There are three main types of radiation detectors: gas-filled detectors which use a gas between electrodes, scintillation detectors which use materials that produce light when irradiated, and semiconductor detectors made of purified crystalline materials. Detectors can also be classified by the type of information they provide, such as counting interactions, measuring energy, or indicating dose. The main challenges for detectors are dead time at high interaction rates and maintaining good energy resolution and detection efficiency.
Geiger–Müller Counter is a hand-held radiation survey instrument used in Radiation Dosimetry,Nuclear Physics,Experimental Physics & Radiological Protection.
Alfred Sloan ran general Motors one hundred years ago.
Peter Drucker was invited to write about GM and wrote The Concept of the corporation.
That book which I read two decades ago, gave me my first read of Mr Sloan. He was the first true General manager. I have been a great admirer of Sloan and what he did in marketing and management. A friend of mine sent me this book, it summarises Sloan’s style and philosophy on management.
Sloan was labelled the manager’s manager, you can see why!
Protein structure determination from hybrid NMR data.Mark Berjanskii
Protein structure determination from hybrid NMR data. Presentation is related to: biochemistry, bioinformatics, biology, biophysics, mark berjanskii, molecular biology, molecular dynamics, molecular modeling, nmr spectroscopy, protein nmr, public speaking, python programming, sparse data, structural biology, structure determination, teaching, web design, web development, web programming, Wishart group, hybrid data, SAXS, WAXS, X-ray crystallography, FRET, CryoEM, EPR, Mass Spectrometry
Pharmaceutical Inorganic chemistry UNIT-V Radiopharmaceutical.pptx
Isotopes Types of decay
Alpha rays, which could barely penetrate a piece of paper
Beta rays, which could penetrate 3 mm of aluminium
Gamma rays, which could penetrate several centimetres of lead
Units of Radioactivity:
Measurement of Radioactivity
The measurement of nuclear radiation and detection is an important aspect in the identification of type of radiations (, , ) and to assay the radionuclide emitting the radiation, suitable detectors are required. The radiations are identified on the basis of their properties.
e.g. Ionization effect is measured in Ionization Chamber, Proportional Counter and Geiger Muller Counter.
The scintillation effect of radiation is measured using scintillation detector and the photographic effect is measured by Autoradiography.
Gas Filled Detectors:
Ionization Chamber:
Proportional Counters:
Geiger-Muller Counter
Properties of α, β, γ radiations
Half –life of Radioelement
Sodium Iodide (I131)
Handling and Storage of Radioactive Material:
Storage of Radioactive Substances –
Precautions For Handling Radioactive Substances
Labelling of Radioactive Substances
Pharmaceutical Application Of Radioactive Substances
Complete detail about the Radiopharmaceutical, General Introduction, Radioactive substance, Radioactive rays like alpha, beta and gamma rays. All the Measurement method to determine the radioactivity of any element and widely used instrument Geiger Muller Counter. And some Radiopharmaceutical product used in many diagnosis , treatment such like sodium iodide solution & capsule, Rose Bengal I 131 and Application of Radiopharmaceuticals.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
2. Types of detectors
• Gas-filled detectors consist of a volume of gas
between two electrodes
• In scintillation detectors, the interaction of
ionizing radiation produces UV and/or visible
light
• Semiconductor detectors are especially pure
crystals of silicon, germanium, or other materials
to which trace amounts of impurity atoms have
been added so that they act as diodes
3. Types of detectors (cont.)
• Detectors may also be classified by the type of
information produced:
– Detectors, such as Geiger-Mueller (GM) detectors, that
indicate the number of interactions occurring in the
detector are called counters
– Detectors that yield information about the energy
distribution of the incident radiation, such as NaI
scintillation detectors, are called spectrometers
– Detectors that indicate the net amount of energy
deposited in the detector by multiple interactions are
called dosimeters
4. Modes of operation
• In pulse mode, the signal from each
interaction is processed individually
• In current mode, the electrical signals from
individual interactions are averaged
together, forming a net current signal
5. Interaction rate
• Main problem with detectors in pulse mode is that
two interactions must be separated by a finite
amount of time if they are to produce distinct
signals
• This interval is called the dead time of the system
• If a second interaction occurs in this interval, its
signal will be lost; if it occurs close enough to the
first interaction, it may distort the signal from the
first interaction
6. Dead time
• Dead time of a detector system largely determined
by the component in the series with the longest
dead time
– Detector has longest dead time in GM counter systems
– In multichannel analyzer systems the analog-to-digital
converter often has the longest dead time
• GM counters have dead times ranging from tens to
hundreds of microseconds, most other systems
have dead times of less than a few microseconds
7. Paralyzable or nonparalyzable
• In a paralyzable system, an interaction that
occurs during the dead time after a previous
interaction extends the dead time
• In a nonparalyzable system, it does not
• At very high interaction rates, a paralyzable
system will be unable to detect any
interactions after the first, causing the
detector to indicate a count rate of zero
8.
