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The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive functioning. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms.
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The document discusses various classes of sedative and hypnotic drugs including barbiturates, benzodiazepines, and newer non-benzodiazepine drugs. It describes the mechanism of action of these drugs as potentiating the effects of the inhibitory neurotransmitter GABA in the brain through binding to GABAA receptors or barbiturate sites. This results in increased chloride conductance, membrane hyperpolarization, and central nervous system depression. The document also provides structure-activity relationships and examples of specific drugs from each class like diazepam, zolpidem, and pentobarbital along with their medical uses, side effects, and synthesis when relevant.
ANTI HYPERTENSIVE AGENTS [MEDICINAL CHEMISTRY] BY P.RAVISANKAR, HYPERTENSION,...
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1) Sympathomimetics are classified as catecholamines which contain a catechol nucleus, or non-catecholamines which do not.
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Introduction.
Classification .
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Structure
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Adverse Drug Reactions .
Uses.
References
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it contain all new discovered the adrenergic drugs with mechanism of action, structure and synthesis.
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Local Anaesthetics
- Local anesthetics are drugs that cause reversible loss of sensation, especially pain, in a localized area of the body when applied topically or injected locally. They block the generation and conduction of nerve impulses at the site of contact without damaging neurons.
- Common uses include dentistry, excision procedures, dermatology, and spinal or regional anesthesia. Local anesthetics work by inhibiting sodium influx through voltage-gated sodium channels in neurons, interrupting action potential generation and signal conduction.
- Examples of side effects include central nervous system stimulation or depression in high doses, cardiovascular effects like arrhythmias and hypotension, and hypersensitivity reactions.
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Organic identification
This document provides information on qualitative organic analysis including:
- Testing for elements like carbon, hydrogen, halogens, nitrogen, and sulfur using sodium fusion.
- Using physical properties and solubility tests to obtain structural information.
- Performing classification tests to identify functional groups like alkanes, alkenes, alcohols, aldehydes, ketones, carboxylic acids, esters, amines, ethers, phenols, nitriles, and nitro compounds.
- Preparing characteristic derivatives to further identify organic compounds such as phenylurethanes for alcohols and arylsulfonamides for amines.
Geometrical isomers
This document discusses geometrical isomers, which occur when rotation is restricted around a carbon-carbon double bond. Geometrical isomers can have different physical properties despite having the same molecular formula. The two types of geometrical isomers are cis-trans isomers and E-Z isomers. Cis-trans isomers have hydrogens on the same side (cis) or opposite sides (trans) of the double bond. E-Z isomers are assigned based on priority rules, with the Z isomer having higher priority groups on the same side and the E isomer having them on opposite sides. Examples are given of how geometrical isomers can impact drug action.
Types of chemical bonds
Chemical bonds form when atoms share or transfer electrons. There are several main types of bonds:
- Ionic bonds form when metals transfer electrons to nonmetals to form positive and negative ions that are attracted to each other. Ionic compounds are crystalline and dissolve in water.
- Covalent bonds form when atoms share two or more valence electrons to achieve stability. Covalent bond strength depends on the number of electron pairs shared. Covalent compounds exist as discrete molecules.
- Metallic bonds result from the attraction between positively charged metal ions and delocalized electrons in the "sea of electrons" in the solid metal. Metallic bonding explains the properties of metals like conductivity.
Transition in ultraviolet and visible light
The document discusses UV-Vis spectroscopy and factors that influence molar absorptivity. It describes the four types of electronic transitions (s-s*, n-s*, n-p*, p-p*) and explains that the p-p* transition is most useful for quantitative analysis due to its high absorptivity at moderate energies. Solvent polarity and conjugation affect transition energies and absorptivities. Chromophores like alkenes and aromatics absorb in the UV-Vis region. The document also discusses applications of UV-Vis spectroscopy for qualitative and quantitative analysis.
