The document outlines the history and development of Mediso, a company specializing in nuclear medicine and imaging technologies, including various gamma camera systems and hybrid imaging solutions. It details significant milestones from its foundation in 1990 through 2008, highlighting innovations like the production of the first Mediso gamma camera and advancements in preclinical imaging systems. Additionally, it describes the extensive product line, including the Nucline™ gamma camera family and other imaging technologies, as well as Mediso's global sales presence and service network.

1. MEDISO COMPANY PORTFOLIO 2008

2. HISTORY Foundation of Gamma Works 1943 George Hevesy receives Nobel Price for developing the theory of In Vivo Tracer Techniques 1960 Gamma works formed the nuclear equipment manufacturing profile 1972 The Gamma Works first NM imaging system with digital data processing 1983 The founder of MEDISO joins the Gamma Works 1990 Foundation of MEDISO THE ROLE OF HUNGARIAN SCIENCE AND INDUSTRY IN THE FORMATION OF NUCLEAR MEDICINE

3. FOUNDATION OF MEDISO 1994 Manufacturing of the first MEDISO gamma camera 199 8 MEDISO acquires the Nuclear Medicine department of Gamma Works, the dominant experts and employees of Gamma Works joined MEDISO 2006 Production of the first MEDISO preclinical SPECT-CT 2007 Production of the first MEDISO human SPECT-CT 2007 MEDISO acquires the PET-CT Ltd .

4. INTRODUCTION OF MEDISO Research Development Manufacturing Sales Services MEDISO IS 100% PRIVATELY OWNED COMPANY Profile: human-diagnostic and preclinical imaging system -

5. MEDISO RECENT PRODUCT LINES Now MEDISO has t he broadest range of molecular imaging devices Nucline ™ gamma camera family Planar line Universal line Dedicated line Human line SPECT-CT-PET SPECT-CT PET-CT Preclinical line Small-animal SPECT-CT Small-animal PET-C OTHER PRODUCTS Upgrade kits for equipment of other manufacturers Clinical software INTERVIEW  SPECT RECONSTRUCTION IMAGING SYSTEM INTERVIE W XP INTERVIEW FUSION Hybrid CT TM family

6. Nucline ™ GAMMA CAMERA FAMILY Planar line Universal line MEDISO PRODUCT RANGE: more than 10 types (planar and dedicated gamma camera, SPECT,) modular-system design (detector, data acquisition console, gantry motion, patient table) TH AP-R (HR), AP-C X-Ring-R (HR), C SPIRIT DH-V

7. Nucline ™ GAMMA CAMERA FAMILY BEST SPATIAL RESOLUTION AVAILABLE IN THE INDUSTRY AT PRESENT typical value: 2.0 mm and 2.6 mm The same high resolution detector-technique in all models (optics, imaging electronics, software) Easy, quick and inexpensive service, due to the integrated service modules (Easy-Box technology) Dedicated line X-Ring-4R Brain Studies Cardio DESK Cardiac Studies

8. Nucline ™ GAMMA CAMERA FAMILY Digital high resolution small FOV gamma c amera Nucline ™ TH for thyroid, heart, mamma and small organ imaging Planar line available with 3 different FOV detectors (22-33-45 high quantum efficiency PMTs) NEMA Specifications: FOV: 180x180 / 230x215 / 270x270 mm intrinsic spatial resolution: 2.5 - 3.9 mm micro cast collimators: LEGP, LEHR, special collimators for thyroid, pinhole isotopes: 99m Tc and 131 I

9. Nucline ™ GAMMA CAMERA FAMILY Digital all purpose rectangular and circular large FOV gamma camera Nucline ™ AP-R (HR), AP-C for all conventional imaging Planar line NEMA Specifications: FOV: 530x390 mm (AP-C FOV:  380 mm) intrinsic spatial resolution: 3.4 - 4.1 mm

10. Nucline ™ GAMMA CAMERA FAMILY Multipurpose single-head rectangular and circular large FOV gamma camera Nucline ™ X-Ring-R (HR), C for all SPECT, whole body and planar imaging Universal line flexible usage outstanding COR parameters NEMA Specifications: FOV: 530x390 mm (X-Ring/C:  380 mm) intrinsic spatial resolution: 3.4 - 3.9 mm

