The document describes a protocol for using ultrasound to assess shock in patients. The protocol, called the "shock screen", is a 3-step process that involves scanning the lungs, heart, and inferior vena cava. An optional fourth step involves scanning other areas if the cause of shock remains unclear. The shock screen provides guidance on fluid resuscitation and helps exclude common causes of shock like pulmonary embolism or tamponade.
The document describes a modified BLUE protocol for evaluating breathless patients. It involves a 4-step ultrasound exam: 1) scanning the anterior lungs, 2) scanning the veins for DVT, 3) scanning the PLAPS (posterior lung) points, and 4) scanning the heart and IVC. Findings at each step help differentiate potential causes of breathlessness such as pneumothorax, pneumonia, pulmonary edema, or pulmonary embolism. The protocol is designed to rapidly identify or rule out life-threatening issues like PE but requires validation in broader clinical studies.
The document outlines a protocol called SESAME for using ultrasound during cardiac arrest. It involves a 3-step scan: 1) Obtain a single view of the heart to identify causes like PE, tamponade, or hypovolaemia. 2) Scan the anterior lung fields to identify pneumothorax. 3) Optionally scan structures like the IVC or abdomen to investigate other potential causes like blood loss. The goal is to rapidly identify reversible causes that could guide treatment and improve outcomes during ongoing resuscitation efforts.
This document provides an overview of lung ultrasound scanning techniques and findings. It discusses how to optimize scanner settings and probe positioning for lung scans. Key scanning points on the chest are described, including the BLUE and PLAPS points. Normal lung appearances and artifacts are explained. Pathological findings covered include pleural fluid, B-lines indicating interstitial syndrome, the lung sliding sign, and alveolar consolidation. The document emphasizes comparing both sides of the chest and using M-mode to help diagnose a pneumothorax based on the absence of lung sliding and B-lines.
1. Critical care ultrasound can rapidly diagnose conditions in critically ill patients to guide treatment when other diagnostic tests are unavailable or too slow.
2. A case example is presented of a patient presenting with breathing difficulties where ultrasound identified a massive pulmonary embolism when other tests were inconclusive or too slow.
3. The key applications of critical care ultrasound are a quick scan of the lungs, inferior vena cava, and heart to assist diagnosis and resuscitation in unstable patients.
Compression ultrasound of the legs can detect deep vein thrombosis (DVT). Key sites to compress include the femoral vein in the groin, the femoral vein just above the knee, and the below knee veins which can be visualized from the front of the leg between the tibia and fibula. Compressing the veins and looking for non-compressibility is the gold standard for diagnosing DVT on ultrasound. Scanning multiple sites increases sensitivity but can be more irritating for patients.
Ultrasound is a useful screening tool for the lungs but has limitations. An 8-view ultrasound exam of the lungs can detect extravascular lung water seen as B lines originating from the pleural line. While a normal exam has evenly spaced A lines, more than 2 B lines in any view outside the lung bases indicates abnormality. Ultrasound has good sensitivity and specificity for detecting diffuse lung abnormalities compared to chest x-ray, but can miss localized findings and has a 15% error rate in certain conditions like fibrosis or resolving illnesses.
To be expert in practicing Lung Ultrasound or even Teaching, you need to understand very easy core concept which I put in this slide.
It include A and B line, major two signs of Lung Ultrasounds.
It doesnot include Pneumothoax, how to differentiate CHF vs ARDS.
Presentation on utility of ultrasound in the arena of prehospital and retrieval medicine.
I intentionally strayed away from e-FAST & focussed more on the ongoing resuscitation of a medically shocked patient.
The document describes a modified BLUE protocol for evaluating breathless patients. It involves a 4-step ultrasound exam: 1) scanning the anterior lungs, 2) scanning the veins for DVT, 3) scanning the PLAPS (posterior lung) points, and 4) scanning the heart and IVC. Findings at each step help differentiate potential causes of breathlessness such as pneumothorax, pneumonia, pulmonary edema, or pulmonary embolism. The protocol is designed to rapidly identify or rule out life-threatening issues like PE but requires validation in broader clinical studies.
The document outlines a protocol called SESAME for using ultrasound during cardiac arrest. It involves a 3-step scan: 1) Obtain a single view of the heart to identify causes like PE, tamponade, or hypovolaemia. 2) Scan the anterior lung fields to identify pneumothorax. 3) Optionally scan structures like the IVC or abdomen to investigate other potential causes like blood loss. The goal is to rapidly identify reversible causes that could guide treatment and improve outcomes during ongoing resuscitation efforts.
This document provides an overview of lung ultrasound scanning techniques and findings. It discusses how to optimize scanner settings and probe positioning for lung scans. Key scanning points on the chest are described, including the BLUE and PLAPS points. Normal lung appearances and artifacts are explained. Pathological findings covered include pleural fluid, B-lines indicating interstitial syndrome, the lung sliding sign, and alveolar consolidation. The document emphasizes comparing both sides of the chest and using M-mode to help diagnose a pneumothorax based on the absence of lung sliding and B-lines.
1. Critical care ultrasound can rapidly diagnose conditions in critically ill patients to guide treatment when other diagnostic tests are unavailable or too slow.
2. A case example is presented of a patient presenting with breathing difficulties where ultrasound identified a massive pulmonary embolism when other tests were inconclusive or too slow.
3. The key applications of critical care ultrasound are a quick scan of the lungs, inferior vena cava, and heart to assist diagnosis and resuscitation in unstable patients.
Compression ultrasound of the legs can detect deep vein thrombosis (DVT). Key sites to compress include the femoral vein in the groin, the femoral vein just above the knee, and the below knee veins which can be visualized from the front of the leg between the tibia and fibula. Compressing the veins and looking for non-compressibility is the gold standard for diagnosing DVT on ultrasound. Scanning multiple sites increases sensitivity but can be more irritating for patients.
Ultrasound is a useful screening tool for the lungs but has limitations. An 8-view ultrasound exam of the lungs can detect extravascular lung water seen as B lines originating from the pleural line. While a normal exam has evenly spaced A lines, more than 2 B lines in any view outside the lung bases indicates abnormality. Ultrasound has good sensitivity and specificity for detecting diffuse lung abnormalities compared to chest x-ray, but can miss localized findings and has a 15% error rate in certain conditions like fibrosis or resolving illnesses.
To be expert in practicing Lung Ultrasound or even Teaching, you need to understand very easy core concept which I put in this slide.
It include A and B line, major two signs of Lung Ultrasounds.
It doesnot include Pneumothoax, how to differentiate CHF vs ARDS.
Presentation on utility of ultrasound in the arena of prehospital and retrieval medicine.
I intentionally strayed away from e-FAST & focussed more on the ongoing resuscitation of a medically shocked patient.
The document describes the RUSH (Rapid Ultrasound in SHock) exam, a 3-step shock ultrasound protocol to rapidly evaluate patients in shock. Step 1 is evaluation of the pump (heart) using focused echocardiography to check for pericardial effusions, assess left ventricular contractility, and compare right and left ventricular sizes. Step 2 evaluates the tank (intravascular volume status) by examining the inferior vena cava size and respiratory changes, jugular veins, lungs, and abdomen. Step 3 evaluates the pipes (arteries and veins) for aneurysms, dissections, and deep vein thromboses. The goal is a quick bedside assessment of the cause of shock to guide initial
Ultrasound has many useful applications in critical care. It can reinvigorate the physical exam by providing valuable information about patients with limited mobility. Basic ultrasound skills should be part of critical care training, as brief training allows intensivists to perform limited transthoracic echocardiography and change patient management in many cases. Ultrasound is portable, avoids radiation, and can be repeated as needed at the bedside. It is useful for diagnosing problems like venous thrombosis, pulmonary diseases, and acute respiratory failure. The BLUE protocol allows rapid ultrasound evaluation of the lungs. Bedside echocardiography also has applications in critical care for assessing hemodynamics, infections, and postoperative complications.
