Multiple sclerosis is a chronic inflammatory neurodegenerative disorder which directly affects Central Nervous System CNS . People with MS suffer with an episodic reversible memory loss during the initial stages and later it leads to the neurological deterioration. Number of research and studies has been done on the natural compounds and phytochemical compounds in order to develop the particular drug for the treatment of MS in vivo andin vitro. The present study focuses on the inhibitory effect of Rosmarinic acid against the effect of CD2 Associated protein with the help of Molecular Docking. Molecular Docking basically screens the ligand and the target protein and shows the interaction between them on the basis of the minimum binding affinities and drug likeliness properties. In our research, docking was performed between CD2 Associated protein and selected ligands with the help of docking software. Ligands were selected on the basis of their minimum Binding affinities and finally by their drug likeliness properties. Rosmarinic acid BA 5.6 was the resultant ligand of our recent study. It showed the perfect interaction with CD2 Associated protein. Therefore, we may conclude that Rosmarinic acid may act as a compound which may be used as a drug for the treatment of multiple sclerosis fromfurther in vitro and in vivostudies in future. Jitin Kumar | Tejaswee Anand | Ritika Sharma | Noopur Khare | Abhimanyu Kumar Jha | Yamini Dixit "A Possible Role of Rosmarinic Acid against CD2-Associated Protein for the Treatment of Multiple Sclerosis through in Silico Approach" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd44979.pdf Paper URL: https://www.ijtsrd.com/biological-science/biotechnology/44979/a-possible-role-of-rosmarinic-acid-against-cd2associated-protein-for-the-treatment-of-multiple-sclerosis-through-in-silico-approach/jitin-kumar
To Assess the Severity and Mortality among Covid 19 Patients after Having Vac...YogeshIJTSRD
The severity and mortality of COVID 19 cases has been associated with the Three category such as vaccination status, severity of disease and outcome. Objective presently study was aimed to assess the severity and mortality among covid 19 patients. Methods Using simple lottery random method 100 samples were selected. From these 100 patients, 50 patients were randomly assigned to case group and 50 patients in control group after informed consents of relative obtained. Patients in the case group who being died after got COVID 19 whereas 50 patients in the control group participated who were survive after got infected from COVID 19 patients. Result It has three categories such as a Vaccination status For the vaccination status we have seen 59 patients were not vaccinated and 41 patients was vaccinated out of 100. b Incidence There were 41 patients were vaccinated whereas 59 patients were not vaccinated. c Severity In the case of mortality we selected 50 patients who were died from the Corona and I got to know that out of 50 patients there were 12 24 patients were vaccinated whereas 38 76 patients were non vaccinated. Although for the 50 control survival group total 29 58 patients were vaccinated and 21 42 patients was not vaccinated all graph start. Conclusion we have find out that those people who got vaccinated were less infected and mortality rate very low. Prof. (Dr) Binod Kumar Singh | Dr. Saroj Kumar | Ms. Anuradha Sharma "To Assess the Severity and Mortality among Covid-19 Patients after Having Vaccinated: A Retrospective Study" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45065.pdf Paper URL: https://www.ijtsrd.com/other-scientific-research-area/other/45065/to-assess-the-severity-and-mortality-among-covid19-patients-after-having-vaccinated-a-retrospective-study/prof-dr-binod-kumar-singh
The Effect on DNMT1 through Compounds for the Treatment of Cancer An In Silic...YogeshIJTSRD
Background Cancer is a disease that involves the abnormal gowth of the cell. After growing uncontrollably in continuation, it influences and grows in other parts of the body as well 1,2 . Benign types of Tumors doesn’t invade other body parts whereas Malignant Tumor support spreading and invading other parts of the body 3 . The main objective of this work is to use Molecular Docking method to develop a drug for the treatment of Cancer. Methods Docking was used to dock all the selected ligands with target protein i.e., DNMT1. The selected ligands were Thiophene, Sulfonamides, Chalcone, and Nitroimidazole. PyRx Software was used for the purpose of virtual screening to check various properties of these selected ligands like the Binding Affinity, RMSD Lower Bound , RMSD Upper Bound etc. PyRx and SwissADME both softwares were used for finding out the Drug Likeliness of every compound and to find out the best Compound to be docked with the target protein. Chalcone was found to be the best compound for Cancer treatment having least binding affinity.Results Molecular Docking of Chalcone with DNMT1 protein was performed with the help of AutoDock Vina Software. Output showed 9 positions of different binding affinities and RMSD values both Lower Bound and Upper Bound . Furthermore, the visualization of results was done with the help of PyMOL Software.Conclusion According to this study, Chalcone was the only compound from selected ligands that may be used to treat Cancer. Chalcone may act as a promising drug for cancer treatment in future perspectives. Mishka Tyagi | Noopur Khare | Abhimanyu Kumar Jha "The Effect on DNMT1 through Compounds for the Treatment of Cancer: An In-Silico Approach" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd43765.pdf Paper URL: https://www.ijtsrd.com/pharmacy/biotechnology-/43765/the-effect-on-dnmt1-through-compounds-for-the-treatment-of-cancer-an-insilico-approach/mishka-tyagi
The Role of Gedunin Against Aquaporin 2 for the Possible Treatment of Diabete...YogeshIJTSRD
Diabetes is one of the major causes of death in the world, affecting around 422 million people or 8.5 percent of the worlds population . Diabetes mellitus, or diabetes, is a disease that causes excessive blood sugar levels. Diabetes mellitus is a condition where a person does not produce enough insulin or does not link directly to insulin, and resulting in excessively high blood sugar glucose levels. Diabetes is classified into several types Prediabetes, Type 1 diabetes, Type 2 diabetes and gestational diabetes. In diabetes research, numerous bioinformatics technologies are used. The current research was carried to study the effect of naturally occurring compounds against Aquaporin 2 as the target protein molecule with the help of molecular docking for diabetes diagnosis. AQP2 is found in the apical cell of the main ducts of the kidney and in the vesicles intracellular in the cells. Docking experiment were performed out by using aquaporin 2 4nef . The technique of molecular docking was utilized to investigate the potential of naturally occurring compounds such as aglycone, gedunin, and harman with the target protein Aquaporin 2 4nef . In diabetes, gedunin may function as a therapeutic drug against the disease causing protein Aquaporin 2 4nef . Further research and then certain clinical and pre clinical studies may be allowed to discover drugs that can be used to treat diabetes. Ayushi Chaudhary | Noopur Khare | Tripti Bhatnagar | Abhimanyu Kumar Jha "The Role of Gedunin Against Aquaporin 2 for the Possible Treatment of Diabetes: An In Silico Study" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd43788.pdf Paper URL: https://www.ijtsrd.com/biological-science/biotechnology/43788/the-role-of-gedunin-against-aquaporin-2-for-the-possible-treatment-of-diabetes-an-in-silico-study/ayushi-chaudhary
To Assess the Severity and Mortality among Covid 19 Patients after Having Vac...YogeshIJTSRD
The severity and mortality of COVID 19 cases has been associated with the Three category such as vaccination status, severity of disease and outcome. Objective presently study was aimed to assess the severity and mortality among covid 19 patients. Methods Using simple lottery random method 100 samples were selected. From these 100 patients, 50 patients were randomly assigned to case group and 50 patients in control group after informed consents of relative obtained. Patients in the case group who being died after got COVID 19 whereas 50 patients in the control group participated who were survive after got infected from COVID 19 patients. Result It has three categories such as a Vaccination status For the vaccination status we have seen 59 patients were not vaccinated and 41 patients was vaccinated out of 100. b Incidence There were 41 patients were vaccinated whereas 59 patients were not vaccinated. c Severity In the case of mortality we selected 50 patients who were died from the Corona and I got to know that out of 50 patients there were 12 24 patients were vaccinated whereas 38 76 patients were non vaccinated. Although for the 50 control survival group total 29 58 patients were vaccinated and 21 42 patients was not vaccinated all graph start. Conclusion we have find out that those people who got vaccinated were less infected and mortality rate very low. Prof. (Dr) Binod Kumar Singh | Dr. Saroj Kumar | Ms. Anuradha Sharma "To Assess the Severity and Mortality among Covid-19 Patients after Having Vaccinated: A Retrospective Study" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45065.pdf Paper URL: https://www.ijtsrd.com/other-scientific-research-area/other/45065/to-assess-the-severity-and-mortality-among-covid19-patients-after-having-vaccinated-a-retrospective-study/prof-dr-binod-kumar-singh
