YOLO (You Only Look Once) is a real-time object detection system that frames object detection as a regression problem. It uses a single neural network that predicts bounding boxes and class probabilities directly from full images in one evaluation. This approach allows YOLO to process images and perform object detection over 45 frames per second while maintaining high accuracy compared to previous systems. YOLO was trained on natural images from PASCAL VOC and can generalize to new domains like artwork without significant degradation in performance, unlike other methods that struggle with domain shift.