Lou gehrig’s disease
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Lou Gehrig's Disease (ALS) is a progressive neurodegenerative disease that attacks motor neurons in the brain and spinal cord, leading to muscle weakness and atrophy. Eventually, it causes paralysis and death, usually within 3-5 years of diagnosis. ALS is named after baseball player Lou Gehrig, who was diagnosed with it in 1939. Symptoms vary but may include muscle twitching, weakness, difficulty speaking, swallowing or breathing. There is no known cure for ALS, but some drugs can help slow progression of symptoms.
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Lou Gehrig’S Disease (Als)
Lou Gehrig's Disease, also known as amyotrophic lateral sclerosis (ALS), is a progressive neurodegenerative disease that affects neurons in the brain and spinal cord. It causes weakness and paralysis as the motor neurons die and the brain loses ability to initiate and control muscle movement. There is no cure for ALS, though some drugs can treat symptoms, and researchers are investigating potential genetic and viral causes as the disease sometimes runs in families. Famous individuals like baseball player Lou Gehrig and physicist Stephen Hawking had ALS.
English als powerpoint
This document provides information about amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. It discusses that ALS is a progressive neurodegenerative disease that affects motor neurons in the brain and spinal cord, leading to muscle weakness, paralysis, and eventually death. Early symptoms can include muscle weakness, twitching, slurred speech, and difficulty breathing. There is no known cure for ALS, but some treatments can help manage symptoms and prolong survival for a few months. Donations can help support research to find an effective treatment for ALS.
Als presentation
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurons, leading to their degeneration and death. This causes muscles to weaken and atrophy, resulting in paralysis. Eventually, respiratory muscles are affected and the disease becomes fatal. ALS has causes linked to glutamate toxicity, mutations in the SOD1 gene, and oxidative stress damaging motor neurons. There is no cure for ALS and available treatments can only moderately slow progression of the disease.
21 June: The Global Day for Amyotrophic Lateral Sclerosis
ALS is a progressive neurological disease that causes the motor neurons controlling voluntary muscles to break down and die. This results in worsening muscle weakness, atrophy, and spasticity over time. There is no cure for ALS, but symptoms can be treated to prolong survival and quality of life. The cause is largely unknown, though some genetic factors have been identified. Most people live 3-5 years after diagnosis but about 10% of cases are inherited and can have longer survival times. Research continues toward finding effective treatments that target the underlying causes and pathways of the disease.
Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a debilitating disease that disrupts motor neurons, causing rapid muscle weakness, atrophy, spasticity, and difficulties with speech, swallowing, and breathing. The cause is unknown but may involve mutations in the SOD1 gene. The only FDA-approved treatment, Rilutek, can slow progression but also endangers liver health. Physical and speech therapy can help delay muscle degeneration and promote independence. There is no cure or prevention for ALS, which affects 20,000-30,000 Americans each year, usually between ages 40-60, with men more likely than women.
ALS ( Amyotrophic Lateral Sclerosis) / Lou Gehrig's Disease
A PPT made by Siddharth Rajah a biology student in his high school on the deadly nervous disease called ALS. It has affected many people like Stephen Hawking. Want to know more about this? You can see my PPT on it which I made for my Grade 11 Biology Project.
Als ppt conditions
The document discusses amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. ALS is a progressive neuromuscular condition that affects motor neurons in the brain and spinal cord. Key symptoms include muscle weakness, atrophy, spasms, and increased reflexes. While sensory and cognitive functions remain intact, over time patients have increasing problems with movement, swallowing, speaking and breathing. There is currently no cure for ALS, though treatments aim to reduce symptoms and multidisciplinary care can help prolong life expectancy and quality of life. Occupational therapy focuses on maintaining independence through adaptive equipment and strategies.
Amyotrophic Lateral Sclerosis (Lou Gehrig’s Disease)
Amyotrophic Lateral Sclerosis, also known as Lou Gehrig’s disease - What is ALS and how is eligible for disability tax credit. Call 1-855-752-0288
Recommended
Lou Gehrig’S Disease (Als)
Lou Gehrig's Disease, also known as amyotrophic lateral sclerosis (ALS), is a progressive neurodegenerative disease that affects neurons in the brain and spinal cord. It causes weakness and paralysis as the motor neurons die and the brain loses ability to initiate and control muscle movement. There is no cure for ALS, though some drugs can treat symptoms, and researchers are investigating potential genetic and viral causes as the disease sometimes runs in families. Famous individuals like baseball player Lou Gehrig and physicist Stephen Hawking had ALS.
English als powerpoint
This document provides information about amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. It discusses that ALS is a progressive neurodegenerative disease that affects motor neurons in the brain and spinal cord, leading to muscle weakness, paralysis, and eventually death. Early symptoms can include muscle weakness, twitching, slurred speech, and difficulty breathing. There is no known cure for ALS, but some treatments can help manage symptoms and prolong survival for a few months. Donations can help support research to find an effective treatment for ALS.
Als presentation
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurons, leading to their degeneration and death. This causes muscles to weaken and atrophy, resulting in paralysis. Eventually, respiratory muscles are affected and the disease becomes fatal. ALS has causes linked to glutamate toxicity, mutations in the SOD1 gene, and oxidative stress damaging motor neurons. There is no cure for ALS and available treatments can only moderately slow progression of the disease.
21 June: The Global Day for Amyotrophic Lateral Sclerosis
ALS is a progressive neurological disease that causes the motor neurons controlling voluntary muscles to break down and die. This results in worsening muscle weakness, atrophy, and spasticity over time. There is no cure for ALS, but symptoms can be treated to prolong survival and quality of life. The cause is largely unknown, though some genetic factors have been identified. Most people live 3-5 years after diagnosis but about 10% of cases are inherited and can have longer survival times. Research continues toward finding effective treatments that target the underlying causes and pathways of the disease.
Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a debilitating disease that disrupts motor neurons, causing rapid muscle weakness, atrophy, spasticity, and difficulties with speech, swallowing, and breathing. The cause is unknown but may involve mutations in the SOD1 gene. The only FDA-approved treatment, Rilutek, can slow progression but also endangers liver health. Physical and speech therapy can help delay muscle degeneration and promote independence. There is no cure or prevention for ALS, which affects 20,000-30,000 Americans each year, usually between ages 40-60, with men more likely than women.
ALS ( Amyotrophic Lateral Sclerosis) / Lou Gehrig's Disease
A PPT made by Siddharth Rajah a biology student in his high school on the deadly nervous disease called ALS. It has affected many people like Stephen Hawking. Want to know more about this? You can see my PPT on it which I made for my Grade 11 Biology Project.
Als ppt conditions
The document discusses amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. ALS is a progressive neuromuscular condition that affects motor neurons in the brain and spinal cord. Key symptoms include muscle weakness, atrophy, spasms, and increased reflexes. While sensory and cognitive functions remain intact, over time patients have increasing problems with movement, swallowing, speaking and breathing. There is currently no cure for ALS, though treatments aim to reduce symptoms and multidisciplinary care can help prolong life expectancy and quality of life. Occupational therapy focuses on maintaining independence through adaptive equipment and strategies.
Amyotrophic Lateral Sclerosis (Lou Gehrig’s Disease)
Amyotrophic Lateral Sclerosis, also known as Lou Gehrig’s disease - What is ALS and how is eligible for disability tax credit. Call 1-855-752-0288
Amyotrophic lateral sclerosis (als)
Amyotrophic lateral sclerosis (als) is a neurological disease, which is categorized under a group of disorders called motor neuron diseases.
