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Eye & Systemic
Diseases
Mohamed Abdelzaher
MD, FRCS
Eyes are
the
mirror
to the
soul.
Metabolic
Disorders
 Diabetes mellitus:
Common Uncommon Rare
Retinopathy Recurrent styes Papillopathy
Unstable refraction Xanthelasma Pupillary LND
Accelerated senile
cataract
Rhino orbital
mucormycosis
Rubeosis irides
Ocular motor nerve
palsies
Reduced corneal
sensitivity
Ocular complications of diabetes mellitus:
Lid Cornea Iris Pupil Lens Refraction Retina Neuro Orbit
Common
Unstable
refraction
Diabetic
retinopat
hy
Uncomm
on
Recurrent
styes
Xanthelasm
a
Reduced
corneal
sensitivity
Rubeosis
irides
Accelerate
d Senile
cataract
Ocular
motor
nerve
palsies
Rare
Pupil Light
near
dissociatio
n
Rhino
orbital
mucor-
mycosis
Recurrent styes
Unstable refraction
Index myopia Index hyperopia
Hyperglycemia Hypoglycemia
Xanthelasma
Rubeosis IridisCauses Management
III nerve palsyPupil
Argyll Robertson Pupil
Dim light
Bright light
Accommodation
Pilocarpine 0.1%
Accelerated senile cataract
Management & Precautions
Diabetic papillopathy
Diabetic retinopathy
NPDR PDR
management
Diabetic maculopathy
management
 Thyrotoxicosis:
Common Uncommon Rare
Proptosis Keratoconjunctivitis
sicca
Optic neuropathy
Lid retraction Diplopia Choroidal folds
Chemosis Superior limbic
keratoconjunctivitis
Exophthalmos
management
Cardiovascular
Diseases
 Systemic hypertension
Common Uncommon Rare
Retinal
arteriolosclerosis
Retinopathy Exudative RD
“Accelerated disease”
RVO RAO
AION
Retinal artery
macroaneurysm
Ocular motor nerve
palsies
Choroidal infarcts
Retinal
arteriolosclerosis:
changes in A-V
crossing
Grading of retinal
arteriolosclerosis
Deflections (Salus sign)
Tapering (Gunn sign)
Copper wiring
Hypertensive Retinopathies
Acute hypertensive retinopathy
CRAO DDx
CRVOManagement
AION
Giant cell arteritis
 AAION
 CRAO: CRA often arises in a common stem with one or
more of the short posterior ciliary arteries
 Cilioretinal artery occlusion: may be combined
with AAION
 OIS: due to involvement of ophthalmic artery, rare
 Transient ischemic attacks (Amaurosis
fugax)
 Diplopia: ischemia to EOM or ocular motor nerves
Timing of vascularization of
peripheral retina
 ROP
ROP
Connective
Tissue Diseases
 Rheumatoid artheritis:
- Keratoconjunctivitis sicca (secondary sjogren
syndrome),
- Scleritis,
- Ulcerative keratitis,
- Complications of ttt (chloroquine maculopathy)
Schirmer test
Normal values
PEE
Dry eye
DDx
Filamentary keratitis
Stain
Nodular scleritis
DDx
Chloroquine maculopathy
Idiopathic juvenile artheritis
AC cells KPs
Anterior uveitis
 Systemic lupus erythematosis:
- Madarosis.
- Keratoconjunctivitis scicca.
- Scleritis.
- Peripheral ulcerative keratitis.
- Retinalvasculitis.
- Optic neuropathy.
 Marfan syndrome:
Common Uncommon Rare
Ectopia lentis Keratoconus Megalocornea
Myopia Microspherophakia
AC angle anomalies Cornea plana
Hypoplasia of dilator
pupillae
RD
Ectopia lentis
Keratoconus “Munson sign”
Management
Penetrating KeratoplastyIndications
Large cornea
DDx
Cornea Plana
Complications
Non Infectious
Multisystem
Diseases
 Sarcoidosis:
- Uveitis
- Keratoconjunctivitis sicca
- Conjunctival nodules
* Behcet syndrome:
-Uveitis
-Conjunctivitis
-Conjunctival ulceration
-Episcleritis
-Scleritis
Anterior uveitis
Managment
Vogt Koyanagi Harada (VKH)
syndrome
Poliosis
Psterior uveitis
Neurology
 Multiple sclerosis:
Common Uncommon Rare
Retrobulbar neuritis Ocular motor nerve
palsies
Intermediate uveitis
Nystagmus Hemianopia Retinal periphlebitis
Internuclear
ophthalmoplegia
Skew deviation
Bitemporal hemianopia
Where is the lesion?
Right homonymous hemianopia
Where is the lesion?
Eye & systemic diseases 4th year

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Eye & systemic diseases 4th year