This document discusses the use of point-of-care ultrasound in emergency and critical care settings. It provides an overview of using ultrasound to diagnose pneumothorax, pulmonary edema, and other conditions. Examples are given of ultrasound findings for a pneumothorax including the lack of lung sliding and presence of a lung point. Signs of pulmonary edema on ultrasound include A-lines and B-lines. The document emphasizes that ultrasound is a rapid, noninvasive tool that can help clinicians diagnose and treat patients, but should be used along with medical history, exams, and clinical judgment.
Point of critical care Ultrasound play a pivotal role in management of critically ill patients admitted in ICU . Its usage in this regard is ever growing . Here we discus about pearls and pitfalls of POCUS in Intensive care medicine.
This document discusses two cases of totally anomalous systemic venous connection (TASVC). TASVC is an extremely rare condition where all systemic veins connect to the morphologically left atrium rather than the right atrium. The document aims to clarify the anatomy, physiology, and hemodynamics of this rare anomaly. It describes the findings and management of two patients diagnosed with TASVC through various imaging modalities. The document also seeks to resolve inconsistencies in previous descriptions of TASVC, especially in settings of isomeric atrial appendages or heterotaxy.
Ultrasonography in Critically Ill PatientsGamal Agmy
This document discusses the use of chest sonography in critically ill patients. It notes that bedside chest radiography has limitations in critically ill patients. Chest sonography can help diagnose various lung conditions at the bedside including pulmonary consolidation, atelectasis, edema, effusions, and pneumothorax. It reviews the sonographic signs and patterns associated with these conditions. The document also discusses using lung ultrasound and IVC views to assess shock states and guide treatment. Overall, it promotes the use of bedside lung ultrasound as a valuable tool to complement radiography in critically ill patients.
Ultrasound can be useful in the evaluation and diagnosis of patients presenting in shock. Integrating bedside ultrasound allows for a more accurate initial diagnosis and earlier treatment. The RUSH protocol assesses the heart, IVC, pericardial space and lungs to help classify the type of shock. Ultrasound findings of a dilated and collapsing IVC along with evidence of free fluid suggest the patient has hypovolemic shock likely due to internal bleeding.
This document discusses the use of echocardiography during cardiac arrest and peri-arrest situations. It provides an overview of basic echo views that can be useful. Echo can help identify the cause of arrest such as tamponade, pulmonary embolism, or wall motion abnormalities. Findings on echo such as hypovolaemia or myocardial activity can help guide management decisions. The document reviews where echo fits within the ACLS algorithm and issues surrounding its use during cardiac arrest. It provides examples of echo findings that may indicate treatable versus non-treatable causes of arrest.
Ultrasound has many advantages for critically ill patients in the ICU. It enables rapid, repeated, and inexpensive bedside evaluation. There are two main probe types: B-mode produces 2D images while M-mode shows motion over time, analogous to video. Ultrasound can assess volume status by measuring the diameter and collapse of the inferior vena cava. It can diagnose pneumothorax by lung sliding signs or stratosphere and seashore artifacts. Ultrasound is also used for vascular access, intubation, diaphragm assessment, and identifying pleural effusions and hemothorax. Critical care physicians should receive training to utilize ultrasound's benefits for critically ill patients.
This document provides an overview of capnography including:
1) The objectives of describing ventilation, perfusion, and their relationship as assessed by capnography.
2) A description of the normal capnogram waveform and factors that can cause abnormal waveforms related to airway, breathing, and circulation problems.
3) Clinical applications of capnography including confirming endotracheal tube placement, assessing ventilation status, and predicting outcomes of cardiac arrest resuscitation.
Central venous pressure (CVP) is the pressure measured in the central veins close to the heart and indicates right atrial pressure. CVP is measured using a catheter placed in a central vein that is connected to a manometer or pressure transducer. Normal CVP ranges from 1-7 mmHg or 5-10 cm H2O. CVP monitoring provides information about cardiac function and volume status and is used to guide fluid administration and assess patients' hemodynamic status. Complications of CVP monitoring include hemorrhage, pneumothorax, infection, and thrombosis.
Point of care ultrasound guided volume management in sepsis and complicated ...Tongtaa Lumlertgul
Presentation at APSR Australia sydney. Bedside ultrasound to assess volume status.
This topic cover pitfall in basic that mostly ignore by bedside ultrasound. WIthout doppler you can learn a lot for sepsis patient
with both good and bad ef.
You can download our application resus ultrasound on APP storre(free)
or visit https://www.facebook.com/resusultrasound/
Presentation at APSR Australia sydney. Bedside ultrasound to assess volume status.
This topic cover pitfall in basic that mostly ignore by bedside ultrasound. WIthout doppler you can learn a lot for sepsis patient
with both good and bad ef.
You can download our application resus ultrasound on APP storre(free)
or visit https://www.facebook.com/resusultrasound/
Apsr 2017 suthaporn lumlertgul
This document discusses thoracic ultrasound and provides guidance on its use. It outlines scanning zones and views that should be used in a focused exam, including the sagittal or coronal views and "bat view" to visualize the pleural line and rib shadows. Key signs of a pneumothorax are described, including the absence of lung sliding and seeing the lung point. The conclusion emphasizes the benefits of thoracic ultrasound and that pathology is rarely isolated, requiring consideration of artifacts and multiple signs.
Dr. Sivanand Patel presented on principles of transesophageal echocardiography (TEE). The presentation covered TEE imaging planes, 3D TEE, and case-based scenarios. Topics included techniques for obtaining standard views, such as adjusting the probe position and using four positions with 28 total views. TEE provides improved visualization of cardiac structures compared to transthoracic echocardiography and guides interventional procedures. Mastering TEE requires understanding three-dimensional orientation and gaining experience through practice.
1) Lung ultrasound is a useful technique for evaluating pulmonary conditions at the bedside with several advantages over other imaging modalities.
2) Normal lung ultrasound findings include lung sliding, the seashore sign, A-lines, and the lung pulse. Absence of lung sliding can indicate a pneumothorax.
3) B-lines appear as laser-like artifacts that arise from the pleural line and indicate excess fluid or interstitial syndrome. A higher number of B-lines correlates with decompensated heart failure.
1) The posterior-anterior (PA) view is the standard and most reliable technique for a chest x-ray. It allows detection of air under the diaphragm.
2) A lateral view helps localize infiltrates and evaluate the cardiomediastinal silhouette, effusions, and left atrial dilation.
3) An anterior-posterior (AP) view is used when a patient is too ill to be transported, but image quality is poorer and structures may appear enlarged compared to a PA view.
This document provides an overview of using ultrasound (ECHO/FOCUS) in the intensive care unit (ICU). It discusses using ultrasound to assess cardiac function, volume status, and diagnose medical emergencies at the bedside. Ultrasound can be used to monitor hemodynamics, fluid responsiveness, and detect issues like cardiac tamponade. The document reviews ultrasound views of the heart and techniques for assessing volume status using the inferior vena cava. It also discusses using chest ultrasound to identify pleural effusions, pneumothorax, consolidation and quantify pleural fluid. The summary provides a concise high-level view of the key applications and techniques discussed in the document.