The Effect on DNMT1 through Compounds for the Treatment of Cancer An In Silic...YogeshIJTSRD
Background Cancer is a disease that involves the abnormal gowth of the cell. After growing uncontrollably in continuation, it influences and grows in other parts of the body as well 1,2 . Benign types of Tumors doesn’t invade other body parts whereas Malignant Tumor support spreading and invading other parts of the body 3 . The main objective of this work is to use Molecular Docking method to develop a drug for the treatment of Cancer. Methods Docking was used to dock all the selected ligands with target protein i.e., DNMT1. The selected ligands were Thiophene, Sulfonamides, Chalcone, and Nitroimidazole. PyRx Software was used for the purpose of virtual screening to check various properties of these selected ligands like the Binding Affinity, RMSD Lower Bound , RMSD Upper Bound etc. PyRx and SwissADME both softwares were used for finding out the Drug Likeliness of every compound and to find out the best Compound to be docked with the target protein. Chalcone was found to be the best compound for Cancer treatment having least binding affinity.Results Molecular Docking of Chalcone with DNMT1 protein was performed with the help of AutoDock Vina Software. Output showed 9 positions of different binding affinities and RMSD values both Lower Bound and Upper Bound . Furthermore, the visualization of results was done with the help of PyMOL Software.Conclusion According to this study, Chalcone was the only compound from selected ligands that may be used to treat Cancer. Chalcone may act as a promising drug for cancer treatment in future perspectives. Mishka Tyagi | Noopur Khare | Abhimanyu Kumar Jha "The Effect on DNMT1 through Compounds for the Treatment of Cancer: An In-Silico Approach" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd43765.pdf Paper URL: https://www.ijtsrd.com/pharmacy/biotechnology-/43765/the-effect-on-dnmt1-through-compounds-for-the-treatment-of-cancer-an-insilico-approach/mishka-tyagi
The Role of Gedunin Against Aquaporin 2 for the Possible Treatment of Diabete...YogeshIJTSRD
Diabetes is one of the major causes of death in the world, affecting around 422 million people or 8.5 percent of the worlds population . Diabetes mellitus, or diabetes, is a disease that causes excessive blood sugar levels. Diabetes mellitus is a condition where a person does not produce enough insulin or does not link directly to insulin, and resulting in excessively high blood sugar glucose levels. Diabetes is classified into several types Prediabetes, Type 1 diabetes, Type 2 diabetes and gestational diabetes. In diabetes research, numerous bioinformatics technologies are used. The current research was carried to study the effect of naturally occurring compounds against Aquaporin 2 as the target protein molecule with the help of molecular docking for diabetes diagnosis. AQP2 is found in the apical cell of the main ducts of the kidney and in the vesicles intracellular in the cells. Docking experiment were performed out by using aquaporin 2 4nef . The technique of molecular docking was utilized to investigate the potential of naturally occurring compounds such as aglycone, gedunin, and harman with the target protein Aquaporin 2 4nef . In diabetes, gedunin may function as a therapeutic drug against the disease causing protein Aquaporin 2 4nef . Further research and then certain clinical and pre clinical studies may be allowed to discover drugs that can be used to treat diabetes. Ayushi Chaudhary | Noopur Khare | Tripti Bhatnagar | Abhimanyu Kumar Jha "The Role of Gedunin Against Aquaporin 2 for the Possible Treatment of Diabetes: An In Silico Study" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd43788.pdf Paper URL: https://www.ijtsrd.com/biological-science/biotechnology/43788/the-role-of-gedunin-against-aquaporin-2-for-the-possible-treatment-of-diabetes-an-in-silico-study/ayushi-chaudhary
Pentoxifylline Associated with Other Antioxidants (Multimodal Therapy) on Pat...science journals
We carried out a controlled study on 240 patients diagnosed with Peyronie's Disease (PD). We have divided two treatment groups, which differ from each other only for the association with PTX-penile injection.
Evaluation of Anti-Retroviral Combination Therapy In Patients With HIV/Aids I...iosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
Inappropriate drug use in hospitalized elderly patients of medicine and cardi...Apollo Hospitals
National committee on quality assurance, USA convened an expert consensus panel and identified the list of drugs which should be avoided in the elderly people. This resulting list of drugs after 2003 beers criteria were added to the 2006 Health Plan Employer Data and Information Set (HEDIS) to assess the drug prescribing in elderly people.
Convalescent Plasma and COVID-19: Ancient Therapy Re-emergedasclepiuspdfs
Convalescent plasma has again re-emerged as a therapy during coronavirus disease (COVID-19) outbreaks currently use as a prophylactic or an interventional treatment in infected patients. Convalescent plasma has been used in the 20th century confronting different infectious diseases where there was no other therapy available. Conceivably, this convalescent plasma therapy tends to be proving a game-changing treatment in some COVID-19 patients and could support treatment, in addition to the current interventions before other developed therapies are available for the population.
IJRET : International Journal of Research in Engineering and Technology is an international peer reviewed, online journal published by eSAT Publishing House for the enhancement of research in various disciplines of Engineering and Technology. The aim and scope of the journal is to provide an academic medium and an important reference for the advancement and dissemination of research results that support high-level learning, teaching and research in the fields of Engineering and Technology. We bring together Scientists, Academician, Field Engineers, Scholars and Students of related fields of Engineering and Technology
Unravelling the molecular linkage of co morbid diseaseseSAT Journals
Abstract ABSTRACT : The incidence of Diabetes Mellitus (DM), Hypertension (HTN) and Coronary artery disease (CAD) in the country has increased alarmingly. Since decades DM and HTN have been proved to be independent risk factors for CAD. Gene and its regulatory action through a protein are vital for the normal metabolism. Any abnormality in regulation would lead to a disease. Our study used the principles of network biology to understand the comorbidity of diseases at the molecular level. We have collected disease genes of DM, HTN and CAD from various public databases and extracted genes common to all the three diseases. We constructed a biological network by considering the protein interaction data obtained from Human Protein Reference Database (HPRD).The network was validated using power law distribution and the genes were ranked using Centiscape. Finally we identified the crucial genes with literature validation which could play a major role in causing disease co-morbidity. Keywords –Biological Network, Coronary Artery Disease, Diabetes Mellitus, Hypertension and Systems Biology
Pentoxifylline Associated with Other Antioxidants (Multimodal Therapy) on Pat...science journals
We carried out a controlled study on 240 patients diagnosed with Peyronie's Disease (PD). We have divided two treatment groups, which differ from each other only for the association with PTX-penile injection.
Evaluation of Anti-Retroviral Combination Therapy In Patients With HIV/Aids I...iosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
Inappropriate drug use in hospitalized elderly patients of medicine and cardi...Apollo Hospitals
National committee on quality assurance, USA convened an expert consensus panel and identified the list of drugs which should be avoided in the elderly people. This resulting list of drugs after 2003 beers criteria were added to the 2006 Health Plan Employer Data and Information Set (HEDIS) to assess the drug prescribing in elderly people.
Convalescent Plasma and COVID-19: Ancient Therapy Re-emergedasclepiuspdfs
Convalescent plasma has again re-emerged as a therapy during coronavirus disease (COVID-19) outbreaks currently use as a prophylactic or an interventional treatment in infected patients. Convalescent plasma has been used in the 20th century confronting different infectious diseases where there was no other therapy available. Conceivably, this convalescent plasma therapy tends to be proving a game-changing treatment in some COVID-19 patients and could support treatment, in addition to the current interventions before other developed therapies are available for the population.
