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ACUTE MEDIA OTITIS
(AMO)
1
Introduction
3
a common complication of upper respiratory tract
infection is highly prevalent among young children
Approximately 80% of children will have at least one
episode of acute otitis media (AOM), and between 80%
and 90% will have at least one episode of otitis media
with effusion (OME) before school age
Acute Otitis Media
(AOM)
Acute otitis media (AOM) is defined as an infection
of the middle ear and is the second most common
pediatric diagnosis in the emergency department
following upper respiratory infections. Although acute
otitis media can occur at any age,the most common age
range to get AOM is 3 to 24 months.
4
Definition
Otitis media is inflammation of part or all of the mucosa of the
middle ear, eustachian tube, mastoid antrum and mastoid cells.
AOM defined by convention as the first 3 weeks of a process in
which the middle ear shows the signs and symptoms of acute
inflammation
AOM is the middle ear infection occurs abruptly causing
swelling and redness. Fluid and mucus become trapped inside the
ear, causing the child to have a fever, ear pain, and hearing loss.
5
Etiology
1. Age
2. Gender
3. Socio-Economic Status
4. Breastfeeding
5. Tobacco and indoor smoke
exposure
6. Season
7. Another Factor
Etiology: Streptococcus pneumoniae, Haemophilus
influenzae dan Moraxella catarrhalis
Risk Factor
Eustachian tube (dysfunction) -> swollen, or
does not open or close properly -> tinnitus,
hearing loss and a feeling of fullness in the ear
6
Pathogenesis
AOM episodes are
triggered by an
URTI
Congestion and edema of the upper
respiratory tract mucosa
congestion and edema of the mucosa of the upper
respiratory tract including the nasopharynx and
Eustachian tube
Eustachian tube narrows
There is a blockage of negative
pressure in the middle ear
Long term
Reflux occurs and aspiration of virus or bacteria from the nasopharynx to the middle
ear through the Eustachian tube
Infection and accumulation of
secretions in the middle ear
proliferation and secretion of
pathogenic microbes
Increase fluids accumulate behind
the eardrum -> The pressure from
the fluid buildup can cause the
tympanic membrane to break or
rupture.
7
Diagnostic Action Statements
From The AAP Guidelines Include The Following
 AOM should be diagnosed when there is moderate to severe tympanic
membrane bulging or new-onset otorrhea not caused by acute otitis
externa
 AOM may be diagnosed from mild tympanic membrane bulging and
ear pain for less than 48 hours or from intense tympanic membrane
erythema; in a nonverbal child, ear holding, tugging, or rubbing
suggests ear pain
• AOM should not be diagnosed when pneumatic otoscopy
and/or tympanometry do not show middle ear effusion
8
Diagnosis of AOM
History Taking
• Children:
• Usually fever (with or without) and
otalgia
• Symptoms of upper respiratory tract
infection and otorrhea, hearing loss,
and irritability.
• The most common symptom of AOM in
adults is sudden ear pain.
Clinical Symptoms
• Bouts of the common cold, upper
respiratory tract infections, urinary
tract infections, and recurrent
exanthematous fevers such as
measles, diphtheria, or whooping
cough.
• Infection of the tonsils and adenoids.
• Chronic rhinitis and sinusitis.
• Nasal allergies.
• Nasopharyngeal tumor
Predisposing Factors
9
Physical Examination
 The tympanic membrane is pulled/retracted and
looks gloomy
 the light reflex disappears
 The tympanic membrane is reddish
 The tympanic membrane is bulging/There is a
yellowish area --> will rupture
 The tympanic membrane can be perforation -->
Starlight appearance
10
Diagnosis
 The diagnosis of otitis media should always begin with a physical
exam and the use of an otoscope and hearing test with tuning fork.
 Laboratory Studies
Laboratory evaluation is rarely necessary. A full sepsis workup in infants
younger than 12 weeks with fever and no obvious source other than associated acute
otitis media may be necessary. Laboratory studies may be needed to confirm or
exclude possible related systemic or congenital diseases.
 Imaging Studies
Imaging studies are not indicated unless intra-temporal or intracranial
complications are a concern.
Intepretation Tuning Fork
12
Occlusion
Acute Otitis Media Stage
• Retraction of the tympanic membrane --> negative pressure in
the middle ear (air absorption).
• Maleus position --> more horizontal
• Light reflex can be reduced
• Edema that occurs in the eustachian tube --> blockage.