Uv-visible spectroscopy
This document provides an overview of UV-visible spectroscopy. It discusses the electromagnetic spectrum and how light exhibits both wave and particle properties. It explains the basic components and principles of UV-visible spectrometers, including sources such as tungsten lamps and lasers, wavelength selectors like monochromators, sample containers, and various types of detectors. It also covers important concepts such as Beer's law, deviations from Beer's law, and the factors that affect spectroscopic measurements.
Temperature and heat hazard by mzgin m. ayoob
This document discusses heat and temperature hazards. It defines heat and temperature, explains how the body is affected by heat, and identifies heat-related illnesses like heat stroke, heat exhaustion, and heat cramps. It also discusses the risks of extreme cold temperatures and ways to monitor and prevent heat stress, such as designating oversight of water, rest, shade, and modified work schedules. The goal is to educate about temperature hazards and suppress risks through awareness and precautions.
Artificial photosynthesis
Artificial photosynthesis aims to replicate the natural process of photosynthesis through chemical reactions. It uses sunlight, water and carbon dioxide to produce carbohydrates or solar fuels like methanol, methane or carbon monoxide. These solar fuels could serve as carbon-neutral, renewable alternatives to fossil fuels. However, current catalysts are not efficient enough to reduce CO2 into fuels at useful rates and selectivities. If developed further, artificial photosynthesis on an industrial scale could help solve global warming by reducing atmospheric CO2 levels.
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Recently uploaded
Nucleic Acid-its structural and functional complexity.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Randomised Optimisation Algorithms in DAPHNE
Slides from talk:
Aleš Zamuda: Randomised Optimisation Algorithms in DAPHNE .
Austrian-Slovenian HPC Meeting 2024 – ASHPC24, Seeblickhotel Grundlsee in Austria, 10–13 June 2024
https://ashpc.eu/
The binding of cosmological structures by massless topological defects
Assuming spherical symmetry and weak field, it is shown that if one solves the Poisson equation or the Einstein field
equations sourced by a topological defect, i.e. a singularity of a very specific form, the result is a localized gravitational
field capable of driving flat rotation (i.e. Keplerian circular orbits at a constant speed for all radii) of test masses on a thin
spherical shell without any underlying mass. Moreover, a large-scale structure which exploits this solution by assembling
concentrically a number of such topological defects can establish a flat stellar or galactic rotation curve, and can also deflect
light in the same manner as an equipotential (isothermal) sphere. Thus, the need for dark matter or modified gravity theory is
mitigated, at least in part.
Bob Reedy - Nitrate in Texas Groundwater.pdf
Presented at June 6-7 Texas Alliance of Groundwater Districts Business Meeting
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
Context. With a mass exceeding several 104 M⊙ and a rich and dense population of massive stars, supermassive young star clusters
represent the most massive star-forming environment that is dominated by the feedback from massive stars and gravitational interactions
among stars.
Aims. In this paper we present the Extended Westerlund 1 and 2 Open Clusters Survey (EWOCS) project, which aims to investigate
the influence of the starburst environment on the formation of stars and planets, and on the evolution of both low and high mass stars.
The primary targets of this project are Westerlund 1 and 2, the closest supermassive star clusters to the Sun.
Methods. The project is based primarily on recent observations conducted with the Chandra and JWST observatories. Specifically,
the Chandra survey of Westerlund 1 consists of 36 new ACIS-I observations, nearly co-pointed, for a total exposure time of 1 Msec.
Additionally, we included 8 archival Chandra/ACIS-S observations. This paper presents the resulting catalog of X-ray sources within
and around Westerlund 1. Sources were detected by combining various existing methods, and photon extraction and source validation
were carried out using the ACIS-Extract software.
Results. The EWOCS X-ray catalog comprises 5963 validated sources out of the 9420 initially provided to ACIS-Extract, reaching a
photon flux threshold of approximately 2 × 10−8 photons cm−2
s
−1
. The X-ray sources exhibit a highly concentrated spatial distribution,
with 1075 sources located within the central 1 arcmin. We have successfully detected X-ray emissions from 126 out of the 166 known
massive stars of the cluster, and we have collected over 71 000 photons from the magnetar CXO J164710.20-455217.