11. RECOGNITIONS, PRIZES Nucline ™ X-Ring-R (HR) Special Prize for Excellence of Industrial Design Award (1998) Universal line

12. Nucline ™ GAMMA CAMERA FAMILY Variable angle dual-head large FOV universal gamma camera Nucline ™ Spirit DH-V for high precision and high throughput SPECT and WB imaging Universal line extra large rectangular FOV - 530x390 mm outstanding intrinsic spatial resolution <3.6 mm variable detector angles (180 o , 102 o or 90 o ) minimal room layout (300x400 cm) special robotic cables high reliability, lifetime warranty dual-line infrared auto body contour minimal patient table height: 59 cm

13. RECOGNITIONS, PRIZES Nucline ™ Spirit DH-V Special Prize for Excellence of Industrial Design Award ( 2002 ) Universal line Innovation Prize of Ministry of Economy and Transport ( 2002 )

14. Nucline ™ GAMMA CAMERA FAMILY Hyper resolution four-head dedicated small FOV SPECT camera Nucline ™ X-Ring-4R (HR) for brain, newborn babies and small animal imaging Dedicated line 33 PMTs/detector (60 PMTs/detector in the High Resolution model) 230x215 mm UFOV intrinsic spatial resolution: 2. 6 mm (HR: 2.0 mm) 1

15. RECOGNITIONS, PRIZES Nucline ™ X-Ring-R (HR) Certificate of merits - Excellence of Industrial Design Competition ( 2001 ) Dedicated line

16. Nucline ™ GAMMA CAMERA FAMILY Fixed 90 o geometry dual-head gamma c amera with outstanding spatial resolution Nucline ™ CardioSpect D90 f or dedicated SPECT studies of heart, brain and small organs Dedicated line NEMA Specifications : FOV: 370x210 mm i ntrinsic s patial r esolution : typical value 2.6 mm

17. Nucline ™ GAMMA CAMERA FAMILY Dual-head dedicated SPECT camera for cardiac studies Nucline ™ Cardio-C Dedicated line intrinsic spatial resolution: typical value 2.6 mm UFOV: 3 7 0x210 mm open, C-shaped tomographic gantry: accommodates patient comfort ease and speed of patient positioning internally mounted dual detectors: enhanced patient safety compact and simple design: minimal footprint and small weight full coverage of cardiac applications high patient throughput easy installation: up and running fast, minimal scheduling lead times

18. Nucline ™ GAMMA CAMERA FAMILY Dual-head Cardiac SPECT Camera Nucline ™ Cardio DESK Dedicated line intrinsic spatial resolution: typical value 2.6 mm UFOV: 3 7 0x210 mm art of integration - the most compact design and ergonomics with smallest footprint imaging in comfortable sitting (non-rotating) position internally mounted dual detectors: enhanced patient safety DVD player for diverting the attention of the patient ease of operation: touch screen monitor high patient throughput

19. Hybrid CT TM FAMILY CT SPECT PET* IMAGING TABLE * Work in progress DHV/CT triple modality system Human line

20. Hybrid CT TM FAMILY IMAGING TABLE DUAL-HEAD SPECT 16-SLICE CT PET/CT* DHV/CT Triple Modality System components flexible, modular system installed system may be extended or split later dual path molecular imaging high precision anatomical imaging * Work in progress OR Human line

21. Hybrid CT TM FAMILY DHV/CT specification of SPECT Ultrahigh performance digital detector DUAL HEAD SPECT * High Performance ** Ultrahigh Performance Human line Detector FOV: 585 x 470 mm Nal (TI) crystal 9.5, (12.5,15.9 mm) No. of PMT: 55 or 59 pcs Shielding: 12- 32 mm lead PMT auto-tuning for gain stabilisation HP* and UHP** detector range NEMA Specifications HP* UHP* * Size of detector FOV: 530 x 390 mm Energy range: 40–600 keV Intrinsic energy resolution for 99m Tc: 9.7% 9.5% Intrinsic Flood Field Uniformity differential CFOV: 1.9% 1.4% differential UFOV: 2.4% 1.9% integral CFOV: 2.4% 1.9% integral UFOV: 2.9% 2.4%