Central venous pressure (CVP) is measured using an indwelling central venous catheter and manometer or transducer. CVP provides information about circulating blood volume and cardiac function. Normal CVP is 5-10 cm H2O. CVP is commonly measured in intensive care to guide fluid management in critically ill patients. Potential complications include infection, hemorrhage, catheter occlusion or displacement. Accurate CVP measurement requires proper patient positioning and use of manometers or transducers at the phlebostatic axis.
1) The document describes lung ultrasound findings for various lung conditions. Lung ultrasound can detect pneumothorax by the absence of lung sliding and evaluate interstitial syndrome by the presence of multiple B-lines.
2) It then discusses a study comparing the diagnoses of 301 ICU patients to their lung ultrasound findings using a standardized protocol. Common lung ultrasound findings and their sensitivity and specificity for different lung diseases are presented.
3) In summary, the document outlines the use of lung ultrasound to evaluate lung abnormalities and validate it as a diagnostic tool by comparing its findings to patient diagnoses in the ICU. Lung ultrasound can rapidly detect conditions like pneumothorax and interstitial syndrome.
Pulmonary artery catheterisation, Cardiac surgeries, Non cardiac surgeries, LVEDD and PA pressure relationship, Technique and complications of PA placement
Image Optimization for Critical Care Ultrasoundnswhems
This document provides guidance on optimizing ultrasound images for critical care applications. It discusses adjusting various image settings like depth, focal zones, harmonics and M-mode to improve image quality for assessing lungs, IVC, and heart. M-mode is recommended for measuring movement and dimensions more accurately than B-mode. The challenges of cardiac imaging are also covered, noting the need for higher frame rates and reduced averaging and spatial resolution to capture fast heart motion. Narrowing the sector width and decreasing depth can help optimize the cardiac image within these limits.
This document discusses shock, including the different types (hypovolemic, obstructive, distributive, cardiogenic), causes, signs and symptoms, stages of progression, and treatment. It emphasizes that shock can be life-threatening and care should not be delayed. The early signs of shock include restlessness, increased heart rate and breathing, and pale skin, while later signs include low blood pressure, slow heart rate, and loss of consciousness.
The document describes the RUSH (Rapid Ultrasound in SHock) exam, a 3-step shock ultrasound protocol to rapidly evaluate patients in shock. Step 1 is evaluation of the pump (heart) using focused echocardiography to check for pericardial effusions, assess left ventricular contractility, and compare right and left ventricular sizes. Step 2 evaluates the tank (intravascular volume status) by examining the inferior vena cava size and respiratory changes, jugular veins, lungs, and abdomen. Step 3 evaluates the pipes (arteries and veins) for aneurysms, dissections, and deep vein thromboses. The goal is a quick bedside assessment of the cause of shock to guide initial
Ultrasound has many useful applications in critical care. It can reinvigorate the physical exam by providing valuable information about patients with limited mobility. Basic ultrasound skills should be part of critical care training, as brief training allows intensivists to perform limited transthoracic echocardiography and change patient management in many cases. Ultrasound is portable, avoids radiation, and can be repeated as needed at the bedside. It is useful for diagnosing problems like venous thrombosis, pulmonary diseases, and acute respiratory failure. The BLUE protocol allows rapid ultrasound evaluation of the lungs. Bedside echocardiography also has applications in critical care for assessing hemodynamics, infections, and postoperative complications.
This document discusses the use of point-of-care ultrasound in emergency and critical care settings. It provides an overview of using ultrasound to diagnose pneumothorax, pulmonary edema, and other conditions. Examples are given of ultrasound findings for a pneumothorax including the lack of lung sliding and presence of a lung point. Signs of pulmonary edema on ultrasound include A-lines and B-lines. The document emphasizes that ultrasound is a rapid, noninvasive tool that can help clinicians diagnose and treat patients, but should be used along with medical history, exams, and clinical judgment.
Point of critical care Ultrasound play a pivotal role in management of critically ill patients admitted in ICU . Its usage in this regard is ever growing . Here we discus about pearls and pitfalls of POCUS in Intensive care medicine.
This document discusses two cases of totally anomalous systemic venous connection (TASVC). TASVC is an extremely rare condition where all systemic veins connect to the morphologically left atrium rather than the right atrium. The document aims to clarify the anatomy, physiology, and hemodynamics of this rare anomaly. It describes the findings and management of two patients diagnosed with TASVC through various imaging modalities. The document also seeks to resolve inconsistencies in previous descriptions of TASVC, especially in settings of isomeric atrial appendages or heterotaxy.
Ultrasonography in Critically Ill PatientsGamal Agmy
This document discusses the use of chest sonography in critically ill patients. It notes that bedside chest radiography has limitations in critically ill patients. Chest sonography can help diagnose various lung conditions at the bedside including pulmonary consolidation, atelectasis, edema, effusions, and pneumothorax. It reviews the sonographic signs and patterns associated with these conditions. The document also discusses using lung ultrasound and IVC views to assess shock states and guide treatment. Overall, it promotes the use of bedside lung ultrasound as a valuable tool to complement radiography in critically ill patients.
Ultrasound can be useful in the evaluation and diagnosis of patients presenting in shock. Integrating bedside ultrasound allows for a more accurate initial diagnosis and earlier treatment. The RUSH protocol assesses the heart, IVC, pericardial space and lungs to help classify the type of shock. Ultrasound findings of a dilated and collapsing IVC along with evidence of free fluid suggest the patient has hypovolemic shock likely due to internal bleeding.
This document discusses the use of echocardiography during cardiac arrest and peri-arrest situations. It provides an overview of basic echo views that can be useful. Echo can help identify the cause of arrest such as tamponade, pulmonary embolism, or wall motion abnormalities. Findings on echo such as hypovolaemia or myocardial activity can help guide management decisions. The document reviews where echo fits within the ACLS algorithm and issues surrounding its use during cardiac arrest. It provides examples of echo findings that may indicate treatable versus non-treatable causes of arrest.
Ultrasound has many advantages for critically ill patients in the ICU. It enables rapid, repeated, and inexpensive bedside evaluation. There are two main probe types: B-mode produces 2D images while M-mode shows motion over time, analogous to video. Ultrasound can assess volume status by measuring the diameter and collapse of the inferior vena cava. It can diagnose pneumothorax by lung sliding signs or stratosphere and seashore artifacts. Ultrasound is also used for vascular access, intubation, diaphragm assessment, and identifying pleural effusions and hemothorax. Critical care physicians should receive training to utilize ultrasound's benefits for critically ill patients.
This document provides an overview of capnography including:
1) The objectives of describing ventilation, perfusion, and their relationship as assessed by capnography.
2) A description of the normal capnogram waveform and factors that can cause abnormal waveforms related to airway, breathing, and circulation problems.
3) Clinical applications of capnography including confirming endotracheal tube placement, assessing ventilation status, and predicting outcomes of cardiac arrest resuscitation.
Central venous pressure (CVP) is the pressure measured in the central veins close to the heart and indicates right atrial pressure. CVP is measured using a catheter placed in a central vein that is connected to a manometer or pressure transducer. Normal CVP ranges from 1-7 mmHg or 5-10 cm H2O. CVP monitoring provides information about cardiac function and volume status and is used to guide fluid administration and assess patients' hemodynamic status. Complications of CVP monitoring include hemorrhage, pneumothorax, infection, and thrombosis.
Point of care ultrasound guided volume management in sepsis and complicated ...Tongtaa Lumlertgul
Presentation at APSR Australia sydney. Bedside ultrasound to assess volume status.
This topic cover pitfall in basic that mostly ignore by bedside ultrasound. WIthout doppler you can learn a lot for sepsis patient
with both good and bad ef.
