VMAT is a new type of intensity-modulated radiation therapy (IMRT) treatment technique that uses the same hardware (i.e. a digital linear accelerator) as used for IMRT or conformal treatment, but delivers the radiotherapy treatment using a rotational or arc geometry rather than several static beams.
This technique uses continuous modulation (i.e. moving the collimator leaves) of the multileaf collimator (MLC) fields, continuous change of the fluence rate (the intensity of the X rays) and gantry rotation speed across a single or multiple 360 degree rotations
1.Stereotactic Radiosurgery (SRS)
SRS is a precise and focused delivery of a single, high dose of irradiation to a small and critically located intracranial volume while sparing normal structure
2.Stereotactic Body Radiation Therapy (SBRT)
SBRT is a treatment procedure similar to SRS, except that it deals extra-cranial radiosurgery
3.Flattening Filter Free (FFF) mode
FFF beam is produced without the use of flattening Filter
In the 1990s, several groups studied about FFF high-energy photon beams. The main interest for that, is to increase the dose rate for radiosurgery or the "physics interest”.
Need of increase in dose rate from traditional 300-600 to 1400-2400MU/min to overcome time-inefficiency and to improve patients comfort specially in SRS/SBRT
Flattening Filter Free (FFF) mode
FFF beam is produced without the use of flattening Filter
In the 1990s, several groups studied about FFF high-energy photon beams. The main interest for that, is to increase the dose rate for radiosurgery or the "physics interest”.
Need of increase in dose rate from traditional 300-600 to 1400-2400MU/min to overcome time-inefficiency and to improve patients comfort specially in SRS/SBRT
A summary of recent innovations in radiation oncology focussing on the priniciples of different techniques and their application. An overview of clinical results has also been given
Robust Challenges of Bladder Protocol management ,Knowledge & UnderstandingSubrata Roy
Bladder protocol is routinely used for patients undergoing pelvic radiation to reduce radiation enteritis. It is very difficult to maintain constant volume, especially in the last two weeks due to radiation enteritis and cystitis
1.Stereotactic Radiosurgery (SRS)
SRS is a precise and focused delivery of a single, high dose of irradiation to a small and critically located intracranial volume while sparing normal structure
2.Stereotactic Body Radiation Therapy (SBRT)
SBRT is a treatment procedure similar to SRS, except that it deals extra-cranial radiosurgery
3.Flattening Filter Free (FFF) mode
FFF beam is produced without the use of flattening Filter
In the 1990s, several groups studied about FFF high-energy photon beams. The main interest for that, is to increase the dose rate for radiosurgery or the "physics interest”.
Need of increase in dose rate from traditional 300-600 to 1400-2400MU/min to overcome time-inefficiency and to improve patients comfort specially in SRS/SBRT
Flattening Filter Free (FFF) mode
FFF beam is produced without the use of flattening Filter
In the 1990s, several groups studied about FFF high-energy photon beams. The main interest for that, is to increase the dose rate for radiosurgery or the "physics interest”.
Need of increase in dose rate from traditional 300-600 to 1400-2400MU/min to overcome time-inefficiency and to improve patients comfort specially in SRS/SBRT
A summary of recent innovations in radiation oncology focussing on the priniciples of different techniques and their application. An overview of clinical results has also been given
Robust Challenges of Bladder Protocol management ,Knowledge & UnderstandingSubrata Roy
Bladder protocol is routinely used for patients undergoing pelvic radiation to reduce radiation enteritis. It is very difficult to maintain constant volume, especially in the last two weeks due to radiation enteritis and cystitis
1.Aim of Radiotherapy
The goal of radiotherapy is to deliver a prescribed dose of radiation to the Target while sparing surrounding Healthy tissues to the largest extent possible
2.Organ Motion
Intra-fraction motion
during the fraction
Heartbeat
Swallowing
Coughing
Eye movement
Inter-fraction motion
- in between the fractions
Tumour change
Weight gain/loss
Positioning deviation
Breathing
Bowel and rectal filling
Bladder filling
Muscle relaxation/tension
3. Respiratory motion affects:
Respiratory motion affects all tumour sites in the thorax, abdomen and Pelvis. Tumours in the Lung, Liver, Pancreas, Oesophagus, Breast, Kidneys, prostate
Tumour displacement varies depending on the site and organ Location
Lung tumours can move several cm in any direction during irradiation
It is most prevalent and prominent in Lung cancers
4. Problems associated with respiratory motion during RT
Image acquisition limitations
Treatment planning limitations
Radiation delivery limitations
5. Methods to Account for Respiratory Motion
1. Motion encompassing methods
2. Respiratory gating methods
3. Breath hold methods
4. Forced shallow breathing with abdominal compression
5. Real-time tumor tracking methods
Summary:
The management of respiratory motion in radiation oncology is an evolving field
IGRT provides a solution for combating organ motion in radiotherapy
Delivering higher dose to tumor and less dose to normal tissue.
