Computerized scan findings and their correlation with outcome in patients wit...Amit Agrawal
CT scan has become the investigation of choice in traumatic brain injury patients . Because of its wide spread availability and ability to precisely detect and locate intracranial lesions
Clinical Profile of Acute Coronary Syndrome among Young AdultsPremier Publishers
Acute Coronary Syndrome accounts for 30% of hospital admissions with cardiovascular diseases. The risk of this syndrome is increasing among the younger adults, and a deep insight into the clinical profile among these patients will help in devising a preventive strategy, in order to alleviate the morbidity and mortality due to the syndrome. A cross sectional study was done among 125 subjects admitted to our tertiary care hospital with Acute Coronary Syndrome. Their risk factors were assessed and a 12 Lead electrocardiogram and 2D Echocardiogram were taken. Cardio III panel which consists of Troponin I, CK MB, BNP by COBAS meter machine was also measured. STEMI was present in 73.6% of the patients, while unstable angina was present in 16%. About 90% of STEMI patients were males and 62% of them were hypertensives. LV Ejection Fraction <30% was found in 9% of STEMI patients. This study elucidates the need for a preventive strategy for primordial prevention of cardiovascular events among young adults. The study envisaged the male, urban preponderance towards these events.
Computerized scan findings and their correlation with outcome in patients wit...Amit Agrawal
CT scan has become the investigation of choice in traumatic brain injury patients . Because of its wide spread availability and ability to precisely detect and locate intracranial lesions
Clinical Profile of Acute Coronary Syndrome among Young AdultsPremier Publishers
Acute Coronary Syndrome accounts for 30% of hospital admissions with cardiovascular diseases. The risk of this syndrome is increasing among the younger adults, and a deep insight into the clinical profile among these patients will help in devising a preventive strategy, in order to alleviate the morbidity and mortality due to the syndrome. A cross sectional study was done among 125 subjects admitted to our tertiary care hospital with Acute Coronary Syndrome. Their risk factors were assessed and a 12 Lead electrocardiogram and 2D Echocardiogram were taken. Cardio III panel which consists of Troponin I, CK MB, BNP by COBAS meter machine was also measured. STEMI was present in 73.6% of the patients, while unstable angina was present in 16%. About 90% of STEMI patients were males and 62% of them were hypertensives. LV Ejection Fraction <30% was found in 9% of STEMI patients. This study elucidates the need for a preventive strategy for primordial prevention of cardiovascular events among young adults. The study envisaged the male, urban preponderance towards these events.
ASA/AHA 2014 guidelines for the Primary Prevention of Stroke
Hypertension and dyslipidemia impact on stroke development and prevention
SPRINT and HOPE-3
Predictors of Ischaemia and Outcomes in Egyptian Patients with Diabetes Mellitus Referred for Perfusion Imaging. Samir Rafla*, Ahmed Abdel-Aaty, Mohamed Ahmed Sadaka, Aly Ahmed Abo Elhoda and Ahmed Mohamed Shams
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
Contact us if you are interested:
Email / Skype : kefaya1771@gmail.com
Threema: PXHY5PDH
New BATCH Ku !!! MUCH IN DEMAND FAST SALE EVERY BATCH HAPPY GOOD EFFECT BIG BATCH !
Contact me on Threema or skype to start big business!!
Hot-sale products:
NEW HOT EUTYLONE WHITE CRYSTAL!!
5cl-adba precursor (semi finished )
5cl-adba raw materials
ADBB precursor (semi finished )
ADBB raw materials
APVP powder
5fadb/4f-adb
Jwh018 / Jwh210
Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
Metonitazene CAS: 14680-51-4
Payment terms: Western Union,MoneyGram,Bitcoin or USDT.
Deliver Time: Usually 7-15days
Shipping method: FedEx, TNT, DHL,UPS etc.Our deliveries are 100% safe, fast, reliable and discreet.
Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
1. 96% of deaths from CHD
or stroke occur in people
aged 55 and over*
*Wald NJ, Law MR. A strategy to reduce cardiovascular disease by more than
80%. BMJ. 2003;326:1419-
4. Circulation 2004;110:227-39Circulation 2004;110:227-39
§ Almost all people with zero or 1 risk factor have a 10-year risk <10%,§ Almost all people with zero or 1 risk factor have a 10-year risk <10%,
and 10-year risk assessment in people with zero or 1 risk factorand 10-year risk assessment in people with zero or 1 risk factor
is thus not necessary.is thus not necessary.
12. 96% of deaths from CHD
or stroke occur in people
aged 55 and over*
*Wald NJ, Law MR. A strategy to reduce cardiovascular disease by more than
80%. BMJ. 2003;326:1419-
Trajectory:
How early?
24. Figure 1. Occurrence of a first coronary event within 10Occurrence of a first coronary event within 10
yearsyears, estimated by Cox proportional hazards models in
percentages.
Left, Percentage estimated by a model with FRS (5
categories) adjusted for survey.
Right, Percentage estimated for each of 5 FRS categories by
a model with CRP (3 categories) adjusted for FRS
(continuous) and survey. Probability values indicate significance status
of CRPCRP in the Cox model.
Wolfgang Koenig, SHAPE Report 2005
25.
26. Clinical utility of very high (>10 mg/L) as well as very low (<0.5 mg/L) levels of
hsCRP among those with 10-year Framingham estimated risks <10% (left) and
between 10% and 20% (right). Circulation 2004;109:2818-25
27. Pepe et al. Am J Epidemiol 2004;159:882-90Pepe et al. Am J Epidemiol 2004;159:882-90
35. Table 1. Direct medical costs (not charges) for numerous cardiovascular imaging and cardiac diagnostic tests as
based upon the published evidence and as synthesized in the recent 34th Bethesda Conference of the American
College of Cardiology and from the recent European Society for Cardiology’s Consensus Panel Report on
cardiovascular magnetic resonance imaging
$39Outpatient Office Visit
$712Added Cost of Intravascular Ultrasound
$296Single Photon Emission Computed Tomography
$67Exercise ECG
$247Advanced Lipid Analysis
$13C-Reactive Protein Laboratory Measurement
$13Cholesterol panel
Comparative Costs
$1,810Right / Left Heart Cateterization
$1,272Positron Emission Tomography
$450Magnetic Resonance Imaging*
$283Other Computed Tomography
$91Rest Echocardiography
$87Electron Beam Tomography / Computed Tomography Coronary
Calcium Scan
$71Carotid Ultrasound
$61Ankle Brachial Index
CV Imaging Costs
*Costs vary widely from ~$200 to $1,100 depending upon the procedure.
SHAPE: Cost-Effectiveness
Leslee Shaw, SHAPE Report 2005
36. Screen Testing
Evaluating the Cost and Effectiveness of Strategies for Atherosclerotic Detection
and Prevention
The SHAPE EquationThe SHAPE Equation
N = nN = n00 ×× ffcc ×× ffss ×× ffdd ×× fftt ×× ffee
N Number of prevented atherosclerotic events
n0
Number of atherosclerotic events in the baseline population
fc
Fraction of candidates in the baseline population
fs
Fraction of candidates who are screened
fd
Fraction of screened candidates who are detected for treatment
ft
Fraction of detected subjects who are effectively treated
fe
Fraction of effectively treated subjects in whom events are prevented
George A. Diamond, SHAPE Writing Group
37. Raymond Bahr, SHAPE Report 2005
Early Heart Attack Care (EHACEHAC) and
Chest Pain Centers ED
38.
39.