You can download our application resus ultrasound on APP storre(free)
or visit https://www.facebook.com/resusultrasound/
Presentation at APSR Australia sydney. Bedside ultrasound to assess volume status.
This topic cover pitfall in basic that mostly ignore by bedside ultrasound. WIthout doppler you can learn a lot for sepsis patient
with both good and bad ef.
You can download our application resus ultrasound on APP storre(free)
or visit https://www.facebook.com/resusultrasound/
Apsr 2017 suthaporn lumlertgul
This document discusses thoracic ultrasound and provides guidance on its use. It outlines scanning zones and views that should be used in a focused exam, including the sagittal or coronal views and "bat view" to visualize the pleural line and rib shadows. Key signs of a pneumothorax are described, including the absence of lung sliding and seeing the lung point. The conclusion emphasizes the benefits of thoracic ultrasound and that pathology is rarely isolated, requiring consideration of artifacts and multiple signs.
Dr. Sivanand Patel presented on principles of transesophageal echocardiography (TEE). The presentation covered TEE imaging planes, 3D TEE, and case-based scenarios. Topics included techniques for obtaining standard views, such as adjusting the probe position and using four positions with 28 total views. TEE provides improved visualization of cardiac structures compared to transthoracic echocardiography and guides interventional procedures. Mastering TEE requires understanding three-dimensional orientation and gaining experience through practice.
1) Lung ultrasound is a useful technique for evaluating pulmonary conditions at the bedside with several advantages over other imaging modalities.
2) Normal lung ultrasound findings include lung sliding, the seashore sign, A-lines, and the lung pulse. Absence of lung sliding can indicate a pneumothorax.
3) B-lines appear as laser-like artifacts that arise from the pleural line and indicate excess fluid or interstitial syndrome. A higher number of B-lines correlates with decompensated heart failure.
1) The posterior-anterior (PA) view is the standard and most reliable technique for a chest x-ray. It allows detection of air under the diaphragm.
2) A lateral view helps localize infiltrates and evaluate the cardiomediastinal silhouette, effusions, and left atrial dilation.
3) An anterior-posterior (AP) view is used when a patient is too ill to be transported, but image quality is poorer and structures may appear enlarged compared to a PA view.
This document provides an overview of using ultrasound (ECHO/FOCUS) in the intensive care unit (ICU). It discusses using ultrasound to assess cardiac function, volume status, and diagnose medical emergencies at the bedside. Ultrasound can be used to monitor hemodynamics, fluid responsiveness, and detect issues like cardiac tamponade. The document reviews ultrasound views of the heart and techniques for assessing volume status using the inferior vena cava. It also discusses using chest ultrasound to identify pleural effusions, pneumothorax, consolidation and quantify pleural fluid. The summary provides a concise high-level view of the key applications and techniques discussed in the document.
Central venous pressure (CVP) is measured using an indwelling central venous catheter and manometer or transducer. CVP provides information about circulating blood volume and cardiac function. Normal CVP is 5-10 cm H2O. CVP is commonly measured in intensive care to guide fluid management in critically ill patients. Potential complications include infection, hemorrhage, catheter occlusion or displacement. Accurate CVP measurement requires proper patient positioning and use of manometers or transducers at the phlebostatic axis.
1) The document describes lung ultrasound findings for various lung conditions. Lung ultrasound can detect pneumothorax by the absence of lung sliding and evaluate interstitial syndrome by the presence of multiple B-lines.
2) It then discusses a study comparing the diagnoses of 301 ICU patients to their lung ultrasound findings using a standardized protocol. Common lung ultrasound findings and their sensitivity and specificity for different lung diseases are presented.
3) In summary, the document outlines the use of lung ultrasound to evaluate lung abnormalities and validate it as a diagnostic tool by comparing its findings to patient diagnoses in the ICU. Lung ultrasound can rapidly detect conditions like pneumothorax and interstitial syndrome.
Pulmonary artery catheterisation, Cardiac surgeries, Non cardiac surgeries, LVEDD and PA pressure relationship, Technique and complications of PA placement
Image Optimization for Critical Care Ultrasoundnswhems
This document provides guidance on optimizing ultrasound images for critical care applications. It discusses adjusting various image settings like depth, focal zones, harmonics and M-mode to improve image quality for assessing lungs, IVC, and heart. M-mode is recommended for measuring movement and dimensions more accurately than B-mode. The challenges of cardiac imaging are also covered, noting the need for higher frame rates and reduced averaging and spatial resolution to capture fast heart motion. Narrowing the sector width and decreasing depth can help optimize the cardiac image within these limits.
This document discusses shock, including the different types (hypovolemic, obstructive, distributive, cardiogenic), causes, signs and symptoms, stages of progression, and treatment. It emphasizes that shock can be life-threatening and care should not be delayed. The early signs of shock include restlessness, increased heart rate and breathing, and pale skin, while later signs include low blood pressure, slow heart rate, and loss of consciousness.
This document provides an overview of different types of shock, including definitions, signs and symptoms, diagnostic testing and treatment approaches. It discusses hypovolemic, cardiogenic, obstructive, septic, anaphylactic and neurogenic shock. For each type, it outlines the pathophysiology, causes, clinical presentation and goals of treatment, which generally involve stabilizing the patient and addressing the underlying condition causing low blood flow. The document emphasizes the importance of early recognition and intervention for shock.
Based on the details provided, the results of this study appear to be applicable and helpful for guiding treatment decisions for patients similar to those enrolled in the trial - namely, patients with moderate PE who are ineligible for full-dose thrombolysis. The treatment appears feasible and significantly reduced important clinical outcomes. As with any intervention, the risks and benefits for an individual patient should be considered.
This document discusses the identification and treatment of various types of shock states. It defines hypovolemic, distributive, cardiogenic, and septic shock and their clinical manifestations. Early diagnosis is key, involving history, physical exam assessing vital signs, perfusion, and urinary output. Treatment focuses on establishing airway, supplying oxygen, restoring circulating volume with fluids, and using vasopressors to improve cardiac output as needed based on the type and severity of shock. Children in particular can maintain blood pressure while showing signs of poor peripheral perfusion.
This document discusses the pathophysiology, classification, and management of shock. It defines shock and classifies it into four main categories: hypovolemic, cardiogenic, obstructive, and distributive shock. For each type, the document discusses causes, characteristics, hemodynamics, and clinical correlates. Key points include that distributive shock is most commonly septic shock, and hypovolemic shock is a major cause of early trauma mortality. The document also reviews the diagnosis and evaluation of shock, including clinical signs, laboratory tests, and invasive monitoring techniques. It outlines initial diagnostic and therapeutic steps for managing a patient in shock.
A Revised Algorithm for PEA Cardiac Arrest: Haney MallematSMACC Conference
Haney Mallemat discusses the treatment for PEA cardiac arrest.
Patients who present with pulseless electrical activity (PEA) arrest have a high mortality. The treatment of PEA requires finding and reversing the underlying cause; therefore a simple and rapid approach is required.
Traditionally we were taught to use the H’s and the T’s, but this diagnostic tool is cumbersome and of questionable utility overall.
Haney discusses the problems with the traditional H’s and T’s as well as focusing on newer approaches to PEA arrest. Haney makes the point that PEA is not a diagnosis, but a ‘waste basket term’ for a lot of possible diagnoses.
Rather than assisting a clinician in the assessment and treatment of a patient, it acts on to lead to pontification.
To that end, Haney wants us to do away with the H’s and T’s. The problem with the algorithm of diagnosing a PEA, as Haney explains, is the reliance on feeling a pulse. It lacks sensitivity and specificity, largely linked to using fingers.
