In this presentation there is complete content regarding its causes, pathophysiology, clinical manifestations, diagnostic evaluations and managements that can be done.
First of all as we know that otitis media is a disease condition related to ear infection and inflammations.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Antimicrobial stewardship to prevent antimicrobial resistanceGovindRankawat1
India is among the nations with the highest burden of bacterial infections.
India is one of the largest consumers of antibiotics worldwide.
India carries one of the largest burdens of drug‑resistant pathogens worldwide.
Highest burden of multidrug‑resistant tuberculosis,
Alarmingly high resistance among Gram‑negative and Gram‑positive bacteria even to newer antimicrobials such as carbapenems.
NDM‑1 ( New Delhi Metallo Beta lactamase 1, an enzyme which inactivates majority of Beta lactam antibiotics including carbapenems) was reported in 2008
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
3. 3
a common complication of upper respiratory tract
infection is highly prevalent among young children
Approximately 80% of children will have at least one
episode of acute otitis media (AOM), and between 80%
and 90% will have at least one episode of otitis media
with effusion (OME) before school age
Acute Otitis Media
(AOM)
Acute otitis media (AOM) is defined as an infection
of the middle ear and is the second most common
pediatric diagnosis in the emergency department
following upper respiratory infections. Although acute
otitis media can occur at any age,the most common age
range to get AOM is 3 to 24 months.
4. 4
Definition
Otitis media is inflammation of part or all of the mucosa of the
middle ear, eustachian tube, mastoid antrum and mastoid cells.
AOM defined by convention as the first 3 weeks of a process in
which the middle ear shows the signs and symptoms of acute
inflammation
AOM is the middle ear infection occurs abruptly causing
swelling and redness. Fluid and mucus become trapped inside the
ear, causing the child to have a fever, ear pain, and hearing loss.
5. 5
Etiology
1. Age
2. Gender
3. Socio-Economic Status
4. Breastfeeding
5. Tobacco and indoor smoke
exposure
6. Season
7. Another Factor
Etiology: Streptococcus pneumoniae, Haemophilus
influenzae dan Moraxella catarrhalis
Risk Factor
Eustachian tube (dysfunction) -> swollen, or
does not open or close properly -> tinnitus,
hearing loss and a feeling of fullness in the ear
6. 6
Pathogenesis
AOM episodes are
triggered by an
URTI
Congestion and edema of the upper
respiratory tract mucosa
congestion and edema of the mucosa of the upper
respiratory tract including the nasopharynx and
Eustachian tube
Eustachian tube narrows
There is a blockage of negative
pressure in the middle ear
Long term
Reflux occurs and aspiration of virus or bacteria from the nasopharynx to the middle
ear through the Eustachian tube
Infection and accumulation of
secretions in the middle ear
proliferation and secretion of
pathogenic microbes
Increase fluids accumulate behind
the eardrum -> The pressure from
the fluid buildup can cause the
tympanic membrane to break or
rupture.
7. 7
Diagnostic Action Statements
From The AAP Guidelines Include The Following
AOM should be diagnosed when there is moderate to severe tympanic
membrane bulging or new-onset otorrhea not caused by acute otitis
externa
AOM may be diagnosed from mild tympanic membrane bulging and
ear pain for less than 48 hours or from intense tympanic membrane
erythema; in a nonverbal child, ear holding, tugging, or rubbing
suggests ear pain
• AOM should not be diagnosed when pneumatic otoscopy
and/or tympanometry do not show middle ear effusion
8. 8
Diagnosis of AOM
History Taking
• Children:
• Usually fever (with or without) and
otalgia
• Symptoms of upper respiratory tract
infection and otorrhea, hearing loss,
and irritability.
• The most common symptom of AOM in
adults is sudden ear pain.
Clinical Symptoms
• Bouts of the common cold, upper
respiratory tract infections, urinary
tract infections, and recurrent
exanthematous fevers such as
measles, diphtheria, or whooping
cough.
• Infection of the tonsils and adenoids.
• Chronic rhinitis and sinusitis.
• Nasal allergies.
• Nasopharyngeal tumor
Predisposing Factors
9. 9
Physical Examination
The tympanic membrane is pulled/retracted and
looks gloomy
the light reflex disappears
The tympanic membrane is reddish
The tympanic membrane is bulging/There is a
yellowish area --> will rupture
The tympanic membrane can be perforation -->
Starlight appearance
10. 10
Diagnosis
The diagnosis of otitis media should always begin with a physical
exam and the use of an otoscope and hearing test with tuning fork.
Laboratory Studies
Laboratory evaluation is rarely necessary. A full sepsis workup in infants
younger than 12 weeks with fever and no obvious source other than associated acute
otitis media may be necessary. Laboratory studies may be needed to confirm or
exclude possible related systemic or congenital diseases.
