System on a Chip (SoC) refers to integrating all components of an electronic system onto a single integrated circuit. A typical SoC contains a processor core, memory blocks, peripherals, and interfaces. Examples of SoCs discussed are the MAESTRO multi-core processor and Xilinx Virtex FPGA, both of which provide significant computing power in a small package. NEPP is interested in SoCs because their smaller size and power consumption could benefit spacecraft, but validating their reliability in space is challenging due to their complexity. NEPP is working to understand SoC failure modes and develop qualification guidelines.