They should not be used in resuscitation scenarios – as the guidelines say we should.
Haney makes the point that despite all the advances in medicine, resuscitation has stayed essentially the same for decades.
He describes two ways in which he thinks we can advance our care.
The first involves the QRS complex. Ask the question – is the QRS complex narrow or wide. Narrow (< 0.12 seconds) leads you to consider mechanical problems, such as tension pneumothorax or tamponade. If it is wide (> 0.12 seconds), then consider metabolic problems such as hypokalaemia.
If the QRS is narrow, and you are thinking a mechanical problem then there is electrical activity, and the heart is still beating underneath. The step should be to use ultrasound immediately to find the focused cause. If it is wide, and you are considering metabolic causes, this is more aligned with a true PEA. Calcium bicarbonate should be considered in the first instance.
Haney describes the limitations with the algorithm that includes the trauma patient or those with underlying cardiac conditions.
Next Haney describes a second algorithm - PREM (pulseless with rhythm and echo motion) and PRES (pulseless with a rhythm and echo standstill). The use of ultrasound is central to this pathway. In PREM the left ventricle is not strong enough to produce a pulse. Does this patient get adrenaline or chest compressions?
Haney discusses the options. In PRES there is electrical activity, but the heart is not squeezing. Maybe these people should get adrenaline and compressions!
The ECG should still play a part in this algorithm. Haney puts it all together for you and takes you through the algorithm he uses when faced with a patient with PEA.
He includes some tips for using the ultrasound probe during cardiac arrest resuscitation scenarios.
A Revised Algorithm for PEA Cardiac Arrest: Haney Mallemat
For more like this, head to our podcast page. #CodaPodcast
Shock is a condition where the cardiovascular system fails to adequately perfuse tissues. It can be caused by an impaired pump (cardiogenic shock), reduced circulating volume (hypovolemic shock), or maldistribution of blood flow (distributive shock). The main effects are cellular hypoxia, impaired metabolism, and organ damage or failure if not treated. Compensatory mechanisms aim to increase perfusion but eventually fail, leading to irreversible cellular damage and death if shock persists.
The document summarizes key points from PALS guidelines regarding the assessment and management of pediatric emergencies. It discusses the primary, secondary, and tertiary assessments using ABCDE/SAMPLE approaches. Signs of life-threatening conditions like airway obstruction, respiratory distress, and shock are outlined. The document also reviews recent PALS recommendations for compressions-to-ventilations ratios, use of cuffed endotracheal tubes, laryngeal mask airways, and exhaled CO2 detectors for confirming endotracheal tube placement.
Approach to child with congenital heart diseaseAnkur Puri
This document provides guidance on evaluating a child with congenital heart disease. It outlines key questions to answer, including whether the condition is cyanotic or acyanotic. A thorough history is important, including prenatal, natal, and postnatal details. A physical exam involves assessing vital signs, growth, precordial examination, palpation of pulses and thrills, and auscultation of heart sounds and murmurs. The goal is to characterize the nature and severity of the congenital heart condition.
Step wise approach to cchd in neonate and infancy oct 2020 pdfrajasthan govt
This document outlines a step-wise approach to diagnosing critical congenital heart disease (CCHD) in infants. It discusses:
1. Taking a thorough history, including signs like feeding difficulties, cyanosis, and increased breathing.
2. Performing a physical exam to check for cyanosis, respiratory rate, chest examination, and weight gain.
3. Using diagnostic tools like chest x-ray, ECG, and echocardiogram to evaluate the heart structure and blood flow.
4. Describing specific findings that may indicate CCHDs like Tetralogy of Fallot, like decreased pulmonary vasculature on x-ray.
5. Explaining additional tests
The document provides an overview and tutorial on atrial fibrillation (AF). It discusses how to assess and manage patients presenting with AF. Key points covered include classifying AF based on its pattern and duration, investigating AF, rate and rhythm control strategies, cardioversion procedures, and indications for anticoagulation. Management is tailored based on whether AF is paroxysmal, persistent, or permanent, with the overall goals being suppression of symptoms, maintaining adequate heart rate control, and preventing thromboembolic complications like stroke.
1) The document provides guidance on performing an initial assessment of a patient which includes rapidly evaluating the respiratory, circulatory and nervous systems to identify and treat any life-threatening conditions.
2) The assessment involves checking the patient's mental status, airway, breathing, circulation, and skin to evaluate condition and determine priority of care as either "stay and play" or "load and go".
3) Key assessments include checking alertness, breathing rate and effort, pulse, bleeding, temperature, skin color, and capillary refill to evaluate perfusion and oxygenation. Life-threatening issues are treated immediately and transportation priority is determined.
Advance life support refer to a constellation of interventions needed to support the vital physiological process during a critical illness, while we await response with definitive therapy. These life support measures are instituted to prevent cardiac arrest.
To recognise physiological derangements that arise out of multiple etiologies and stabilize them first.
EVALUATE – IDENTIFY – INTERVENE
The steps of evaluation are
1.Initial impression
2. Primary assessment
3. Secondary assessment
4. Diagnostic test
Gives insight to overall physiological status and functioning of the brain.
TICLS
Tone: Look for general posture of the child has adopted
Interactive: Is the child responsive and interacting appropriately, unresponsive or lethargic.
Consolable: Irritable, consolable or inconsolable
Look\Gaze: How is the child looking at mother, any vacant gaze
Speech: Is the child able to speak or vocalise as is appropriate for age or is there a paucity\weak\hoarseness of voice.
IDENTIFY = Abnormality in any of these parameters point towards a brain dysfunction
Impaired consciousness is a significant alteration in the awareness of self and environment with varying degree of wakefulness.
Unconsciousness persisting for at lest 1 hr – Coma.
Younger children more likely to have coma or altered sensorium secondary to non-traumatic etiology, where as traumatic brain injury is more common in older children.
Always rule out reversible causes of coma, like hypoglycemia, hyperglycaemia and electrolyte imbalance.
Any severe systemic illness can cause altered consciousness as a result of hypoxic ischemic insult, which if on-going can aggravate raised ICT.
This document provides guidance on performing a cardiovascular examination. It outlines the basic approach, including general observations, examination of pulses, blood pressure, eyes/face, neck, legs, and praecordium. Specific techniques are described for palpation, auscultation, and accentuating murmurs. Potential case scenarios involving aortic stenosis, mitral regurgitation, and aortic regurgitation are reviewed. The summary emphasizes performing the exam systematically and using any inability to detect findings as a learning opportunity.
The document provides details about a registrar training workshop final quiz on lung ultrasound. It includes 9 cases with ultrasound images of the right and left lungs and two possible chest x-ray images to choose from for each case. For each case, trainees are asked to identify their findings for each region of the lungs on ultrasound and choose the correct chest x-ray. The document also provides background information on common ultrasound lung findings like A-lines, B-lines, and hepatization.
This document discusses shock management and summarizes the key factors involved in assessing and treating shock. It outlines an approach to evaluating shock by looking at blood pressure, cardiac output, and systemic vascular resistance. Low systemic vascular resistance can be caused by sepsis, spinal cord injury, or vasodilators. Signs of low systemic vascular resistance include warm skin and a rapid heart rate. Low cardiac output may be due to low heart rate, low stroke volume, or factors affecting preload and contractility. The document then presents three case studies to demonstrate how these principles can be applied.
