This document discusses inflammation in coronary artery plaques and its relationship to vulnerable plaques. It reports that: 1) Inflammation is common in deeper layers of atherosclerotic plaques and is associated with lipid content but not necessarily plaque rupture. 2) Patients with unstable angina tend to have evidence of widespread coronary inflammation, not just at the culprit lesion, suggesting vulnerable plaques may form throughout the arteries. 3) Given that vulnerable patients often have many inflamed plaques, targeting a single coated stent to one region may not be sufficient as a treatment approach for reducing acute coronary events risk.