The document discusses the simplex method for solving linear programming problems. It begins by introducing the simplex method and explaining that it is an iterative procedure that examines corner points to find an optimal solution. It then defines key terms like slack, surplus, and artificial variables. The majority of the document outlines the step-by-step procedures for using the simplex method to solve maximization and minimization problems. It also discusses how to handle special cases that may arise, such as degeneracy, unbounded problems, and infeasible problems.
A quick introduction to linear and logistic regression using Python. Part of the Data Science Bootcamp held in Amman by the Jordan Open Source Association Dec/Jan 2015. Reference code can be found on Github https://github.com/jordanopensource/data-science-bootcamp/tree/master/MachineLearning/Session1
It is essential for all regression models that the relationship between the independent and dependent variables are represented correctly. Functional form tries to do exactly this. A functional form will give an equation for the dependent and independent variables so that the hypothesis tests can be carried out properly. Copy the link given below and paste it in new browser window to get more information on Functional Forms of Regression Analysis:- http://www.transtutors.com/homework-help/economics/functional-forms-of-regression-models.aspx
This lab discusses selections and provides examples of if statement, nested if, and switch. It also covers logical operators and relational operators. It gives many examples to help the student develop logical think and structure computer logic.
For a good business plan creative thinking is important. A business plan is very important and strategic tool for entrepreneurs. A good business plan not only helps entrepreneurs focus on specific steps necessary for them to make business ideas succeed, but it also helps them to achieve short-term and long-term objectives. As an inspiring entrepreneur who is looking towards starting a business, one of the businesses you can successfully start without much stress is book servicing café.
Importance:
Nowadays, network plays an important role in people’s life. In the process of the improvement of the people’s living standard, people’s demand of the life’s quality and efficiency is more higher, the traditional bookstore’s inconvenience gradually emerge, and the online book store has gradually be used in public. The online book store system based on the principle of providing convenience and service to people.
With the online book servicing café, college student do not need to blindly go to various places to find their own books, but only in a computer connected to the internet log on online book servicing café in the search box, type u want to find of the book information retrieval, you can efficiently know whether a site has its own books, if you can online direct purchase, if not u can change the home book store to continue to search or provide advice to the seller in order to supply. This greatly facilitates every college student saving time.
The online book servicing café’s main users are divided into two categories, one is the front user, and one is the background user. The main business model for Book Servicing Café relies on college students providing textbooks, auctions, classifieds teacher evaluations available on website. Therefore, our focus will be on the marketing strategy to increase student traffic and usage. In turn, visitor volume and transactions will maintain the inventory of products and services offered.
Online bookstore system i.e. Book Servicing Café not only can easily find the information and purchase books, and the operating conditions are simple, user-friendly, to a large extent to solve real-life problems in the purchase of the books.
When you shop in online book servicing cafe, you have the chance of accessing and going through customers who have shopped at book servicing café and review about the book you intend to buy. This will give you beforehand information about that book.
While purchasing or selling books at the book servicing café, you save money, energy and time for your favorite book online. The book servicing café will offer discount coupons which help college students save money or make money on their purchases or selling. Shopping for books online is economical too because of the low shipping price.
Book servicing café tend to work with multiple suppliers, which allows them to offer a wider variety of books than a traditional retail store without accruing a large, costly inventory which will help colle
A quick introduction to linear and logistic regression using Python. Part of the Data Science Bootcamp held in Amman by the Jordan Open Source Association Dec/Jan 2015. Reference code can be found on Github https://github.com/jordanopensource/data-science-bootcamp/tree/master/MachineLearning/Session1
It is essential for all regression models that the relationship between the independent and dependent variables are represented correctly. Functional form tries to do exactly this. A functional form will give an equation for the dependent and independent variables so that the hypothesis tests can be carried out properly. Copy the link given below and paste it in new browser window to get more information on Functional Forms of Regression Analysis:- http://www.transtutors.com/homework-help/economics/functional-forms-of-regression-models.aspx
This lab discusses selections and provides examples of if statement, nested if, and switch. It also covers logical operators and relational operators. It gives many examples to help the student develop logical think and structure computer logic.