• The tympanic membrane may be normal (occasionally) or pale
cloudy in color.
• An effusion may have occurred, but could not be detected.
• Tympanic membrane: hyperemia and edema.
• Secretion --> exudate
• Hyperemia (prolonged tubal occlusion) --> invasion of
pyogenic microorganisms --> inflammation of the middle ear
and tympanic membrane --> congestion.
• Symptoms: otalgia, ear fullness and fever.
• Hearing: normal / loss hearing (there is an increase in air
pressure in the tympanic cavity)
Hyperemis
13
Supuration
Stadium OMA
• Purulent exudate discharge from the tympanic
cavity -> Bulging of the tympanic membrane
• Symptoms: ear ->severe pain (getting worse),
tachycardia and fever
• The pressure of pus in the tympanic cavity does not
decrease -> ischemia (pressure in the capillaries) ->
thrombophlebitis in small veins -> mucosal and
submucosal necrosis.
• Tympanic membrane -> soft area (yellow
color/yellow spot -> this place will rupture)
b.
Acute Otitis Media Stage
14
Perforation
• Delay in antibiotic administration
(high virulence and bacteria-->
tympanic membrane rupture--> pus
draining from the middle ear to the
outer ear (secretion out-->
pulsating).
• The child; previously restless ->
now calm, the body temperature is
drops and the child can sleep
soundly.
Acute Otitis Media Stage
15
Resolution
• MT intact --> MT will return to normal
• Perforation --> the secret will decrease and eventually dry -->
MT will return to normal
• Hearing returned to normal.
• If the immune system is good or the virulence of the bacteria
is low, resolution can occur even without treatment.
• Acute otitis media can cause sequelae --> serous otitis media
if the secretions persist in the tympanic cavity (without
perforation).
Despite appropriate therapy, AOM can progress to chronic suppurative OM (CSOM) -> no
clinical improvement occurs (resolution stage failed). Failure of this stage is persistent
tympanic membrane perforation, with persistent or intermittent discharge.
16
16
17
Algorithm
Therapy
18
18
Acute Otitis Media Treatment
Occlusion
Hyperemis
Suppuration
Perforation
Resolution
Topical decongestants ->ephedrine HCl 0.5% for children <12 years or 1%
ephedrine HCl >12 years. With oral antibiotics (Ampicillin 50 mg/KgBW/day in 4
doses or amoxicillin 40 mg/KgBW/day in 3 doses)
Ampicillin 50-100 mg/kg/day in 4 divided doses or amoxicillin 40 mg/kg/day in 3
divided doses, or erythromycin 40 mg/kg/day given for 7 days and can be given
analgesics
Myryngotomy + oral AB
H2O2 3% for 3-5 days and oral administration of AB
if AOM cannot occur resolution phase, continue AB for 3
weeks
19
First and Second Line Antybiotics Therapy
20
Myryngotomy
Location of surgery --> posterior-inferior
Myryngotomy : incision in the pars tensa tympanic membrane
--> Fluid from the middle ear will then be
drained --> outer ear
Definition of myringotomy with paracentesis --> often equated
Myringotomy : A tiny incision will be made in the tympanic
membrane
Paracentesis : A minor surgical procedure that refers to puncture
of the tympanic membrane for microbiological
examination
21
Prevention
Environmental Assessment and
Modification
Vaccination
• Approx. 60–80% of children
≤ 3 years old experience
AOM at least once. The
incidence of AOM has been
declining since the
introduction of the
pneumococcal and influenza
vaccinations
• Modification --> avoid cigarette
smoke
• Babies --> breastfeeding (exclusive
breastfeeding + up to 2 years of
age)
• Eating a healthy and variety of
foods
22
Complication Acute Media Otitis
Ekstracranial Intracranial
Mastoiditis Meningitis
Bezold abscess Brain abscess
Labyrinthitis Lateral sinus thrombosis
Facial paralysis
Mastoiditis
with Bezold
Abscess
23
Prognosis
Children who develop complications can be difficult to treat and have high
rates of recurrence. Intratemporal and intracranial complications, while very
rare, have significant mortality rates.
The prognosis for most of the patients with otitis media is excellent. Death
from AOM is rare With effective antibiotic therapy. The systemic signs of
fever, lethargy and localized pain should begin to dissipate, within 48 hours.
Patients is also recover the conductive hearing loss associated with AOM.
Effective antibiotic therapy is the mainstay of treatment.
Children with otitis media in the first 24 months of life often have difficulty
perceiving strident or high-frequency consonants, such as sibilants.