This document provides information on cardiovascular history taking and physical examination. It discusses important symptoms of heart disease like dyspnea, palpitations, edema, and chest pain. It also outlines the steps for examining arterial pulses, blood pressure, jugular venous pressure, auscultation of heart sounds, and palpation of the precordium. The physical exam aims to evaluate symptoms, risk factors, and detect any abnormalities that could indicate cardiac issues.
Assessment of circulation system by TUYIZERE DelphinDelphin12
This document outlines the steps for assessing a patient's circulation system. It describes:
1) Initial steps including ensuring safety, observing the patient's condition, and asking questions.
2) Taking vital signs such as blood pressure, pulse, temperature, respiration rate, and oxygen saturation.
3) General appearance assessment of the patient's condition including skin color and texture.
4) Detailed assessment steps of inspection, palpation, and auscultation of pulses, heart, neck vessels, and other signs. Key notes on normal ranges are also provided.
assessing neonatal systolic and diastolic cardiac function by echo. also assessing how PDA influences cardiac and systemic flow in neonates.
a new unique modility in NICU
This document discusses functional echocardiography for assessing cardiovascular function in neonates. Targeted neonatal echocardiography can be used to evaluate conditions like patent ductus arteriosus, cyanosis, and shock. Functional echocardiography longitudinally assesses cardiac function, blood flows, and shunts. It provides objective evaluation of cardiac output and tissue perfusion that indirect measures cannot. Views used in echocardiography include four-chamber, ductal, and superior vena cava flow views. Superior vena cava flow can estimate systemic blood flow and cerebral blood flow. Functional echocardiography is useful for hypotensive neonates to differentiate causes and guide management.
Normal and abnormal of Obstetric , Slidshare ppt.pptxapplec1
Obstetric ultrasound, also known as prenatal or pregnancy ultrasound, uses high-frequency sound waves to produce images of a developing embryo or fetus. The procedure also monitors the health of the mother's uterus, ovaries, and the blood flow through the umbilical cord to the placenta.
Abnormal seems to imply that something is wrong with your baby,
- The document provides guidance on performing a respiratory exam, including positioning the patient, inspecting the patient and areas around the bed, examining the hands, face, neck, chest, and auscultating breath sounds.
- Key steps are inspecting for signs of distress, noting peripheral clues, assessing expansion and movements of the chest, percussion findings, breath sounds, and timing of crackles.
- Performing techniques like assessing forced expiratory time can help evaluate for obstructive lung diseases like COPD.
Pulmonary embolism presenation by Henok OnchoHenok Oncho
A pulmonary embolism is a blockage in the lungs caused by a blood clot that forms elsewhere in the body and travels through the bloodstream. Symptoms include shortness of breath, chest pain, and anxiety. Diagnosis involves tests like CT scans, ventilation-perfusion scans, and pulmonary angiograms. Treatment focuses on anticoagulant medications like heparin to prevent further clotting and reduce the risk of additional embolisms. Nursing care monitors the patient's oxygenation status and educates them on preventing future clots.
The document discusses the respiratory system, including its anatomy, physiology, and pathophysiology. It focuses on the initial assessment and management of a patient experiencing respiratory distress or failure. Key steps include assessing the patient's airway, breathing, circulation, and disability (ABCDS), providing oxygen, assisting ventilation if needed, and considering underlying conditions that may be causing respiratory distress.
This document provides an online guide for medical residents with information to help them survive overnight calls. It includes sections on common overnight issues organized by specialty, procedures and calculators, electrolyte repletion guidelines, call survival tips, and important phone numbers. Users can access this information and links to additional online resources to assist them during overnight calls.
This document provides guidance on performing a cardiovascular examination, including:
1. Examining the general appearance, vital signs, jugular venous pressure, peripheral edema, and hands of the patient.
2. Performing a local heart examination using the IPPA sequence of inspection, palpation, percussion, and auscultation of the four heart valve areas.
3. During auscultation, commenting on heart sounds, extra sounds like murmurs, and lung bases.
A look at the practicalities, applicability and evidence for medical interventions not currently supported by the guidelines in medical cardiac arrests. Sydney HEMs cardiac education day 9th January 2019.
This document provides 4 pre-hospital scenarios to calculate COAST scores and determine if the patient should be enrolled in PATCH (Pre-hospital Analgesia Trial for Children in Helicopter Emergency Medical Services).
Case 1 involves a 23-year old female driver trapped in her vehicle after an MVA with a head injury, chest pain, and decreased breath sounds. Case 2 is a 41-year old male farmhand who fell 10 meters and has a possible hip fracture and chest pain. Case 3 is a 70-year old restrained driver in an MVA complaining of abdominal pain. Case 4 is an unknown male teenager thrown from his motorcycle with a head injury, chest wall abrasions, and a clinical flail
This document discusses the serratus anterior plane block for pain management following rib fractures. It provides anatomy of what nerves are blocked, including the intercostal, long thoracic, and thoracodorsal nerves. Evidence for how the block provides analgesia is limited but may include direct spread to the periosteum of fractured ribs or splinting of the external intercostal muscle. The document recommends using an e-cath needle to administer 20-40mL of 0.2-1% ropivacaine as a single shot or continuous infusion of 20mL boluses every 4 hours for rib fracture pain management.
This document discusses the use of pre-hospital thigh blocks for trauma patients with femoral fractures or other major thigh injuries. It notes that 17% of patients with clinically suspected femoral shaft fractures received a pre-hospital nerve block, which reduced scene time. The document then describes different types of thigh blocks - fascia iliaca compartment block, femoral nerve block, and adductor canal block. It provides sonoanatomy images and tips for performing each block, noting their roles in pain management for various thigh injuries. Safety considerations for performing nerve blocks in the pre-hospital setting are also discussed.
This document discusses the aeromedical retrieval of a contagious patient with pneumonia and asthma exacerbation from Broken Hill to a higher level of care. It outlines infection control precautions and personal protective equipment that should be used, including N95 masks. It also considers the risks to the patient, crew, disease transmission and modes of transportation. It provides examples from the H1N1 outbreak in 2009 and recommendations for decontaminating equipment after transporting contagious patients.
Prehospital Emergency Anaesthesia in Ambulancenswhems
When weather or hostile scene factors necessitate in-vehicle anaesthesia, it pays to have considered the optimal configuration of personnel, equipment and monitoring. Here is one example.
Pitfalls in paediatric trauma resuscitationnswhems
This document discusses key considerations for paediatric resuscitation. Severe traumatic brain injury and hemorrhage are top killers in trauma for children. Errors of omission and cognitive overload are risks. For hemorrhage, early whole blood products are ideal, and minimizing crystalloids to avoid dilutional coagulopathy. Tranexamic acid within 3 hours of injury for those at high risk can improve outcomes. A predefined massive transfusion protocol with balanced transfusions reduces complications. Physiology, injury patterns, and psychosocial factors differ for children compared to adults.
This document discusses prehospital resuscitative thoracotomy (RT) for traumatic cardiac arrest. It notes that while survival rates are poor, comparable survival has been seen for out-of-hospital cardiac arrest from any cause. For penetrating trauma, RT within 10 minutes of cardiac arrest or pericardiotomy within 2-3 minutes of knife to skin can potentially save lives. The document outlines the indications, contraindications, and steps for performing clamshell thoracotomy and argues that developing the skills and systems for prehospital RT access to the central circulation is crucial for trauma resuscitation.
E-FAST (extended focused assessment with sonography for trauma) has several limitations for assessing trauma patients. It provides quick exams without radiation but clinical exams can be unreliable and findings must be reliably communicated to decision-makers. While specific injuries like free fluid can be identified, it has limited ability to diagnose solid organ injuries or retroperitoneal bleeding. Operator competency and proper training are also major limitations, as interpretation skills require significant experience. Overall, E-FAST provides rapid initial information but has limitations that require correlation with the full clinical picture.