For a good business plan creative thinking is important. A business plan is very important and strategic tool for entrepreneurs. A good business plan not only helps entrepreneurs focus on specific steps necessary for them to make business ideas succeed, but it also helps them to achieve short-term and long-term objectives. As an inspiring entrepreneur who is looking towards starting a business, one of the businesses you can successfully start without much stress is book servicing café.
Importance:
Nowadays, network plays an important role in people’s life. In the process of the improvement of the people’s living standard, people’s demand of the life’s quality and efficiency is more higher, the traditional bookstore’s inconvenience gradually emerge, and the online book store has gradually be used in public. The online book store system based on the principle of providing convenience and service to people.
With the online book servicing café, college student do not need to blindly go to various places to find their own books, but only in a computer connected to the internet log on online book servicing café in the search box, type u want to find of the book information retrieval, you can efficiently know whether a site has its own books, if you can online direct purchase, if not u can change the home book store to continue to search or provide advice to the seller in order to supply. This greatly facilitates every college student saving time.
The online book servicing café’s main users are divided into two categories, one is the front user, and one is the background user. The main business model for Book Servicing Café relies on college students providing textbooks, auctions, classifieds teacher evaluations available on website. Therefore, our focus will be on the marketing strategy to increase student traffic and usage. In turn, visitor volume and transactions will maintain the inventory of products and services offered.
Online bookstore system i.e. Book Servicing Café not only can easily find the information and purchase books, and the operating conditions are simple, user-friendly, to a large extent to solve real-life problems in the purchase of the books.
When you shop in online book servicing cafe, you have the chance of accessing and going through customers who have shopped at book servicing café and review about the book you intend to buy. This will give you beforehand information about that book.
While purchasing or selling books at the book servicing café, you save money, energy and time for your favorite book online. The book servicing café will offer discount coupons which help college students save money or make money on their purchases or selling. Shopping for books online is economical too because of the low shipping price.
Book servicing café tend to work with multiple suppliers, which allows them to offer a wider variety of books than a traditional retail store without accruing a large, costly inventory which will help colle
A problem is provided which is solved by using graphical and analytical method of linear programming method and then it is solved by using geometrical concept and algebraic concept of simplex method.
A brief study on linear programming solving methodsMayurjyotiNeog
This small presentation includes a brief study on various linear programming solving methods. These methods (graphical & simplex) are used to solve industrial engineering related problems in practical use.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
2. Introduction
With only two decision variables it is possible
to use graphical methods to solve LP problems
But most real life LP problems are too complex
for simple graphical procedures
We need a more powerful procedure called the
simplex method
The simplex method examines the corner
points in a systematic fashion using basic
algebraic concepts
It does this in an iterative manner until an
optimal solution is found
Each iteration moves us closer to the optimal
solution
3. Basic Terms
Slack Variables – A variable added to
convert an inequality of equal to or less than
type (≤) to equality.
Surplus Variable – A variable subtracted to
convert an equality of equal to or greater
than type (≥) to equality.
Artificial Variable – A fictitious variable
included in the case of inequality of (≥) type
and equality (=), to satisfy the non negativity
condition of a basic feasible solution.
4. Particulars Slack Variable Surplus
Variable
Artificial
Variable
Meaning Unused
resources or
idle resources
Excess amount
of resources
utilized
No physical or
economic
meaning. It is
fictitious
When to be
used
(≤) inequality (≥) inequality (≥) and (=)
constraints
Co-efficient in
the constraint
+1 -1 +1
Co-efficient in
the objective
function Z
0 0 +M for
minimization
and –M for
maximization
Use as Initial
Program
Variable
Used as starting
point (Initial
Table)
Cannot be used
since unit
matrix condition
is not satisfied
Initially used
but later on
eliminated
Presence in
the Optimal
Table
Helps to
interpret idle &
key resources
- - - Indicates
infeasible
solution
5. Procedure for Maximization Problems
1. Set up the inequalities describing the
problem constraints.
2. Introduce slack variables and convert
inequalities into equations.
3. Enter the equalities into the simplex
table.
4. Calculate the Zj and Cj – Zj value for
this solution.
5. Determine the entering variable by
choosing the highest Cj – Zj.
6. 6. Determine the row to be replaced from
the minimum ratio column (only
compute the ratios for rows whose
element is greater than zero).