IJRET : International Journal of Research in Engineering and Technology is an international peer reviewed, online journal published by eSAT Publishing House for the enhancement of research in various disciplines of Engineering and Technology. The aim and scope of the journal is to provide an academic medium and an important reference for the advancement and dissemination of research results that support high-level learning, teaching and research in the fields of Engineering and Technology. We bring together Scientists, Academician, Field Engineers, Scholars and Students of related fields of Engineering and Technology
Unravelling the molecular linkage of co morbid diseaseseSAT Journals
Abstract ABSTRACT : The incidence of Diabetes Mellitus (DM), Hypertension (HTN) and Coronary artery disease (CAD) in the country has increased alarmingly. Since decades DM and HTN have been proved to be independent risk factors for CAD. Gene and its regulatory action through a protein are vital for the normal metabolism. Any abnormality in regulation would lead to a disease. Our study used the principles of network biology to understand the comorbidity of diseases at the molecular level. We have collected disease genes of DM, HTN and CAD from various public databases and extracted genes common to all the three diseases. We constructed a biological network by considering the protein interaction data obtained from Human Protein Reference Database (HPRD).The network was validated using power law distribution and the genes were ranked using Centiscape. Finally we identified the crucial genes with literature validation which could play a major role in causing disease co-morbidity. Keywords –Biological Network, Coronary Artery Disease, Diabetes Mellitus, Hypertension and Systems Biology
Dissecting the underlying pharmaceutical mechanism of Danggui Buxue decoction...LucyPi1
Abstract Backgroud: Danggui Buxue decoction (DBD), a classical prescription in traditional Chinese medicine, has been found to have protective effect on bleomycin-induced pulmonary fibrosis in rats by reducing alveolar inflammation and fibrosis. However, the biological activity of individual chemical components and mechanism of action of whole formula are not clear. Methods: Potential targets of active ingredients of DBD were collected through Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform and SymMap database. Target genes related to idiopathic pulmonary fibrosis were obtained from the Online Mendelian Inheritance in Man database, Therapeutic Targets Database and Gkb database. Then, the common targets were obtained by overlapping the potential targets of active ingredients in DBD and diseases related targets. The selected targets were subjected to Kyoto Encyclopedia of Genes and Genomes signaling pathway and Gene Ontology analysis, and the network map of active component-target-pathway was established using Cytoscape 3.7.1 software. The active components of DBD with most targets were selected for fibrosis-related marker verification. The mRNA and protein expression of fibrosis markers, α-smooth muscle actin, collagen 1 and fibronectin, were detected in TGF-β1-induced fibroblast cell line after treatment with the active components. Results: The 14 active ingredients, such as quercetin and kaempferol, were screened from DBD. It acts on 26 targets like estrogen receptor 2 and prostaglandin-endoperoxide synthase 2, and mainly involves 38 signaling pathways such as cell inflammation and autophagy. Kaempferol and quercetin are the two compounds with the highest network regulation, which can inhibit the transformation of fibroblasts into myofibroblasts and reduce the expression of fibrosis markers α-smooth muscle actin, collagen 1 and fibronectin. Conclusion: The integration mode of multi-component, multi-target, multi-channel and mechanism of DBD in the treatment of idiopathic pulmonary fibrosis are predicted by means of network pharmacology. Our study could indicate the direction of further anti-fibrotic mechanism research.
Mucopolysaccharidosis type II MPS II or Hunter syndrome is Metabolism by lysosomal accumulation with a recessive inheritance pattern associated with the X chromosome. It is caused by lack of activity of the lysosomal enzyme iduronate 2 sulfatase, encoded by the IDS gene. Plasma iduronate 2 sulfatase enzymatic activity was measured and the IDS gene in genomic DNA was analyzed by automated direct sequencing. The enzyme activity was 1.2 mol l h reference value 2 mol l h and molecular analysis detected the mutation c.1403G A p.R468Q , confirming the diagnosis of MPS II. rice field. In conclusion, there are few groups dedicated to this disease family here in Mexico, highlighting the need to form an expert team of physicians and scientists dedicated to inborn errors of metabolism to stay up to date. Miss. Parimala L | Babu M "Hunter Syndrome: A Case Report" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-7 | Issue-1 , February 2023, URL: https://www.ijtsrd.com/papers/ijtsrd52814.pdf Paper URL: https://www.ijtsrd.com/medicine/other/52814/hunter-syndrome-a-case-report/miss-parimala-l
The role of natural products in regulating pyroptosisLucyPi1
Abstract In recent years, large numbers of novel cell death types have been reported such as autophagic death, paraptosis, mitosis, oncosis and pyroptosis. As a new type of proinflammatory programmed cell death, pyroptosis has attracted increasing attentions gradually, and its morphological characteristics and molecular mechanisms are significantly different from other cell death types such as necrosis and apoptosis. Many research groups have demonstrated the association between pyroptosis and various human diseases including immunological disease, cancer, atherosclerosis, infectious disease, and cardiovascular and cerebrovascular disease. Natural products are small molecules synthetized in organisms including primary and secondary metabolites. Natural products are important sources of modern innovative drugs discovery and can be used as key tools to explore the molecular mechanism of cell fate. The aim of this study is to review the molecular mechanisms and pathways of pyroptosis, and to categorize and conclude research results on the correlation between different natural products and pyroptosis in recent years. In this study, a total of 39 papers were enrolled in analyses. The molecular pathways and mechanisms of pyroptosis were clearly described. Fourteen types of natural products, their sources, effects, mechanisms and therapeutic potentials are categorized and illuminated. It is showed that a variety of natural products and pyroptosis have close correlations. They negatively or positively affect or act on different positions of pyroptosis inflammatory pathways, indicating that they may have certain potential therapeutic effects on pyroptosis-related diseases. Pyroptosis, a relatively new way of cell death, is closely associated with a variety of diseases. Natural products can have obvious effects on the process of pyroptosis as potential sources of new drugs. In-depth studies using natural products to investigate pyroptosis will help to enhance our understandings of human diseases and establish effective prevention and treatment strategies.
Identification of potent inhibitors against potentialDanish Malik
Schizophrenia is related with physiological condition. It affects brain sections including the prefrontal cortex, the basal ganglia as well as limbic system. There are certain neurotransmitters present in the brain such as dopamine. When level of dopamine is disturbed it causes schizophrenia. Environmental factors like stress, depression and anxiety also contribute to schizophrenia. Several drugs including first and second generation are available to provide treatment against schizophrenia. Second generation drugs have better results and fewer side effects than first generation. Clozapine is second generation drug which was recommended as best drug for schizophrenia. It rebalances dopamine and helps to treat the patients of schizophrenia as well as diminishing of suicidal thoughts. Therapies and counseling also help to overcome this disorder. Dopamine Beta Hydroxylase catalyzes the synthesis of norepinephrine. Dopamine beta hydroxylase activity was suggested as a biological marker for schizophrenia alongside other psychiatric disorders.
Immune system dysregulation is well-recognized in autism and thought to be part of the etiology of this disorder. The endocannabinoid system is a key regulator of the immune system via the cannabinoid receptor type 2 (CB2R) which is highly expressed on macrophages and microglial cells. We have previously published significant differences in peripheral blood mononuclear cell CB2R gene expression in the autism population. The use of the Gc protein-derived Macrophage Activating Factor (GcMAF), an endogenous glycosylated vitamin D binding protein responsible for macrophage cell activation has demonstrated positive effects in the treatment of autistic children. In this current study, we investigated the in vitro effects of GcMAF treatment on the endocannabinoid system gene expression, as well as cellular activation in blood monocyte-derived macrophages (BMDMs) from autistic patients compared to age-matched healthy developing controls.
Conclusions
This study presents the first observations of GcMAF effects on the transcriptionomics of the endocannabinoid system and expression of CB2R protein. These data point to a potential nexus between endocannabinoids, vitamin D and its transporter proteins, and the immune dysregulations observed with autism.