22. Hybrid CT TM FAMILY DUAL HEAD SPECT * High Performance ** Ultrahigh Performance DHV/CT specification of SPECT NEMA specifications Human line NEMA Specifications HP* UHP* * Intrinsic Spatial Resolution: CFOV (FWHM) 3.6 mm 3.1 mm CFOV (FWTM) 7.2 mm 6.1 mm UFOV (FWHM) 3.7 mm 3.2 mm UFOV (FWTM) 7.4 mm 6.2 mm Intrinsic Spatial Linearity differential CFOV: 0.18 mm 0.09 mm differential UFOV: 0.20 mm 0.10 mm absolute CFOV: 0.38 mm 0.28 mm absolute UFOV: 0.40 mm 0.30 mm System Spatial Resolution with LEHR collimator: (FWHM) 7.3 mm 7.2 mm (FWTM) 13.9 mm 13.4 mm Max. count rate with full correction: >0.5 Mcps System sensitivity (with LEHR collimator): 160 cpm/mCi

23. Hybrid CT TM FAMILY DHV/CT technical specification of CT module 16-SLICE CT * Optional Human line CT Gantry Patient aperture: 70 cm Scan field of view: 50 cm Acquisition times 360 o : 0.4*, 0.5, 0.7, 1, 1.5, 2 sec X-ray Generator Max power: 60 kW Max tube Voltage: 140 kVp Max tube current: 500 mA Detector Ceramic detector: 24 x 896 elements Rows: 16 Width: 20 mm at iso-centre Image reconstruction matrix: 512 x 512 Scan Parameters Acquired slice thickness: 16 rows of 0.625 or 1.25 mm Displayed slice thickness: 0.625, 1.25, 2.5 , 3.75, 5, 7.5, 10 mm

24. Hybrid CT TM FAMILY PET*(CT) More alternatives for all modalities … … in all modalities the best parameters ! Molecular PET Imager module High resolution LYSO detector technology High precision digital imaging electronics Selectable FOV for higher sensitivity * Work in progress Human line DHV/CT preliminary specification of PET * Field Of View (FOV) 12 cm 16 cm 24 cm Relative Sensitivity x 1 x 1.75 x 3.3

25. Hybrid CT TM FAMILY DHV/CT specification of Imaging Table Universal patient table for all modalities IMAGING TABLE Carbon fibre table top Length: 2580 – 6180 mm Width: 670 mm Height: 450 – 850 mm Weight: 3 5 0 kg Max. patient weight: 2 2 9 kg Axial motion range: 3600 mm ( 2000 mm + 1600 mm ) Horizontal motion speed: max. 15 cm/sec Human line

26. Hybrid CT TM FAMILY DHV-SPECT FIELDS OF APPLICATION Extra large rectangular FOV Outstanding intrinsic spatial resolution Variable detector angles Dual line infrared auto body contour Latest robot technology electronic design Human line

27. Hybrid CT TM FAMILY SPECT/CT FIELDS OF APPLICATION Diagnostic CT capability Attenuation correction Enhanced patient comfort Excellent industrial design Human line

28. SPECT/CT IMAGES CLINICAL APPLICATIONS (SPECT/CT) 56 years old female, 131 I therapy monitoring, 3D visualisation 68 years old female, Abdominal 111 In-octreotide (120MBq) study 47 years old female, Parathyroid scan, 99m Tc-MIBI (370MBq) 54 years old male, Bone scan, 99m Tc-MDP (800MBq) 53 years old male, Cardiac perfusion scan: AC vs. no AC, 99m Tc-MIBI (550MBq) 63 years old female, Lung scan, 99m Tc-depreotide (740MBq) Human line

29. Hybrid CT TM FAMILY PET/CT* FIELDS OF APPLICATION Whole body PET/CT Diagnostic CT capability Attenuation correction Excellent industrial design * Work in progress Human line

30. ADD- ON UPGRADE PATH PET* (third purchase ) SPECT (first purchase ) + = SPECT-CT SPECT-CT-PET* CT (second purchase ) + + * Work in progress Human line