Limited clinical studies, needs to be studied further
IGRT – the future of radiotherapy
Introduction
Time dose & fractionation
Therapeutic index
Four R’s Of Radiobiology
Radiation response
Survival Curves Of Early & Late Responding Cells
Various fractionation schedules
Clinical trials of altered fractionation
Radiation Oncology in 21st Century - Changing the ParadigmsApollo Hospitals
Since its inception radiation therapy has been used as one of
the essential treatment options in the management of malignant and some benign tumors. With better understanding of tumor biology many new molecules have been added to the armamentarium of an oncologist. There is continuous improvement in surgical techniques with more emphasis on minimally invasive, organ- and function-preserving techniques. Neoadjuvant chemotherapy with or without addition of radiation therapy has helped surgeon downsizing the tumor and obtaining clearer margins.
1.Aim of Radiotherapy
The goal of radiotherapy is to deliver a prescribed dose of radiation to the Target while sparing surrounding Healthy tissues to the largest extent possible
2.Organ Motion
Intra-fraction motion
during the fraction
Heartbeat
Swallowing
Coughing
Eye movement
Inter-fraction motion
- in between the fractions
Tumour change
Weight gain/loss
Positioning deviation
Breathing
Bowel and rectal filling
Bladder filling
Muscle relaxation/tension
3. Respiratory motion affects:
Respiratory motion affects all tumour sites in the thorax, abdomen and Pelvis. Tumours in the Lung, Liver, Pancreas, Oesophagus, Breast, Kidneys, prostate
Tumour displacement varies depending on the site and organ Location
Lung tumours can move several cm in any direction during irradiation
It is most prevalent and prominent in Lung cancers
4. Problems associated with respiratory motion during RT
Image acquisition limitations
Treatment planning limitations
Radiation delivery limitations
5. Methods to Account for Respiratory Motion
1. Motion encompassing methods
2. Respiratory gating methods
3. Breath hold methods
4. Forced shallow breathing with abdominal compression
5. Real-time tumor tracking methods
Summary:
The management of respiratory motion in radiation oncology is an evolving field
IGRT provides a solution for combating organ motion in radiotherapy
Delivering higher dose to tumor and less dose to normal tissue.
Limited clinical studies, needs to be studied further
IGRT – the future of radiotherapy
Introduction
Time dose & fractionation
Therapeutic index
Four R’s Of Radiobiology
Radiation response
Survival Curves Of Early & Late Responding Cells
Various fractionation schedules
Clinical trials of altered fractionation
Radiation Oncology in 21st Century - Changing the ParadigmsApollo Hospitals
Since its inception radiation therapy has been used as one of
the essential treatment options in the management of malignant and some benign tumors. With better understanding of tumor biology many new molecules have been added to the armamentarium of an oncologist. There is continuous improvement in surgical techniques with more emphasis on minimally invasive, organ- and function-preserving techniques. Neoadjuvant chemotherapy with or without addition of radiation therapy has helped surgeon downsizing the tumor and obtaining clearer margins.
