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EUTECTIC METHOD

This document discusses the eutectic method, which involves creating a mixture of components in a specific ratio that melts at a temperature below the melting point of the individual components. It explains that a eutectic mixture is miscible in liquid state but immiscible in solid state, and the melting point is always fixed. Factors like ratio and impurities can affect formation. Eutectic mixtures are commonly used in drug design and delivery for controlling melting points and solidification. Some examples of eutectic mixtures provided are curcumin-nicotinamide, ibuprofen-thymol, and borneol-menthol.

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BCDA COLLEGE OF PHARMACY AND TECHNOLOGY TITHI JANA 20101921017 212010201910076 Physical Pharmaceutics 1 (CA1) PT-316 Eutectic Method
CONTENTS  Introduction  Properties  Principle  Factors  Uses  Example  Reference
INTRODUCTION An eutectic mixture is a mixture of several components is a particular ratio, which melts sharply below the melting point of any individual component.. Eutectic Mixture: Eg- Menthol, Thymol.
Melts below the melting point of individual component During formation, the components are miscible in liquid state but immiscible in solid state The melting point is always fixed
PRINCIPLES OF EUTECTIC MIXTURE  Below the eutectic temperature the mixture of the two mixture of the two substances will exist as a solid..  While above it the mixture will convert into a liquid.
 Composition of substance A and B showing eutectic point E.
FACTORS AFFECTING THE FORMATION OF EUTECTIC MIXTURE  This is because unadjusted ratios and presence of impurities may causes imbalance to the mixture and throw all the solidification point. It is necessary to adjust the ratio of the components in the mixture. It is also necessary to closely control the components of impurities
Uses  It becomes necessary to identify the formation of eutectic mixture between components of formulation to avoid the problems of manufacturing.  It is commonly used in drug designing and delivery processes for various routes of administration
Example Some eutectic mixture are : Curcumin - Nicotinamide(1:2) Ibuprofen – Thymol (2:3) Borneol – Menthol(1:9)
Reference Agarwal , khanna : Physical pharmaceutics, C.V.S Subhramonyam ; Physical pharmaceutics , Dr. Ashok A Hajare
EUTECTIC METHOD