ABSTRACT- Neurodegenerative diseases (NDDs) are traditionally defined as disorders with selective loss of neurons and distinct involvement of functional systems defining clinical presentation. Alzheimer’s Disease, being one of the most detrimental Neurodegenerative diseases, an irreversible, progressive brain disorder with changes in nerve cells resulting in their death and furthermore leading to the loss of intellectual and cognitive abilities. Despite the commercial availability of few drugs, Alzheimer’s disease is the sixth leading causes of death globally and the major public health concern, owing to a constraining coercion for action against it. For the same, many drug targets were identified of which one among the most potential one’s is the Microtubule- associated Tau protein that contributes to the pathological lesions of Alzheimer’s disease, the Neurofibrillary Tangles or Paired Helical Filaments. Believing that preventing the formation of these pathological lesions, the Neurofibrillary Tangles, is much more a prominent strategy, in the present study, two approaches one approach plying compounds belonging to the class of Cannabinoids and the other approach employing a set of small molecules were used, with the help of Bioinformatics tools, such as Discovery Studio in designing the therapeutic molecules that can obliquely and potentially combat against these Neurofibrillary Tangles or NFTs and actuate to reduce their content in neurons, which might result in an improved communication and thereby enhancing the condition of the diseased person.
Key-words- Alzheimer’s disease, Cannabinoids, Cognitive abilities, Discovery Studio, Neurofibrillary Tangles, Tau protein
Curcumin Based Nanotherapy of Cancer A Reviewijtsrd
Cancer is the most prevalent disease not only in the United States but worldwide. The most representative polyphenol component extracted from the rhizomes of Curcuma long a known as turmeric is curcumin. The therapeutic benefits of curcumin have been demonstrated in multiple chronic diseases inflammation, arthritis, metabolic syndrome, liver disease, obesity, neurodegenerative diseases and, above all, in several cancers. Chemotherapy is a major form of treatment modality for various human diseases and disorders in both developing and developed countries. This intervention has been associated with a number of side effects and poor compliance. Therefore, in recent years, a significant effort has been put forward for finding a better treatment modality that uses natural compounds or extracts. Among many naturally occurring polyphenol compounds, curcumin is a highly safe yellow pigment molecule, widely used as a food coloring agent, and can be used to treat various pathological conditions. Rushikesh Mulay | Rishikesh Bachhav "Curcumin Based Nanotherapy of Cancer - A Review" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-6 , October 2021, URL: https://www.ijtsrd.com/papers/ijtsrd46376.pdf Paper URL : https://www.ijtsrd.com/pharmacy/analytical-chemistry/46376/curcumin-based-nanotherapy-of-cancer--a-review/rushikesh-mulay
Chlorogenic acid may be a potent inhibitor of dimeric SARS-CoV-2 main proteas...LucyPi1
Abstract Background: Since the emergence of coronavirus disease 2019 to date, there is no available approved drug or definitive treatment for coronavirus disease 2019 viral infection, and the identification of novel hits against therapeutic targets has become a global emergency. Echinacea purpurea is a traditional herb utilized to treat cough, fever, sore throat, respiratory tract infection, and so on as an immune stimulant. In this study, in silico molecular docking approach was used to screen phytocompounds from E. purpurea against severe acute respiratory syndrome coronavirus 2 main protease 3C-like protease (3CLpro) and severe acute respiratory syndrome coronavirus main peptidase (96% sequence similarity) to blunt the viral gene expression and viral replication. Methods: Initially, we screened phytocompounds for their druggability and ADMET property. Furthermore, x-ray crystallographic structures of main proteases 3CLpro and main peptidase having Protein Data Bank ID 6LU7 and 2GTB were used as protein targets for the identification of potential drug candidates. We performed docking using AutoDock Vina by PyRx 0.8 software. BIOVIA Discovery Studio Visualizer v2019 was used to analyze ligand-protein complex. The probable protein targets of the selected compound were predicted by BindingDB (P ≥ 0.7). STRING and Kyoto Encyclopedia of Genes and Genomes pathways are utilized to identify the molecular pathways modulated by the predicted targets (FDR ≤ 0.05), and the network interaction between compounds and protein pathways was constricted by Cytoscape 3.6.1. Results: Among all the compounds, chlorogenic acid showed druggable characteristics and scored the lowest binding energy with main protease and main peptidase via interacting with active site 1 domain amino acid residues. Interestingly, chlorogenic acid interacted with Phe140 main protease 3CLpro, which is potentially involved in the dimerization. Enrichment analysis identified chlorogenic acid to modulate insulin resistance, necroptosis, interleukin-17, tumor necrosis factor signaling pathway, legionellosis, T helper 17 cell differentiation, advanced glycation end products and receptor for advanced glycation end products, mitogen-activated protein kinase, Ras, estrogen, vascular endothelial growth factor, B-cell receptor, nuclear factor kappa B, Rap1, hypoxia inducible factor-1, phosphatidylinositide 3-kinase-Akt, insulin, mechanistic target of rapamycin, p53, retinoic acid inducible gene I like receptor, and ErbB signaling pathways. Conclusion: Chlorogenic acid may act as a potent main protease 3CLpro inhibitor and may also inhibit the severe acute respiratory syndrome coronavirus 2 dimerization, viral gene expression, and replication within the lung epithelium. Chlorogenic acid may go a long way in finding one of the multipronged solutions to tackle coronavirus disease 2019 viral infection in the future.
Cosmetics are defined as “items with mild action on the human body for the purpose of cleaning, beautifying, adding to the attractiveness, altering the appearance, or keeping or promoting the skin or hair in good condition- while functional cosmetics, even if falling under the cosmetic definition, are designated as “items fulfilling specific actions like skin whitening, minimizing the appearance of lines in the face and body, protecting from the sun and sun tanning-. Ahiya Noor | Dr. Gaurav Kumar Sharma | Dr. Kaushal Kishore Chandrul "Cosmetic Science: An Overview" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45135.pdf Paper URL: https://www.ijtsrd.com/pharmacy/other/45135/cosmetic-science-an-overview/ahiya-noor
Standardization and Formulations of Calotropis ProceraYogeshIJTSRD
Plants growing in arid regions have elicited increased attention, because the hostile environment, in which these plants survive, forces them to develop chemical protective systems through adaptation which is rarely found in vegetation of other ecosystems. Furthermore, many of the plants grow in areas, where the dependence on traditional, plant based medicines over industrially produced pharmaceuticals persists to this day. The two plants, Calotopris Procera giant milkweed, also named C. Persica and Calotropis gigantea crown ower , have been used widely in traditional medicine in North Africa, the Middle East, and South and South East Asia. This has led to extensive research on the chemical constituents of the plants. Both plants are known to be sources of cardenolides, and newer research has yielded a number of interesting cancer active constituents. In addition, extracts of both plants have remarkable nematocidal, molluscidal and insecticidal activities. In many regions, the wood of Calotropis plants has been used as a building material and as a source of fuel. In addition, certain parts of the plants have been used as feed for livestock. In other regions, Calotropis plants are seen as invasive species that threaten local plant life and that due to their toxicity also pose a threat to grazing eld animals. Jaffar Khan | Pankaj Chasta | Dr. Gaurav Kumar Sharma | Dr. Kaushal Kishore Chandrul "Standardization and Formulations of Calotropis Procera" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45145.pdf Paper URL: https://www.ijtsrd.com/pharmacy/other/45145/standardization-and-formulations-of-calotropis-procera/jaffar-khan
Review of the Diagnosis and Treatment of ParalysisYogeshIJTSRD
Paralysis is a complete loss of motor power in any muscle group. When paralysis affects all four extremities, it is called quadriplegia when it affects only the lower extremities, paraplegia and when it affects the extremities on one side of the body, hemiplegic. For this reason, the term paralysis is generally reserved for more focal, less stereotyped weakness, for instance, affecting all the muscles innervated by a peripheral nerve. Many different anatomical lesions and etiologies can cause paralysis and determine its treatment. Bikash Debsingha | Dr. Gourav Kr. Sharma | Dr. Kausal Kishore Chandrul "Review of the Diagnosis and Treatment of Paralysis" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45108.pdf Paper URL: https://www.ijtsrd.com/pharmacy/pharmacology-/45108/review-of-the-diagnosis-and-treatment-of-paralysis/bikash-debsingha
Comparative Analysis of Forced Draft Cooling Tower Using Two Design Methods A...YogeshIJTSRD
