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What do 7.5 billion human brains need to thrive in the Digital Age, and what are key opportunities to better equip them?

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*Álvaro Fernández, CEO and Editor-in-Chief of SharpBrains
*Sarah Lenz Lock, Senior Vice President for Policy at AARP and Executive Director of the Global Council on Brain Health (GCBH)
*Dr. April Benasich, Director of the Baby Lab at the Rutgers Center for Molecular and Behavioral Neuroscience
*Chaired by: Dr. Cori Lathan, Co-Chair of the World Economic Forum’s Council on the Future of Human Enhancement

Slidedeck supporting session held during the 2017 SharpBrains Virtual Summit: Brain Health & Enhancement in the Digital Age (December 5-7th). Learn more at: https://sharpbrains.com/summit-2017/

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What do 7.5 billion human brains need to thrive in the Digital Age, and what are key opportunities to better equip them?

  1. 1. What do 7.5 billion human brains need to thrive in the Digital Age, and what are key opportunities to better equip them? Chaired by: Dr. Cori Lathan, Co-Chair of the World Economic Forum’s Council on the Future of Human Enhancement Sarah Lenz Lock, Senior Vice President for Policy at AARP and Executive Director of the Global Council on Brain Health (GCBH) Álvaro Fernández, CEO and Editor-in-Chief of SharpBrains Dr. April Benasich, Director of the Baby Lab at the Rutgers Center for Molecular and Behavioral Neuroscience
  2. 2. Alvaro Fernandez SharpBrains CEO & Editor-In-Chief December 5th, 2017 The Future of Brain Health and Enhancement
  3. 3. 1) 7.5 billion human brains need help to thrive in the digital age 2) Lifelong neuroplasticity means those brains can be enhanced 3) Mobile, sensing, wearable technologies, coupled with AI, provide a new platform to harness that neuroplasticity 4) Entrepreneurship and investments are fueling accelerated growth 5) Professionals are stepping up to help ensure appropriate use Five reasons the future of brain enhancement is digital, pervasive and (hopefully) bright
  4. 4. Improve performance Delay disease
  5. 5. 5 Data Points
  6. 6. Source: The SharpBrains Guide to Brain Fitness
  7. 7. Brain health as HC priority Offers great BH care Monitor systematically Annual mental check-up AD pharma treatment BT doesn’t work Take charge 1-Strongly Disagree 2-Disagree 3-Neutral 4-Agree 5-Strongly Agree Brain Health in 2025 will look very different than in 2017…
  8. 8. Brain health as HC priority Offers great BH care Monitor systematically Annual mental check-up AD pharma treatment BT doesn’t work Take charge 1-Strongly Disagree 2-Disagree 3-Neutral 4-Agree 5-Strongly Agree Brain Health in 2025 will look very different than in 2017…
  9. 9. Enjoy a great virtual Summit ☺ Learn a lot, and Connect a lot! Finally…
  10. 10. WHAT DO 7. 5 BILLION BRAINS NEED TO THRIVE IN THE DIGITAL AGE, AND WHAT ARE KEY OPPORTUNITIES TO BETTER EQUIP THEM? 2017 SHARPBRAINS VIRTUAL SUMMIT: BRAIN HEALTH & ENHANCEMENT IN THE DIGITAL AGE DECEMBER 5-7, 2017 Sarah Lenz Lock, JD SVP for Policy, AARP Executive Director, GCBH Kathy Washa, Senior Advisor, Member Value Product, AARP
  11. 11. 21 A nonprofit helping people 50 and older improve the quality of their lives PURPOSE: Empower people to choose how they live as they age GLOBAL COUNCIL ON BRAIN HEALTH (GCBH): Independent collaborative of experts from around the world working on brain health & human cognition. Convened by AARP w/ support from AgeUK PURPOSE - Offer trusted advice on what older adults can do to maintain and improve brain health.
  12. 12. 10,000 people a day are turning 65 in the U.S. Between 2012 and 2050, adults age 65+ will nearly double in the U.S., reaching 84 million By 2030, 1 in 5 Americans will be age 65 and older
  13. 13. 23 • People age 85+ will roughly triple in the U.S. between 2012 – 2050 • By 2050, more than 18 million Americans will be age 85 or older • By 2050, more than 439,000 Americans will be age 100 or older
  14. 14. 24 2015-2017 BRAIN HEALTH SURVEYS: 12,835 TOTAL RESPONSES 2015 Survey on Brain Health 2,621 responses 2016 Survey on Healthy Behaviors and Well-Being 2,600 responses 2016 Survey on Physical Activity 2,554 responses 2016 AARP Sleep and Brain Health Survey 2,464 responses 2016 AARP Social Engagement and Brain Health Survey 2,596 responses AARP Research Colleagues Laura Mehegan, Chuck Rainville, Laura Skufca
  15. 15. 25
