Cells undergo checkpoints to ensure DNA is properly replicated and any damage is repaired before dividing. Checkpoints monitor several criteria including chromosome alignment and nutrient levels. If issues are detected, the cell will either fix the problem or self-destruct. Cancer can occur if a mutation disrupts checkpoint proteins, allowing damaged cells to divide uncontrollably and form tumors. Unregulated growth leads to abnormal cell piles that attract blood vessels and can metastasize to other areas.