Als(Amyotrophic Lateral Sclerosis)
ALS is a disease that causes the loss of neurons in the brain and spinal cord, weakening muscles and potentially affecting movement, speech, swallowing, and breathing. It typically affects people in their 40s and 50s and is more common in men. While the mind and memory are unaffected, the disease is usually fatal within 3 to 5 years as muscles continue to weaken. Notable people who have been diagnosed with ALS include physicist Stephen Hawking and footballer Sedat Balkanlı.
Amyotrophic lateral sclerosis (als)
ALS, also known as Lou Gehrig's disease, is a neurodegenerative disease that causes the motor neurons in the brain and spinal cord to progressively degenerate. This leads to muscle weakness and atrophy throughout the body. While the causes are largely unknown, about 5-10% of ALS cases are inherited. The disease usually starts in the limbs and causes symptoms like muscle cramps, weakness, and atrophy. Over time, it spreads and also affects muscles used for breathing, swallowing, and speaking. Currently, there is no cure for ALS and the goal of treatment is to manage symptoms and prolong life using medications, respiratory support, and multidisciplinary care.
amyotrophic lateral sclerosis & Gehrig's disease & moror neuron disease
Gehrig's disease ALS motor neurone disease (MND), or Lou Gehrig's disease, is a specific disease which causes the death of neurons controlling voluntary muscles.
Amyotrophic Lateral Sclerosis Competitive Landscape, Market Insights, Epidem...
Amyotrophic Lateral Sclerosis Competitive Landscape, Market Insights, Epidem...DelveInsight Business Research
Amyotrophic Lateral Sclerosis (ALS) is also known as Lou Gehrig’s disease. It is a progressive, rarely occurring neurological disease that mainly involves the nerve cells (neurons) which are responsible for controlling voluntary muscle movements. With time, it leads to muscle weakness, gradually affecting the functions of the body.
Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a fatal neurodegenerative disease that affects motor neurons in the brain and spinal cord. It leads to the degeneration and death of motor neurons, resulting in paralysis. There is no known cure for ALS, and the disease is usually fatal within 3 years of diagnosis. The disease causes motor neurons to gradually break down and die, affecting muscle movement. Over time, increased numbers of motor neurons stop working, resulting in paralysis and increased disability. Eventually, the paralysis will reach the respiratory muscles, leading to death.
Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS), AKA "Lou Gehrig's Disease," is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. Motor neurons reach from the brain to the spinal cord and from the spinal cord to the muscles throughout the body. The progressive degeneration of the motor neurons in ALS eventually leads to their death. When the motor neurons die, the ability of the brain to initiate and control muscle movement is lost. With voluntary muscle action progressively affected, patients in the later stages of the disease may become totally paralyzed.
Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a rare neurological disease that primarily affects the nerve cells (neurons) responsible for controlling voluntary muscle movement (those muscles we choose to move). Voluntary muscles produce movements like chewing, walking, and talking.
Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurons in the brain and spinal cord. The document discusses the pathology, epidemiology, clinical presentation, diagnosis, and management of ALS. Key points include that ALS causes the degeneration of upper and lower motor neurons, leading to muscle weakness, atrophy, and fasciculations. The average age of onset is in the mid-50s. Diagnosis is based on clinical signs and requires the exclusion of other potential causes through laboratory testing. Currently, riluzole is the only approved treatment and modestly prolongs survival. Management involves a multidisciplinary approach to address symptoms like weakness, fatigue, nutrition, and
Amyotrophic lateral sclerosis (als)
ALS is a progressive neurodegenerative disease that affects motor neurons in the brain and spinal cord. It causes the motor neurons to gradually degenerate and die, resulting in muscle weakness and atrophy. Over time, this leads to increasing paralysis as more motor neurons are damaged. While the exact causes are unknown, excitotoxicity from glutamate and mutations in genes like SOD1 are thought to be involved in the neurodegeneration. The main treatment is riluzole, which extends life by a few months. Other therapies focus on managing symptoms and maintaining function and quality of life for as long as possible. Regular dental care is important for oral health and to reduce risks of pneumonia. Adaptations may be needed to accommodate physical
Document
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a progressive neurodegenerative disease that affects motor neurons in the brain and spinal cord. As the motor neurons die, it leads to the loss of ability to initiate and control muscle movement, resulting in increasing muscle weakness and eventual paralysis. While the cause is unknown, early symptoms often include weakness in the limbs, difficulty speaking, swallowing, or breathing. There is currently no cure and treatments can only modestly slow progression, but assistive devices and therapies can help maintain independence for as long as possible.
Als
Lou Gehrig's Disease, also known as amyotrophic lateral sclerosis (ALS), is a disease that causes motor neurons in the brain and spinal cord to die. This leads to weakness and paralysis as the brain loses ability to control voluntary muscles. ALS was named after baseball player Lou Gehrig, who died from the disease in 1941. There is probably a genetic link as the disease often runs in families. While thinking and memory remain intact, diagnosis is difficult as symptoms are similar to other treatable neuromuscular disorders. Examinations would show muscle weakness and wasting. There are drugs to treat symptoms but no cure, and the cause is still unknown though a virus may be involved.
Diagnosis and clinical management of amyotrophic lateral sclerosis (2)
This document provides an overview of amyotrophic lateral sclerosis (ALS), including its diagnosis, clinical presentation, disease course, treatment and management. Some key points:
- ALS is a progressive neurodegenerative disease that affects motor neurons, leading to weakness. Median survival is 2-4 years from symptom onset.
- Diagnosis involves assessing for signs of both upper and lower motor neuron dysfunction via clinical exam, electrodiagnostic testing, and ruling out other potential causes.
- Symptoms vary depending on site of onset but commonly include limb weakness, bulbar dysfunction, and respiratory impairment. Disease progression eventually involves multiple regions.
- Currently the only FDA-approved treatments are riluzole, which extends survival
ALS - amyotrophic lateral sclerosis
ALS is a neurodegenerative disease that affects motor neurons in the brain and spinal cord. It causes progressive muscle weakness and atrophy. There is currently no cure, and the average survival time is 3-5 years from symptom onset. Riluzole is the only approved treatment shown to modestly prolong survival. Supportive care focuses on managing symptoms like spasticity, secretions, and respiratory failure to prolong function and quality of life. The ice bucket challenge raised significant funds for ALS research. Diagnosis requires ruling out other causes and demonstrating both upper and lower motor neuron signs that progress over time.
Neuromuscular diseases by aayupta mohanty
The document discusses several neuromuscular disorders including amyotrophic lateral sclerosis (ALS), multiple sclerosis, and muscular dystrophy. It provides details on ALS such as its symptoms, causes, risk factors, and complications. ALS causes motor neurons to break down and leads to muscle weakness and atrophy. It typically begins in the hands, feet or limbs and eventually affects movement, speech, swallowing and breathing. While most cases have no known cause, genetic mutations and environmental factors may play a role. Complications include breathing and eating problems as well as potential dementia. Tests like EMGs, MRIs and biopsies can help diagnose ALS and rule out other conditions.
