Five European nations established colonies in the Americas during the early modern period: Spain, Portugal, France, Britain, and the Netherlands. Spain conquered large empires in Central and South America through conquistadors like Cortes and Pizarro. Britain established colonies along the eastern seaboard for economic and religious reasons, including the Plymouth and Jamestown settlements. France focused on fur trading in Canada and adopted local customs. The colonization had massive consequences, including the deaths of most indigenous peoples from disease and violence, the introduction of crops and animals through the Columbian Exchange, and the rise of the transatlantic slave trade.