.
Pathogenesis of Influenza
• If not neutralized by mucosal antibodies, virus attacks
respiratory tract epithelium
• Infection of respiratory epithelial cells leads to cellular
dysfunction, viral replication, and release of viral progeny
• Release of inflammatory mediators contributes to
systemic manifestations of disease
• Influenza can be transmitted through small or large particle
• aerosols or through contact with contaminated surfaces
14. ACIP. MMWR. 2004,53(RR06)1-40. Kavet J. Am J Public Health. 1977;67:1063-70. Frank AL et al. J Infect Dis. 1981;144:433-441. Hayden FG et al. JAMA. 1999;282:1240-6.
• Sudden onset of symptoms, persist for
7+ days
• Incubation period: 1-4 days, average 2
days
• Infectious period of wild type virus:
– Adults shed virus typically from 1 day before
through 5 days after onset of symptoms
– Children shed higher titers for a longer
duration than adults
Clinical Features of Influenza
16. A Comparison of Common Cold
and Influenza Characteristic
Alternative Medicine Review Volume 12, Number 1 2007
17. Tonsillitis
• Tonsillitis is defined as an inflammation of
the tonsils and is a common upper RTI in
children
commonly encountered in primary care.
ages of 5 and 15 years
The prevalence of bacterial tonsillitis,
specifically group A beta hemolytic
streptococci (GABHS), is 15% to 30% of
children with sore throat and 5% to 15% of
adults with sore throat
InnovAiT · August 2017
Tonsillitis is usually viral; it is most
commonly caused by the rhinovirus,
followed by the coronavirus, and the
adenovirus
18. Clinical Signs and symptoms
• Frequent throat infections
• Breathing difficulties
• Dysphagia
• Redness of anterior
pillers
• Breathing through mouth
Dry mucous membrane
Oedema
• Local signs of tonsillitis
Unpleasant mouth odor
Unpleasant feeling in the
throat Lymph nodes are
small and dense Pus or
tonsil stones in lacunae
19. D/D of tonsillitis in children
• Scarlet fever
• Infectious mononucleosis
• HIV
• Herpes simplex virus infection
20. Scarlet fever
• Scarlet fever is caused by toxin-producing strains of
Streptococcus Pyogenes, a beta-haemolytic bacterium that is
classified as a Group A Streptococcus
• Highly contagious
• There is an exudative tonsillopharyngitis, and there may be
small red haemorrhagic spots on the hard and soft palate
InnovAiT · August 2017
21. Glandular fever
(infectious mononucleosis)
• EBV is the causative agent
• Patients typically presenting with a triad of sore
throat, fever and lymphadenopathy.
• There may be splenomegaly in up to 50% of patients
InnovAiT · August 2017
22. HIV
• HIV can cause ulcerative tonsillitis and pharyngitis
with fever. It occurs after an incubation period of
3–5 weeks with symptoms of myalgia, arthralgia,
lethargy, and in some people a non-itchy
maculopapular rash. Lymphadenopathy develops a
week later (Caserta & Flores, 2010)
InnovAiT · August 2017
23. Herpes simplex virus
• Herpes simplex virus (HSV) pharyngitis presents with red,
swollen tonsils that may have aphthous ulcers on their
surfaces.
• Herpes simplex virus (HSV) pharyngitis presents
with red, swollen tonsils that may have aphthous
ulcers on their surfaces.
InnovAiT · August 2017
24. Complications of tonsillitis
• Peri-tonsillar abscess/quinsy
• Airway obstruction
• Post-Streptococcal glomerulonephritis
• Rheumatic fever
InnovAiT · August 2017
25. Sinusitis
• Sinusitis is one of the most common and
serious childhood infections
• It has been demonstrated that children have
upper respiratory tract infections 6-8 times per
year of which 5-10% are associated with
sinusitis.
Classification by duration of disease
• 1. Acute
• 2. Subacute
• 3. Recurrent acute
• 4. Chronic
Lieser, John D., and Craig S. Derkay. "Pediatric sinusitis: when do we operate?." Current opinion in otolaryngology & head and neck
surgery 13.1 (2005): 60-66.
27. Diagnosis
• Diagnosis requires presence of two
major or one major-two minor symptoms
Major Symptoms
• Facial pain,
• Feeling of pressure and fullness
• Nasal congestion Nasal
• Postnasal purulent discharge
Lieser, John D., and Craig S. Derkay. "Pediatric sinusitis: when do we operate?." Current opinion in otolaryngology & head and neck
surgery 13.1 (2005): 60-66.
