This document presents an optimal operation model for a wind-thermal power generation system using differential evolution (DE). DE is an evolutionary algorithm inspired by biological evolution that can solve complex constrained optimization problems. The paper formulates the economic dispatch problem to minimize total generation cost of the wind and thermal plants subject to various constraints like power balance, generator limits, ramp rates, and valve point loading effects. Five different DE mutation strategies are analyzed for solving the wind-thermal economic dispatch problem on a test system with 10 thermal units. The results show that the best mutation strategy and control parameter values (mutation rate and crossover rate) depend on the problem and can significantly impact the solution quality and consistency obtained by the DE algorithm.