ALS (Amytropic Lateral Sclerosis)
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a fatal neurological disease that causes progressive muscle weakness and paralysis. The exact causes are unknown but may include genetic and environmental factors. Symptoms start with muscle weakness and progress to include slurred speech, difficulty swallowing, and eventually paralysis of the diaphragm leading to respiratory failure. While there is no cure, treatments can help manage symptoms and some medications may slow disease progression. The average life expectancy is 2-5 years from diagnosis but can vary significantly.
Approach to quadriparesis
This document provides an approach to evaluating a case of quadriparesis (weakness of all four limbs). It discusses obtaining a detailed history regarding onset and progression of weakness, risk factors, and family history. A neurological examination including assessment of upper and lower motor neuron signs is recommended. Various etiologies are considered depending on examination findings such as compressive vs. non-compressive myelopathy, motor neuron disease, subacute combined degeneration, anterior spinal artery syndrome, and myasthenia gravis. Differential diagnoses are formulated based on characteristics such as sensory involvement, reflex changes, symmetry of weakness, and associated symptoms.
Motor neuron disease
Motor neuron disease (MND) refers to conditions characterized by degeneration of upper and lower motor neurons. Amyotrophic lateral sclerosis (ALS) is the most common form of MND and involves both upper and lower motor neurons. ALS is clinically defined based on involvement of motor neurons and includes features such as muscle weakness, atrophy, fasciculations, and stiffness. The pathology of ALS involves degeneration and death of motor neurons in the brain, brainstem, and spinal cord leading to muscle denervation and atrophy. While the cause of ALS is largely unknown, factors such as oxidative stress, protein aggregation, mitochondrial dysfunction, and glutamate excitotoxicity are hypothesized to contribute to motor neuron de
Motor neurone disease pathogenesis and therapeutic potential
Motor Neurone Disease (MND), also known as amyotrophic lateral sclerosis (ALS), is a fatal neurodegenerative disease that causes the death of motor neurons. While most research has focused on mutations in superoxide dismutase 1 (SOD1), recent evidence suggests abnormal SOD1 folding may be present in both familial and sporadic ALS. This could provide a unifying pathogenesis and help develop more targeted treatments. Current drug trials primarily target downstream effects like glutamate excitotoxicity and oxidative stress, but emerging research on gene silencing and stem cells may lead to therapies that address the underlying causes of MND.
Amyotrophic lateral sclerosis- A review
This document provides a review of amyotrophic lateral sclerosis (ALS). It begins with an introduction that defines ALS and discusses its classification. It then covers the epidemiology, clinical features, diagnosis, etiology, pathogenesis, and differential diagnosis of ALS. Some key points include that ALS is a rare neurodegenerative disease that causes motor neuron death and muscle paralysis. It can be sporadic or familial. Common symptoms include muscle weakness, spasticity, and difficulty speaking, swallowing, or breathing. The cause is largely unknown but may involve genetic mutations, oxidative stress, protein misfolding, or mitochondrial dysfunction.
The Medical Report Podcast - ALS.pptx
The podcast discusses Lou Gehrig's Disease, also known as Amyotrophic Lateral Sclerosis (ALS). It begins with an overview of the disease and its history, named after baseball player Lou Gehrig who was diagnosed in 1936. Symptoms include muscle weakness that spreads and worsens over time, starting in limbs and spreading. Causes involve degradation of motor neurons, and risk factors include genetics, age, sex, and environmental exposures. Diagnosis involves tests like EMGs and MRIs. Unfortunately, there is no cure and treatments can only help relieve symptoms, though recent drugs may help slow progression. Complications involve breathing and eating problems as muscles are affected. The disease progresses over months to years until the last stage
Alzheimers presentation...........
The document provides information about Alzheimer's disease. It discusses:
- The objectives of educating people about Alzheimer's and how to prevent and control it.
- What Alzheimer's disease is, its causes, risk factors, signs and symptoms, stages of progression, diagnosis, and current treatment approaches.
- Key points include that it is a progressive brain disorder that destroys memory and thinking skills, and that while there is no cure, treatments can temporarily slow the worsening of dementia symptoms.
The summary captures the key topics and goals covered in the document in a concise manner.
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Amyotrophic lateral sclerosis (als)
Amyotrophic lateral sclerosis (als) is a neurological disease, which is categorized under a group of disorders called motor neuron diseases.
Als(Amyotrophic Lateral Sclerosis)
ALS is a disease that causes the loss of neurons in the brain and spinal cord, weakening muscles and potentially affecting movement, speech, swallowing, and breathing. It typically affects people in their 40s and 50s and is more common in men. While the mind and memory are unaffected, the disease is usually fatal within 3 to 5 years as muscles continue to weaken. Notable people who have been diagnosed with ALS include physicist Stephen Hawking and footballer Sedat Balkanlı.
Amyotrophic lateral sclerosis (als)
ALS, also known as Lou Gehrig's disease, is a neurodegenerative disease that causes the motor neurons in the brain and spinal cord to progressively degenerate. This leads to muscle weakness and atrophy throughout the body. While the causes are largely unknown, about 5-10% of ALS cases are inherited. The disease usually starts in the limbs and causes symptoms like muscle cramps, weakness, and atrophy. Over time, it spreads and also affects muscles used for breathing, swallowing, and speaking. Currently, there is no cure for ALS and the goal of treatment is to manage symptoms and prolong life using medications, respiratory support, and multidisciplinary care.
amyotrophic lateral sclerosis & Gehrig's disease & moror neuron disease
Gehrig's disease ALS motor neurone disease (MND), or Lou Gehrig's disease, is a specific disease which causes the death of neurons controlling voluntary muscles.
Amyotrophic Lateral Sclerosis Competitive Landscape, Market Insights, Epidem...
Amyotrophic Lateral Sclerosis Competitive Landscape, Market Insights, Epidem...DelveInsight Business Research
Amyotrophic Lateral Sclerosis (ALS) is also known as Lou Gehrig’s disease. It is a progressive, rarely occurring neurological disease that mainly involves the nerve cells (neurons) which are responsible for controlling voluntary muscle movements. With time, it leads to muscle weakness, gradually affecting the functions of the body.
Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a fatal neurodegenerative disease that affects motor neurons in the brain and spinal cord. It leads to the degeneration and death of motor neurons, resulting in paralysis. There is no known cure for ALS, and the disease is usually fatal within 3 years of diagnosis. The disease causes motor neurons to gradually break down and die, affecting muscle movement. Over time, increased numbers of motor neurons stop working, resulting in paralysis and increased disability. Eventually, the paralysis will reach the respiratory muscles, leading to death.
Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS), AKA "Lou Gehrig's Disease," is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. Motor neurons reach from the brain to the spinal cord and from the spinal cord to the muscles throughout the body. The progressive degeneration of the motor neurons in ALS eventually leads to their death. When the motor neurons die, the ability of the brain to initiate and control muscle movement is lost. With voluntary muscle action progressively affected, patients in the later stages of the disease may become totally paralyzed.
Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a rare neurological disease that primarily affects the nerve cells (neurons) responsible for controlling voluntary muscle movement (those muscles we choose to move). Voluntary muscles produce movements like chewing, walking, and talking.
Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurons in the brain and spinal cord. The document discusses the pathology, epidemiology, clinical presentation, diagnosis, and management of ALS. Key points include that ALS causes the degeneration of upper and lower motor neurons, leading to muscle weakness, atrophy, and fasciculations. The average age of onset is in the mid-50s. Diagnosis is based on clinical signs and requires the exclusion of other potential causes through laboratory testing. Currently, riluzole is the only approved treatment and modestly prolongs survival. Management involves a multidisciplinary approach to address symptoms like weakness, fatigue, nutrition, and
Amyotrophic lateral sclerosis (als)
ALS is a progressive neurodegenerative disease that affects motor neurons in the brain and spinal cord. It causes the motor neurons to gradually degenerate and die, resulting in muscle weakness and atrophy. Over time, this leads to increasing paralysis as more motor neurons are damaged. While the exact causes are unknown, excitotoxicity from glutamate and mutations in genes like SOD1 are thought to be involved in the neurodegeneration. The main treatment is riluzole, which extends life by a few months. Other therapies focus on managing symptoms and maintaining function and quality of life for as long as possible. Regular dental care is important for oral health and to reduce risks of pneumonia. Adaptations may be needed to accommodate physical
Document
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a progressive neurodegenerative disease that affects motor neurons in the brain and spinal cord. As the motor neurons die, it leads to the loss of ability to initiate and control muscle movement, resulting in increasing muscle weakness and eventual paralysis. While the cause is unknown, early symptoms often include weakness in the limbs, difficulty speaking, swallowing, or breathing. There is currently no cure and treatments can only modestly slow progression, but assistive devices and therapies can help maintain independence for as long as possible.
Als
Lou Gehrig's Disease, also known as amyotrophic lateral sclerosis (ALS), is a disease that causes motor neurons in the brain and spinal cord to die. This leads to weakness and paralysis as the brain loses ability to control voluntary muscles. ALS was named after baseball player Lou Gehrig, who died from the disease in 1941. There is probably a genetic link as the disease often runs in families. While thinking and memory remain intact, diagnosis is difficult as symptoms are similar to other treatable neuromuscular disorders. Examinations would show muscle weakness and wasting. There are drugs to treat symptoms but no cure, and the cause is still unknown though a virus may be involved.
Diagnosis and clinical management of amyotrophic lateral sclerosis (2)
This document provides an overview of amyotrophic lateral sclerosis (ALS), including its diagnosis, clinical presentation, disease course, treatment and management. Some key points:
- ALS is a progressive neurodegenerative disease that affects motor neurons, leading to weakness. Median survival is 2-4 years from symptom onset.
- Diagnosis involves assessing for signs of both upper and lower motor neuron dysfunction via clinical exam, electrodiagnostic testing, and ruling out other potential causes.
- Symptoms vary depending on site of onset but commonly include limb weakness, bulbar dysfunction, and respiratory impairment. Disease progression eventually involves multiple regions.
- Currently the only FDA-approved treatments are riluzole, which extends survival
ALS - amyotrophic lateral sclerosis
ALS is a neurodegenerative disease that affects motor neurons in the brain and spinal cord. It causes progressive muscle weakness and atrophy. There is currently no cure, and the average survival time is 3-5 years from symptom onset. Riluzole is the only approved treatment shown to modestly prolong survival. Supportive care focuses on managing symptoms like spasticity, secretions, and respiratory failure to prolong function and quality of life. The ice bucket challenge raised significant funds for ALS research. Diagnosis requires ruling out other causes and demonstrating both upper and lower motor neuron signs that progress over time.
Neuromuscular diseases by aayupta mohanty
The document discusses several neuromuscular disorders including amyotrophic lateral sclerosis (ALS), multiple sclerosis, and muscular dystrophy. It provides details on ALS such as its symptoms, causes, risk factors, and complications. ALS causes motor neurons to break down and leads to muscle weakness and atrophy. It typically begins in the hands, feet or limbs and eventually affects movement, speech, swallowing and breathing. While most cases have no known cause, genetic mutations and environmental factors may play a role. Complications include breathing and eating problems as well as potential dementia. Tests like EMGs, MRIs and biopsies can help diagnose ALS and rule out other conditions.
ALS (Amytropic Lateral Sclerosis)
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a fatal neurological disease that causes progressive muscle weakness and paralysis. The exact causes are unknown but may include genetic and environmental factors. Symptoms start with muscle weakness and progress to include slurred speech, difficulty swallowing, and eventually paralysis of the diaphragm leading to respiratory failure. While there is no cure, treatments can help manage symptoms and some medications may slow disease progression. The average life expectancy is 2-5 years from diagnosis but can vary significantly.
Approach to quadriparesis
This document provides an approach to evaluating a case of quadriparesis (weakness of all four limbs). It discusses obtaining a detailed history regarding onset and progression of weakness, risk factors, and family history. A neurological examination including assessment of upper and lower motor neuron signs is recommended. Various etiologies are considered depending on examination findings such as compressive vs. non-compressive myelopathy, motor neuron disease, subacute combined degeneration, anterior spinal artery syndrome, and myasthenia gravis. Differential diagnoses are formulated based on characteristics such as sensory involvement, reflex changes, symmetry of weakness, and associated symptoms.
Motor neuron disease
Motor neuron disease (MND) refers to conditions characterized by degeneration of upper and lower motor neurons. Amyotrophic lateral sclerosis (ALS) is the most common form of MND and involves both upper and lower motor neurons. ALS is clinically defined based on involvement of motor neurons and includes features such as muscle weakness, atrophy, fasciculations, and stiffness. The pathology of ALS involves degeneration and death of motor neurons in the brain, brainstem, and spinal cord leading to muscle denervation and atrophy. While the cause of ALS is largely unknown, factors such as oxidative stress, protein aggregation, mitochondrial dysfunction, and glutamate excitotoxicity are hypothesized to contribute to motor neuron de
Motor neurone disease pathogenesis and therapeutic potential
Motor Neurone Disease (MND), also known as amyotrophic lateral sclerosis (ALS), is a fatal neurodegenerative disease that causes the death of motor neurons. While most research has focused on mutations in superoxide dismutase 1 (SOD1), recent evidence suggests abnormal SOD1 folding may be present in both familial and sporadic ALS. This could provide a unifying pathogenesis and help develop more targeted treatments. Current drug trials primarily target downstream effects like glutamate excitotoxicity and oxidative stress, but emerging research on gene silencing and stem cells may lead to therapies that address the underlying causes of MND.
Amyotrophic lateral sclerosis- A review
This document provides a review of amyotrophic lateral sclerosis (ALS). It begins with an introduction that defines ALS and discusses its classification. It then covers the epidemiology, clinical features, diagnosis, etiology, pathogenesis, and differential diagnosis of ALS. Some key points include that ALS is a rare neurodegenerative disease that causes motor neuron death and muscle paralysis. It can be sporadic or familial. Common symptoms include muscle weakness, spasticity, and difficulty speaking, swallowing, or breathing. The cause is largely unknown but may involve genetic mutations, oxidative stress, protein misfolding, or mitochondrial dysfunction.
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amyotrophic lateral sclerosis & Gehrig's disease & moror neuron disease
amyotrophic lateral sclerosis & Gehrig's disease & moror neuron disease
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Amyotrophic Lateral Sclerosis Competitive Landscape, Market Insights, Epidem...
Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis
Diagnosis and clinical management of amyotrophic lateral sclerosis (2)
Diagnosis and clinical management of amyotrophic lateral sclerosis (2)
Motor neurone disease pathogenesis and therapeutic potential
Motor neurone disease pathogenesis and therapeutic potential
Similar to Lou gehrig’s disease
The Medical Report Podcast - ALS.pptx
The podcast discusses Lou Gehrig's Disease, also known as Amyotrophic Lateral Sclerosis (ALS). It begins with an overview of the disease and its history, named after baseball player Lou Gehrig who was diagnosed in 1936. Symptoms include muscle weakness that spreads and worsens over time, starting in limbs and spreading. Causes involve degradation of motor neurons, and risk factors include genetics, age, sex, and environmental exposures. Diagnosis involves tests like EMGs and MRIs. Unfortunately, there is no cure and treatments can only help relieve symptoms, though recent drugs may help slow progression. Complications involve breathing and eating problems as muscles are affected. The disease progresses over months to years until the last stage
Alzheimers presentation...........
The document provides information about Alzheimer's disease. It discusses:
- The objectives of educating people about Alzheimer's and how to prevent and control it.
- What Alzheimer's disease is, its causes, risk factors, signs and symptoms, stages of progression, diagnosis, and current treatment approaches.
- Key points include that it is a progressive brain disorder that destroys memory and thinking skills, and that while there is no cure, treatments can temporarily slow the worsening of dementia symptoms.
The summary captures the key topics and goals covered in the document in a concise manner.
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Nuerodegenrative diseases
Neurodegenerative diseases such as Alzheimer's, Huntington's, and Parkinson's cause the progressive loss of structure and function of neurons in the brain and spinal cord. Neurons cannot be replaced when damaged or died. Common symptoms include memory loss, movement difficulties, and behavioral changes. While there are currently no cures for these diseases, medications can help manage symptoms. Caregiving requires adapting to the patient's changing abilities from early to late stages of the disease.
Movement disorder
Movement disorders are a group of diseases that affect the ability to control bodily movements. They vary in prevalence depending on the type, with restless legs syndrome affecting about 12 million Americans. Common causes include issues with the motor cortex, antagonistic muscle pairs, cerebellum, and basal ganglia. Symptoms can include tremors, tics, spasms, rigidity, and lack of movement. Diagnosis involves medical history, exams, and imaging tests. While there is no cure, treatment options include physical therapy, medications, and sometimes surgery, with the long-term prognosis depending on severity.
1 SSaammppllee,, SSaarraahh Communication Studies 10.docx
1
SSaammppllee,, SSaarraahh
Communication Studies 105
(Day and Time)
SAMPLE OUTLINE
DESCRIPTIVE SPEECH
Amyotrophic Lateral Sclerosis
INTRODUCTION:
Attention Getter: When my grandmother passed away six years ago on my fourteenth
birthday, I was determined to understand exactly what was responsible for taking her young,
exuberant life away from her. The disease responsible for this was Amyotrophic Lateral
Sclerosis, also known as ALS or Lou Gehrig's disease. Named after baseball great Lou Gehrig,
who was diagnosed with the disease in 1939, ALS is a disorder that is considered rare, even
though more and more occurrences are being reported every year. ALS is known for its
inconsistency and the harsh toll that it takes on the body, and is feared by both patients and
medical professionals alike.
Central Idea (Thesis): Amyotrophic Lateral Sclerosis is a rare but extremely devastating
disease that affects every patient differently.
Credibility Statement: I witnessed my grandma's deterioration from this disease, and can tell
you first hand that ALS is a horrible disease that does not have a single definitive aspect.
Preview: Today I would like to tell you what ALS is, the various symptoms associated with it,
the progression of the disease, and possible treatment options.
BODY:
I. ALS is a disease of the nervous system that gradually destroys voluntary motor neurons,
the neurons responsible for contracting skeletal muscles, eventually causing complete
muscle atrophy.
A. ALS affects two major parts of the brain, including the cerebrum and the brain
stem.
1. ALS attacks motor neurons in these areas, causing the patient to lose
control of different muscles one group at a time.
2. Mary Dodson Wade, author of the book ALS-Lou Gehrig's Disease,
explains that the disease progresses and eventually leaves the body
unable to function. (Wade 42).
a. This is due to the fact that there are no motor neurons to send
messages between the brain, spinal cord, and the muscles.
2
b. However, sensory neurons are left unaffected, meaning that the
patient is completely alert when his or her body is ceasing to
function.
B. According to Wade, ALS occurs most often in persons between the ages of forty
and seventy. (Wade, 47).
1. The average age when disease becomes apparent is 55 years old.
2. There are some cases of patients in their early twenties, and also of
people in their eighties.
C. There are three different types of ALS.
1. Sporadic ALS, which occurs randomly, is the most common form,
comprising 90% of all cases.
2. Familial ALS, which is inherited, is not nearly as common, making up 5-
10% of all cases.
3. Guamanian ALS, which is found in small places of the Pacific (Guam), is
very rare.
(Internal Summary/Preview: Now that I have defined ALS, I would like to describe
some of the symptoms that can be associated with the disease.)
II. The symptoms that a ...
[INFOGRAPHIC] Fighting ALS – From the Beginning
Amyotrophic lateral sclerosis (ALS) — also known as Lou Gehrig’s Disease — is a disease that affects motor neurons in the brain and the spinal cord. Motor neurons reach from the brain to the spinal cord and affect muscle movement. The ongoing damage from ALS causes motor neurons to die. When this occurs, the brain can no longer start or control muscle movement. This eventually can lead to paralysis.
Alzheimer's Disease
A better way of knowing such an essential problem facing most of popularity all over the world .
This presentation aims at increasing the awareness of the people of the Alzheimer's Disease and its dangerous complications .
Low Back Pain.pdf
Low back pain is a common global problem that affects around 577 million people worldwide. While 85-95% of cases have no identifiable pathological cause, red flags should be evaluated to rule out serious spinal conditions. A history and physical exam including inspection, palpation, range of motion testing, and neurological exam can help classify the duration and potential causes of low back pain such as muscle strains, ligament injuries, or disc issues. The pain is usually worsened by activities that strain the back and improved with rest.
SERO-NEGATIVE ARTHRITIS
This document discusses seronegative arthritis, specifically focusing on spondyloarthropathies. It defines spondyloarthropathies as a group of inflammatory arthropathies that share clinical, radiographic, and genetic features, including ankylosing spondylitis, reactive arthritis, psoriatic arthritis, and enteropathic arthritis. It then provides detailed information on the pathogenesis, clinical manifestations, diagnostic findings, and treatment approaches for ankylosing spondylitis and reactive arthritis. Psoriatic arthritis is also briefly discussed.
Neuromuscular Disorders
This document discusses several neuromuscular disorders including Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), Spinal Cord Injury, Huntington's Chorea, and Spinal Muscle Atrophy. It provides details on ALS such as the pathophysiology, signs and symptoms, course of the disease, etiology, epidemiology, diagnosis, treatment, and complications. Comparisons are made between ALS and other disorders such as MS, Spinal Cord Injury, Huntington's Chorea, and Spinal Muscle Atrophy.
Craniosacral Inservice
Craniosacral therapy was developed in the late 19th century by William Garner Sutherland who believed that the bones of the skull were capable of subtle movement, in contrast to accepted anatomical views. John Upledger later expanded on Sutherland's work in the 1970s. Craniosacral therapy involves gentle palpation to detect and manipulate the cranial bones and release restrictions in the craniosacral system to support health and healing. While some research studies show promise for reducing migraine symptoms, the subtle and variable nature of craniosacral therapy makes it difficult to study and research results are mixed.