2
Conclusion
“
25
Oitis media is inflammation of part or all
of the mucosa of the middle ear,
eustachian tube, mastoid antrum and
mastoid cells. .
AOM episodes are triggered by an URTI. The etyology of
AOM are Streptococcus pneumoniae, Haemophilus influenzae
and Moraxella catarrhalis.
AOM's symptom are otalgia, otorrhoea, reduced hearing, ear
fullness, fever. AOM consists of 5 stages, they are occlusion,
hyperemia, suppuration, perforation, resolution. Therapy is
given according to the stage of the disease.
Complications of AOM include
mastoiditis, subperiosteal abscess, brain
abscess and meningitis.
AOM defined by convention as the first 3 weeks of a process
in which the middle ear shows the signs and symptoms of
acute inflammation
26
• Baehr, M, Frotscher, M., 2016, Diagnosis Topik Neurologi DUUS, edisi 5, Penerbit Buku Kedokteran EGC, Jakarta, pp.135-145.
• Casale, J., & Hatcher, J. D., 2021, ‘Physiology, Eustachian Tube Function’, Treasure Island (FL): StatPearls Publishing, Accessed at: 30 Janiari 2022, Avaiable at:
https://www.ncbi.nlm.nih.gov/books/NBK532284/
• Danishyar, A., & Ashurst, J., V, 2021, ‘Acute Otitis Media’, StatPearls, accessed at: 24 Januari 2022, Avaiable at:
https://www.ncbi.nlm.nih.gov/books/NBK470332/
• Ellis, H., Mahadevan,V., 2019, Clinical Anatomy Applied Anatomy For Students And Junior Doctors, John Wiley and Sons Ltd, United Kingdom, pp. 411.
• Franqois, M., 1997, ‘New views on the pathogenesis of acute otitis media and its complications’, Elsevier: Clinical Microbiology and Infection, vol. 3, no. 3, pp
3S5-3S12, Accessed at 06 februari 2022, Doi: https://doi.org/10.1016/S1198-743X(14)64946-6
• Hayashi, T., Kitamura, K., Hashimoto, S., et al, 2020, ’Clinical practice guidelines for the diagnosis and management of acute otitis media in children—2018
update’, Elsevier: Auris Nasus Larynx ,no. 4, vol. 47, pp. 493-526, Accessed at: 06 Februari 2022, DOI: 10.1016/j.anl.2020.05.019
• IKA FK UNAIR, 2017, Accessed at: 24 Januari 2022, Avaiable at: https://spesialis1.ika.fk.unair.ac.id/wp-content/uploads/2017/03/TI15_Otitis-Media-Akut-Q.pdf
• Kerschner, J.E., & Preciado, D., Otitis Media. In: Nelson Textbook of Pediatrics, 21st Edition. Philadelphia: Elsevier Inc; 2020. pp.3418-31.
• Irwin, G. M., 2020, ‘Otitis Media’, Conn’s Current Therapy Inc, Philadelphia: Elsevier, pp. 493-497.
• John, S. E., Tyler, S. R., & Nicholas, A. R., 2018, ‘Ear Pain: Diagnosing Common and Uncommon Causes’, American Family Physician, no.1, vol. 97, pp. 20-27.
• Paulsen, F., & Waschke, J., 2018, Sobotta Atlas of Human anatommy, 15th edition, Elsevier Urban & Fischer, Germany, pp. 136-157.
• Paul, C. R., & Moreno, M. A., 2020, ‘Acute Otitis Media’, JAMA Pediatrics Patient, no. 3, vol. 174, pp. 308, Accessed at: 06 februari 2022,
doi:10.1001/jamapediatrics.2019.5664
• Prof. dr. Soepardi, EA. dkk., 2010, Buku ajar ilmu kesehatan THT Edisi VI. Fakultas kedokteran UI: Jakarta.
• Royal Children's Hospital Melbourne (RCH), 2021, 'Acute otitis media', Accessed at: 06 Februari 2022, Avaiable at:
• https://www.rch.org.au/clinicalguide/guideline_index/Acute_otitis_media/
• Sherwood, L. 2013, Introduction to Human Physiology, 8th edition, Brooks/Cole Cengage Learning, China, pp. 229-240.
• Thomas, J. P., Berner,R.,Zahnert, T., & Dazert,S., 2016, ‘Acute Otitis Media—a Structured Approach’, Deutsches Ärzteblatt International, no. 9, vol.111, pp.