Cooling towers make use of evaporation whereby some of the water is evaporated into a moving air stream and subsequently discharged into the atmosphere which results in cooling of the remainder water. The current research reviews various studies conducted on cooling tower using experimental and numerical techniques. Different design configuration and operating conditions on cooling towers are evaluated by various researchers. Significant findings from researches have shown new and improved design of cooling tower with much better performance as compared to conventional design. Neetish Kumar Sao | Dr. Surendra K. Dwivedi "Comparative Analysis of Forced Draft Cooling Tower Using Two Design Methods: A Review" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45100.pdf Paper URL: https://www.ijtsrd.com/engineering/mechanical-engineering/45100/comparative-analysis-of-forced-draft-cooling-tower-using-two-design-methods-a-review/neetish-kumar-sao
Criminology Educators Triumphs and StrugglesYogeshIJTSRD
This research study is geared on determining the triumphs and struggles of criminology educators. Included on the aim is to know their experiences and story being considered as teacher by accident. A qualitative research design was applied in this study. Researchers conducted a personal interview with the respondents with the aid of a guide questions which all points to main issue of this study. The findings of the study revealed that out of seven respondents, four are on the age bracket of 21 to 25 years old, two respondents are on the age bracket of 26 to 30 years old and a single respondent is on the age bracket of 36 to 40 years. Most of the respondents find enthusiasm in teaching and are aware that there is a need for them to proceed in post graduate studies for them to have a considerable salary. As to financial stability, only 1out of 7 considers herself as financially stable. The rest are saying that as of the moment, they are not yet financially stable basing on the rate of their salary. Qualification matters a lot in the field of academe because this was being shared by one of the respondents who considers herself as financially stable. Also, all of the respondents do not consider teaching as their first career of choice but most of them does not have any plan of shifting to another career. Girlie N. Cañete | Harry Santiago P. Achas | Pamela N. Cañete "Criminology Educators: Triumphs and Struggles" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45082.pdf Paper URL: https://www.ijtsrd.com/humanities-and-the-arts/education/45082/criminology-educators-triumphs-and-struggles/girlie-n-cañete
A Review Herbal Drugs Used in Skin DisorderYogeshIJTSRD
The human bodys skin is an organ that allows it to interact with the environment while also shielding it from harmful external influences. People of all ages suffer from skin diseases all over the world. Its vital to keep your skin in good form for a healthy physique. Plants have been employed in some form or another since the beginning of time. This research has highlighted some prevalent skin disease issues, as well as the herbals utilized in disease therapy and the various formulations accessible in the pharmaceutical industry. Some medicinal plants have been shown to be quite effective in removing or reducing skin infection disorders. Chandramita Borah | Dr. Gaurav Kumar Sharma | Dr. Kaushal Kishore Chandrul "A Review: Herbal Drugs Used in Skin Disorder" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45118.pdf Paper URL: https://www.ijtsrd.com/pharmacy/other/45118/a-review-herbal-drugs-used-in-skin-disorder/chandramita-borah
Automatic Query Expansion Using Word Embedding Based on Fuzzy Graph Connectiv...YogeshIJTSRD
The aim of information retrieval systems is to retrieve relevant information according to the query provided. The queries are often vague and uncertain. Thus, to improve the system, we propose an Automatic Query Expansion technique, to expand the query by adding new terms to the user s initial query so as to minimize query mismatch and thereby improving retrieval performance. Most of the existing techniques for expanding queries do not take into account the degree of semantic relationship among words. In this paper, the query is expanded by exploring terms which are semantically similar to the initial query terms as well as considering the degree of relationship, that is, “fuzzy membership- between them. The terms which seemed most relevant are used in expanded query and improve the information retrieval process. The experiments conducted on the queries set show that the proposed Automatic query expansion approach gave a higher precision, recall, and F measure then non fuzzy edge weights. Tarun Goyal | Ms. Shalini Bhadola | Ms. Kirti Bhatia "Automatic Query Expansion Using Word Embedding Based on Fuzzy Graph Connectivity Measures" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45074.pdf Paper URL: https://www.ijtsrd.com/computer-science/artificial-intelligence/45074/automatic-query-expansion-using-word-embedding-based-on-fuzzy-graph-connectivity-measures/tarun-goyal
A New Proposal for Smartphone Based Drowsiness Detection and Warning System f...YogeshIJTSRD
This paper proposes a Smartphone based system for the detection of drowsiness in automotive drivers. The proposed system uses three stage drowsiness detection technique. The first stage uses the percentage of eyelid closure PERCLOS which is obtained by capturing images with the front camera of the Smartphone with a modified eye state classification method. The system uses near infrared lighting for illuminating the face of the driver during night driving. The second step uses the voiced to the unvoiced ratio VUR obtained from the speech data from the microphone, in the event PERCLOS crosses the threshold. The VUR is also compared with a threshold and if it is a value greater than that of the threshold, it moves on to the next verification stage. In the final verification stage, touch response is required within the stipulated time to declare whether the driver is drowsy or not and subsequently sound an alarm. To awake the driver, a vibrating mechanism is done and also the live GPS location is also sent to an emergency contact. We have studied eight other reference papers for the literature review. The system has three advantages over existing drowsiness detection systems. First, the three stage verification process makes the system more reliable. The second advantage is its implementation on an Android smart phone, which is readily available to most drivers or cab owners as compared to other general purpose embedded platforms. The third advantage is the use of SMS service to inform the control room as well as the passenger regarding the loss of attention of the driver. Abishek K Biju | Godwin Jolly | Asif Mohammed C A | Dr. Paul P Mathai | Derek Joseph "A New Proposal for Smartphone-Based Drowsiness Detection and Warning System for Automotive Drivers" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45083.pdf Paper URL: https://www.ijtsrd.com/engineering/computer-engineering/45083/a-new-proposal-for-smartphonebased-drowsiness-detection-and-warning-system-for-automotive-drivers/abishek-k-biju
Data Security by AES Advanced Encryption StandardYogeshIJTSRD
Now a days with the rapid development of multimedia technologies, research on safety and security are becoming more important. Multimedia data are generated and transmitted through the communication channels and the wireless media. The efficiencies of encryption based on different existing algorithms are not up to the satisfactory limit. Hence researchers are trying to modify the existing algorithm or even develop new algorithms that help to increase security with a little encryption time. Here in this paper, we have furnished a new technology to modify the AES algorithm which gives more security with a little encryption time and which can be used to encrypt using 128 bit key. Theoretical analysis on the proposed algorithm with the existing reveals the novelty of our work. Here we have proposed a technique to randomize the key and hidden the key data into an encrypted digital image using the basics concept of cryptography and also using the concept of digital watermarking, the concept of key hide has also been encrypted. We have also proposed a new technique to reposition the pixels to break the correlation between them. So, the proposed scheme offers a more secure and cost effective mechanism for encryption. Next on the AES criteria list good performance. Widespread market adoption will require reasonably good performance on a variety of platforms, ranging from easy tocrack smart cards to the largest servers. Good algorithm performance includes speed for the encryption and decryption process as well as the key schedule. Prateek Goyal | Ms. Shalini Bhadola | Ms. Kirti Bhatia "Data Security by AES (Advanced Encryption Standard)" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45073.pdf Paper URL: https://www.ijtsrd.com/computer-science/computer-security/45073/data-security-by-aes-advanced-encryption-standard/prateek-goyal
Antimicrobial and Phytochemical Screening of Phyllantus NiruriYogeshIJTSRD