Alzheimer's Presentation
Alzheimer's disease is a progressive brain disorder that destroys memory and thinking skills. It was first described in 1906 by Dr. Alois Alzheimer based on autopsy findings. Approximately 5.8 million Americans over 65 have Alzheimer's, with most cases affecting those over 75. The disease causes toxic protein buildups in the brain that damage neurons, particularly in the hippocampus and entorhinal cortex, leading to loss of connections and cell death over time. Common symptoms include increasing memory loss, confusion, inability to learn new things, and shortened attention span.
Sle n stroke
This document discusses stroke and lupus. Lupus is an autoimmune disease that can affect multiple organs, including lungs, kidneys, heart, blood, and nervous system. Stroke occurs when blood flow to the brain is interrupted. Lupus can cause stroke through abnormal antibodies that attack blood vessels and cause blood clots, vasculitis which decreases blood flow, and atherosclerosis which narrows arteries. Some symptoms of stroke include weakness, trouble speaking, vision issues, dizziness, and numbness. It is important to seek immediate medical help if experiencing stroke symptoms. Controlling lupus through medication and lifestyle changes can help reduce the risk of stroke.
Sle and stroke for lupeans
This document discusses stroke and lupus. Lupus is an autoimmune disease that can affect multiple organs, including lungs, kidneys, heart, blood, and nervous system. Stroke occurs when blood flow to the brain is interrupted. Lupus can cause stroke through abnormal antibodies that attack blood vessels and cause blood clots, vasculitis which causes inflammation and reduced blood flow, and atherosclerosis where arteries are narrowed. Managing lupus through medication and lifestyle changes such as diet, exercise, and stress reduction can help reduce the risk of stroke. It is important for people with lupus to see their doctor regularly and seek immediate medical help if they experience signs of stroke.
Alzheimer Project
1) Alzheimer's disease is a brain disease that causes problems with memory, thinking, and behavior and is the most common cause of dementia.
2) The document discusses the history and progression of Alzheimer's as well as risk factors, symptoms, current treatments, and personal stories about how the disease affects individuals and their families.
3) The search for a cure is ongoing through continued research, but so far a cure has remained elusive.
Brittany sutton sw 201 final presentation
Lupus is a chronic autoimmune disease that can damage any parts of the body including the skin, joints, organs and blood cells. It primarily affects young women and occurs most between the ages of 15 to 40. The immune system mistakenly attacks healthy cells and tissues, which can cause inflammation and organ damage. Common symptoms include painful or swollen joints, rash, fatigue, and sensitivity to sunlight. While there is no cure for lupus, treatment can effectively manage symptoms and allow people to live healthy lives.
ACV isquémico.ppt
This document provides information about cerebrovascular accidents or strokes. It begins by defining a stroke as an interruption in blood flow to the brain, which can cause brain cell death. It then discusses that strokes are a leading cause of death and disability worldwide. The document is a case study of an individual, Julio Aldriano Medina Salaverry, who suffered 4 heart attacks and 15 strokes between ages 34-46. It details his symptoms, likely causes including a B12 deficiency, and treatment approach involving nutrition, supplementation, physical activity and training, and mental health support. It concludes by noting his motor functions were compromised but not severely due to his strength training, and that he has now gone 8 years without further heart
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1 SSaammppllee,, SSaarraahh Communication Studies 10.docx
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Authoring a personal GPT for your research and practice: How we created the Q...
Thematic analysis in qualitative research is a time-consuming and systematic task, typically done using teams. Team members must ground their activities on common understandings of the major concepts underlying the thematic analysis, and define criteria for its development. However, conceptual misunderstandings, equivocations, and lack of adherence to criteria are challenges to the quality and speed of this process. Given the distributed and uncertain nature of this process, we wondered if the tasks in thematic analysis could be supported by readily available artificial intelligence chatbots. Our early efforts point to potential benefits: not just saving time in the coding process but better adherence to criteria and grounding, by increasing triangulation between humans and artificial intelligence. This tutorial will provide a description and demonstration of the process we followed, as two academic researchers, to develop a custom ChatGPT to assist with qualitative coding in the thematic data analysis process of immersive learning accounts in a survey of the academic literature: QUAL-E Immersive Learning Thematic Analysis Helper. In the hands-on time, participants will try out QUAL-E and develop their ideas for their own qualitative coding ChatGPT. Participants that have the paid ChatGPT Plus subscription can create a draft of their assistants. The organizers will provide course materials and slide deck that participants will be able to utilize to continue development of their custom GPT. The paid subscription to ChatGPT Plus is not required to participate in this workshop, just for trying out personal GPTs during it.
Discovery of An Apparent Red, High-Velocity Type Ia Supernova at 𝐳 = 2.9 wi...
We present the JWST discovery of SN 2023adsy, a transient object located in a host galaxy JADES-GS
+
53.13485
−
27.82088
with a host spectroscopic redshift of
2.903
±
0.007
. The transient was identified in deep James Webb Space Telescope (JWST)/NIRCam imaging from the JWST Advanced Deep Extragalactic Survey (JADES) program. Photometric and spectroscopic followup with NIRCam and NIRSpec, respectively, confirm the redshift and yield UV-NIR light-curve, NIR color, and spectroscopic information all consistent with a Type Ia classification. Despite its classification as a likely SN Ia, SN 2023adsy is both fairly red (
�
(
�
−
�
)
∼
0.9
) despite a host galaxy with low-extinction and has a high Ca II velocity (
19
,
000
±
2
,
000
km/s) compared to the general population of SNe Ia. While these characteristics are consistent with some Ca-rich SNe Ia, particularly SN 2016hnk, SN 2023adsy is intrinsically brighter than the low-
�
Ca-rich population. Although such an object is too red for any low-
�
cosmological sample, we apply a fiducial standardization approach to SN 2023adsy and find that the SN 2023adsy luminosity distance measurement is in excellent agreement (
≲
1
�
) with
Λ
CDM. Therefore unlike low-
�
Ca-rich SNe Ia, SN 2023adsy is standardizable and gives no indication that SN Ia standardized luminosities change significantly with redshift. A larger sample of distant SNe Ia is required to determine if SN Ia population characteristics at high-
�
truly diverge from their low-
�
counterparts, and to confirm that standardized luminosities nevertheless remain constant with redshift.
(June 12, 2024) Webinar: Development of PET theranostics targeting the molecu...
(June 12, 2024) Webinar: Development of PET theranostics targeting the molecu...Scintica Instrumentation
Targeting Hsp90 and its pathogen Orthologs with Tethered Inhibitors as a Diagnostic and Therapeutic Strategy for cancer and infectious diseases with Dr. Timothy Haystead.Farming systems analysis: what have we learnt?.pptx
Presentation given at the official farewell of Prof Ken Gillet at Wageningen on 13 June 2024
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How do you know your food is safe?
Last Friday was world World Food Safety Day, facilitated by the Food and Agriculture Organization of the United Nations (FAO) and the World Health Organization (WHO) in which the slogan rightly says, 'food safety is everyone's business'. Due to this, I thought it would be worth sharing some data that I have worked on in this field!
Working at Markes International has really opened my eyes (and unfortunately my friends and family 🤣) to food safety and quality, especially with my recent application work on ethylene oxide and 2-chloroethanol residues in foodstuffs, as of the biggest global food recalls in history was and is still being implemented by the Rapid alert system for food and feed (RASFF) in 2021, for high levels of these carcinogenic compounds.