151−60.
• Waseem, M., 2020, ‘Otitis Media Clinical Presentation’, Accessed at: 06 Februari 2022, Avaiable at: https://emedicine.medscape.com/article/994656-clinical#b3.
Thank You

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Acute Otitis Media

  • 3. 3 a common complication of upper respiratory tract infection is highly prevalent among young children Approximately 80% of children will have at least one episode of acute otitis media (AOM), and between 80% and 90% will have at least one episode of otitis media with effusion (OME) before school age Acute Otitis Media (AOM) Acute otitis media (AOM) is defined as an infection of the middle ear and is the second most common pediatric diagnosis in the emergency department following upper respiratory infections. Although acute otitis media can occur at any age,the most common age range to get AOM is 3 to 24 months.
  • 4. 4 Definition Otitis media is inflammation of part or all of the mucosa of the middle ear, eustachian tube, mastoid antrum and mastoid cells. AOM defined by convention as the first 3 weeks of a process in which the middle ear shows the signs and symptoms of acute inflammation AOM is the middle ear infection occurs abruptly causing swelling and redness. Fluid and mucus become trapped inside the ear, causing the child to have a fever, ear pain, and hearing loss.
  • 5. 5 Etiology 1. Age 2. Gender 3. Socio-Economic Status 4. Breastfeeding 5. Tobacco and indoor smoke exposure 6. Season 7. Another Factor Etiology: Streptococcus pneumoniae, Haemophilus influenzae dan Moraxella catarrhalis Risk Factor Eustachian tube (dysfunction) -> swollen, or does not open or close properly -> tinnitus, hearing loss and a feeling of fullness in the ear
  • 6. 6 Pathogenesis AOM episodes are triggered by an URTI Congestion and edema of the upper respiratory tract mucosa congestion and edema of the mucosa of the upper respiratory tract including the nasopharynx and Eustachian tube Eustachian tube narrows There is a blockage of negative pressure in the middle ear Long term Reflux occurs and aspiration of virus or bacteria from the nasopharynx to the middle ear through the Eustachian tube Infection and accumulation of secretions in the middle ear proliferation and secretion of pathogenic microbes Increase fluids accumulate behind the eardrum -> The pressure from the fluid buildup can cause the tympanic membrane to break or rupture.
  • 7. 7 Diagnostic Action Statements From The AAP Guidelines Include The Following  AOM should be diagnosed when there is moderate to severe tympanic membrane bulging or new-onset otorrhea not caused by acute otitis externa  AOM may be diagnosed from mild tympanic membrane bulging and ear pain for less than 48 hours or from intense tympanic membrane erythema; in a nonverbal child, ear holding, tugging, or rubbing suggests ear pain • AOM should not be diagnosed when pneumatic otoscopy and/or tympanometry do not show middle ear effusion
  • 8. 8 Diagnosis of AOM History Taking • Children: • Usually fever (with or without) and otalgia • Symptoms of upper respiratory tract infection and otorrhea, hearing loss, and irritability. • The most common symptom of AOM in adults is sudden ear pain. Clinical Symptoms • Bouts of the common cold, upper respiratory tract infections, urinary tract infections, and recurrent exanthematous fevers such as measles, diphtheria, or whooping cough. • Infection of the tonsils and adenoids. • Chronic rhinitis and sinusitis. • Nasal allergies. • Nasopharyngeal tumor Predisposing Factors
  • 9. 9 Physical Examination  The tympanic membrane is pulled/retracted and looks gloomy  the light reflex disappears  The tympanic membrane is reddish  The tympanic membrane is bulging/There is a yellowish area --> will rupture  The tympanic membrane can be perforation --> Starlight appearance
  • 10. 10 Diagnosis  The diagnosis of otitis media should always begin with a physical exam and the use of an otoscope and hearing test with tuning fork.  Laboratory Studies Laboratory evaluation is rarely necessary. A full sepsis workup in infants younger than 12 weeks with fever and no obvious source other than associated acute otitis media may be necessary. Laboratory studies may be needed to confirm or exclude possible related systemic or congenital diseases.  Imaging Studies Imaging studies are not indicated unless intra-temporal or intracranial complications are a concern.
