- The English initially lacked the resources to establish risky colonies far from home, but by 1604 a peace treaty with Spain reduced the threat of attack, allowing colonization of Virginia to begin in 1606.
- John Smith led the Jamestown colony and forced colonists to work, but by 1616 the colony was still unprofitable until John Rolfe discovered tobacco could thrive there.
- During the 1620s, tobacco from Virginia sold for much higher prices in England, making the colony profitable.