Randomised Optimisation Algorithms in DAPHNE
Slides from talk:
Aleš Zamuda: Randomised Optimisation Algorithms in DAPHNE .
Austrian-Slovenian HPC Meeting 2024 – ASHPC24, Seeblickhotel Grundlsee in Austria, 10–13 June 2024
https://ashpc.eu/
ESA/ACT Science Coffee: Diego Blas - Gravitational wave detection with orbita...
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Presentation in the Science Coffee of the Advanced Concepts Team of the European Space Agency on the 07.06.2024.
Speaker: Diego Blas (IFAE/ICREA)
Title: Gravitational wave detection with orbital motion of Moon and artificial
Abstract:
In this talk I will describe some recent ideas to find gravitational waves from supermassive black holes or of primordial origin by studying their secular effect on the orbital motion of the Moon or satellites that are laser ranged.The binding of cosmological structures by massless topological defects
Assuming spherical symmetry and weak field, it is shown that if one solves the Poisson equation or the Einstein field
equations sourced by a topological defect, i.e. a singularity of a very specific form, the result is a localized gravitational
field capable of driving flat rotation (i.e. Keplerian circular orbits at a constant speed for all radii) of test masses on a thin
spherical shell without any underlying mass. Moreover, a large-scale structure which exploits this solution by assembling
concentrically a number of such topological defects can establish a flat stellar or galactic rotation curve, and can also deflect
light in the same manner as an equipotential (isothermal) sphere. Thus, the need for dark matter or modified gravity theory is
mitigated, at least in part.
MICROBIAL INTERACTION PPT/ MICROBIAL INTERACTION AND THEIR TYPES // PLANT MIC...
MICROBIAL INTERACTION PPT/ MICROBIAL INTERACTION AND THEIR TYPES // PLANT MIC...ABHISHEK SONI NIMT INSTITUTE OF MEDICAL AND PARAMEDCIAL SCIENCES , GOVT PG COLLEGE NOIDA
Microbial interaction
Microorganisms interacts with each other and can be physically associated with another organisms in a variety of ways.
One organism can be located on the surface of another organism as an ectobiont or located within another organism as endobiont.
Microbial interaction may be positive such as mutualism, proto-cooperation, commensalism or may be negative such as parasitism, predation or competition
Types of microbial interaction
Positive interaction: mutualism, proto-cooperation, commensalism
Negative interaction: Ammensalism (antagonism), parasitism, predation, competition
I. Mutualism:
It is defined as the relationship in which each organism in interaction gets benefits from association. It is an obligatory relationship in which mutualist and host are metabolically dependent on each other.
Mutualistic relationship is very specific where one member of association cannot be replaced by another species.
Mutualism require close physical contact between interacting organisms.
Relationship of mutualism allows organisms to exist in habitat that could not occupied by either species alone.
Mutualistic relationship between organisms allows them to act as a single organism.
Examples of mutualism:
i. Lichens:
Lichens are excellent example of mutualism.
They are the association of specific fungi and certain genus of algae. In lichen, fungal partner is called mycobiont and algal partner is called
II. Syntrophism:
It is an association in which the growth of one organism either depends on or improved by the substrate provided by another organism.
In syntrophism both organism in association gets benefits.
Compound A
Utilized by population 1
Compound B
Utilized by population 2
Compound C
utilized by both Population 1+2
Products
In this theoretical example of syntrophism, population 1 is able to utilize and metabolize compound A, forming compound B but cannot metabolize beyond compound B without co-operation of population 2. Population 2is unable to utilize compound A but it can metabolize compound B forming compound C. Then both population 1 and 2 are able to carry out metabolic reaction which leads to formation of end product that neither population could produce alone.
Examples of syntrophism:
i. Methanogenic ecosystem in sludge digester
Methane produced by methanogenic bacteria depends upon interspecies hydrogen transfer by other fermentative bacteria.
Anaerobic fermentative bacteria generate CO2 and H2 utilizing carbohydrates which is then utilized by methanogenic bacteria (Methanobacter) to produce methane.
ii. Lactobacillus arobinosus and Enterococcus faecalis:
In the minimal media, Lactobacillus arobinosus and Enterococcus faecalis are able to grow together but not alone.
The synergistic relationship between E. faecalis and L. arobinosus occurs in which E. faecalis require folic acid
Anti-Universe And Emergent Gravity and the Dark Universe
Recent theoretical progress indicates that spacetime and gravity emerge together from the entanglement structure of an underlying microscopic theory. These ideas are best understood in Anti-de Sitter space, where they rely on the area law for entanglement entropy. The extension to de Sitter space requires taking into account the entropy and temperature associated with the cosmological horizon. Using insights from string theory, black hole physics and quantum information theory we argue that the positive dark energy leads to a thermal volume law contribution to the entropy that overtakes the area law precisely at the cosmological horizon. Due to the competition between area and volume law entanglement the microscopic de Sitter states do not thermalise at sub-Hubble scales: they exhibit memory effects in the form of an entropy displacement caused by matter. The emergent laws of gravity contain an additional ‘dark’ gravitational force describing the ‘elastic’ response due to the entropy displacement. We derive an estimate of the strength of this extra force in terms of the baryonic mass, Newton’s constant and the Hubble acceleration scale a0 = cH0, and provide evidence for the fact that this additional ‘dark gravity force’ explains the observed phenomena in galaxies and clusters currently attributed to dark matter.
Describing and Interpreting an Immersive Learning Case with the Immersion Cub...
Current descriptions of immersive learning cases are often difficult or impossible to compare. This is due to a myriad of different options on what details to include, which aspects are relevant, and on the descriptive approaches employed. Also, these aspects often combine very specific details with more general guidelines or indicate intents and rationales without clarifying their implementation. In this paper we provide a method to describe immersive learning cases that is structured to enable comparisons, yet flexible enough to allow researchers and practitioners to decide which aspects to include. This method leverages a taxonomy that classifies educational aspects at three levels (uses, practices, and strategies) and then utilizes two frameworks, the Immersive Learning Brain and the Immersion Cube, to enable a structured description and interpretation of immersive learning cases. The method is then demonstrated on a published immersive learning case on training for wind turbine maintenance using virtual reality. Applying the method results in a structured artifact, the Immersive Learning Case Sheet, that tags the case with its proximal uses, practices, and strategies, and refines the free text case description to ensure that matching details are included. This contribution is thus a case description method in support of future comparative research of immersive learning cases. We then discuss how the resulting description and interpretation can be leveraged to change immersion learning cases, by enriching them (considering low-effort changes or additions) or innovating (exploring more challenging avenues of transformation). The method holds significant promise to support better-grounded research in immersive learning.
Candidate young stellar objects in the S-cluster: Kinematic analysis of a sub...