  • 12. 12 Occlusion Acute Otitis Media Stage • Retraction of the tympanic membrane --> negative pressure in the middle ear (air absorption). • Maleus position --> more horizontal • Light reflex can be reduced • Edema that occurs in the eustachian tube --> blockage. • The tympanic membrane may be normal (occasionally) or pale cloudy in color. • An effusion may have occurred, but could not be detected. • Tympanic membrane: hyperemia and edema. • Secretion --> exudate • Hyperemia (prolonged tubal occlusion) --> invasion of pyogenic microorganisms --> inflammation of the middle ear and tympanic membrane --> congestion. • Symptoms: otalgia, ear fullness and fever. • Hearing: normal / loss hearing (there is an increase in air pressure in the tympanic cavity) Hyperemis
  • 13. 13 Supuration Stadium OMA • Purulent exudate discharge from the tympanic cavity -> Bulging of the tympanic membrane • Symptoms: ear ->severe pain (getting worse), tachycardia and fever • The pressure of pus in the tympanic cavity does not decrease -> ischemia (pressure in the capillaries) -> thrombophlebitis in small veins -> mucosal and submucosal necrosis. • Tympanic membrane -> soft area (yellow color/yellow spot -> this place will rupture) b. Acute Otitis Media Stage
  • 14. 14 Perforation • Delay in antibiotic administration (high virulence and bacteria--> tympanic membrane rupture--> pus draining from the middle ear to the outer ear (secretion out--> pulsating). • The child; previously restless -> now calm, the body temperature is drops and the child can sleep soundly. Acute Otitis Media Stage
  • 15. 15 Resolution • MT intact --> MT will return to normal • Perforation --> the secret will decrease and eventually dry --> MT will return to normal • Hearing returned to normal. • If the immune system is good or the virulence of the bacteria is low, resolution can occur even without treatment. • Acute otitis media can cause sequelae --> serous otitis media if the secretions persist in the tympanic cavity (without perforation). Despite appropriate therapy, AOM can progress to chronic suppurative OM (CSOM) -> no clinical improvement occurs (resolution stage failed). Failure of this stage is persistent tympanic membrane perforation, with persistent or intermittent discharge.
  • 16. 16 16
  • 18. 18 18 Acute Otitis Media Treatment Occlusion Hyperemis Suppuration Perforation Resolution Topical decongestants ->ephedrine HCl 0.5% for children <12 years or 1% ephedrine HCl >12 years. With oral antibiotics (Ampicillin 50 mg/KgBW/day in 4 doses or amoxicillin 40 mg/KgBW/day in 3 doses) Ampicillin 50-100 mg/kg/day in 4 divided doses or amoxicillin 40 mg/kg/day in 3 divided doses, or erythromycin 40 mg/kg/day given for 7 days and can be given analgesics Myryngotomy + oral AB H2O2 3% for 3-5 days and oral administration of AB if AOM cannot occur resolution phase, continue AB for 3 weeks
  • 19. 19 First and Second Line Antybiotics Therapy
  • 20. 20 Myryngotomy Location of surgery --> posterior-inferior Myryngotomy : incision in the pars tensa tympanic membrane --> Fluid from the middle ear will then be drained --> outer ear Definition of myringotomy with paracentesis --> often equated Myringotomy : A tiny incision will be made in the tympanic membrane Paracentesis : A minor surgical procedure that refers to puncture of the tympanic membrane for microbiological examination
  • 21. 21 Prevention Environmental Assessment and Modification Vaccination • Approx. 60–80% of children ≤ 3 years old experience AOM at least once. The incidence of AOM has been declining since the introduction of the pneumococcal and influenza vaccinations • Modification --> avoid cigarette smoke • Babies --> breastfeeding (exclusive breastfeeding + up to 2 years of age) • Eating a healthy and variety of foods
  • 22. 22 Complication Acute Media Otitis Ekstracranial Intracranial Mastoiditis Meningitis Bezold abscess Brain abscess Labyrinthitis Lateral sinus thrombosis Facial paralysis Mastoiditis with Bezold Abscess
  • 23. 23 Prognosis Children who develop complications can be difficult to treat and have high rates of recurrence. Intratemporal and intracranial complications, while very rare, have significant mortality rates. The prognosis for most of the patients with otitis media is excellent. Death from AOM is rare With effective antibiotic therapy. The systemic signs of fever, lethargy and localized pain should begin to dissipate, within 48 hours. Patients is also recover the conductive hearing loss associated with AOM. Effective antibiotic therapy is the mainstay of treatment. Children with otitis media in the first 24 months of life often have difficulty perceiving strident or high-frequency consonants, such as sibilants.