This document discusses fluid resuscitation and cautions regarding the use of 0.9% saline and Hartmann's solution. It notes that 0.9% saline can cause hyperchloremic acidosis and does not contain potassium. Hartmann's solution contains lactate and potassium but carries a risk of hyponatremia. The document also addresses signs of adequate resuscitation including warmth, wakefulness, and normalization of lactate levels without acidosis.
Apnoeic Oxygenation: Essential in Prehospital RSInswhems
This document discusses apnoeic oxygenation and its importance for prehospital rapid sequence intubation (RSI). It notes that apnoeic oxygenation was first described in 1959 in a study by Frumin et al. and references standards for monitoring during RSI similar to in-hospital anesthesia. The document questions whether a randomized controlled trial is needed and highlights apnoeic oxygenation as just one component of first pass success for difficult airway intubation. It is authored by Cliff Reid, Director of Training for Greater Sydney Area HEMS.
There are three scenarios when resuscitation should not be attempted: 1) if a patient has explicitly stated they do not want resuscitation, 2) if medical assessment determines the patient has no chance of meaningful recovery, and 3) if further medical intervention would be futile as nothing more can be done to help the patient. The document also lists potential underlying causes for pulseless electrical activity and provides two case examples.
This document discusses the history and development of emergency medicine. It mentions that the first director of a casualty department in Australia was appointed in 1967. It also discusses concepts like sunk cost fallacy, choice supportive bias, overjustification effect, and the hedonic treadmill. The document contains random words and images related to emergency medicine, psychology, and self-improvement.
This document discusses and questions various established medical opinions and protocols related to resuscitation through a format of posing statements and questions. It highlights that some commonly held views may be based on outdated evidence and explores alternative perspectives and approaches through respectful debate and references to recent literature. The goal appears to be advancing medical practice through re-examining established dogmas and protocols in light of the latest scientific evidence.
This document discusses and questions various established medical opinions and protocols related to resuscitation through a format of posing statements and questions. It suggests reexamining certain dogmas and standard practices through a process of dissolution and challenges the reader to consider new evidence and perspectives rather than relying on authority alone. Interactions are presented that encourage open debate of ideas while focusing on providing the best care for patients.
Jimmy arrived at the hospital in critical condition with a GCS of 7, low oxygen levels, and low blood pressure. While hospitals focus on clinical interventions like diagnosis and treatment, meaningful interventions for trauma patients must also consider logistical and cognitive factors. These include things like efficient triage, attention to patient cognition and memory, and advanced critical decision making around procedures. Looking to the future, technologies like advanced blood products, REBOA, ECMO, and intra-aortic occlusion devices may further improve trauma care both within and beyond the hospital.
The EMMA monitor and fingertip pulse oximeter are portable devices used by Greater Sydney HEMS for airway monitoring and pulse oximetry. The EMMA provides quantitative end-tidal carbon dioxide (EtCO2) monitoring using a disposable airway adapter and operates for 8 hours on 2 AAA batteries. It alarms for low battery, disconnected or missing adapter, and apnea or EtCO2 levels outside user-defined limits. The fingertip pulse oximeter noninvasively measures heart rate and oxygen saturation levels from 70-99% using light absorption and operates for 30 hours on 2 AAA batteries. Both devices are stored in a hard case along with spare batteries and accessories in the monitoring pouch of the pre-
The document provides instructions for daily checks and maintenance of a Lifepak 15 defibrillator. Key points include:
- Performing daily battery level checks and automatic self tests, replacing batteries if below 3 bars.
- Inspecting the device, consumables and cables for damage and referring any faults to be repaired.
- Batteries providing over 5 hours of monitoring on a single charge and automatic switching between batteries.
- The monitor is pre-set to display ECG, pulse oximetry and capnography waveforms but these can be altered.
- Additional events have been added to the event log for RSI medications.
This document provides an overview of emerging topics in clinical toxicology. It discusses new therapies for toxicological emergencies such as high-dose insulin for calcium channel blocker overdose. Intralipid emulsion is emerging as a treatment for local anesthetic toxicity. Methylene blue shows promise for ifosfamide-induced encephalopathy. Commonly encountered toxins like quetiapine now cause more ICU admissions. "New drugs" like synthetic cannabinoids can cause unpredictable effects. Recommendations for snake antivenom and redback spider antivenom use have also changed in recent years. The document emphasizes that a risk assessment approach is key to managing poisonings.
Pictorial and detailed description of patellar instability with sign and symptoms and how to diagnose , what investigations you should go with and how to approach with treatment options . I have presented this slide in my 2nd year junior residency in orthopedics at LLRM medical college Meerut and got good reviews for it
After getting it read you will definitely understand the topic.
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
“Psychiatry and the Humanities”: An Innovative Course at the University of Mo...Université de Montréal
“Psychiatry and the Humanities”: An Innovative Course at the University of Montreal Expanding the medical model to embrace the humanities. Link: https://www.psychiatrictimes.com/view/-psychiatry-and-the-humanities-an-innovative-course-at-the-university-of-montreal
5-hydroxytryptamine or 5-HT or Serotonin is a neurotransmitter that serves a range of roles in the human body. It is sometimes referred to as the happy chemical since it promotes overall well-being and happiness.
It is mostly found in the brain, intestines, and blood platelets.
5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
It is hypothesised to regulate hunger, emotions, motor, cognitive, and autonomic processes.
Computer in pharmaceutical research and development-Mpharm(Pharmaceutics)MuskanShingari
Statistics- Statistics is the science of collecting, organizing, presenting, analyzing and interpreting numerical data to assist in making more effective decisions.
A statistics is a measure which is used to estimate the population parameter
Parameters-It is used to describe the properties of an entire population.
Examples-Measures of central tendency Dispersion, Variance, Standard Deviation (SD), Absolute Error, Mean Absolute Error (MAE), Eigen Value
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7shruti jagirdar
Unit 4: MRA 103T Regulatory affairs
This guideline is directed principally toward new Molecular Entities that are
likely to have significant use in the elderly, either because the disease intended
to be treated is characteristically a disease of aging ( e.g., Alzheimer's disease) or
because the population to be treated is known to include substantial numbers of
geriatric patients (e.g., hypertension).
Are you looking for a long-lasting solution to your missing tooth?
Dental implants are the most common type of method for replacing the missing tooth. Unlike dentures or bridges, implants are surgically placed in the jawbone. In layman’s terms, a dental implant is similar to the natural root of the tooth. It offers a stable foundation for the artificial tooth giving it the look, feel, and function similar to the natural tooth.
PGx Analysis in VarSeq: A User’s PerspectiveGolden Helix
Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
Summer is a time for fun in the sun, but the heat and humidity can also wreak havoc on your skin. From itchy rashes to unwanted pigmentation, several skin conditions become more prevalent during these warmer months.
Travel Clinic Cardiff: Health Advice for International TravelersNX Healthcare
Travel Clinic Cardiff offers comprehensive travel health services, including vaccinations, travel advice, and preventive care for international travelers. Our expert team ensures you are well-prepared and protected for your journey, providing personalized consultations tailored to your destination. Conveniently located in Cardiff, we help you travel with confidence and peace of mind. Visit us: www.nxhealthcare.co.uk
4. 1. Formulate the question
a. Should I give more fluids? (Or inotropes,
or vasopressors?)
b. Why is the patient shocked?
