This document provides an overview of art in 16th century Italy. It discusses major Italian Renaissance artists such as Leonardo da Vinci, Raphael, and Michelangelo. For Leonardo, it summarizes key works like the Mona Lisa and Last Supper. For Raphael, it describes Madonna paintings and his famous School of Athens fresco. For Michelangelo, it mentions his early Pietà sculpture and famous David statue. The document also provides context on trends, patrons, and the development of oil painting during this influential period of Italian Renaissance art.