  16. 16. 26 While everyone is interested in brain health, the older you are, the more likely you are worried about your brain health 40 + • 33% say ability to remember has decreased • 68% know someone who has or had dementia 65+ • 45% say ability to remember has decreased • 83% know someone who has or had dementia
  17. 17. 27 Two-thirds of the 50+ are concerned about their own brain health or a family member’s brain health declining. However, a higher percentage are “very concerned” about a family member’s brain health compared to their own. 24% 40% 18% 17% 33% 33% 15% 18% 0% 20% 40% 60% 80% 100% Very concerned Somewhat concerned Not very concerned Not at all concerned Your brain health Family member's brain health
  18. 18. 28
  19. 19. BRAIN HEALTH Empowering people to have a healthier brain over their lifetime.
  20. 20. 30www.GlobalCouncilonBrainHealth.org
  21. 21. 31 GCBH Members Expert Collaboration Thus Far • 61 experts (13 Governance; 48 Issue Specialists) • 41 Liaisons • 19 countries represented • 53 universities/organizations
  22. 22. 32 GCBH Reports & Infographics Download at www.GlobalCouncilOnBrainHealth.org
  23. 23. MOVE DISCOVER RELAX NOURISH CONNECT
  24. 24. “Am I normal?” “Who can I trust for brain health info and guidance?” “What should I be doing to improve my brain health?”
  25. 25. Science-based Content Brain Health Assessment A Personalized Pathway “Am I normal?” “Who can I trust for brain health info and guidance?” “What should I be doing to improve my brain health?”
  26. 26. Brain Health Assessment
  27. 27. Assess Scientifically validated, evidence-based brain health assessment, based on nearly 100,000 neuro-imaging studies and validated by numerous peer-reviewed research. Measures: Executive Function Processing Speed Recall Memory Sustained Attention Working Memory Cognitive Flexibility Questions address current lifestyle behaviors around the five pillars of brain health. Cognitive Assessment Lifestyle Assessment How is my brain performing? How do my daily habits support my brain health? Results inform and feed the Staying Sharp activity engine, and a provide users with personalized recommendations.
  28. 28. Behavior Change through Small Steps 39 Methodology: Build behavior change into all aspects of the Staying Sharp platform. Approach: Through small incremental changes which users will progress in endurance, difficulty, or frequency over time. Every activity will allow the individual to select where they start. Metrics: Staying Sharp’s data will allow us to measure and truly understand our impact. 39
  29. 29. “I’ll do whatever it takes for me to stay sharp.”
  30. 30. 41 GlobalCouncilonBrainHealth.Org StayingSharp.Org Sarah Lenz Lock slock@aarp.org @seniors2seniors
  31. 31. April A. Benasich Ph.D. Elisabeth H. Solomon Professor of Developmental Cognitive Neuroscience Director, Infancy Studies Laboratory Center for Molecular & Behavioral Neuroscience Rutgers University - Newark and Chief Scientific Officer, AAB Research, LLC Harnessing Early Brain Plasticity To Support Lifelong Cognitive Enhancement
  32. 32. Why focus on the infant brain? • Most effective point to enhance/remediate brain development • Ability to produce lifelong results • Knock-on effect of building the most optimal brain RAPT® and Early Brain Plasticity A Once in a Life-Time Opportunity
  33. 33. The earlier you start, the easier and quicker it is to optimize brain development - and the more lasting the results Early investment results in bigger bang for the buck—lifelong improvement in cognition and earnings, lower costs required for intervention, special ed, tutoring, juvenile delinquency, incarceration WHY BOTHER WITH BABIES—THEY DON’T VOTE AND DON’T HAVE ANY MONEY!
  34. 34. EARLY LANGUAGE ACQUISITION and RAP Starting at birth, the baby’s developing brain is constructing an acoustic map of the varying sounds of his or her surrounding native language. Mapping of language-specific acoustic contrasts in the 10s of ms domain ultimately allows the child to respond in a fast automatic way to the incoming language stream. The infant’s Rapid Auditory Processing or RAP skill determines how well or poorly its acoustic map is formed.
  35. 35. Imagine if parents could easily and naturally “train” their babies’ brains to become the best possible language processors! Allow them to acquire and use words – and the information those words convey – faster and more easily . . . Help them be stronger, more advanced learners across their entire lives . .
