Conquistadors were Spanish soldiers and explorers who brought much of the Americas under Spanish control following Columbus' discovery. Hernan Cortes conquered the Aztec Empire in Mexico with just 500 men, defeating them at their capital Tenochtitlan after a smallpox epidemic weakened them. Francisco Pizarro similarly conquered the vast Inca Empire in Peru, capturing its emperor Atahualpa and looting its gold before destroying the empire. Both conquests had immense impacts, destroying native civilizations and establishing Spanish rule.