Context. The observation of several L-band emission sources in the S cluster has led to a rich discussion of their nature. However, a definitive answer to the classification of the dusty objects requires an explanation for the detection of compact Doppler-shifted Brγ emission. The ionized hydrogen in combination with the observation of mid-infrared L-band continuum emission suggests that most of these sources are embedded in a dusty envelope. These embedded sources are part of the S-cluster, and their relationship to the S-stars is still under debate. To date, the question of the origin of these two populations has been vague, although all explanations favor migration processes for the individual cluster members. Aims. This work revisits the S-cluster and its dusty members orbiting the supermassive black hole SgrA* on bound Keplerian orbits from a kinematic perspective. The aim is to explore the Keplerian parameters for patterns that might imply a nonrandom distribution of the sample. Additionally, various analytical aspects are considered to address the nature of the dusty sources. Methods. Based on the photometric analysis, we estimated the individual H−K and K−L colors for the source sample and compared the results to known cluster members. The classification revealed a noticeable contrast between the S-stars and the dusty sources. To fit the flux-density distribution, we utilized the radiative transfer code HYPERION and implemented a young stellar object Class I model. We obtained the position angle from the Keplerian fit results; additionally, we analyzed the distribution of the inclinations and the longitudes of the ascending node. Results. The colors of the dusty sources suggest a stellar nature consistent with the spectral energy distribution in the near and midinfrared domains. Furthermore, the evaporation timescales of dusty and gaseous clumps in the vicinity of SgrA* are much shorter ( 2yr) than the epochs covered by the observations (≈15yr). In addition to the strong evidence for the stellar classification of the D-sources, we also find a clear disk-like pattern following the arrangements of S-stars proposed in the literature. Furthermore, we find a global intrinsic inclination for all dusty sources of 60 ± 20◦, implying a common formation process. Conclusions. The pattern of the dusty sources manifested in the distribution of the position angles, inclinations, and longitudes of the ascending node strongly suggests two different scenarios: the main-sequence stars and the dusty stellar S-cluster sources share a common formation history or migrated with a similar formation channel in the vicinity of SgrA*. Alternatively, the gravitational influence of SgrA* in combination with a massive perturber, such as a putative intermediate mass black hole in the IRS 13 cluster, forces the dusty objects and S-stars to follow a particular orbital arrangement. Key words. stars: black holes– stars: formation– Galaxy: center– galaxies: star formation
Sexuality - Issues, Attitude and Behaviour - Applied Social Psychology - Psyc...
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
HUMAN EYE By-R.M Class 10 phy best digital notes.pdf
Class 10 human eye notes physics
Handwritten best quality
SDSS1335+0728: The awakening of a ∼ 106M⊙ black hole⋆
Context. The early-type galaxy SDSS J133519.91+072807.4 (hereafter SDSS1335+0728), which had exhibited no prior optical variations during the preceding two decades, began showing significant nuclear variability in the Zwicky Transient Facility (ZTF) alert stream from December 2019 (as ZTF19acnskyy). This variability behaviour, coupled with the host-galaxy properties, suggests that SDSS1335+0728 hosts a ∼ 106M⊙ black hole (BH) that is currently in the process of ‘turning on’. Aims. We present a multi-wavelength photometric analysis and spectroscopic follow-up performed with the aim of better understanding the origin of the nuclear variations detected in SDSS1335+0728. Methods. We used archival photometry (from WISE, 2MASS, SDSS, GALEX, eROSITA) and spectroscopic data (from SDSS and LAMOST) to study the state of SDSS1335+0728 prior to December 2019, and new observations from Swift, SOAR/Goodman, VLT/X-shooter, and Keck/LRIS taken after its turn-on to characterise its current state. We analysed the variability of SDSS1335+0728 in the X-ray/UV/optical/mid-infrared range, modelled its spectral energy distribution prior to and after December 2019, and studied the evolution of its UV/optical spectra. Results. From our multi-wavelength photometric analysis, we find that: (a) since 2021, the UV flux (from Swift/UVOT observations) is four times brighter than the flux reported by GALEX in 2004; (b) since June 2022, the mid-infrared flux has risen more than two times, and the W1−W2 WISE colour has become redder; and (c) since February 2024, the source has begun showing X-ray emission. From our spectroscopic follow-up, we see that (i) the narrow emission line ratios are now consistent with a more energetic ionising continuum; (ii) broad emission lines are not detected; and (iii) the [OIII] line increased its flux ∼ 3.6 years after the first ZTF alert, which implies a relatively compact narrow-line-emitting region. Conclusions. We conclude that the variations observed in SDSS1335+0728 could be either explained by a ∼ 106M⊙ AGN that is just turning on or by an exotic tidal disruption event (TDE). If the former is true, SDSS1335+0728 is one of the strongest cases of an AGNobserved in the process of activating. If the latter were found to be the case, it would correspond to the longest and faintest TDE ever observed (or another class of still unknown nuclear transient). Future observations of SDSS1335+0728 are crucial to further understand its behaviour. Key words. galaxies: active– accretion, accretion discs– galaxies: individual: SDSS J133519.91+072807.4
Pests of Storage_Identification_Dr.UPR.pdf
InIndia-post-harvestlosses-unscientificstorage,insects,rodents,micro-organismsetc.,accountforabout10percentoftotalfoodgrains
Graininfestation
Directdamage
Indirectly
•theexuviae,skin,deadinsects
•theirexcretawhichmakefoodunfitforhumanconsumption
About600speciesofinsectshavebeenassociatedwithstoredgrainproducts
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Authoring a personal GPT for your research and practice: How we created the Q...
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Lou gehrig’s disease
- 1. Lou Gehrig’s Disease (ALS) By Nick D’Ambra
- 2. What is ALS • Amyotrophic Lateral Sclerosis • Amyotrophic translates to No muscle nourishment • Is a disease that attacks the spinal cord, brain, and nerve cells. • It is a slow process that will lead from minor joint pains to slowing down the motor neuron system eventually leading to paralyzation and death.
- 3. Who was Lou Gehrig • New York Yankees Baseball Player (1923-1939) • Diagnosed with ALS in the middle of the 1939 season. • Announced his retirement June 21st • “The luckiest Man on the Face of The Earth”
- 4. Basic Facts about ALS • Every 2-100,000 People are diagnosed with ALS • Not Contagious. • Males are more commonly diagnosed with ALS • Average age diagnosed: 40-70 (Average about 55 years old) • About 5600 are diagnosed every year • No racial or ethnic group: could happen to anyone
- 5. Symptoms of ALS • Muscle Weakness, twitching, impairment of arms and legs. • Difficulty Speaking: Shortness of Breath, difficulty breathing or swallowing. • Initial Symptoms can Vary Greatly. • As the symptoms increase the need of help continues to greatly rise.
- 6. Diagnosing ALS ALS is Not easily diagnosing. There are many different steps that are used to diagnose it: blood and urine studies and 24-hour urine collection for heavy metals spinal tap x-rays, including magnetic resonance imaging (MRI) myelogram of cervical spine muscle and/or nerve biopsy thorough neurological examination
- 7. Treatment • To this day there is still not treatment for ALS although there is a slow down drug called Rilutek. • Increases survival by several months • Reduces symptoms and time needed before ventilation support.
- 8. What is it Like to Have ALS • A metaphor is commonly used by people who have ALS: Picture that you start with 5 pound weights on each arm and each leg and that every time you sleep you are sleeping with a 20 pound bag of sand right on your chest, and that every day those weights keep increasing up till when you can’t breath.
- 9. Works Cited "About ALS." - The ALS Association. N.p., n.d. Web. 03 June 2014. "Amyotrophic Lateral Sclerosis (ALS) Fact Sheet." : National Institute of Neurological Disorders and Stroke (NINDS). N.p., n.d. Web. 02 June 2014. "Connect With Us." Homepage. N.p., n.d. Web. 01 June 2014. "Lou Gehrig's Disease (ALS)." KidsHealth - the Web's Most Visited Site about Children's Health. Ed. Steven Dowshen. The Nemours Foundation, 01 Jan. 2013. Web. 02 June 2014.