Minor Symptoms
• Headache
• Cough
• Halitosis
• Fever Fatigue
• Dental pain
• Ear pain
• Feeling of pressure and fullness
28. Otitis media (OM).
in Children
• inflammation of middle ear that most often occur in
infant & young children but can occur at any age”
• but children get them more often than adults.
• Five out of six children will have at least one ear
infection by their third birthday.
Classification
• Acute otitis media
• Chronic otitis media
• Serous otitis media
• Secretory otitis media
• Suppurative otitis media
29. Aetiology/ Risk factors
• The most common bacterial causes of
AOM are Streptococcus pneumoniae,
non-typeable Haemophilus influenzae,
and Moraxella catarrhalis.
• There is increasing evidence
that the predominant causative
pathogen in AOM is changing
from Streptococcus
pneumoniae to non-
typeable Haemophilus
influenzae since the introduction
of pneumococcal conjugate
vaccines.
30.
31. Clinical manifestation
• Otorrhea
• Otalgia
• Fever
• Rhinitis
• Tympanic membrane erythema,
may be perforated
• Hearing loss
• Irritability
32. Differential diagnosis
• Otitis externa
• Impacted cerumen or foreign body in ear
• Tympanosclerosis
• Otitis media with effusion
• Injury of the ear
33. Pathophysiology
Essentially, it is inflammation of the airways/pulmonary tissue,
due to viral or bacterial infection, below the level of the larynx.
Gastro-oesophageal reflux may cause a chemical pneumonitis.
Smoke and chemical inhalation may cause pulmonary
inflammation
34. LRTI : infection below the level of
larynx
Larynogotracheobronchitis
Bronchitis
Bronchiolitis
Pneumonia
35. Clinical Manifestation of
Respiratory tract Infections
• Cough
• Fever
• Hoarseness of voice
• Stridor
• Fast breathing
• Breathing difficulties
• Cyanosis
36. Characteristics of Cough and their
etiological significance
Type of Cough Likely condition
Loose
(discontinuous),
productive
Bronchitis, asthmatic bronchitis
Brassy Tracheitis, habit cough
With stridor Laryngeal obstruction, pertussis
Paroxysmal Pertussis syndrome, F. body
Staccato Chlamydial pneumonia
37. Characteristics of Cough and their
etiological significance (contd…)
Type of Cough Likely condition
Nocturnal Upper or lower respiratory
tract allergic reaction.
With vigorous exercise Exercise induced asthma
Tight (wheezy) Reactive airway
38. Signs of significant respiratory
disease
• Fast Breathing (Tachypnoea)
– A proxy for hypoxia
– suggests significant respiratory disease.
Remember
• Normal RR vary with age
• Fever alone can increase the respiratory
distress
39. Signs of significant respiratory distress
Nasal flaring:
With inspiration, the side of the nostrils flares outwards
40. Signs of significant respiratory distress
Lower chest wall indrawing:
With inspiration, the lower chest wall moves in
41. P, 5 year old female
• Presents with an acute history of fever, cough
for 3 days
• She is irritable and has significant cough
• O/E She has a respiratory rate of 48/min and
chest indrawing.
• The parents are worried because the local
practitioner has told them that she has
pneumonia and should be admitted. They seek
your opinion.
How will you arrive at the diagnosis?
42. TACHYPNEA –
Most consistent clinical sign of pneumonia
Age Respiratory rate
(breaths/min)
< 2 months 60 or more
2 months upto 12 mo 50 or more
12 months upto 5 years 40 or more
WHO recommends using these Respiratory rate cutoffs to
diagnose pneumonia at the community level
RR should be counted for full 60 secs.
43. P, has a respiratory rate of 48/min
• She has tachypnoea and a
RR higher than the age
specific cutoffs suggested by
WHO
• “Does this mean she has
pneumonia? This is simple
but is it good enough for me
to use for diagnosis in clinics
/hospital settings?”, wonders
your junior doctor.
Age Respiratory rate
(breaths/min)
< 2 months 60 or more
2 months upto
12 months
50 or more
12 months upto
5 years
40 or more
44. Child with cough, rapid and difficult
breathing
Pneumonia-
Any cause
WALRI, Asthma,
LTB, Bronchiolitis
Non respiratory
causes
45. Tachypnoea
• A sensitive and specific tool – 66% approx.
– as good or better than auscultation for pneumonia
• Any clinician therefore must use this merely as a
beginning step (Triage Sign).
• And then, use all their clinical skills for the final
conclusion.
• Remember several other clinical situations that
cause rapid breathing e.g.