THEMATIC APPERCEPTION TEST(TAT) cognitive abilities, creativity, and critic...
THEMATIC APPERCEPTION TEST(TAT) cognitive abilities, creativity, and critic...Abdul Wali Khan University Mardan,kP,Pakistan
hematic appreciation test is a psychological assessment tool used to measure an individual's appreciation and understanding of specific themes or topics. This test helps to evaluate an individual's ability to connect different ideas and concepts within a given theme, as well as their overall comprehension and interpretation skills. The results of the test can provide valuable insights into an individual's cognitive abilities, creativity, and critical thinking skillsRemote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...University of Maribor
Slides from talk:
Aleš Zamuda: Remote Sensing and Computational, Evolutionary, Supercomputing, and Intelligent Systems.
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Inter-Society Networking Panel GRSS/MTT-S/CIS Panel Session: Promoting Connection and Cooperation
https://www.etran.rs/2024/en/home-english/Sharlene Leurig - Enabling Onsite Water Use with Net Zero Water
Sharlene Leurig - Enabling Onsite Water Use with Net Zero WaterTexas Alliance of Groundwater Districts
Presented at June 6-7 Texas Alliance of Groundwater Districts Business MeetingShallowest Oil Discovery of Turkiye.pptx
The Petroleum System of the Çukurova Field - the Shallowest Oil Discovery of Türkiye, Adana
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptx
Although Artemia has been known to man for centuries, its use as a food for the culture of larval organisms apparently began only in the 1930s, when several investigators found that it made an excellent food for newly hatched fish larvae (Litvinenko et al., 2023). As aquaculture developed in the 1960s and ‘70s, the use of Artemia also became more widespread, due both to its convenience and to its nutritional value for larval organisms (Arenas-Pardo et al., 2024). The fact that Artemia dormant cysts can be stored for long periods in cans, and then used as an off-the-shelf food requiring only 24 h of incubation makes them the most convenient, least labor-intensive, live food available for aquaculture (Sorgeloos & Roubach, 2021). The nutritional value of Artemia, especially for marine organisms, is not constant, but varies both geographically and temporally. During the last decade, however, both the causes of Artemia nutritional variability and methods to improve poorquality Artemia have been identified (Loufi et al., 2024).
Brine shrimp (Artemia spp.) are used in marine aquaculture worldwide. Annually, more than 2,000 metric tons of dry cysts are used for cultivation of fish, crustacean, and shellfish larva. Brine shrimp are important to aquaculture because newly hatched brine shrimp nauplii (larvae) provide a food source for many fish fry (Mozanzadeh et al., 2021). Culture and harvesting of brine shrimp eggs represents another aspect of the aquaculture industry. Nauplii and metanauplii of Artemia, commonly known as brine shrimp, play a crucial role in aquaculture due to their nutritional value and suitability as live feed for many aquatic species, particularly in larval stages (Sorgeloos & Roubach, 2021).
ESR spectroscopy in liquid food and beverages.pptx
With increasing population, people need to rely on packaged food stuffs. Packaging of food materials requires the preservation of food. There are various methods for the treatment of food to preserve them and irradiation treatment of food is one of them. It is the most common and the most harmless method for the food preservation as it does not alter the necessary micronutrients of food materials. Although irradiated food doesn’t cause any harm to the human health but still the quality assessment of food is required to provide consumers with necessary information about the food. ESR spectroscopy is the most sophisticated way to investigate the quality of the food and the free radicals induced during the processing of the food. ESR spin trapping technique is useful for the detection of highly unstable radicals in the food. The antioxidant capability of liquid food and beverages in mainly performed by spin trapping technique.
Nucleophilic Addition of carbonyl compounds.pptx
Nucleophilic addition is the most important reaction of carbonyls. Not just aldehydes and ketones, but also carboxylic acid derivatives in general.
Carbonyls undergo addition reactions with a large range of nucleophiles.
Comparing the relative basicity of the nucleophile and the product is extremely helpful in determining how reversible the addition reaction is. Reactions with Grignards and hydrides are irreversible. Reactions with weak bases like halides and carboxylates generally don’t happen.
