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Wound healing (cutaneous)
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- 3. SEMANTICS OF WOUNDHEALING • • • 3-4 • 4-6
- 5. PHASES OF WOUNDHEALING • • •
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- 7. Fibrillar collagen and Tissuefactor Platelet aggregation Provisional matrix Neutrophils (48 hrs) Monocytes/ Macrophages (48-72 hrs) Lymphocytes (5-7 days) Coagulation cascade Scaffold for cell recruitment Remove dead tissue. Prevent infection.
- 10. PROLIFERATIVE PHASE (DAY4-21) • • •
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- 12. GRANULATION TISSUE • • ECMFORMATION AND ANGIOGENESIS • •
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- 15. PROLIFERATION – SWITCH OFF REMODELLING– SWITCH ON
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- 21. RECOVERY OF STRENGTH • •COLLAGEN DEGRADATION VS SYNTHESIS • CROSS LINKING • • •
- 24. FACTORS AFFECTING WOUNDHEALING SYSTEMIC FACTORS LOCAL FACTORS Age Obesity Smoking Nutrition Anemia Diabetes Malignancy Immunosupressive diseases Circulatory status Steroids/cytotoxic drugs Infections Mechanical factors Foreign bodies Venous or lymph stasis Hematoma Location of wound Size of wound Recurrent trauma Underlying disease like osteomyelitis/malignancy
- 25. PATHOLOGICAL ASPECTS OFREPAIR 1. 2. 3.
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- 27. EXCESSIVE FORMATION OFREPAIR PROCESS • • •
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