31. SPLITTING UPGRADE PATH GENERAL NUCLEAR MEDICINE DEPARTMENT SPECT-CT-PET* (first purchase ) IMAGING TABLE (later purchase) 8 PET /CT + 8 SPECT /CT = 16 examinations in one shift Possibilities for performing more examinations: Decide on a second shift Purchase a n additional imaging table and have a SPECT and a PET -CT in separate rooms PET/CT* ( in a separate room ) = SPECT + * Work in progress Human line

32. SYSTEM COMBINATIONS SPECT SPECT-CT SPECT-CT-PET* PET-CT* * Work in progress Human line

33. NanoSPECT/CT ® 4-detector multi-pinhole dedicated SPECT-CT for pre-clinical small-animal examinations biotechnological research pharmacological research Ultrahigh SPECT resolution: <0 . 4 mm Ultrahigh CT resolution: < 0 . 05 mm Preclinical line

34. PRE-CLINICAL IMAGES PRECLINICAL APPLICATIONS (SMALL ANIMAL SPECT/CT) Rat, 111 In-Octreotide (0.9mCi) 3h p.i., 35mins scan ( Courtesy of M. De Jong , E rasmus MC, Rotterdam ) Scid mouse, Liver scan 99m Tc-Colloid (1mCi), 1h p.i., 10mins scan Mouse, Funcional liver scan 125 I-GSA (150 μ Ci), 20mins p.i. 30mins scan ( Courtesy of Dr. H. Fujii and Dr. Y. Kojima, National Cancer Center East, Japan ) Nude mouse, Benzodiazepin-receptor imaging 125 I-Iomazenil (300μCi), 35mins scan ( Courtesy of Dr. H. Fujii and Dr. Y. Kojima, N CC East, Japan ) Rat, Brain perfusion imaging 99m Tc-HMPAO (1.5mCi), 1h p.i., 45mins scan (C ourtesy of J. Norenberg, University of New Mexico , USA) Rat lung , Perfusion imaging 99m Tc-MAA ( 1mCi ), 30min p .i., 15mins scan ( Courtesy of M. De Jong , E rasmus MC, Rotterdam ) Mouse Dual isotope study 99m Tc-MIBI (1mCi) 123 I (100 μ Ci) (Courtesy of University of New Mexico, USA) Mouse head CT, Volume rendering 45kV, 177 μ A, 3mins scan Preclinical line

35. RECOGNITIONS, PRIZES NanoSPECT/CT ® in vivo system for small animal examination 2006. Grand Prize For Innovation 2007. Special Prize of Hungarian Industrial Design Award–National Institution of Research and Technology

36. Hybrid CT TM FAMILY MEDISO PRE-CLINICAL PET-CT, CT AniScan PET/CT, CT dedicated PET -CT for pre-clinical small-animal examinations biotechnological research pharmacological research Ultrahigh PET resolution: < 1.2 mm Ultrahigh CT resolution: < 0 . 05 mm Preclinical line

37. MEDISO SALES MEDISO DISTRIBUTED 600 + CAMERAS IN MORE THAN 70 COUNTRIES OF THE WORLD UNTIL THE YEAR 2008 MEDISO SALES CHANNELS Sales Department at MEDISO Foreign distributors by contract Two MEDISO Distributor Offices abroad Poland : MEDISO P olska , Ł ódz Germany : MEDISO GmbH, L aer GmbH, Laer

39. MEDISO SERVICE SERVICE NETWORK FOR MEDISO PRODUCTS Installation Application training Periodic check-ups Telediagnosis

40. PET-CT Ltd. MEDISO provides : T he new Nuclear Medicine C entre Continuous renewal of equipment 64-slice high resolution TOF PET-CT was installed i n Debrecen Centre in 2007 THE PET-CT MEDICAL DIAGNOSTIC Ltd. FROM 2007 JANUARY 100 % OWNED BY MEDISO The PET-CT Ltd. operates two medical centres: University of Debrecen Medical and Health Science Centre PET-CT and Nuclear Medicine Centre Budapest OITI PET-CT Centre

41. PET-CT Ltd. Being directly involved in the nuclear medicine services, direct experience and information feedback are helping MEDISO in the research and improvement of the new products