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5c & d: Checkpoints in the Cell 
& Cancer
Checkpoints 
 While preparing for division, a cell does a self-check to see if 
everything is proceeding as normal. 
 A cell will not divide if: 
 There are not enough nutrients available to support continued 
growth 
 The DNA has not been replicated 
 The DNA is damaged 
 If an issue is detected the cell either repairs or destroys itself.
Checkpoints 
 Chromosomes attached to 
spindle fibers? 
 Chromosomes split evenly 
during anaphase? 
 Enough nutrients to 
support cell? 
 Damaged DNA? 
 DNA replicated? 
 Damaged DNA?
Cancer 
 If a mutation occurs in a gene that produces instructions for a 
checkpoint protein, cell cycle control will be lost. 
 Damaged cells divide without control – uncontrolled division 
is called cancer. 
 Instead of division stopping after a single layer of cells is 
produced, cancer cells grow in multiple layers called a tumor
Cancer 
 Cancer cells are abnormal and do not carry out the normal 
functions of the tissue where the tumor has grown 
 Cancer cells have large abnormal nuclei due to uncontrolled 
cell division from lack of regulation by checkpoints 
 Cancer cells attract blood vessels to supply the tumor with 
nutrients for continued growth 
 Some cancer cells can enter the blood stream and spread to 
other parts of the body and form new tumors – Metastasize

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5cd checkpoints and cancer

  • 1. 5c & d: Checkpoints in the Cell & Cancer
  • 2. Checkpoints  While preparing for division, a cell does a self-check to see if everything is proceeding as normal.  A cell will not divide if:  There are not enough nutrients available to support continued growth  The DNA has not been replicated  The DNA is damaged  If an issue is detected the cell either repairs or destroys itself.
  • 3. Checkpoints  Chromosomes attached to spindle fibers?  Chromosomes split evenly during anaphase?  Enough nutrients to support cell?  Damaged DNA?  DNA replicated?  Damaged DNA?
  • 4. Cancer  If a mutation occurs in a gene that produces instructions for a checkpoint protein, cell cycle control will be lost.  Damaged cells divide without control – uncontrolled division is called cancer.  Instead of division stopping after a single layer of cells is produced, cancer cells grow in multiple layers called a tumor
  • 5. Cancer  Cancer cells are abnormal and do not carry out the normal functions of the tissue where the tumor has grown  Cancer cells have large abnormal nuclei due to uncontrolled cell division from lack of regulation by checkpoints  Cancer cells attract blood vessels to supply the tumor with nutrients for continued growth  Some cancer cells can enter the blood stream and spread to other parts of the body and form new tumors – Metastasize