  36. 36. 47 THEY CAN! Introducing Rapid Auditory Processing Technology (RAPT®) RAPT® is a patented and peer-reviewed interactive, infant brain training technology that optimizes a child’s auditory processing skills, leading to higher performance in reading and language skills at five and six years old and ultimately, improved lifelong cognitive outcomes.
  37. 37. 48 Active Auditory Exposure Impacts Prelinguistic Acoustic Mapping Benasich, A.A., Choudhury, N.A., Realpe-Bonilla, T., & Roesler, C. (2014). Plasticity in Developing Brain: Active Auditory Exposure Impacts Prelinguistic Acoustic Mapping. J. Neuroscience; 2014; 34(40):13349- 13363.
  38. 38. Benasich, A.A., Choudhury, N.A., Realpe-Bonilla, T., & Roesler, C. (2014). Plasticity in Developing Brain: Active Auditory Exposure Impacts Prelinguistic Acoustic Mapping. J. Neuroscience; 2014; 34(40):13349- 13363.
  39. 39. Group differences in latency and amplitude at 70ms ISI among the three groups at the 7-month post-test The AEx group is significantly faster than both PEx and NC groups The PEx group is significantly faster than the NC group.
  40. 40. Untrained Infants vs. RAPT® Trained Infants Faster, Stronger, More Accurate Brain Responses to Speech-like Sounds 7-Month Typically Developing Untrained 7-Month Typically Developing RAPT® TRAINED
  41. 41. ➢Demonstrated that while both active and passive acoustic experience from 4 to 7 months, using temporally modulated non-speech stimuli, impacts acoustic mapping, active experience confers a significant advantage. ➢Via ERPs, showed that active experience increases attention to environmental acoustic stimuli (e.g., larger, faster P2 peaks) compared to passive experience or maturation alone. ➢Showed faster latencies for change discrimination peak (N2*) that has been shown to be a robust infant predictor of later language through age 5 years. ➢Evidenced sharpening for both trained and untrained stimuli over and above that seen for maturation alone. RAPT® Research Results
  42. 42. DO THESE EFFECTS GENERALIZE TO LANGUAGE? Active Exp Passive Exp Naïve Controls ALL STANDARDS “DA” Ortiz-Mantilla, Realpe- Bonilla, Benasich, 2017 YES!
  43. 43. ➢ The accuracy of these crucial acoustic maps, and the child’s rapid response to acoustic cues that signal “language”, are significant factors in language and cognitive development and future learning. RAPT® sharpens those maps and increases processing speed. ➢RAP abilities vary widely even in typically developing children. A baby- friendly pre-linguistic, language-free intervention could narrow the ability gap and put children on a level playing field by the time they go to school. RAPT® improves processing speed and accuracy in ALL children. ➢8-15% of children will go on to suffer from language learning disorders such as dyslexia that are linked to early auditory processing deficits. The negative impacts of learning disorders are both substantial and exponential, encompassing increased rates of educational failure, drug abuse, crime and a loss of productive potential in afflicted individuals. RAPT® alters EEG biomarkers that predict to later language deficits. What do these RAPT® Research Results mean in REAL WORLD terms
  44. 44. The RAPT® AABy is HERE! The London Times Educational Supplement
  45. 45. TRANSLATION TO REAL WORLD RAPT® AABy™ Prototype AABy™ is currently available as an infant-controlled, baby-friendly working prototype. Babies playing with AABy™ for as few as 8 to 10 minutes/week for 6 weeks can achieve the same results as babies exposed to RAPT® in the lab.
  46. 46. INFANT CONTROL & PARENTAL FEEDBACK ON BLUETOOTH
  47. 47. RAPT® Opportunity and Challenges • Implements a neuroscience-based technology with scientifically proven ability to bootstrap brain plasticity and advance the natural brain development of young children. • Embodied in an interactive, fun, “educational” toy which engages and challenges infants without requiring active adult participation – unlike many educational toys that claim to “enhance brain development”– AABy™ is based on 15 years of peer-reviewed neuroscience research. • Provides parents an easy way to realize their desire to help their children maximize their ability to learn. RAPT®/AABy™ is pioneering a new category of highly effective science-validated infant and children’s products that may enhance lifetime brain function, support lifetime brain plasticity and fend off learning disorders. Want to know more? Contact me: benasich@rutgers.edu
  48. 48. Thank you, Speakers & Participants!
  49. 49. Thank you, Summit Sponsors!
  50. 50. Thank you, Summit Partners!
  51. 51. To learn more, visit sharpbrains.com

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