7. Compute the value of the new key row.
8. Compute the values for remaining rows.
9. Calculate Cj and Zj value for this
solution.
10. If there is non-negative Cj – Zj value
and return to step 5 above.
11. If there is no non – negative Cj – Zj
values the final solution has been
obtained.
7. Procedure for Minimization Problems
1. Set up the inequalities describing the
problem constraints.
2. Convert any inequalities to equalities by
introducing surplus variables.
3. Add artificial variable to all equalities
involving surplus variables.
4. Enter the resulting equalities in the
simplex table.
5. Calculate Cj – Zj value for this solution.
8. 6. Determine the entering variable selecting
the one with the largest negative Cj – Zj
values.
7. Determine the departing row by choosing
the smallest non – negative ratio ignoring
infinity and negative. Zero is positive for
the purpose.
8. Compute the values for the new key row.
9. Calculate the values for the remaining rows.
10. Calculate the Cj – Zj value for this solution.
11. If there is negative element in the Cj – Zj
row then return to step 6. If there is no
negative Cj – Zj then final solution has been
obtained.
9. Simplex Problem (Mixed Constraints)
1. A situation may arise when the
constraints are ≥ type or ≤ type or =
type i.e. mixed constraints.
2. If any constraint has –ve constant at
the RHS, then multiply both sides with -
1 and it will reverse the directions of
inequalities.
3. Introduce slack variable, in case of ≤
type constraint.
4. Introduce surplus variables and artificial
variables in case of ≥ type constraints.
10. 5. Introduce artificial variables if the
constraint is ‘=‘ type.
6. Assign zero co-efficient to the slack
variables and surplus variables in the
objective function.
7. Assign +M in case of minimization and –M
in case of maximization problems to the
artificial variables in the objective
function.
8. In case of maximization, stop where Cj –
Zj row contains zero or negative elements.
9. In case of minimization, stop where Cj – Zj
row contains all elements zero or positive
values.
11. Special Cases
1. Tie for key column
2. Tie for key row (Degeneracy)
3. Unbounded problems
4. Multiple optimal solutions
5. Infeasible problems
6. Redundant constraints
7. Unrestricted variables
12. 1. Tie for key column
Problem can arise in case of tie
between identical Cj – Zj values,
i.e., two or more columns.
In such a case, selection for key
column can be made arbitrarily.
There is no wrong choice, although
selection of one variable may result
in more iteration.
13. 2. Tie for key row (Degeneracy)
Degeneracy occurs when there is tie
for minimum ratio for choosing the
departing variable.
Methods to select the key row:
1. Choose arbitrarily.
2. Use alternate method.
14. Alternate Procedure for Degeneracy
i. Locate the rows in which smallest non-negative
ratio are tied (equal).
ii. Find the coefficient of the slack variables and divide
each coefficient by the corresponding positive
numbers of the key column in the row, starting
from left to right in order to break the tie.
iii. If the ratios do not break the tie, find the similar
ratios for the coefficients of decision variables.
iv. Compare the resulting ratio, column by column.
v. Select the row which contains smallest ratio. This
row becomes the key row.
vi. After the resolving of this tie, simplex method is
applied to obtain the optimum tie.
15. 3. Unbounded problems
It is a situation when key row
cannot be selected because
minimum ratio column contains all
negative or infinity, the solution is
unbounded.
The table does not indicate optimal
solution, yet the simplex process is
prohibited from continuing.
16. 4. Multiple optimal solutions
In the final simplex table, if the
index row indicates the value of Cj
– Zj for a non-basic variable to
be zero, there exists an
alternative optimum solution.
17. 5. Infeasible problems
It is a situation when an artificial
variable is present as a basic
variable in the final solution.
This condition occurs when the
problem has incompatible
constraints.
18. 6. Redundant constraints
When on constraint is less
restrictive than the other, it is
redundant constraint.
For example
4x1 + 3x2 < 12
4x1 + 3x2 < 16 (Redundant)
19. 7. Unrestricted variables
Unrestricted variable is that decision
variable which does not carry any
value.
This variable can take positive,
negative and zero values.
To solve the problem, this variable
can take two values one +ve and
one –ve because difference between
these two is zero.