Electronic effects (inductive effects, electron donation) have a large impact on reactivity.
Large groups adjacent to the carbonyl will slow the rate of reaction.
Neutral nucleophiles can also add to carbonyls, although their additions are generally slower and more reversible. Acid catalysis is sometimes employed to increase the rate of addition.
Equivariant neural networks and representation theory
Or: Beyond linear.
Abstract: Equivariant neural networks are neural networks that incorporate symmetries. The nonlinear activation functions in these networks result in interesting nonlinear equivariant maps between simple representations, and motivate the key player of this talk: piecewise linear representation theory.
Disclaimer: No one is perfect, so please mind that there might be mistakes and typos.
dtubbenhauer@gmail.com
Corrected slides: dtubbenhauer.com/talks.html
8.Isolation of pure cultures and preservation of cultures.pdf
Isolation of pure culture, its various method.
20240520 Planning a Circuit Simulator in JavaScript.pptx
Evaporation step counter work. I have done a physical experiment.
(Work in progress.)
Deep Software Variability and Frictionless Reproducibility
Deep Software Variability and Frictionless ReproducibilityUniversity of Rennes, INSA Rennes, Inria/IRISA, CNRS
The ability to recreate computational results with minimal effort and actionable metrics provides a solid foundation for scientific research and software development. When people can replicate an analysis at the touch of a button using open-source software, open data, and methods to assess and compare proposals, it significantly eases verification of results, engagement with a diverse range of contributors, and progress. However, we have yet to fully achieve this; there are still many sociotechnical frictions.
Inspired by David Donoho's vision, this talk aims to revisit the three crucial pillars of frictionless reproducibility (data sharing, code sharing, and competitive challenges) with the perspective of deep software variability.
Our observation is that multiple layers — hardware, operating systems, third-party libraries, software versions, input data, compile-time options, and parameters — are subject to variability that exacerbates frictions but is also essential for achieving robust, generalizable results and fostering innovation. I will first review the literature, providing evidence of how the complex variability interactions across these layers affect qualitative and quantitative software properties, thereby complicating the reproduction and replication of scientific studies in various fields.
I will then present some software engineering and AI techniques that can support the strategic exploration of variability spaces. These include the use of abstractions and models (e.g., feature models), sampling strategies (e.g., uniform, random), cost-effective measurements (e.g., incremental build of software configurations), and dimensionality reduction methods (e.g., transfer learning, feature selection, software debloating).
I will finally argue that deep variability is both the problem and solution of frictionless reproducibility, calling the software science community to develop new methods and tools to manage variability and foster reproducibility in software systems.
Exposé invité Journées Nationales du GDR GPL 2024
Recently uploaded (20)
Nucleic Acid-its structural and functional complexity.
Nucleic Acid-its structural and functional complexity.
The binding of cosmological structures by massless topological defects
The binding of cosmological structures by massless topological defects
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
THEMATIC APPERCEPTION TEST(TAT) cognitive abilities, creativity, and critic...
THEMATIC APPERCEPTION TEST(TAT) cognitive abilities, creativity, and critic...
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...
mô tả các thí nghiệm về đánh giá tác động dòng khí hóa sau đốt
mô tả các thí nghiệm về đánh giá tác động dòng khí hóa sau đốt
Sharlene Leurig - Enabling Onsite Water Use with Net Zero Water
Sharlene Leurig - Enabling Onsite Water Use with Net Zero Water
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptx
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptx
ESR spectroscopy in liquid food and beverages.pptx
ESR spectroscopy in liquid food and beverages.pptx
Equivariant neural networks and representation theory
Equivariant neural networks and representation theory
8.Isolation of pure cultures and preservation of cultures.pdf
8.Isolation of pure cultures and preservation of cultures.pdf
20240520 Planning a Circuit Simulator in JavaScript.pptx
20240520 Planning a Circuit Simulator in JavaScript.pptx
Deep Software Variability and Frictionless Reproducibility
Deep Software Variability and Frictionless Reproducibility