– Respiratory causes: Asthma / Bronchiolitis/ WALRI
– Non- respiratory causes: metabolic acidosis, CHF,
raised ICT
46. What now?
• First rule out non –respiratory causes for
tachypnoea,
• You may have concluded that the focus of
infection is lower respiratory tract due to
presence of other chest signs,
• In this setting of child with cough, rapid and
difficult breathing, the likelihoods are:
– Pneumonia + complications
– Bronchiolitis
– Wheeze associated with Lower respiratory tract infxns
– Asthma
– Croup
47. Differential diagnosis
Asthma
Inhaled foreign body
Pneumothorax
Cardiac dyspnoea
Pneumonitis from other causes:
Extrinsic allergic alveolitis
Smoke inhalation
Gastro-oesophageal reflux
48. Child with Cough, Rapid, Difficult
breathing
• Consider Bronchiolitis if:
– Age 1mo -2yr
– 1st episode in infancy
– Presence of Upper
respiratory catarrh
– Progressive increase in
respiratory distress
(tachypnoea, retractions)
– Wheeze + crackles
– Clinical and radiological
evidence of hyperinflation
• Consider Wheeze assoc with
LRTI (WALRI) if:
– Recurrent episodes of
distress under 3 years of age
– Presence of Upper respiratory
catarrh
– Progressive increase in resp
distress (tachypnoea,
retractions)
– Wheeze + crackles
– Clinical and radiological
evidence of hyperinflation
– No family or personal history
of atopy
49. Child with Cough, Rapid,
Difficult breathing
• Consider Asthma if:
– Recurrent episode, 3 or
more
– Wheeze
– Good response to
bronchodilator
– Hyperinflation
– H/o afebrile episodes
– Family/personal history of
atopy
• Consider Laryngo-
tracheo-bronchitis -
Croup if:
– Hoarseness of voice and
barking/ brassy cough
– Stridor
– Mild to marked respiratory
distress
– Sonorous rhonchi
– Fever usually mild or
spiking (tracheitis, rare)
50. Can viral LRTI or bacterial
pneumonia be clinically distinguished
• May be difficult as the investigations do not
confirm etiology
• Advantage of using the suggested
methodology- decreases the confounders to
viral pneumonia alone rather than broad ARI
53. Differentiating features of typical and
atypical pneumonia
Features Typical Atypical
Onset Sudden Gradual
Fever +++ ±
Cough Productive Dry
Symptoms Pulmonary Systemic
Chest X-ray Localized Diffuse
54. Let us focus on Community
aquired Pneumonia (CAP) now
• CAP is an acute infection of the
pulmonary parenchyma in a
previously healthy child, acquired
outside of a hospital setting.
– not have been hospitalized within 14
days prior to the onset of symptoms, or
– has been hospitalized less than 4 days
prior to onset of symptoms.
• It excludes
– Child with any immune-deficiency
• Severe Malnutrition
• Post measles state
– Ventilator assoc Pneum/ Nosocomial
spread
– Recurrent pneumonias
55. The doctor is now convinced. She says,
“Now I know that simple clinical tools used
judiciously can differentiate between
different causes for cough and rapid
breathing. And therefore help us be rational
in management.”
But Sir,
A. How do I confirm the diagnosis?
and if I have to use the correct antibiotics,
B. How can I suspect or confirm the
probable organisms?”
56. Investigations and their relevance
• CBC, ESR
• CRP
• Radiograph of chest
• Cultures:
– Throat swab
– Cough swab
– Sputum
– Lung tap
– Blood
CBC:
White cell count is often elevated.
Microbiological studies:
Blood cultures are seldom positive in
pneumonia (fewer than 10% are
bacteraemic in pneumococcal disease).
Sputum culture
Imaging:
Chest radiography (CXR) is not routinely
indicated in OPD .
CXR cannot differentiate reliably between
bacterial and viral infections.
57. Role of acute phase reactants,
etc. in pneumonia
• TLC, DLC, CRP are not diagnostic
• May be useful to monitor the
response to treatment.
58. Diagnosis- Radiological
• Do all patients require a chest radiograph?
• NO,
– Not all CAP, particularly if on domiciliary treatment
• Few -Yes,
– If severely ill
– If complication suspected (for example, pleural effusion)
– Ambiguous Diagnosis- tachypnoea without chest signs, etc.
• Does it differentiate between the etiological agents
• NO, Poor correlation
59. The Bronchovascular shadows are heavy, small patches of
increased density are scattered throughout both lung
61. A guide to radiological diagnosis of
pneumonia
Acute lobar pneumonia – consider pneumococcal
pneumonia.
