Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.

Amyotrophic Lateral Sclerosis

8,069 views

Published on

Amyotrophic lateral sclerosis (ALS), AKA "Lou Gehrig's Disease," is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. Motor neurons reach from the brain to the spinal cord and from the spinal cord to the muscles throughout the body. The progressive degeneration of the motor neurons in ALS eventually leads to their death. When the motor neurons die, the ability of the brain to initiate and control muscle movement is lost. With voluntary muscle action progressively affected, patients in the later stages of the disease may become totally paralyzed.

Published in: Health & Medicine
  • ⇒ www.HelpWriting.net ⇐ This service will write as best as they can. So you do not need to waste the time on rewritings.
       Reply 
    Are you sure you want to  Yes  No
    Your message goes here
  • My brother found Custom Writing Service ⇒ www.WritePaper.info ⇐ and ordered a couple of works. Their customer service is outstanding, never left a query unanswered.
       Reply 
    Are you sure you want to  Yes  No
    Your message goes here
  • You can hardly find a student who enjoys writing a college papers. Among all the other tasks they get assigned in college, writing essays is one of the most difficult assignments. Fortunately for students, there are many offers nowadays which help to make this process easier. The best service which can help you is ⇒ www.HelpWriting.net ⇐
       Reply 
    Are you sure you want to  Yes  No
    Your message goes here
  • Hi I was diagnosed March 2017 but was running around from doctor to doctor before I finally get a result that I was free from MND ALS. Mine started on top and progressed into bottom I could walk very little but need assistance as I have no balance. It is sad all time that we thought this disease has no cure with all the technology we have while there re some formulas at there that can relief all symptoms and get this of ALS  . I’m passing this info to anyone at there because totalcureherbsfoundation com has the right cure and caregiver this disease ….I took various supplements, medicine prescribed by neurologist,massage and physiotherapy still the disease is was progressing very fast until the the ALS formula from that company .
       Reply 
    Are you sure you want to  Yes  No
    Your message goes here
  • Follow the link, new dating source: ❶❶❶ http://bit.ly/2ZDZFYj ❶❶❶
       Reply 
    Are you sure you want to  Yes  No
    Your message goes here

Amyotrophic Lateral Sclerosis

  1. 1. Amyotrophic Lateral Sclerosis
  2. 2. Epidemiology  Prevalence: 5-7 per 100,000 worldwide  More common in men by ratio of 1.5 to 1  Ages affected: 50 to 70 years old
  3. 3. Etiology  Idiopathic in most cases  Autosomal dominant inheritance in 5-10% of cases
  4. 4. Pathophysiology  Upper and lower motor neuron degeneration  Affects anterior horn cells  Subtypes  Progressive Bulbar Palsy  Primary Lateral Sclerosis  Spinal Muscular Atrophy
  5. 5. Symptoms  Muscle aches and muscle cramps  Weakness of distal upper limbs  Weakness progresses inferiorly (towards feet)  Dysarthria  Dysphagia  Drooling
  6. 6. Signs  Muscle fibrillation and atrophy (upper limbs)  Hyperreflexia  Spasticity of lower limbs
  7. 7. Diagnosis: Electromyogram (EMG)  Muscle fibrillation on mechanical stimulation  Increased duration and amplitude of action potentials
  8. 8. Prognosis  Majority of patients die within 1-3 years of diagnosis  Only 10% survive beyond 5 years
  9. 9. Treatment  Riluzole 50 mg bid  Anti-glutamate properties  Only modest effect at best (extended life 3 months)  Best effect if used early  Vitamin E and Vitamin C  Immunosuppressants not effective or indicated
  10. 10. Supportive Management  Treat at ALS center  Physical Therapy  Occupational Therapy  Dietitian  Neurologist  Symptomatic treatment  Progressive Pseudobulbar palsy  Spontaneous laugh (Tricyclic Antidepressants)
  11. 11. Sources:  Harrison’s  Oxford  Google http://crisbertcualteros.page.tl

×