Imaging Studies
Imaging studies are not indicated unless intra-temporal or intracranial
complications are a concern.
12. 12
Occlusion
Acute Otitis Media Stage
• Retraction of the tympanic membrane --> negative pressure in
the middle ear (air absorption).
• Maleus position --> more horizontal
• Light reflex can be reduced
• Edema that occurs in the eustachian tube --> blockage.
• The tympanic membrane may be normal (occasionally) or pale
cloudy in color.
• An effusion may have occurred, but could not be detected.
• Tympanic membrane: hyperemia and edema.
• Secretion --> exudate
• Hyperemia (prolonged tubal occlusion) --> invasion of
pyogenic microorganisms --> inflammation of the middle ear
and tympanic membrane --> congestion.
• Symptoms: otalgia, ear fullness and fever.
• Hearing: normal / loss hearing (there is an increase in air
pressure in the tympanic cavity)
Hyperemis
13. 13
Supuration
Stadium OMA
• Purulent exudate discharge from the tympanic
cavity -> Bulging of the tympanic membrane
• Symptoms: ear ->severe pain (getting worse),
tachycardia and fever
• The pressure of pus in the tympanic cavity does not
decrease -> ischemia (pressure in the capillaries) ->
thrombophlebitis in small veins -> mucosal and
submucosal necrosis.
• Tympanic membrane -> soft area (yellow
color/yellow spot -> this place will rupture)
b.
Acute Otitis Media Stage
14. 14
Perforation
• Delay in antibiotic administration
(high virulence and bacteria-->
tympanic membrane rupture--> pus
draining from the middle ear to the
outer ear (secretion out-->
pulsating).
• The child; previously restless ->
now calm, the body temperature is
drops and the child can sleep
soundly.
Acute Otitis Media Stage
15. 15
Resolution
• MT intact --> MT will return to normal
• Perforation --> the secret will decrease and eventually dry -->
MT will return to normal
• Hearing returned to normal.
• If the immune system is good or the virulence of the bacteria
is low, resolution can occur even without treatment.
• Acute otitis media can cause sequelae --> serous otitis media
if the secretions persist in the tympanic cavity (without
perforation).
Despite appropriate therapy, AOM can progress to chronic suppurative OM (CSOM) -> no
clinical improvement occurs (resolution stage failed). Failure of this stage is persistent
tympanic membrane perforation, with persistent or intermittent discharge.
18. 18
18
Acute Otitis Media Treatment
Occlusion
Hyperemis
Suppuration
Perforation
Resolution
Topical decongestants ->ephedrine HCl 0.5% for children <12 years or 1%
ephedrine HCl >12 years. With oral antibiotics (Ampicillin 50 mg/KgBW/day in 4
doses or amoxicillin 40 mg/KgBW/day in 3 doses)
Ampicillin 50-100 mg/kg/day in 4 divided doses or amoxicillin 40 mg/kg/day in 3
divided doses, or erythromycin 40 mg/kg/day given for 7 days and can be given
analgesics
Myryngotomy + oral AB
H2O2 3% for 3-5 days and oral administration of AB
if AOM cannot occur resolution phase, continue AB for 3
weeks
20. 20
Myryngotomy
Location of surgery --> posterior-inferior
Myryngotomy : incision in the pars tensa tympanic membrane
--> Fluid from the middle ear will then be
drained --> outer ear
Definition of myringotomy with paracentesis --> often equated
Myringotomy : A tiny incision will be made in the tympanic
membrane
Paracentesis : A minor surgical procedure that refers to puncture
of the tympanic membrane for microbiological
examination
21. 21
Prevention
Environmental Assessment and
Modification
Vaccination
• Approx. 60–80% of children
≤ 3 years old experience
AOM at least once. The
incidence of AOM has been
declining since the
introduction of the
pneumococcal and influenza
vaccinations
• Modification --> avoid cigarette
smoke
• Babies --> breastfeeding (exclusive
breastfeeding + up to 2 years of
age)
• Eating a healthy and variety of
foods
23. 23
Prognosis
Children who develop complications can be difficult to treat and have high
rates of recurrence. Intratemporal and intracranial complications, while very
rare, have significant mortality rates.
The prognosis for most of the patients with otitis media is excellent. Death
from AOM is rare With effective antibiotic therapy. The systemic signs of
fever, lethargy and localized pain should begin to dissipate, within 48 hours.
Patients is also recover the conductive hearing loss associated with AOM.
Effective antibiotic therapy is the mainstay of treatment.
Children with otitis media in the first 24 months of life often have difficulty
perceiving strident or high-frequency consonants, such as sibilants.