Right upper lobe pneumonia – suspect aspiration,
especially in neonates and infants.
Recurrent right middle lobe pneumonitis – consider
partial bronchial obstruction due to glands and
others.
Multiple small abscesses – staphylococcal
/Klebsiella pneumonia.
Severe bilateral interstitial pneumonia – virus
62. Microbiological Cultures
• Not recommended routinely
• Takes a long time and hence has limited
utility
• Sputum cultures / cough swabs have
relatively poor reliability
• Invasive methods can not be justified for
routine pneumonias.
63. QUESTIONS?????
• In the absence of a microbiological
diagnosis in most cases, How does one
know which bacteria is the offending
organism?
• Are there any other supportive evidences
for the probable etiology?
65. 0-3 months Gram Negative, E. Coli, Klebsiella
St pyogenes,
Chlamydia
Viruses- CMV, Herpes
3mo-5yrs Str pneumoniae
H Influenzae
Staph aureus
Viruses – CMV, RSV, Influenza,
Parainfluenza
Mycoplasma pneum
>5 yrs Str pneumoniae
Staph aureus
Viruses – Influenza, Varicella
Mycoplasma pneum
St pyogenes
Age related Pathogens involved in
Community Aq Pneumonia
66. Reliability of predicting a specific
etiological agent based on clinical
features and/or radiography
• Generally POOR
• ONE EXCEPTION - STAPH
– More likely if
• Very rapid progression
• Skin Lesions, infected scabies
• Pleural Effusion or Empyema/ Pneumothorax
• post measles
67. Treatment of CAP
• Out patient
• In patient
Out Patient
• Supportive Care
• Withhold antibiotics (if not sick and viral etiology)
• Features of atypical pneumonia – Start Macrolides
• Reassess the child after 48 hr.
68. Indications for admission to hospital
(in patients)
– Marked tachypnea
– difficulty in breathing
– marked chest indrawing
– intermittent apnea, grunting
– not feeding/ dehydrated
– family not able to provide appropriate
observation or supervision.
– Failure of OPD treatment
– Presence of high risk factors
69. Inpatient management of pneumonia
Specific Supportive
Antimicrobial Hydration
Nutrition
Oxygen
Antipyretics
Physiotherapy
Adjuvants
70. Treatment of CAP
• Antibiotic Treatment shall be discussed in
the following slides in this manner
– Pneumonia (non-severe disease)
– Severe – very severe pneumonia
– Suspected Staphylococcal disease
• It gives the first and second line options
as per IAP-RTI consensus guidelines.
71. *Use Separately in 1:2 ratio as
combinations available are not
scientifically correct
# Second line domicillary therapy is for
patients who show inadequate or no
response to first line treatment after
48hrs, though have no deterioration or
increase in severity.
Disease Pneumonia
Setting Domicilliary
AGE First Line Second Line# Suspected Staphylococcal ds
Upto 3mo Usually Severe, treated as inpatients
3mo-
5yrs of
age
Amoxycillin Co-amoxy
clavulinic acid
OR
Chloremphenicol
Cefuroxime
OR
Co-amoxy clavulinic acid OR
Amoxycillin+ Cloxacillin*
5 yrs plus Amoxycillin Macrolide
OR
Co-amoxy-
clavulinic acid
Cefuroxime
OR
Co-amoxy clavulinic acid
OR
Amoxycillin+ Cloxacillin*
72. Severe – Very Severe Pneumonia
Treat as In-patient
Age First Line Second Line
0-3 mo Inj 3rd Gen Cephalosporins:
Cefotaxime/Ceftriaxone
+
Aminoglycoside (Gent/Amika)
Inj Co-amoxy clavulinic acid
+
Aminoglycoside (Gent/Amika)
3mo-5 years Inj Ampicillin
OR
Inj Chloremphenicol
OR
Inj Ampicillin +
Inj Chloremphenicol (<2 years of age)
OR
Inj Co-amoxyclavulinic acid
Inj Co-amoxy clavulinic acid
OR
Inj 3rd Gen Cephalosporins:
Cefotaxime/Ceftriaxone
5 years + Inj Ampicillin
OR
Inj Co-amoxyclavulinic acid
OR
Macrolides (if Mycoplasma
suspected)
Inj Co-amoxy clavulinic acid
OR
Inj 3rd Gen Cephalosporins:
Cefotaxime/Ceftriaxone
AND
Macrolides
73. Severe- Very Severe Disease
SUSPECTED STAPHYLOCOCCAL DS
Inj 3rd Gen Cephalosporins: Cefotaxime/Ceftriaxone
+ Cloxacillin
OR
Inj Cefuroxime + Aminoglycoside
OR
Inj Co-amoxyclavulinic acid + Aminoglycoside
Second line: Vancomycin/ Teicoplanin/ Linezolid
+
Inj 3rd Gen Cephalosporins
74. When to switch to the second line
therapy
Second line domiciliary therapy (non-
severe) is for patients who show
inadequate or no response to first line
treatment after 48hrs, though have no
deterioration or increase in severity.