Theorigin of Phyllanthus niruri is tropical America from there it spread as a weed to other tropic and sub tropics. It is a tropical annual herb shrub which grows as weed in moist humid waste land. Phyllanthus niruri is among more than 500 Phyllanthus species that are widely spread in temperate and tropical climates region Lizuka et al., 2007. It grows 30 40 cm in height, has small leaves and yellow flowers the stem has green capsule, and blooms with flowers with 5 white sepals and apical acute anther.38g of Mueller Hinton Agar was dissolved in 1000ml distilled water in a conical flask, the mouth of the conical flask was plugged with cotton woo wrapped in aluminium foil. This was sterilized in an autoclave at 121oC for 15mns. The media was removed and allowed to cool to 45oC, later poured into a sterilized plastic petri plates which were appropriately labeled. The present study revealed the antimicrobial activity and phytochemical screening of phyllanthus niruri. The antimicrobial activity of phyllanthus niruri shows great significant against pathogens which are responsible for common infections of skin, respiratory, urinary and gastrointestinal tracts. The phytochemical screening of oxalate, terpenoids, tannins, phenols, quinones, flavonoids, alkaloids, saponins and steroids were all found to be active within the plant. This bioactive phytochemicals present in P. niruri can be useful for further researches on the plant P. nururi since the phytochemicals have shown preclinical efficacies for treating human diseases’ which include hepatitis and HIV AIDS. This work has compiled the chemical constituents present and can be useful for further researches Dr. Mohammed Musa Lawan | Yusuf Sale Baba "Antimicrobial and Phytochemical Screening of Phyllantus Niruri" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd44948.pdf Paper URL: https://www.ijtsrd.com/chemistry/other/44948/antimicrobial-and-phytochemical-screening-of-phyllantus-niruri/dr-mohammed-musa-lawan
There is a need for temperature drop in a buried pipeline based on the media and process. Need of some methodology and design requirement for a set of conditions by reducing pipeline surface temperature and the temperature drops to atmospheric temperature at a particular distance of pipeline. Based on the conduction principle, desire reduction up to atmospheric temperature can be possible. Let us understand by below methods and design of Heat sink for buried pipe line. Natvarbhai Prabhudas Gajjar "Heat Sink for Underground Pipe Line" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45117.pdf Paper URL: https://www.ijtsrd.com/engineering/other/45117/heat-sink-for-underground-pipe-line/natvarbhai-prabhudas-gajjar
Newly Proposed Multi Channel Fiber Optic Cable CoreYogeshIJTSRD
Fiber optic cables have single core and multiple core options, but single and multiple core fiber cable -˜s core design need to be updated. Newly proposed design gives facilities to multiple usage than traditional design of cable core. Cable core design needs improvement by using present technology for decreasing material and cost and by improving efficiency of cable. Research need to be carried out in this direction. What do you think Natvarbhai Prabhudas Gajjar "Newly Proposed Multi Channel Fiber-Optic Cable Core" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45116.pdf Paper URL: https://www.ijtsrd.com/engineering/other/45116/newly-proposed-multi-channel-fiberoptic-cable-core/natvarbhai-prabhudas-gajjar
Security Sector Reform toward Professionalism of Military and PoliceYogeshIJTSRD
The need to understand and at the same time give prescriptions for the direction of security reform in Third world countries after the end of World War II has prompted the emergence of a big project called the study of security reform SSR . Within this framework emerge various theories and strategies for security reform, with various variations, including ideological variations that underlie these theories. The reform of the structural aspect is a reform of the institutional and structure of an institution, the instrumental reform includes the reform of the system, laws and regulations, while the reform of the cultural aspect is a reform of the habits or organizational culture in institutions in general and in particular the Timor Leste’s security institutions, both military and police. Arquimino Ramos "Security Sector Reform toward Professionalism of Military and Police" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45061.pdf Paper URL: https://www.ijtsrd.com/humanities-and-the-arts/political-science/45061/security-sector-reform-toward-professionalism-of-military-and-police/arquimino-ramos
Stress An Undetachable Condition of LifeYogeshIJTSRD
Stressful life events affects human body, which may lead to cardiovascular diseases and effect metabolism and immune system. Recent studies showed increase in stress levels in developing countries. This study aimed to determine the stress levels in MBBS students. The objectives of the study are a To determine the current stress level, b To assess relation between stress level and lifestyle of college students. The present study was carried out in Ahmedabad City of Gujarat State. A total of 400 medical students were included in the study, which were selected using multi stage sampling aged between 18 years to 25 years. Students were questioned regarding their socioeconomic and life style parameters. The results showed that physical activity such as walking, exercise, yoga, meditation etc. were associated to stress levels. College students showed high stress levels with more satisfaction were mostly smokers. Their major reason for eating junk food and smoking was, increase in stress. Conclusion Majority of students suffered from moderate stress levels. Despite of having stress they were happy and satisfied with life with less no internet addiction. Spirituality and stress scales had a positive correlation as most of the students were averagely highly spiritual. Discriminant function can be used to determine the stress level of a person using age, BMI, internet addiction, spirituality, happiness scale and life satisfaction scale of that person. Jayshree N. Tolani | Dr. Nitinkumar D. Shah "Stress: An Undetachable Condition of Life" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45054.pdf Paper URL: https://www.ijtsrd.com/other-scientific-research-area/other/45054/stress-an-undetachable-condition-of-life/jayshree-n-tolani
Comparative Studies of Diabetes in Adult Nigerians Lipid Profile and Antioxid...YogeshIJTSRD
The study sought to determine the extent to which the usage of social media in the marketing of agricultural products in South West Nigeria can enhance farmers turnover. It employed the survey research design to collect data with the help of a structured questionnaire to elicit information from respondents selected from six 6 south western states. Research data were analysed using structural equation modelling. The results showed that the use of social media WhatsApp and Facebook in marketing of agricultural products significantly enhances farmers turnover. The managerial implication is that use of Whatsapp and Facebook in the marketing of agricultural products for the enhancement of farmers’ turnover was found to have significant influence on the enhancement in farmers’ turnover from agricultural products. Policy makers in government should provide the enabling environment for the telecommunication companies to enhance their reach by installing their facilities across the length and breadth of the country so that the network coverage will be strong at all times so that the benefits of social media usage will not be constrained. Egejuru, Leonard O | Akubugwo, Emmanuel I | Ugorji, Beatrice N "Comparative Studies of Diabetes in Adult Nigerians: Lipid Profile and Antioxidants Vitamins (A and C)" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45021.pdf Paper URL: https://www.ijtsrd.com/biological-science/biochemistry/45021/comparative-studies-of-diabetes-in-adult-nigerians-lipid-profile-and-antioxidants-vitamins-a-and-c/egejuru-leonard-o
Novel Drug Delivery System An OverviewYogeshIJTSRD
In present scenario evolution of an existing drug molecule from a old form to a novel delivery system can significantly improve its performance in terms of patient compliance, safety and efficacy. In the form of a control drug delivery system an existing drug molecule can get a new life. An appropriately designed Novel Drug Delivery System can be a major advance for solving the problems related towards the release of the drug at specific site with specific rate. The porpuse for delivering drugs to patients efficiently and with fewer side effects has prompted pharmaceutical companies to engage in the development of new drug delivery system. This article covers the basic information regarding Novel Drug Delivery Systems and also advantages, factor etc. Chiranjit Barman | Dr. Gaurav Kumar Sharma | Dr. Kausal Kishore Chandrul "Novel Drug Delivery System: An Overview" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45068.pdf Paper URL: https://www.ijtsrd.com/pharmacy/novel-drug-delivery-sys/45068/novel-drug-delivery-system-an-overview/chiranjit-barman
With the growth of technology their grows threat to our data which is just secured by passwords so to make it more secure biometrics came into existence. As biometric systems are adopted and accepted for security purpose for various information and security systems. Hence it is immune to attacks. This paper deals with the security of biometric details of individuals. In this paper we will be discussing about biometrics and its types and the threats and security issues which is not talked about usually. The different technologies evolved and had contributed to biometrics in long run and their effects. Sushmita Raulo | Saurabh Gawade "Security Issues Related to Biometrics" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd44951.pdf Paper URL: https://www.ijtsrd.com/computer-science/computer-security/44951/security-issues-related-to-biometrics/sushmita-raulo