40. Raggi et al. AHJ 2001;141:375-82Raggi et al. AHJ 2001;141:375-82
41. Fatal and nonfatal MI
risk and OR for each decile of calciumrisk and OR for each decile of calcium
score (CS)score (CS)
Raggi et al. AHJ 2001;141:375-82Raggi et al. AHJ 2001;141:375-82
n=676, age ~52y
42. Author N Mean
Age, y
(years
)
Follow-up
Duration,
y
(years)
Calcium
Score Cutoff
Comparator
Group for RR
Calculation
Relative
Risk
Ratio
Arad (11) 1,173 53 3.6 CAC
>160
CAC
< 160
20.2
Detrano (12) 1,196 66 3.4 CAC >44 CAC <44 2.3
Park (13) 967 67 6.4 CAC >142.1 CAC <3.7 4.9
Raggi (14) 632 52 2.7 Top
Quartile*
Lowest Quartile 13
Wong (15) 926 54 3.3 Top Quartile
(>270)
First Score
Quartile
8.8
Arad (16) 5,585 59 4.3 CAC ≥ 100 CAC <100 10.7
Kondos (17) 5,635 51 3.1 CAC No CAC 10.5
Greenland (18) 1,312 66 7.0 CAC>300 No CAC 3.9
Shaw (19) 10,377 53 5 CAC >400 CAC <10 8.4**
Pletcher (20)
(meta-analysis)
3,970 56 3.3 CAC >400 CAC=0 10.0
Harvey Hecht, SHAPE Report 2005
Predictive studies: Characteristics and Risk Ratio for Follow-
Up Studies Using
EBCT in Asymptomatic Persons
47. Figure 2: B-mode imaging of right carotid artery,
bifurcation and internal and external carotid
arteries. Images are obtained with ultrasound beam
perpendicular to the vessel wall showing near wall,
lumen and far wall. Distal 1 cm of common carotid,
1 cm of carotid bulb and 1 cm of proximal internal
carotid artery are imaged for IMT measurement
and detection of plaque.and detection of plaque.
Naqvi and Douglas, SHAPE Report 2005
48. Best Marker of Susceptibility to CHD
prevalent arterial diseaseprevalent arterial disease
CHD risk equivalentsCHD risk equivalents
NCEP ATP III
49. 96% of deaths from CHD
or stroke occur in people
aged 55 and over*
*Wald NJ, Law MR. A strategy to reduce cardiovascular disease by more than
80%. BMJ. 2003;326:1419-
Future research:
• Outcome studies
• Disease activity
• Search for the VP
50.
51. From Vulnerable Plaque to Vulnerable Patient – Part III
Introducing a New Paradigm for the Prevention of Heart Attack;
Identification and Treatment of the Asymptomatic Vulnerable Patient
Screening for Heart Attack Prevention and Education (SHAPE)
Task Force Report
Chairman… Editorial Committee… Writing Group … Advisors…
Morteza Naghavi,
…… Harvey S. Hecht, Jay Cohn, Michael Jamieson, Daniel Berman, Ole Faergeman,
Matthew J. Budoff, Zahi Fayad, John Rumberger, George A. Diamond, Leslee Shaw,
Tasneem Z. Naqvi, Pamela Douglas, Raymond Bahr, Wolfgang Koenig, Jasenka
Demirovic, Dan Arking, Victoria L.M. Herrera, Juan Badimon, Sanjay Kaul, Juhani
Airaksinen, Yoram Rudy, Arturo G. Touchard, Robert S. Schwartz, Daniel Lane, Henrik
Sillesen, Roger Blumenthal, Roxana Mehran, Stephane Carlier, Allen J. Taylor, ……
Prediman K. Shah.
52. From:From: Morteza Naghavi, M.D.Morteza Naghavi, M.D. [mailto:mn2@vp.org]
Sent:Sent: Thu 3/3/2005 1:29 AMThu 3/3/2005 1:29 AM
To: Erling Falk
Subject:
Erling, please note the yellow box is Lower Risk not Low Risk, … . Mort
53. Risk assessment and stratification
Risk factor/office-basedNCEP
, 10-year risk
Intermediate Risk
10-20%
High Risk
>20%
Low(er) Risk
<10%
RR ~2RR ~2
Pletcher et al
Arch Intern Med
2004;164:1285-92