9. Current mode operation
• In current mode, all information regarding
individual interactions is lost
• If the amount of electrical charge collected from
each interaction is proportional to the energy
deposited by that interaction, then the net current
is proportional to the dose rate in the detector
material
• Used for detectors subjected to very high
interaction rates
10. Spectroscopy
• Most spectrometers operated in pulse mode
• Amplitude of each pulse is proportional to the
energy deposited in the detector by the interaction
causing that pulse
• The energy deposited by an interaction is not
always the total energy of the incident particle or
photon
• A pulse height spectrum is usually depicted as a
graph of the number of interactions depositing a
particular amount of energy in the spectrometer as
a function of energy
11.
12. Detection efficiency
• The efficiency (sensitivity) of a detector is a
measure of its ability to detect radiation
• Efficiency of a detection system operated in
pulse mode is defined as the probability that
a particle or photon emitted by a source will
be detected
13. Number detected
Efficiency =
Number emitted
Number reaching detector
Efficiency = ×
Number emitted
Number detected
Number reaching detector
Efficiency = Geometric efficiency × Intrinsic efficiency
14.
15. Intrinsic efficiency
• Often called the quantum detection efficiency or
QDE
• Determined by the energy of the photons and the
atomic number, density, and thickness of the
detector
• For a a parallel beam of monoenergetic photons
incident on a detector of uniform thickness:
− µx
Intrinsic efficiency = 1 - e
16. Gas-filled detectors
• A gas-filled detector consists of a volume of gas
between two electrodes, with an electrical
potential difference (voltage) applied between the
electrodes
• Ionizing radiation produces ion pairs in the gas
• Positive ions (cations) attracted to negative
electrode (cathode); electrons or anions attracted
to positive electrode (anode)
• In most detectors, cathode is the wall of the
container that holds the gas and anode is a wire
inside the container
17.
18. Types of gas-filled detectors
• Three types of gas-filled detectors in common use:
– Ionization chambers
– Proportional counters
– Geiger-Mueller (GM) counters
• Type determined primarily by the voltage applied
between the two electrodes
• Ionization chambers have wider range of physical
shape (parallel plates, concentric cylinders, etc.)
• Proportional counters and GM counters must have
thin wire anode
19.
20. Ionization chambers
• If gas is air and walls of chamber are of a material
whose effective atomic number is similar to air,
the amount of current produced is proportional to
the exposure rate
• Air-filled ion chambers are used in portable
survey meters, for performing QA testing of
diagnostic and therapeutic x-ray machines, and are
the detectors in most x-ray machine phototimers
• Low intrinsic efficiencies because of low densities
of gases and low atomic numbers of most gases
21.
22. Proportional counters
• Must contain a gas with specific properties
• Commonly used in standards laboratories,
health physics laboratories, and for physics
research
• Seldom used in medical centers
23. GM counters
• GM counters also must contain gases with specific
properties
• Gas amplification produces billions of ion pairs
after an interaction – signal from detector requires
little amplification
• Often used for inexpensive survey meters
• In general, GM survey meters are inefficient
detectors of x-rays and gamma rays
• Over-response to low energy x-rays – partially
corrected by placing a thin layer of higher atomic
number material around the detector
24.
25.
26. GM counters (cont.)
• GM detectors suffer from extremely long dead
times – seldom used when accurate measurements
are required of count rates greater than a few
hundred counts per second
• Portable GM survey meter may become paralyzed
in a very high radiation field – should always use
ionization chamber instruments for measuring
such fields
27. Scintillation detectors
• Scintillators are used in conventional film-screen
radiography, many digital radiographic receptors,
fluoroscopy, scintillation cameras, most CT
scanners, and PET scanners
• Scintillation detectors consist of a scintillator and
a device, such as a PMT, that converts the light
into an electrical signal
28. Scintillators
• Desirable properties:
– High conversion efficiency
– Decay times of excited states should be short
– Material transparent to its own emissions
– Color of emitted light should match spectral sensitivity
of the light receptor
– For x-ray and gamma-ray detectors, µ should be large –
high detection efficiencies
– Rugged, unaffected by moisture, and inexpensive to
manufacture
29. Scintillators (cont.)
• Amount of light emitted after an interaction
increases with energy deposited by the
interaction
• May be operated in pulse mode as
spectrometers
• High conversion efficiency produces
superior energy resolution
30. Materials
• Sodium iodide activated with thallium
[NaI(Tl)], coupled to PMTs and operated in
pulse mode, is used for most nuclear
medicine applications
– Fragile and hygroscopic
• Bismuth germanate (BGO) is coupled to
PMTs and used in pulse mode as detectors
in most PET scanners
31. Photomultiplier tubes
• PMTs perform two functions:
– Conversion of ultraviolet and visible light
photons into an electrical signal
– Signal amplification, on the order of millions to
billions
• Consists of an evacuated glass tube
containing a photocathode, typically 10 to
12 electrodes called dynodes, and an anode
32.
33.
34. Dynodes
• Electrons emitted by the photocathode are
attracted to the first dynode and are accelerated to
kinetic energies equal to the potential difference
between the photocathode and the first dynode
• When these electrons strike the first dynode, about
5 electrons are ejected from the dynode for each
electron hitting it
• These electrons are attracted to the second dynode,
and so on, finally reaching the anode
35. PMT amplification
• Total amplification of the PMT is the product of
the individual amplifications at each dynode
• If a PMT has ten dynodes and the amplification at
each stage is 5, the total amplification will be
approximately 10,000,000
• Amplification can be adjusted by changing the
voltage applied to the PMT