25. “
25
Oitis media is inflammation of part or all
of the mucosa of the middle ear,
eustachian tube, mastoid antrum and
mastoid cells. .
AOM episodes are triggered by an URTI. The etyology of
AOM are Streptococcus pneumoniae, Haemophilus influenzae
and Moraxella catarrhalis.
AOM's symptom are otalgia, otorrhoea, reduced hearing, ear
fullness, fever. AOM consists of 5 stages, they are occlusion,
hyperemia, suppuration, perforation, resolution. Therapy is
given according to the stage of the disease.
Complications of AOM include
mastoiditis, subperiosteal abscess, brain
abscess and meningitis.
AOM defined by convention as the first 3 weeks of a process
in which the middle ear shows the signs and symptoms of
acute inflammation
26. 26
• Baehr, M, Frotscher, M., 2016, Diagnosis Topik Neurologi DUUS, edisi 5, Penerbit Buku Kedokteran EGC, Jakarta, pp.135-145.
• Casale, J., & Hatcher, J. D., 2021, ‘Physiology, Eustachian Tube Function’, Treasure Island (FL): StatPearls Publishing, Accessed at: 30 Janiari 2022, Avaiable at:
https://www.ncbi.nlm.nih.gov/books/NBK532284/
• Danishyar, A., & Ashurst, J., V, 2021, ‘Acute Otitis Media’, StatPearls, accessed at: 24 Januari 2022, Avaiable at:
https://www.ncbi.nlm.nih.gov/books/NBK470332/
• Ellis, H., Mahadevan,V., 2019, Clinical Anatomy Applied Anatomy For Students And Junior Doctors, John Wiley and Sons Ltd, United Kingdom, pp. 411.
• Franqois, M., 1997, ‘New views on the pathogenesis of acute otitis media and its complications’, Elsevier: Clinical Microbiology and Infection, vol. 3, no. 3, pp
3S5-3S12, Accessed at 06 februari 2022, Doi: https://doi.org/10.1016/S1198-743X(14)64946-6
• Hayashi, T., Kitamura, K., Hashimoto, S., et al, 2020, ’Clinical practice guidelines for the diagnosis and management of acute otitis media in children—2018
update’, Elsevier: Auris Nasus Larynx ,no. 4, vol. 47, pp. 493-526, Accessed at: 06 Februari 2022, DOI: 10.1016/j.anl.2020.05.019
• IKA FK UNAIR, 2017, Accessed at: 24 Januari 2022, Avaiable at: https://spesialis1.ika.fk.unair.ac.id/wp-content/uploads/2017/03/TI15_Otitis-Media-Akut-Q.pdf
• Kerschner, J.E., & Preciado, D., Otitis Media. In: Nelson Textbook of Pediatrics, 21st Edition. Philadelphia: Elsevier Inc; 2020. pp.3418-31.
• Irwin, G. M., 2020, ‘Otitis Media’, Conn’s Current Therapy Inc, Philadelphia: Elsevier, pp. 493-497.
• John, S. E., Tyler, S. R., & Nicholas, A. R., 2018, ‘Ear Pain: Diagnosing Common and Uncommon Causes’, American Family Physician, no.1, vol. 97, pp. 20-27.
• Paulsen, F., & Waschke, J., 2018, Sobotta Atlas of Human anatommy, 15th edition, Elsevier Urban & Fischer, Germany, pp. 136-157.
• Paul, C. R., & Moreno, M. A., 2020, ‘Acute Otitis Media’, JAMA Pediatrics Patient, no. 3, vol. 174, pp. 308, Accessed at: 06 februari 2022,
doi:10.1001/jamapediatrics.2019.5664
• Prof. dr. Soepardi, EA. dkk., 2010, Buku ajar ilmu kesehatan THT Edisi VI. Fakultas kedokteran UI: Jakarta.
• Royal Children's Hospital Melbourne (RCH), 2021, 'Acute otitis media', Accessed at: 06 Februari 2022, Avaiable at:
• https://www.rch.org.au/clinicalguide/guideline_index/Acute_otitis_media/
• Sherwood, L. 2013, Introduction to Human Physiology, 8th edition, Brooks/Cole Cengage Learning, China, pp. 229-240.
• Thomas, J. P., Berner,R.,Zahnert, T., & Dazert,S., 2016, ‘Acute Otitis Media—a Structured Approach’, Deutsches Ärzteblatt International, no. 9, vol.111, pp.
151−60.
• Waseem, M., 2020, ‘Otitis Media Clinical Presentation’, Accessed at: 06 Februari 2022, Avaiable at: https://emedicine.medscape.com/article/994656-clinical#b3.