Comparative dosimetry of forward and inverse treatment planning for Intensity...iosrjce
IOSR Journal of Applied Physics (IOSR-JAP) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of physics and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications in applied physics. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Multiparametric Quantitative MRI as a Metric for Radiation Treatment PlanningCrimsonpublishersCancer
Magnetic resonance imaging (MRI) provides excellent soft tissue contrast, and in combination with its quantitative functional imaging capability, this modality is ideal for use in radiotherapy. MRI images, either used directly or fused with CT, play an increasingly important role in contouring gross tumor volume (GTV) and organs at risk (OAR) in radiation treatment planning (RTP) systems. The soft tissue contrast of MRI images provides more accurate tumor delineation than CT, although CT images have sufficient geometrical stability and electron density information for accurate radiation treatment planning. Many vendors now offer 70 cm wide-bore MRI systems with dedicated radiofrequency (RF) coils and immobilization devices for RTP simulation comparable to CT simulators.
A short overview of Image Guided Radiotherapy process in Lung Cancer presented at TMC Kolkata circa 2016. Basic principles and concepts as well as examples are outlined.
Advances of Radiation Oncology in CancManagement: Vision for Role of Theranos...CrimsonpublishersCancer
Significant computational and technological advances in radiation therapy have enhanced our ability to more accurately plan and deliver increasing doses of radiation therapy to limited target volumes in many patients with cancer. Recent developments on magnetic resonance on-line imaging and use of implanted markers allow more precise on-time tumor localization with lower doses delivered to surrounding organs at risk leading to less treatment morbidity. Biological markers and molecular imaging (theranostics) will add new dimensions and precision to radiation therapy techniques. Nanoparticles are promising tools in therapeutic programs. Further research in efficacy, safety, cost utility (value) and institution of robust quality assurance programs will be necessary to optimize these contributions in clinical practice.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Mastering Wealth: A Path to Financial FreedomFatimaMary4
### Understanding Wealth: A Comprehensive Guide
Wealth is a multifaceted concept that extends beyond mere financial assets. It encompasses a range of elements including money, investments, property, and other valuable resources. However, true wealth also includes non-material aspects such as health, relationships, and personal fulfillment. This guide delves into the various dimensions of wealth, exploring how it can be created, sustained, and enjoyed.
#### Defining Wealth
Traditionally, wealth is defined as the abundance of valuable resources or material possessions. It includes financial assets like cash, savings, stocks, bonds, and real estate. However, a broader understanding of wealth considers factors such as personal well-being, emotional health, social connections, and intellectual growth. This holistic view recognizes that true wealth is not solely about accumulating money but also about enhancing one's quality of life.
#### The Importance of Financial Wealth
Financial wealth remains a critical component of overall wealth. It provides security, freedom, and the ability to pursue opportunities. Key elements of financial wealth include:
1. **Savings**: Money set aside for future use. It is crucial for emergencies, large purchases, and financial goals.
2. **Investments**: Assets purchased with the expectation that they will generate income or appreciate over time. Common investments include stocks, bonds, mutual funds, real estate, and businesses.
3. **Income**: Regular earnings from work, investments, or other sources. Consistent income is essential for maintaining and growing wealth.
4. **Debt Management**: Effectively managing debt ensures that it does not erode financial wealth. This includes paying off high-interest debt and using credit wisely.
#### Creating Wealth
Creating wealth involves generating and accumulating financial and non-financial resources. The process can be broken down into several key strategies:
1. Education and Skill Development: Investing in education and skills enhances earning potential. Higher education, professional certifications, and continuous learning can lead to better job opportunities and higher salaries.
2. Entrepreneurship: Starting and running a successful business can be a significant source of wealth. Entrepreneurship requires innovation, risk-taking, and effective management.
3. Investing: Making smart investments is essential for wealth creation. This involves understanding different types of investments, assessing risks, and making informed decisions. Diversifying investments can reduce risk and increase potential returns.
4. Saving and Budgeting: Effective saving and budgeting help accumulate wealth over time. Setting financial goals, creating a budget, and sticking to it are foundational steps in wealth creation.