In case of severe disease, once again the
second line treatment is started if there is
any increase in severity in 48 hours or
clinical non response in 72-96 hours
75. Supportive therapy for CAP
• Oxygen :
– as indicated by pulse oxymetry and/ or ,
– clinical signs of hypoxia like rapid breathing as well as retractions
• IV Fluids:
– If dehydrated,
– Tachypnoea severe enough to make the child unable to drink, or
– impending respiratory failure.
• Fever management
– Important as fever increase oxygen requirement
– Paracetamol and sponging are useful in most situations.
• Bronchodilators, where indicated
– should be used to decrease the work of breathing.
76. Duration and mode of therapy
• Domiciliary 5-7 days, Oral
• If on second line, then treat for
7-10days
• If admitted:
– All antibiotics by parenteral
route (i.v.) to begin with
– Switch to oral after 48-72
hrs or earlier if can accept
– Step-down/ switch therapy
for Inj 3rd generation
Cephalosporins
• 3rd generation oral like
Cefpodoxime
• NOT Cefixime because it
lacks action against Strep.
Pneumoniae
• Fluoroquinolones are not
recommended
– Total 5-7 days more
If Staphylococcal disease:
• 2 weeks if no complication; Else 4-6 weeks
77. Presence of comorbidity :
congenital heart disease,
chronic lung disease of prematurity,
chronic respiratory conditions such as
- cystic fibrosis,
- bronchiectasis or
- immune deficiency
Admission should also be considered for
All children under the age of 6 months
Children in whom treatment with antibiotics has failed (most
children improve after 48 hours of oral, outpatient antibiotics)
Patients with troublesome pleuritic pain
78. Be sure to offer the patient and parents general support, explanation and reassurance.
Respiratory support as required, including oxygen
Pulse oximetry to guide management
Severe respiratory distress with ↓level of consciousness and failure to maintain
oxygenation indicates a need for intubation
complication & prognosis
Complete resolution after treatment should be expected in
the vast majority of cases.
Bacterial invasion of the lung tissue can cause pneumonic
consolidation, septicemia, empyema, lung abscess
(especially S. aureus) and pleural effusion.
Respiratory failure, hypoxia and death are rare unless
there is previous lung disease or the patient is
immunocompromised.
79. Prevention
Prevention of pneumococcal pneumonia and influenza by
vaccination, for high-risk individuals with pre-existing
heart or lung disease.
Smoking in the home is a major risk factor for all
childhood respiratory infection.
80. Conclusion
• URI are common during the winter season and for the most part, are benign, but
they can seriously affect the quality of life for a few weeks.
• Complications of upper respiratory tract infections are relatively rare,
except with influenza.
• Its important to timely diagnose and treat with appropriate treatment to
prevent further complications
Understanding the pathophysiology of LRTI
Conducting proper History
Performing careful physical Examination
Comprehension the Impact of the disease on the family
Close follow up after discharge
81. 12 - References
Guidelines for the management of community acquired pneumonia in children;
British Thoracic Society (2011)
Pediatric Essntial Nelson 21th edition2019
van Woensel JB, van Aalderen WM, Kimpen JL; Viral lower respiratory tract
infection in infants and young children. BMJ. 2003 Jul 5;327(7405):36-40.
Michelow IC, Olsen K, Lozano J, et al; Epidemiology and clinical
characteristics of community-acquired pneumonia in hospitalized children.
Pediatrics. 2004 Apr;113(4):701-7.
Krilov LR; Respiratory syncytial virus disease: update on treatment and
prevention. Expert Rev Anti Infect Ther. 2011 Jan;9(1):27-32.
Feverish illness in children - Assessment and initial management in children
younger than 5 years; NICE Guideline (May 2013)
Mahabee-Gittens EM, Grupp-Phelan J, Brody AS, et al; Identifying children
with pneumonia in the emergency department. Clin Pediatr (Phila). 2005
Jun;44(5):427-35.
Haider BA, Saeed MA, Bhutta ZA; Short-course versus long-course antibiotic
therapy for non-severe Cochrane Database Syst Rev. 2008 Apr
16;(2):CD005976.