  • 25. “ 25 Oitis media is inflammation of part or all of the mucosa of the middle ear, eustachian tube, mastoid antrum and mastoid cells. . AOM episodes are triggered by an URTI. The etyology of AOM are Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis. AOM's symptom are otalgia, otorrhoea, reduced hearing, ear fullness, fever. AOM consists of 5 stages, they are occlusion, hyperemia, suppuration, perforation, resolution. Therapy is given according to the stage of the disease. Complications of AOM include mastoiditis, subperiosteal abscess, brain abscess and meningitis. AOM defined by convention as the first 3 weeks of a process in which the middle ear shows the signs and symptoms of acute inflammation
  • 26. 26 • Baehr, M, Frotscher, M., 2016, Diagnosis Topik Neurologi DUUS, edisi 5, Penerbit Buku Kedokteran EGC, Jakarta, pp.135-145. • Casale, J., & Hatcher, J. D., 2021, ‘Physiology, Eustachian Tube Function’, Treasure Island (FL): StatPearls Publishing, Accessed at: 30 Janiari 2022, Avaiable at: https://www.ncbi.nlm.nih.gov/books/NBK532284/ • Danishyar, A., & Ashurst, J., V, 2021, ‘Acute Otitis Media’, StatPearls, accessed at: 24 Januari 2022, Avaiable at: https://www.ncbi.nlm.nih.gov/books/NBK470332/ • Ellis, H., Mahadevan,V., 2019, Clinical Anatomy Applied Anatomy For Students And Junior Doctors, John Wiley and Sons Ltd, United Kingdom, pp. 411. • Franqois, M., 1997, ‘New views on the pathogenesis of acute otitis media and its complications’, Elsevier: Clinical Microbiology and Infection, vol. 3, no. 3, pp 3S5-3S12, Accessed at 06 februari 2022, Doi: https://doi.org/10.1016/S1198-743X(14)64946-6 • Hayashi, T., Kitamura, K., Hashimoto, S., et al, 2020, ’Clinical practice guidelines for the diagnosis and management of acute otitis media in children—2018 update’, Elsevier: Auris Nasus Larynx ,no. 4, vol. 47, pp. 493-526, Accessed at: 06 Februari 2022, DOI: 10.1016/j.anl.2020.05.019 • IKA FK UNAIR, 2017, Accessed at: 24 Januari 2022, Avaiable at: https://spesialis1.ika.fk.unair.ac.id/wp-content/uploads/2017/03/TI15_Otitis-Media-Akut-Q.pdf • Kerschner, J.E., & Preciado, D., Otitis Media. In: Nelson Textbook of Pediatrics, 21st Edition. Philadelphia: Elsevier Inc; 2020. pp.3418-31. • Irwin, G. M., 2020, ‘Otitis Media’, Conn’s Current Therapy Inc, Philadelphia: Elsevier, pp. 493-497. • John, S. E., Tyler, S. R., & Nicholas, A. R., 2018, ‘Ear Pain: Diagnosing Common and Uncommon Causes’, American Family Physician, no.1, vol. 97, pp. 20-27. • Paulsen, F., & Waschke, J., 2018, Sobotta Atlas of Human anatommy, 15th edition, Elsevier Urban & Fischer, Germany, pp. 136-157. • Paul, C. R., & Moreno, M. A., 2020, ‘Acute Otitis Media’, JAMA Pediatrics Patient, no. 3, vol. 174, pp. 308, Accessed at: 06 februari 2022, doi:10.1001/jamapediatrics.2019.5664 • Prof. dr. Soepardi, EA. dkk., 2010, Buku ajar ilmu kesehatan THT Edisi VI. Fakultas kedokteran UI: Jakarta. • Royal Children's Hospital Melbourne (RCH), 2021, 'Acute otitis media', Accessed at: 06 Februari 2022, Avaiable at: • https://www.rch.org.au/clinicalguide/guideline_index/Acute_otitis_media/ • Sherwood, L. 2013, Introduction to Human Physiology, 8th edition, Brooks/Cole Cengage Learning, China, pp. 229-240. • Thomas, J. P., Berner,R.,Zahnert, T., & Dazert,S., 2016, ‘Acute Otitis Media—a Structured Approach’, Deutsches Ärzteblatt International, no. 9, vol.111, pp. 151−60. • Waseem, M., 2020, ‘Otitis Media Clinical Presentation’, Accessed at: 06 Februari 2022, Avaiable at: https://emedicine.medscape.com/article/994656-clinical#b3.