5. Real Estate: Investing in property can provide rental income and capital appreciation. Real estate is a tangible asset that can hedge against inflation
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
2. OBJECTIVE
INTRODUCTION
EVOLUTION OR HISTORY
DEFINITIONS
PRINCIPLES OF VARIOUS TECHNIQUES
VOLUMETRIC ARCH THERAPY
• PHYSICAL ASPECTS
• ELEKTA MACHINE
• VARIAN
COMPARISM
JOURNAL DISCUSSIONS
CONCLUSION
3. INTRODUCTION
There are two broad categories of radiation therapy; both
are designed to target the tumor precisely while minimizing
exposure to the surrounding, healthy tissue.
In the first category, external beam radiation therapy
(EBRT), the radiation is usually delivered by a machine
called a linear accelerator, or linac.
In the second treatment category, the radiation is
delivered by radioactive material placed inside the body
near the cancer
4. It all started……
RADIATION SOURCES
Early 1900 - Radium was used in various forms.
Mid 1900 – Cobalt therapy with 2-D technique
1971, 3D planning became a possibility and created a
shift from 2-D to 3-D radiation delivery
5. 1980 Shift to IMRT technique (moving MLCs)
presently IMRT is improved to VMAT
Gantry motion
Variable dose rate
Movement of MLCs
6. DEFINITIONS OF TERMS
Three-dimensional (3D) conformal radiation therapy is a
technique where the beams of radiation used in treatment are
shaped to match the tumor.
7. Stereotactic radiotherapy is a way of targeting
radiotherapy very precisely at the tumor, with the
radiotherapy beams
8. Intensity-modulated radiation therapy (IMRT) is an
advanced mode of high-precision radiotherapy that uses
computer-controlled linear accelerators
9. VMAT is a new type of IMRT technique. The
radiotherapy machine rotates around the patient during
treatment
10. PRINCIPLES
3-D CONFORMAL
3-DCRT begins with virtual simulation
Virtual simulation creates a permanent digital file
Scanned images are then linked into treatment planning
software that allows physicians to visualize the treatment area in
three dimensions.
Clinicians input these selections into computer systems that
control treatment delivery.
Elith, C., et al (2011)
11. CONT’
Intensity Modulated Radiation Therapy
IMRT links CT scans to treatment planning software that allows the
cancerous area to be visualized in three dimensions
3DCRT and IMRT differ in how the pattern and volume of radiation
delivered to the tumor is determined.
In IMRT, the physician designates specific doses of radiation
(constraints) that the tumor and normal surrounding tissues should
receive.
A sophisticated computer program is used to develop an
individualized plan to meet the constraints.
This process is termed "inverse treatment planning“.
As a unique feature, it also involves dynamic multi-leaf collimators
(DMLCs)
12. CONT’
Stereotactic
SRS, or stereotactic radiosurgery, is a technique that is most commonly
used for tumors in the brain or spinal column.
Unlike IMRT, SRS is typically delivered in a maximum of five sessions
using higher doses of radiation with each session.
A focused high-intensity beam of radiation is used to target the tumor.
SBRT, or stereotactic body radiation therapy, is a very similar technique to
SRS, but is used for targets that are outside the brain and the spine.
SBRT is most commonly used for targets in the lung, liver, pancreas and
kidney, and is typically delivered in a maximum of five sessions.
13. THE VMAT
VMAT is a new type of intensity-modulated radiation therapy
(IMRT) treatment technique that uses the same hardware (i.e. a
digital linear accelerator) as used for IMRT or conformal
treatment, but delivers the radiotherapy treatment using a
rotational or arc geometry rather than several static beams.
This technique uses continuous modulation (i.e. moving the
collimator leaves) of the multileaf collimator (MLC) fields,
continuous change of the fluence rate (the intensity of the X rays)
and gantry rotation speed across a single or multiple 360 degree
rotations
14.
15.
16. HOW VMAT IS PLANNED
A step-and-shoot treatment plan is created in the
treatment planning system with beams separated
by 10 degrees.
The optimized intensity maps are extracted and
sent to our arc-sequencing algorithm.