The shock screen won’t tell you the diagnosis
every time, but it will tell you when not to
give IV fluids… or when to stop (B profile
appears)
4
7. Should I give more fluids?
• Lungs: wet or dry?
• IVC: collapsing or distended?
7
8. Should I give more fluids?
Wet lungs Dry lungs
Distended IVC Small IVC
… probably not …yes
(NB look for ‘APO (but re-scan with every
mimics’ eg fibrosis, and bag of IV fluid: if still
‘fluid overload mimics’ shocked & B profile
eg cor pulmonale) appears, cease fluids)
8
9. What if lungs dry & large IVC?
(or lungs wet & small IVC?)
A. Each sign has false positives & negatives.
Go back & reassess the patient, then
synthesize your findings.
=Be a doctor.
9
10. What about large LA/LV?
Surely that suggests I should avoid IVT?
A. Not in isolation.
Even patients with dilated cardiomyopathy
can suffer hypovolaemic shock.
But be sensible & consider smaller boluses,
and correlate with other findings.
10
20. Recall: A lines versus B lines
A lines B lines
Horizontal artefacts Vertical artefacts
Only air is present Air/fluid mix in lung
Present in dry lungs Not seen in PTX
Present in PTX Even 1 B line rules
out PTX at that site
26. A & A’ profile
A lines (or no lines) in all 4 lung windows
+
Pleural sliding present = A profile = dry lungs
Pleural sliding absent = A’ profile = PTX /
1 lung ventilation / other
27. B & B’ profile:
Multiple B lines = wet lungs
Multiple B lines = pulmonary oedema
APO = cardiogenic oedema
ARDS = non cardiogenic oedema
Pneumonia = local oedema
28. Note the difference w.r.t. pleural sliding
ARDS/ disseminated APO:
pneumonia: Transudate
Exudate Lung sliding is
Proteinaceous preserved, smooth
‘sticky’ pleural line
Reduced / absent lung B profile
sliding, irregular
pleural line
B’ profile
32. B & B’ profile
At least 3 B lines in all 4 anterior windows
= wet lungs
Pleural sliding present = B profile = APO
Pleural sliding reduced /absent, irregular
pleural line = B’ profile = disseminated
pneumonia / ARDS
33. Is that 100% true?
No, but it’s close.
B profile + preserved lung sliding = almost
always APO.
B profile + absent sliding = almost always
pneumonia.
NB remember the 90% rule
36. Recall: C profile
The windows show anterior consolidation
=
Pneumonia
ARDS
(rarely: PE)
Small amounts of consolidation = ‘irregular pleural line’
37. Step 1 findings
One lung not Both lungs sliding
sliding
A’ profile B’ profile A profile B profile A/B or C
profile
38. Step 1 findings
One lung not Both lungs sliding
sliding
A’ profile: B’ profile: A profile: B profile: A/B or C
PTX? Pneumonia Continue Pulmonary profile:
Look for Treat. IVT Oedema Pneumonia
lung point, Treat. Continue
consider IVT
DDX. Step 2 Treat cause.
Treat
40. Wait a minute!
Do I need to scan the heart if I already have a
diagnosis from the lung scan (PTX,
pneumonia, APO)?
41. Controversial
Most of us would still scan heart to be sure.
Some wouldn’t.
(See APO note next slide)
This step only yields useful information if it demonstrates
obvious pathology: ie ‘rule in, not rule out’.
If negative, you will need to proceed to step 3.
42. Step 2 (if lung sliding & B profile)
This is usually acute cardiogenic pulmonary
oedema (APO). Occasionally severe bilateral
pneumonia / ARDS can look like this.
Fibrosis can look like this, but is usually
limited to upper or lower lobes.
43. If you saw B profile on step 1…
… and step 2 shows poor And step 2 shows ‘normal’ LV
LV function Still probably APO- start
= acute cardiogenic treating
pulmonary oedema (but re-check clinical picture
(APO) to be sure it's not severe
bilateral pneumonia /
ARDS)
LV failure commonly appears as spuriously 'normal' LV on
basic 2D echo. So if B profile but heart looks OK, start
treating for APO, then proceed to focused TTE & reassess
patient.
44. Back to the heart.
What am I looking for?
Tamponade?
Massive PE?
Hypovolaemia?
45. Step 2: single view heart
• Using the curved probe, subcostal view is easiest
• Probe transverse, marker to patient's right
• ID heart (probe angled cephalad)
• Options if you can't obtain an adequate view:
• Try different window (apical, parasternal)
• Try different probe (phased array)
• Get help
40
47. Step 2: single view heart (& dry lungs)
Big RV Pericardial fluid Small volume Heart grossly Inadequate
Squashing LV heart NAD view
?
48. Step 2: single view heart (& dry lungs)
Big RV Pericardial Small chambers or Inadequate
heart grossly
Squashing LV fluid normal view
PE (probably) Tamponade Hypovolaemia/ sepsis?
(probably) Could still be PE!
Try another window
Consider Drainage IV fluid Try cardiac probe
thrombolysis
Proceed to step 3 Get help
50. Hang on!
Do I need to scan the IVC if I already have a
diagnosis from steps 1 & 2?
(PTX, massive PE, tamponade, pneumonia,
APO)
51. Controversial
Not if Dx already obvious (eg tamponade).
Yes if Dx still unclear: dry lungs, small volume
heart (e.g. you haven’t ruled out PE yet)
But remember that IVC can be ‘falsely’ large
(eg cor pulmonale) and ‘falsely’ small (eg
XS probe pressure)
52. So proceed to step 3...
...if lungs are dry & no obvious PE or
tamponade
But be a doctor & synthesize the findings.
47
53. Step 3: dry lungs, small vol heart, IVC
Large IVC Anything else Inadequate
<50% collapse Small IVC view
Large IVC & collapsing
?
62. So: dry lungs, small vol heart, IVC…
Large IVC Anything else Inadequate
<50% collapse Small IVC, not collapsing view
Large IVC, collapsing
Caution with fluids Give fluids Get help or cut your
Proceed to step 4 Proceed to step 4 losses
Proceed to step 4
63. Step 4
• Take a step back
• Have a think (& another look at the patient &
other information)
• What causes have I excluded?
• What else is left?
• Can bedside US help any further?
• Abdomen (hypovol: AAA / free fluid)
• Leg veins (obstructive: PE)
56
64. Who needs step 4?
Anyone with:
Dry lungs, lung sliding present, diagnosis still
unclear, and…
***shock unresponsive to fluids***
Is it sepsis?
Is it a ruptured AAA?
Is it PE?
57
65. Step 4
Options: either/ both of:
3-point compression DVT scan (is it a PE?)
Abdomen (is it AAA? Free fluid?)
58
66. Step 4: dry lungs, diagnosis unclear,
shock unresponsive to IV fluids
3-point compression DVT seen
leg veins = PE
DVT not seen: AAA seen =
Scan the abdomen Ruptured AAA
Normal aorta
AAA ruled out
Now what?
PTO
67. Now what?
You’ve reached the end of the scan
Patient still shocked
Fluids didn’t work
You’ve ruled out cardiogenic, PTX,
tamponade
…but not PE.
If it’s still on your list, you need a different
test.
60
68. But while arranging other tests…
Keep scanning the lungs
If lungs still dry, you can give more IV fluid
Once B profile appears or patient improves,
cease fluids
61
73. Further tests?
After resuscitation phase
If shock screen didn't suffice
If clinical picture demands it
65
74. Summary
The shock screen won’t tell you the diagnosis
every time, but it will tell you when it’s
safe to give IV fluids (dry lungs & small
IVC)… or when to stop (wet lungs, large
IVC).
66