Comparative Analysis of Different Numerical Methods for the Solution of Initi...YogeshIJTSRD
A mathematical equation which involves a function and its derivatives is called a differential equation. We consider a real life situation, from this form a mathematical model, solve that model using some mathematical concepts and take interpretation of solution. It is a well known and popular concept in mathematics because of its massive application in real world problems. Differential equations are one of the most important mathematical tools used in modeling problems in Physics, Biology, Economics, Chemistry, Engineering and medical Sciences. Differential equation can describe many situations viz exponential growth and de cay, the population growth of species, the change in investment return over time. We can solve differential equations using classical as well as numerical methods, In this paper we compare numerical methods of solving initial valued first order ordinary differential equations namely Euler method, Improved Euler method, Runge Kutta method and their accuracy level. We use here Scilab Software to obtain direct solution for these methods. Vibahvari Tukaram Dhokrat "Comparative Analysis of Different Numerical Methods for the Solution of Initial Value Problems in First Order Ordinary Differential Equations" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45066.pdf Paper URL: https://www.ijtsrd.com/mathemetics/applied-mathematics/45066/comparative-analysis-of-different-numerical-methods-for-the-solution-of-initial-value-problems-in-first-order-ordinary-differential-equations/vibahvari-tukaram-dhokrat
Evaluation of Different Paving Mixes Using Optimum Stabilizing ContentYogeshIJTSRD
Bituminous mixes are most commonly used all over the world in flexible pavement construction. It consists of asphalt or bitumen used as a binder and mineral aggregate which are mixed together, laid down in layers and then compacted. Under normal circumstances, conventional bituminous pavements if designed and executed properly perform quite satisfactorily but the performance of bituminous mixes is very poor under various situations. Today’s asphaltic concrete pavements are expected to perform better as they are experiencing increased volume of traffic, increased loads and increased variations in daily or seasonal temperature over what has been experienced in the past. In addition, the performance of bituminous pavements is found to be very poor in moisture induced situations. Considering this a lot of work has been done on use of additives in bituminous mixtures and as well as on modification of bitumen. Research has indicated that the addition of polymers to asphalt binders helps to increase the interfacial cohesiveness of the bond between the aggregate and the binder which can enhance many properties of the asphalt pavements to help meet these increased demands. However, the additive that is to be used for modification of mix or binder should satisfy both the strength requirements as well as economical aspects. Naveen Kumar | Ms. Shivani "Evaluation of Different Paving Mixes Using Optimum Stabilizing Content" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45089.pdf Paper URL: https://www.ijtsrd.com/engineering/civil-engineering/45089/evaluation-of-different-paving-mixes-using-optimum-stabilizing-content/naveen-kumar
There are various roadway construction activities and plans that involve the use of flexible pavement having hot mix technique. This hot mix technique is a traditional method for the construction of road that has fulfilled the performance evaluation from infrastructure point of view throughout the past years. The various processes which are involved in this technique are providing heat to the aggregate and binder, proper mixing, provision of tack coat as per the specifications, laying of the mixed, the process of compaction. The cold mixed technique having use of bitumen emulsion on large scale should be epicenter of the study such that this technology may advance its application in present as well as future with proper specifications, testing throughout. The Hot mixed based techniques have gone through the significant advancements with time. The Cold mixed based technology is somewhere lagging in terms of applications which might be observed in the developing countries. In the present study, it has been the primary motivation that underlies the selection of cold mixed technique. Manoj Sheoran | Ms. Shivani "An Experimental Investigation on CMA" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45088.pdf Paper URL: https://www.ijtsrd.com/engineering/civil-engineering/45088/an-experimental-investigation-on-cma/manoj-sheoran
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
A Strategic Approach: GenAI in EducationPeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
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worsen. Lack of relapses or remissions followed
by occasional plateaus rarely. The most resistant
form of MS towards drugs.
Progressive-relapsing MS: This form is the rare
form of MSwhich effect of about less than 5% of
MS population. This also lacks the period of
remission.
MS do not have any single diagnostic test. There are
few evidence which are based on the diagnostic of
MS and they are: the white matter of CNS must have
at least two different lesions (plaques or scars); at
least two different episodes in the disease course (the
time dissemination criterion); and there must be
chronic inflammation of the CNS. The presence of
one or more symptoms may determine that the person
is suffering from MS [2]. Typically people of age
between 20 to 40 years suffer from MS; occasionally,
it present in late middle age or in childhood [6]. CD2-
associated protein (CD2AP), an adaptor protein
which is associated with various membrane proteins
which include polycystin-2, being mutated in type 2
autosomal dominant polycystic kidney disorder and
nephrin, which is mutated in congenital nephrotic
syndrome of the Finnish type. It is proved that both
protein functions in maintenance maintenance of the
integrity of the nephrons [14, 15].
It has been proved that according to Crespo-Bujosa,
[7] report MS has three types of categorized
symptoms that are Physical, Neurocognitive and
Psychological. Since from time it has been proved
that the phytochemical and natural compounds are
coming in picture for making drug for MS as proper
cure and diagnose is still unknown. It has been proved
that Curcumin is considered as the phytochemical
compound which has traditionally been used to treat
inflammatory disorders and healing wounds [8].
According to the number of experiments conducted it
has been proved till now that Curcumin act as an
antioxidant by protecting the brain against various
oxidative stressors, act as an anti-aging agent [9]. A
plant named Hypericum perforatum belongs to
Hypericaceae family has been proved to be used in
making traditional medicines in treating mild and
moderate depression, and also has been used as
wound healing agent, antioxidant and anti-
inflammatory agent [10]. Some other natural products
such as hemp, evening primrose, Ginko biloba has
been proved to have the antioxidant and anti-
inflammatory properties which directly act on the
CNS [11-13].
Molecular docking is one of the emerging tools which
are used in drug designing and drug discovery. The
drugs are designed on the basis of technique of
computer-assisted drug design (CADD). Molecular
docking is the most frequent virtual screening
method, most commonly at the place when there is
availability of 3D structures of the selected target
protein and ligand. Both the structures of protein-
ligand complexes along with binding affinity between
ligand and protein is considered as important
information for lead optimization for designing drug.
There are two steps involved in docking process: to
predict the position and confirmation of ligand
molecule along with its orientation with ligand sites
and their assessment with the binding affinity. We
studied these steps in detail in our theory section.
Protein- ligand docking is one of the important and
frequently used molecular docking due to its
therapeutic applications in modern structure-based
drug design.
In our research we studied about three natural
compounds named pulegone, rosmarinic acid and allo
ocimene. The main aim of our current was to analyze
the interaction of the ligands we selected against CD-
2 Associated protein for the treating Multiple
Sclerosis with in silico docking approach.
MATERIALS AND METHOD
Identification of protein target
CD2-associated protein (CD2AP), an adaptor protein
which is associated with various membrane proteins
which include polycystin-2, being mutated in type 2
autosomal dominant polycystic kidney disorder and
nephrin, which is mutated in congenital nephrotic
syndrome of the Finnish type. It is proved that both
protein functions in maintenance maintenance of the
integrity of the nephrons [14, 15]. In our research it
was reported that CD2-associated protein shows its
involvement in pathogenesis of Multiple Sclerosis.
The structure of CD2 associated protein from UniProt
(https://www.uniprot.org/) having good resolution
was selected. The selected protein 3D structure
having resolution 1.58 Å with PDB ID 4X1V was
retrieved from RCSB Protein Data Bank (PDB)
(https://www.rcsb.org/) in .pdb format. Then water
molecules were deleted followed by addition of
hydrogen molecules. Brookhaven National
Laboratories established PDB in year 1971. PDB is
the universal tool containing all the structural data of
biological macromolecule [16].