The sequencer produces a VMAT plan that is read
back to the planning system for a final
convolution/superposition dose calculation.
17. ADVANTAGES
Conformal dose distribution around
tumor
Avoidance of critical structures and
less local toxicity
Computer-generated optimization
18. DISADVANTAGES
Equipment costs higher
Treatment time often longer
Learning curve can be steep
Additional quality assurance
necessary
Special immobilization required
19.
20. JOURNAL DISCUSSION
O VMAT for node-positive left-sided breast
cancer allows the maximum doses to
organs at risk (the heart) while retaining
target homogeneity and coverage when
compared to IMRT.
Pasler, M. et al (2013)
21. JOURNAL DISCUSSION
O Two other studies conducted on 10 and 9
prostate patients treatment plans shows
VMAT being the most efficient treatment
technique with improved quality when
comparing to 3D-conformal treatments,
providing best OAR sparing especially for
the rectum.
Wolff, D. et al (2009)
Palma, D. et al (2008)
22. JOURNAL DISCUSSION
O Another article comparing VMAT to
stereotactic body radiotherapy (SBRT) in
15 lung cancer patients mention that
faster delivery times, better conformity to
target, sharper dose fall-off in normal
tissues and lower dose to normal lung
than the 3D plans for lung SBRT was
demonstrated VMAT plans.
Zhang, G.G et al (2011)
26. REFERENCE
Pasler, M., Georg, D., Bartelt, S. & Lutterbach, J., (2013) Node-positive
left-sided breast cancer: does VMAT improve treatment plan quality with
respect to IMRT? Strahlentherapie und Onkologie, vol 5, no 189, 380-
386
Onal, C., Arslan, G., Parlak, C. & Sonmez S., (2014) Comparison of
IMRT and VMAT plans with different energy levels using Monte-Carlo
algorithm for prostate cancer. Jpn J Radiol, vol 1, no 32, 224–232
Alvarez-Moret, J., Pohl, F., Koelbl, O. & Dobler, B. (2010) Evaluation of
volumetric modulated arc therapy (VMAT) with Oncentra MasterPlan®
for the treatment of head and neck cancer. Radiation Oncology, Vol 5,
no 110
27. REFERENCE
Wolff a, D., Stieler, F., Welzel, G., Lorenz, F., Abo-Madyan , Y., Mai, S.,
Herskind, C., Polednik, M., Steil, V., Wenz, F. & Lohr, F., (2009) Volumetric
modulated arc therapy (VMAT) vs. serial tomotherapy, step-and-shoot
IMRT and 3D-conformal RT for treatment of prostate cancer.
Radiotherapy and Oncology, vol 1, no 93, 226-233
Palma, D., Vollans, E., James, K., Nakano, S., Moiseenko, V., Shaffer,
R., Mckenzie, M., Morris, J. & Otto, K., (2008) Volumetric modulated arc
therapy for delivery of prostate radiotherapy: comparison with intensity
modulated radiotherapy and 3D-conformal radiotherapy. Radiation
Oncology, Vol. 72, No. 4, 996–1001.
Elith, C.,Dempsey, S.E.,Findlay, L.,Warren-Forward, H.M.,
(2011) An Introduction to the Intensity-modulated Radiation Therapy
(IMRT) Techniques, Tomotherapy, and VMAT. Journal of Medical
Imaging and Radiation Science,vol 1,no. 42,37-43
28. REFERENCES
Zhang, G.G., Ku, L., Thomas J Dilling, T.J., Stevens, C.W., Ray R Zhang,
R.R., Li, W., & Vladimir Feygelman V., (2011) Volumetric modulated arc
planning for lung stereotactic body radiotherapy using conventional and
unflattened photon beams: a dosimetric comparison with 3D technique.
Radiation Oncology, vol 6, no 152
Huang, C., (2012) Treatment of Multiple Brain Metastases Using
Stereotactic Radiosurgery with Single-Isocenter Volumetric Modulated
Arc Therapy: Comparison with Conventional Dynamic Conformal Arc and
Static Beam Stereotactic Radiosurgery. Radiation Oncology. vol 1