Retrieval of Ligand
Our recent Research focuses on three natural
compounds named Rosmarinic Acid, Allo ocimene
and Pulegone.
Rosmarinic acid is one of the common ester which is
formed by caffeic acid and lactic acid which is
accumulated in various plant species [17, 18]. Allo
ocimene have shown the healing property against MS.
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Pulegone is a monoterpene which is found in essential
oils made from plants of the Labiatae family [19].
These three ligands were chosen on the behalf of the
literature. The 3D structures of the ligands were
retrieved from PubChem, an online database
(https://pubchem.ncbi.nlm.nih.gov/) in .sdf format.
Then compounds in .sdf format were converted to
.pdb format through Online SMILES Translator
(https://cactus.nci.nih.gov/translate/). The converted
files in .pdb format were further downloaded and later
were used to run in different softwares and tools.
Virtual Screening
Virtual screening of ligands were performed through
PyRx software. PyRx basically screens the ligands
which have minimum binding energy with the
selected protein target. This software runs on .pdbqt
format. Initially, protein molecule was loaded in the
PyRx screen and .pdf format files of the ligand were
converted into .pdbqt format. In addition to this step
the ligand molecules which were in .sdf format were
downloaded. The energies from the selected ligands
were minimized at first and then they were converted
to .pdbqt format. Further docking was carried out
between ligand molecules and protein targets. The
results were analyzed on the basis of the ligands
minimum binding affinities.
Drug Likeliness Property Analysis
After analyzing the binding affinity drug likeliness
property was checked for the selected ligands which
was based on Lipinski’s Rule of Five which states the
following:
Ligands molecular weight must be less than 500
Dalton.
High Lipophilicity (expressed as LogP (partition
coefficient) less than 5)
Number of Hydrogen Donors must be less than 5.
Number of Hydrogen bond acceptors must be less
than 10.
Only one rule should violate among the above 4.
Final docking step was conducted on the screened
ligand which show drug like properties. We analyzed
Lipinski’s rule of five through SwissADME
(http://www.swissadme.ch/.) an online server. The
SMILE notations of the selected screened ligands
were copied from PubChem and were pasted in
SwissADME for the analyses of Lipinski’s rule of
five. The resultant ligands which were following
Lipinski’s rule of five were further taken for final
docking. Final docking step was performed through
AutoDock Vina.
Docking through AutoDock Vina using MGL
Tools
The protein target was loaded which was in .pdb
format on the graphical window of AutoDock Vina.
Further the water molecules were deleted followed by
addition of polar hydrogen atoms along with Kollman
charges into the protein target molecule. The final
resultant protein molecule was converted to .pdbqt
format. The selected ligands which were having less
binding energy and were also following Lipinski's
rule of five were then imported on the graphical
window. Through this step all the ligands were
converted into .pdbqt format from .pdb format.
Afterwards, both the protein molecule and the final
selected ligand in .pdbqt format were loaded on
AutoDock Vina graphical window. Further the
boundaries along with dimensions of the Grid box
were adjusted as shown in Figure 1 for final docking
After preparing protein and ligand molecule docking
was performed by using Command Prompt and then
analyzed the final result.
Figure 1: Grid Box
Structural Visualization through PyMOL
PyMOL is the freely available software tool which
was used for visualizing the structure of protein and
ligand molecule along with their interaction. When
docking step through AutoDock Vina was completed,
the output file with a name output.pdbqt was
automatically saved. The output.pdbqt and
protein.pdbqt file were loaded on the graphical screen
of PyMOL 2.4. The final interaction between the
ligand and protein were visualized.
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RESULT AND DISCUSSION
CD2-Associated protein (PDB ID 4X1V) having resolution 1.58Å was downloaded from Protein Data Bank as
shown in Figure 2. The 3D structures of Pulegone (CID: 442495), Allo ocimene (CID: 5368821) and Rosmarinic
acid (CID: 5281792) were retrieved from PubChem in .sdf format as shown in Figure 3. It was further converted
to .sdf format and the structure was downloaded in .pdb format.
Figure 2: 3D Structure of CD2-Associated protein
ALLO OCIMENE
CID : 5368821
MF : C10H16
MW: 136.23 g/mol
PULEGONE
CID: 442495
MF: C10H16O
MW: 152.23g/mol
ROSMARINIC ACID
CID: 5281792
MF: C18H16O8
MW: 360.31g/mol
Figure 3: 3D Structure of Ligand
Virtual screening of the following ligands named Pulegone, Allo ocimene and Rosmarinic acid was done via
PyRx Software. The binding affinities of the selected ligands Pulegone, Allo ocimene and rosmarinic acid are
shown in Table 1. Binding energies of the compounds Pulegone, Allo ocimene and rosmarinic acid are shown in
Table 2.
TABLE 1: Ligand Binding Affinity, RMSD upper bond, RMSD lower bond and mode.
LIGAND BINDING AFFINITY MODE RMSD Upper Bond RMSD Lower Bond
PULEGONE -5.5 0 0 0
ALLO OCIMENE -4.8 0 0 0
ROSMARINIC ACID -5.6 0 0 0
TABLE 2: Binding Energy of Natural compounds
NATURAL COMPOUNDS BINDING ENERGY
PULEGONE -5.5
ALLO OCIMENE -4.8
ROSMARINIC ACID -5.6
The ligands based on their minimum Binding energy were selected. Pulegone and Rosmarinic acid were the final
selected ligands from PyRx results. The ligands were further screened on the basis of Drug likeliness property.
This property analysis was performed with the help of SwissADME. The selected ligands were later analyzed on
the basis of Lipinski’s Rule of Five as shown in Table 3. After complete analysis Allo ocimene was the only
resulted ligand which was having minimum binding energy with our protein molecule and also it also followed
the Lipinski’s Rule of Five.
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LIGAND
MOLECULAR
WEIGHT
LOG
Po/w
H-
DONAR
H-
ACCEPTOR
LIPINSKI
PULEGONE 152.2.g/mol 2.20 1 0
YES, 0
VOILATION
ROSMARINIC
ACID
360.31g/mol 0.90 8 5
YES, 0
VOILATION
TABLE 3: Drug Likeliness Property of Ligand
Finally the docking between CD2-Associated protein (PDB ID: 4XIV) and Rosmarinic acid (CID: 5281792) was
performed via AutoDock Vina software. As per the results, total 9 poses having different binding affinities, Root
Mean Square lower bound, Root Mean Square upper bound were observed as shown in Table 4. Final interaction
between the selected Ligand molecule and the Protein target was observed in PyMOL.
Mode
Binding Affinity
(K cal/mol)
Distance from best mode
RMSD lower bound RMSD upper bound
1 -9.6 0 0
2 -9.5 21.225 22.145
3 -9.5 20.158 21.456
4 -9.4 19.257 22.146
5 -9.4 22.879 25.143
6 -9.4 22.187 25.357
7 -9.4 21.457 23.571
8 -9.3 23.192 24.127
9 -9.3 24.137 25.163
TABLE 4: Auto Dock Vina Result
CONCLUSION
Several studies have been carried out to study the
development of drug for the treatment of Multiple
Sclerosis. Various neuroprotective compounds have
been studied with other phytochemicals for treatment
of this disease as there is no particular drug and the
diagnostic method for treating MS. In our study, we
worked on different natural compounds such as
rosmarinic acid, Pulegone and Allo Ocimene and a
protein CD2 -Associated protein. Molecular Docking
was performed on the basis of binding affinity and
drug likeliness property of the natural compound in
association with selected protein. Rosmarinic acid
was the only protein which showed the best
interaction with the target protein. Therefore, we may
consider rosmarinic acid as the natural compound
which may be used as a drug for treatment of MS.
CONFLICT OF INTEREST
The authors declare that there is no conflict of
interest.
ACKNOWLEDGEMENT
The authors acknowledge the help provided by the
Department of Biotechnology, Faculty of Life
Sciences, Institute of Applied medicines and
Research, Ghaziabad, Uttar Pradesh, India.
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